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Current Osteoporosis Reports

PET/CT for the Opportunistic Screening of Osteoporosis and Fractures in Cancer Patients

Published in:
Authors
Peter Sang Uk Park
Thomas J. Werner
Abass Alavi
Published in
Current Osteoporosis Reports | Issue 6/2024

Abstract

Purpose of Review

In this review, we outline the different etiologies of osteoporosis in the oncologic setting and describe the basis for using PET/CT as screening tool for osteoporosis with a focus on the radiotracers [18F]FDG and [18F]NaF.

Recent Findings

Osteoporosis is a condition commonly affecting cancer patients due to their age, cancer-specific treatment agents, and effects of cancer. In terms of the unifying mechanism, decreased ratio of osteoblast-bone formation to osteoclast-bone resorption is responsible for causing osteoporosis. PET/CT, a crucial metabolic imaging modality in the oncologic imaging, could be a useful tool for the opportunistic screening of osteoporosis.

Summary

There are two approaches with which osteoporosis could be identified with PET/CT—using either the (1) CT- based or (2) PET- based approaches. While the CT-based approach has been used with [18F]FDG PET/CT, both CT- and PET-based approaches can be employed with [18F]NaF-PET/CT as [18F]NaF is a radiotracer specific for osteoblast activity.
Title
PET/CT for the Opportunistic Screening of Osteoporosis and Fractures in Cancer Patients
Authors
Peter Sang Uk Park
Thomas J. Werner
Abass Alavi
Publication date
14-09-2024
Publisher
Springer US
Published in
Current Osteoporosis Reports / Issue 6/2024
Print ISSN: 1544-1873
Electronic ISSN: 1544-2241
DOI
https://doi.org/10.1007/s11914-024-00887-x
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