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13-09-2024 | Osteoporosis | Review

Dairy and Exercise for Bone Health: Evidence from Randomized Controlled Trials and Recommendations for Future Research

Authors: Nicholas Cheng, Andrea R. Josse

Published in: Current Osteoporosis Reports

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Abstract

Purpose of Review

To examine evidence from randomized controlled trials (RCTs) on how modifiable factors such as exercise and nutrition, with a focus on dairy products, play a role in improving bone health across the lifespan.

Recent Findings

Meta-analyses of RCTs demonstrate the advantages of consuming dairy products to improve bone mineral density/content (BMD/BMC) and markers of bone metabolism and turnover (BTMs). Eighteen RCTs were conducted investigating the combined effects of dairy and exercise, with most indicating a benefit in youth and adult populations. Results were less conclusive in older adults, perhaps due to altered requirements for dairy/nutrients and exercise with increased age.  

Summary

RCTs demonstrate that dairy product consumption alone benefits bone health and can enhance the effects of exercise on bone. This may help improve skeletal growth and development in adolescence and prevent osteoporosis with increased age. Future RCTs should account for habitual nutrient intakes, and dairy dosage, timing, and matrix effects.
Literature
1.
go back to reference Sözen T, Özışık L, Başaran NÇ. An overview and management of osteoporosis. Eur J Rheumatol. 2017;4(1):46–56.PubMedCrossRef Sözen T, Özışık L, Başaran NÇ. An overview and management of osteoporosis. Eur J Rheumatol. 2017;4(1):46–56.PubMedCrossRef
2.
4.
go back to reference Rizzoli R. Nutritional aspects of bone health. Best Pract Res Clin Endocrinol Metab. 2014;28(6):795–808.PubMedCrossRef Rizzoli R. Nutritional aspects of bone health. Best Pract Res Clin Endocrinol Metab. 2014;28(6):795–808.PubMedCrossRef
5.
go back to reference Huth PJ, DiRienzo DB, Miller GD. Major Scientific Advances with Dairy Foods in Nutrition and Health. J Dairy Sci. 2006;89(4):1207–21.PubMedCrossRef Huth PJ, DiRienzo DB, Miller GD. Major Scientific Advances with Dairy Foods in Nutrition and Health. J Dairy Sci. 2006;89(4):1207–21.PubMedCrossRef
6.
go back to reference Weaver CM, Gordon CM, Janz KF, Kalkwarf HJ, Lappe JM, Lewis R, et al. The National Osteoporosis Foundation’s position statement on peak bone mass development and lifestyle factors: a systematic review and implementation recommendations. Osteoporos Int. 2016;27(4):1281–386.PubMedPubMedCentralCrossRef Weaver CM, Gordon CM, Janz KF, Kalkwarf HJ, Lappe JM, Lewis R, et al. The National Osteoporosis Foundation’s position statement on peak bone mass development and lifestyle factors: a systematic review and implementation recommendations. Osteoporos Int. 2016;27(4):1281–386.PubMedPubMedCentralCrossRef
7.
go back to reference Bonjour JP. Dietary Protein: An Essential Nutrient For Bone Health. J Am Coll Nutr. 2005;24(sup6):526S-536S.PubMedCrossRef Bonjour JP. Dietary Protein: An Essential Nutrient For Bone Health. J Am Coll Nutr. 2005;24(sup6):526S-536S.PubMedCrossRef
8.
go back to reference Zhang L, Zheng YL, Wang R, Wang XQ, Zhang H. Exercise for osteoporosis: A literature review of pathology and mechanism. Front Immunol. 2022;13:1005665.PubMedPubMedCentralCrossRef Zhang L, Zheng YL, Wang R, Wang XQ, Zhang H. Exercise for osteoporosis: A literature review of pathology and mechanism. Front Immunol. 2022;13:1005665.PubMedPubMedCentralCrossRef
9.
go back to reference Chang X, Xu S, Zhang H. Regulation of bone health through physical exercise: Mechanisms and types. Front Endocrinol. 2022;7(13):1029475.CrossRef Chang X, Xu S, Zhang H. Regulation of bone health through physical exercise: Mechanisms and types. Front Endocrinol. 2022;7(13):1029475.CrossRef
12.
13.
go back to reference Rizzoli R, Biver E. Effects of Fermented Milk Products on Bone. Calcif Tissue Int. 2018;102(4):489–500.PubMedCrossRef Rizzoli R, Biver E. Effects of Fermented Milk Products on Bone. Calcif Tissue Int. 2018;102(4):489–500.PubMedCrossRef
15.
go back to reference Nih Consensus Development Panel On Osteoporosis Prevention, Diagnosis, And Therapy. Osteoporosis Prevention, Diagnosis, and Therapy. JAMA J Am Med Assoc. 2001 Feb 14;285(6):785–95 Nih Consensus Development Panel On Osteoporosis Prevention, Diagnosis, And Therapy. Osteoporosis Prevention, Diagnosis, and Therapy. JAMA J Am Med Assoc. 2001 Feb 14;285(6):785–95
16.
go back to reference Azzolino D, Spolidoro GCI, Saporiti E, Luchetti C, Agostoni C, Cesari M. Musculoskeletal Changes Across the Lifespan: Nutrition and the Life-Course Approach to Prevention. Front Med. 2021;31(8):697954.CrossRef Azzolino D, Spolidoro GCI, Saporiti E, Luchetti C, Agostoni C, Cesari M. Musculoskeletal Changes Across the Lifespan: Nutrition and the Life-Course Approach to Prevention. Front Med. 2021;31(8):697954.CrossRef
17.
go back to reference Bailey DA, Mckay HA, Mirwald RL, Crocker PRE, Faulkner RA. A Six-Year Longitudinal Study of the Relationship of Physical Activity to Bone Mineral Accrual in Growing Children: The University of Saskatchewan Bone Mineral Accrual Study. J Bone Miner Res. 1999;14(10):1672–9.PubMedCrossRef Bailey DA, Mckay HA, Mirwald RL, Crocker PRE, Faulkner RA. A Six-Year Longitudinal Study of the Relationship of Physical Activity to Bone Mineral Accrual in Growing Children: The University of Saskatchewan Bone Mineral Accrual Study. J Bone Miner Res. 1999;14(10):1672–9.PubMedCrossRef
18.
go back to reference Rizzoli R, Bianchi ML, Garabédian M, McKay HA, Moreno LA. Maximizing bone mineral mass gain during growth for the prevention of fractures in the adolescents and the elderly. Bone. 2010;46(2):294–305.PubMedCrossRef Rizzoli R, Bianchi ML, Garabédian M, McKay HA, Moreno LA. Maximizing bone mineral mass gain during growth for the prevention of fractures in the adolescents and the elderly. Bone. 2010;46(2):294–305.PubMedCrossRef
19.
go back to reference Heaney RP, Abrams S, Dawson-Hughes B, Looker A, Looker A, Marcus R, et al. Peak Bone Mass. Osteoporos Int. 2000;11(12):985–1009.PubMedCrossRef Heaney RP, Abrams S, Dawson-Hughes B, Looker A, Looker A, Marcus R, et al. Peak Bone Mass. Osteoporos Int. 2000;11(12):985–1009.PubMedCrossRef
20.
go back to reference Schönau E. The peak bone mass concept: is it still relevant? Pediatr Nephrol. 2004;19(8):825–31.PubMedCrossRef Schönau E. The peak bone mass concept: is it still relevant? Pediatr Nephrol. 2004;19(8):825–31.PubMedCrossRef
23.
go back to reference Khosla S, Oursler MJ, Monroe DG. Estrogen and the skeleton. Trends Endocrinol Metab TEM. 2012;23(11):576–81.PubMedCrossRef Khosla S, Oursler MJ, Monroe DG. Estrogen and the skeleton. Trends Endocrinol Metab TEM. 2012;23(11):576–81.PubMedCrossRef
24.
go back to reference Klentrou P, Kouvelioti R. Biochemistry of Exercise Training: Effects on Bone. In: Tiidus PM, MacPherson REK, LeBlanc PJ, Josse AR, editors. The Routledge Handbook on Biochemistry of Exercise [Internet]. 1st ed. Routledge; 2020 [cited 2024 May 26]. p. 513–31. https://doi.org/10.4324/9781003123835-32 Klentrou P, Kouvelioti R. Biochemistry of Exercise Training: Effects on Bone. In: Tiidus PM, MacPherson REK, LeBlanc PJ, Josse AR, editors. The Routledge Handbook on Biochemistry of Exercise [Internet]. 1st ed. Routledge; 2020 [cited 2024 May 26]. p. 513–31. https://​doi.​org/​10.​4324/​9781003123835-32
26.
go back to reference Lorentzon M, Cummings SR. Osteoporosis: the evolution of a diagnosis. J Intern Med. 2015;277(6):650–61.PubMedCrossRef Lorentzon M, Cummings SR. Osteoporosis: the evolution of a diagnosis. J Intern Med. 2015;277(6):650–61.PubMedCrossRef
27.
go back to reference Genant HK, Cooper C, Poor G, Reid I, Ehrlich G, Kanis J, et al. Interim Report and Recommendations of the World Health Organization Task-Force for Osteoporosis. Osteoporos Int. 1999;10(4):259–64.PubMedCrossRef Genant HK, Cooper C, Poor G, Reid I, Ehrlich G, Kanis J, et al. Interim Report and Recommendations of the World Health Organization Task-Force for Osteoporosis. Osteoporos Int. 1999;10(4):259–64.PubMedCrossRef
28.
go back to reference Lorentzon M, Johansson H, Harvey NC, Liu E, Vandenput L, McCloskey EV, et al. Osteoporosis and fractures in women: the burden of disease. Climacteric. 2022;25(1):4–10.PubMedCrossRef Lorentzon M, Johansson H, Harvey NC, Liu E, Vandenput L, McCloskey EV, et al. Osteoporosis and fractures in women: the burden of disease. Climacteric. 2022;25(1):4–10.PubMedCrossRef
29.
go back to reference Hopkins RB, Burke N, Von Keyserlingk C, Leslie WD, Morin SN, Adachi JD, et al. The current economic burden of illness of osteoporosis in Canada. Osteoporos Int. 2016;27(10):3023–32.PubMedPubMedCentralCrossRef Hopkins RB, Burke N, Von Keyserlingk C, Leslie WD, Morin SN, Adachi JD, et al. The current economic burden of illness of osteoporosis in Canada. Osteoporos Int. 2016;27(10):3023–32.PubMedPubMedCentralCrossRef
31.
go back to reference Svedbom A, Ivergård M, Hernlund E, Rizzoli R, Kanis JA. Epidemiology and economic burden of osteoporosis in Switzerland. Arch Osteoporos. 2014;9:187.PubMedCrossRef Svedbom A, Ivergård M, Hernlund E, Rizzoli R, Kanis JA. Epidemiology and economic burden of osteoporosis in Switzerland. Arch Osteoporos. 2014;9:187.PubMedCrossRef
32.
go back to reference Aziziyeh R, Amin M, Habib M, Garcia Perlaza J, Szafranski K, McTavish RK, et al. The burden of osteoporosis in four Latin American countries: Brazil, Mexico, Colombia, and Argentina. J Med Econ. 2019;22(7):638–44.PubMedCrossRef Aziziyeh R, Amin M, Habib M, Garcia Perlaza J, Szafranski K, McTavish RK, et al. The burden of osteoporosis in four Latin American countries: Brazil, Mexico, Colombia, and Argentina. J Med Econ. 2019;22(7):638–44.PubMedCrossRef
33.
go back to reference Klentrou P. Influence of Exercise and Training on Critical Stages of Bone Growth and Development. Pediatr Exerc Sci. 2016;28(2):178–86.PubMedCrossRef Klentrou P. Influence of Exercise and Training on Critical Stages of Bone Growth and Development. Pediatr Exerc Sci. 2016;28(2):178–86.PubMedCrossRef
34.
go back to reference Hannan MT, Tucker KL, Dawson-Hughes B, Cupples LA, Felson DT, Kiel DP. Effect of Dietary Protein on Bone Loss in Elderly Men and Women: The Framingham Osteoporosis Study. J Bone Miner Res. 2000;15(12):2504–12.PubMedCrossRef Hannan MT, Tucker KL, Dawson-Hughes B, Cupples LA, Felson DT, Kiel DP. Effect of Dietary Protein on Bone Loss in Elderly Men and Women: The Framingham Osteoporosis Study. J Bone Miner Res. 2000;15(12):2504–12.PubMedCrossRef
35.
go back to reference Alexy U, Remer T, Manz F, Neu CM, Schoenau E. Long-term protein intake and dietary potential renal acid load are associated with bone modeling and remodeling at the proximal radius in healthy children. Am J Clin Nutr. 2005;82(5):1107–14.PubMedCrossRef Alexy U, Remer T, Manz F, Neu CM, Schoenau E. Long-term protein intake and dietary potential renal acid load are associated with bone modeling and remodeling at the proximal radius in healthy children. Am J Clin Nutr. 2005;82(5):1107–14.PubMedCrossRef
36.
go back to reference Promislow JHE, Goodman-Gruen D, Slymen DJ, Barrett-Connor E. Protein Consumption and Bone Mineral Density in the Elderly : The Rancho Bernardo Study. Am J Epidemiol. 2002;155(7):636–44.PubMedCrossRef Promislow JHE, Goodman-Gruen D, Slymen DJ, Barrett-Connor E. Protein Consumption and Bone Mineral Density in the Elderly : The Rancho Bernardo Study. Am J Epidemiol. 2002;155(7):636–44.PubMedCrossRef
37.
go back to reference Cao JJ. High Dietary Protein Intake and Protein-Related Acid Load on Bone Health. Curr Osteoporos Rep. 2017;15(6):571–6.PubMedCrossRef Cao JJ. High Dietary Protein Intake and Protein-Related Acid Load on Bone Health. Curr Osteoporos Rep. 2017;15(6):571–6.PubMedCrossRef
38.
go back to reference Crowe FL, Key TJ, Allen NE, Appleby PN, Roddam A, Overvad K, et al. The Association between Diet and Serum Concentrations of IGF-I, IGFBP-1, IGFBP-2, and IGFBP-3 in the European Prospective Investigation into Cancer and Nutrition. Cancer Epidemiol Biomarkers Prev. 2009;18(5):1333–40.PubMedCrossRef Crowe FL, Key TJ, Allen NE, Appleby PN, Roddam A, Overvad K, et al. The Association between Diet and Serum Concentrations of IGF-I, IGFBP-1, IGFBP-2, and IGFBP-3 in the European Prospective Investigation into Cancer and Nutrition. Cancer Epidemiol Biomarkers Prev. 2009;18(5):1333–40.PubMedCrossRef
39.
go back to reference Bonjour JP. The dietary protein, IGF-I, skeletal health axis. Horm Mol Biol Clin Investig. 2016;28(1):39–53.PubMedCrossRef Bonjour JP. The dietary protein, IGF-I, skeletal health axis. Horm Mol Biol Clin Investig. 2016;28(1):39–53.PubMedCrossRef
40.
go back to reference Florencio-Silva R, Sasso GRDS, Sasso-Cerri E, Simões MJ, Cerri PS. Biology of Bone Tissue: Structure, Function, and Factors That Influence Bone Cells. BioMed Res Int. 2015;2015:1–17.CrossRef Florencio-Silva R, Sasso GRDS, Sasso-Cerri E, Simões MJ, Cerri PS. Biology of Bone Tissue: Structure, Function, and Factors That Influence Bone Cells. BioMed Res Int. 2015;2015:1–17.CrossRef
41.
go back to reference Bonjour JP, Schüren MA, Chevalley T, Ammann P, Rizzoli R. Protein intake, IGF-1 and osteoporosis. Osteoporos Int. 1997;7(3):36–42.CrossRef Bonjour JP, Schüren MA, Chevalley T, Ammann P, Rizzoli R. Protein intake, IGF-1 and osteoporosis. Osteoporos Int. 1997;7(3):36–42.CrossRef
42.
go back to reference Tahimic CGT, Wang Y, Bikle DD. Anabolic effects of IGF-1 signaling on the skeleton. Front Endocrinol. 2013;4:6.CrossRef Tahimic CGT, Wang Y, Bikle DD. Anabolic effects of IGF-1 signaling on the skeleton. Front Endocrinol. 2013;4:6.CrossRef
43.
go back to reference Masuyama R, Nakaya Y, Katsumata S, Kajita Y, Uehara M, Tanaka S, et al. Dietary Calcium and Phosphorus Ratio Regulates Bone Mineralization and Turnover in Vitamin D Receptor Knockout Mice by Affecting Intestinal Calcium and Phosphorus Absorption. J Bone Miner Res. 2003;18(7):1217–26.PubMedCrossRef Masuyama R, Nakaya Y, Katsumata S, Kajita Y, Uehara M, Tanaka S, et al. Dietary Calcium and Phosphorus Ratio Regulates Bone Mineralization and Turnover in Vitamin D Receptor Knockout Mice by Affecting Intestinal Calcium and Phosphorus Absorption. J Bone Miner Res. 2003;18(7):1217–26.PubMedCrossRef
45.
go back to reference BabićLeko M, Pleić N, Gunjača I, Zemunik T. Environmental Factors That Affect Parathyroid Hormone and Calcitonin Levels. Int J Mol Sci. 2022;23(1):44.CrossRef BabićLeko M, Pleić N, Gunjača I, Zemunik T. Environmental Factors That Affect Parathyroid Hormone and Calcitonin Levels. Int J Mol Sci. 2022;23(1):44.CrossRef
46.
go back to reference Blaine J, Chonchol M, Levi M. Renal Control of Calcium, Phosphate, and Magnesium Homeostasis. Clin J Am Soc Nephrol. 2015;10(7):1257–72.PubMedCrossRef Blaine J, Chonchol M, Levi M. Renal Control of Calcium, Phosphate, and Magnesium Homeostasis. Clin J Am Soc Nephrol. 2015;10(7):1257–72.PubMedCrossRef
47.
go back to reference Moor MB, Bonny O. Ways of calcium reabsorption in the kidney. Am J Physiol-Ren Physiol. 2016;310(11):F1337–50.CrossRef Moor MB, Bonny O. Ways of calcium reabsorption in the kidney. Am J Physiol-Ren Physiol. 2016;310(11):F1337–50.CrossRef
50.
go back to reference Itkonen ST, Erkkola M, Lamberg-Allardt CJE. Vitamin D Fortification of Fluid Milk Products and Their Contribution to Vitamin D Intake and Vitamin D Status in Observational Studies-A Review. Nutrients. 2018;10(8):1054.PubMedPubMedCentralCrossRef Itkonen ST, Erkkola M, Lamberg-Allardt CJE. Vitamin D Fortification of Fluid Milk Products and Their Contribution to Vitamin D Intake and Vitamin D Status in Observational Studies-A Review. Nutrients. 2018;10(8):1054.PubMedPubMedCentralCrossRef
53.
go back to reference Laird E, Ward M, McSorley E, Strain JJ, Wallace J. Vitamin D and Bone Health. Potential Mechanisms Nutrients. 2010;2(7):693–724.PubMedCrossRef Laird E, Ward M, McSorley E, Strain JJ, Wallace J. Vitamin D and Bone Health. Potential Mechanisms Nutrients. 2010;2(7):693–724.PubMedCrossRef
58.
go back to reference Rizzoli R, Biver E, Bonjour JP, Coxam V, Goltzman D, Kanis JA, et al. Benefits and safety of dietary protein for bone health—an expert consensus paper endorsed by the European Society for Clinical and Economical Aspects of Osteopororosis, Osteoarthritis, and Musculoskeletal Diseases and by the International Osteoporosis Foundation. Osteoporos Int. 2018;29(9):1933–48.PubMedCrossRef Rizzoli R, Biver E, Bonjour JP, Coxam V, Goltzman D, Kanis JA, et al. Benefits and safety of dietary protein for bone health—an expert consensus paper endorsed by the European Society for Clinical and Economical Aspects of Osteopororosis, Osteoarthritis, and Musculoskeletal Diseases and by the International Osteoporosis Foundation. Osteoporos Int. 2018;29(9):1933–48.PubMedCrossRef
59.
go back to reference Dawson-Hughes B, Harris SS. Calcium intake influences the association of protein intake with rates of bone loss in elderly men and women. Am J Clin Nutr. 2002;75(4):773–9.PubMedCrossRef Dawson-Hughes B, Harris SS. Calcium intake influences the association of protein intake with rates of bone loss in elderly men and women. Am J Clin Nutr. 2002;75(4):773–9.PubMedCrossRef
60.
go back to reference Thorpe DL, Beeson WL, Knutsen R, Fraser GE, Knutsen SF. Dietary patterns and hip fracture in the Adventist Health Study 2: combined vitamin D and calcium supplementation mitigate increased hip fracture risk among vegans. Am J Clin Nutr. 2021;114(2):488–95.PubMedPubMedCentralCrossRef Thorpe DL, Beeson WL, Knutsen R, Fraser GE, Knutsen SF. Dietary patterns and hip fracture in the Adventist Health Study 2: combined vitamin D and calcium supplementation mitigate increased hip fracture risk among vegans. Am J Clin Nutr. 2021;114(2):488–95.PubMedPubMedCentralCrossRef
62.
go back to reference Caroli A, Poli A, Ricotta D, Banfi G, Cocchi D. Invited review: Dairy intake and bone health: A viewpoint from the state of the art. J Dairy Sci. 2011;94(11):5249–62.PubMedCrossRef Caroli A, Poli A, Ricotta D, Banfi G, Cocchi D. Invited review: Dairy intake and bone health: A viewpoint from the state of the art. J Dairy Sci. 2011;94(11):5249–62.PubMedCrossRef
63.
go back to reference Melse-Boonstra A. Bioavailability of Micronutrients From Nutrient-Dense Whole Foods: Zooming in on Dairy, Vegetables, and Fruits. Front Nutr. 2020;24(7):101.CrossRef Melse-Boonstra A. Bioavailability of Micronutrients From Nutrient-Dense Whole Foods: Zooming in on Dairy, Vegetables, and Fruits. Front Nutr. 2020;24(7):101.CrossRef
64.
go back to reference Davoodi SH, Shahbazi R, Esmaeili S, Sohrabvandi S, Mortazavian A, Jazayeri S, et al. Health-Related Aspects of Milk Proteins. 2016 Davoodi SH, Shahbazi R, Esmaeili S, Sohrabvandi S, Mortazavian A, Jazayeri S, et al. Health-Related Aspects of Milk Proteins. 2016
65.
go back to reference Ye A. Gastric colloidal behaviour of milk protein as a tool for manipulating nutrient digestion in dairy products and protein emulsions. Food Hydrocoll. 2021;115:106599.CrossRef Ye A. Gastric colloidal behaviour of milk protein as a tool for manipulating nutrient digestion in dairy products and protein emulsions. Food Hydrocoll. 2021;115:106599.CrossRef
66.
go back to reference Thorning TK, Bertram HC, Bonjour JP, De Groot L, Dupont D, Feeney E, et al. Whole dairy matrix or single nutrients in assessment of health effects: current evidence and knowledge gaps. Am J Clin Nutr. 2017;105(5):1033–45.PubMedCrossRef Thorning TK, Bertram HC, Bonjour JP, De Groot L, Dupont D, Feeney E, et al. Whole dairy matrix or single nutrients in assessment of health effects: current evidence and knowledge gaps. Am J Clin Nutr. 2017;105(5):1033–45.PubMedCrossRef
67.
go back to reference Brown JK, Perry CGR, Prior ET, Phillips SM, Skelly LE, Josse AR. Differential plasma branched-chain amino acid responses following the consumption of Greek-style yogurt and skimmed milk. Appl Physiol Nutr Metab. 2023;48(7):544–9.PubMedCrossRef Brown JK, Perry CGR, Prior ET, Phillips SM, Skelly LE, Josse AR. Differential plasma branched-chain amino acid responses following the consumption of Greek-style yogurt and skimmed milk. Appl Physiol Nutr Metab. 2023;48(7):544–9.PubMedCrossRef
69.
go back to reference Viljakainen HT. Factors influencing bone mass accrual: focus on nutritional aspects. Proc Nutr Soc. 2016;75(3):415–9.PubMedCrossRef Viljakainen HT. Factors influencing bone mass accrual: focus on nutritional aspects. Proc Nutr Soc. 2016;75(3):415–9.PubMedCrossRef
70.
go back to reference Mozaffarian D, Ludwig DS. Dietary Guidelines in the 21st Century—a Time for Food. JAMA. 2010;304(6):681–2.PubMedCrossRef Mozaffarian D, Ludwig DS. Dietary Guidelines in the 21st Century—a Time for Food. JAMA. 2010;304(6):681–2.PubMedCrossRef
71.
go back to reference Ma DF, Zheng W, Ding M, Zhang YM, Wang PY. Milk intake increases bone mineral content through inhibiting bone resorption: Meta-analysis of randomized controlled trials. E-SPEN J. 2013;8(1):e1-7.CrossRef Ma DF, Zheng W, Ding M, Zhang YM, Wang PY. Milk intake increases bone mineral content through inhibiting bone resorption: Meta-analysis of randomized controlled trials. E-SPEN J. 2013;8(1):e1-7.CrossRef
72.
go back to reference Hidayat K, Zhang LL, Rizzoli R, Guo YX, Zhou Y, Shi YJ, et al. The Effects of Dairy Product Supplementation on Bone Health Indices in Children Aged 3 to 18 Years: A Meta-Analysis of Randomized Controlled Trials. Adv Nutr. 2023;14(5):1187–96.PubMedPubMedCentralCrossRef Hidayat K, Zhang LL, Rizzoli R, Guo YX, Zhou Y, Shi YJ, et al. The Effects of Dairy Product Supplementation on Bone Health Indices in Children Aged 3 to 18 Years: A Meta-Analysis of Randomized Controlled Trials. Adv Nutr. 2023;14(5):1187–96.PubMedPubMedCentralCrossRef
73.
go back to reference Huncharek M, Muscat J, Kupelnick B. Impact of dairy products and dietary calcium on bone-mineral content in children: Results of a meta-analysis. Bone. 2008;43(2):312–21.PubMedCrossRef Huncharek M, Muscat J, Kupelnick B. Impact of dairy products and dietary calcium on bone-mineral content in children: Results of a meta-analysis. Bone. 2008;43(2):312–21.PubMedCrossRef
74.
go back to reference Hidayat K, Chen JS, Wang TC, Liu YJ, Shi YJ, Su HW, et al. The Effects of Milk Supplementation on Bone Health Indices in Adults: A Meta-Analysis of Randomized Controlled Trials. Adv Nutr. 2022;13(4):1186–99.PubMedCrossRef Hidayat K, Chen JS, Wang TC, Liu YJ, Shi YJ, Su HW, et al. The Effects of Milk Supplementation on Bone Health Indices in Adults: A Meta-Analysis of Randomized Controlled Trials. Adv Nutr. 2022;13(4):1186–99.PubMedCrossRef
75.
go back to reference Tai V, Leung W, Grey A, Reid IR, Bolland MJ. Calcium intake and bone mineral density: systematic review and meta-analysis. BMJ. 2015;29:h4183.CrossRef Tai V, Leung W, Grey A, Reid IR, Bolland MJ. Calcium intake and bone mineral density: systematic review and meta-analysis. BMJ. 2015;29:h4183.CrossRef
76.
go back to reference Shi Y, Zhan Y, Chen Y, Jiang Y. Effects of dairy products on bone mineral density in healthy postmenopausal women: a systematic review and meta-analysis of randomized controlled trials. Arch Osteoporos. 2020;15(1):48.PubMedCrossRef Shi Y, Zhan Y, Chen Y, Jiang Y. Effects of dairy products on bone mineral density in healthy postmenopausal women: a systematic review and meta-analysis of randomized controlled trials. Arch Osteoporos. 2020;15(1):48.PubMedCrossRef
77.
go back to reference Shams-White MM, Chung M, Du M, Fu Z, Insogna KL, Karlsen MC, et al. Dietary protein and bone health: a systematic review and meta-analysis from the National Osteoporosis Foundation. Am J Clin Nutr. 2017;105(6):1528–43.PubMedCrossRef Shams-White MM, Chung M, Du M, Fu Z, Insogna KL, Karlsen MC, et al. Dietary protein and bone health: a systematic review and meta-analysis from the National Osteoporosis Foundation. Am J Clin Nutr. 2017;105(6):1528–43.PubMedCrossRef
78.
go back to reference Wallace TC, Frankenfeld CL. Dietary Protein Intake above the Current RDA and Bone Health: A Systematic Review and Meta-Analysis. J Am Coll Nutr. 2017;36(6):481–96.PubMedCrossRef Wallace TC, Frankenfeld CL. Dietary Protein Intake above the Current RDA and Bone Health: A Systematic Review and Meta-Analysis. J Am Coll Nutr. 2017;36(6):481–96.PubMedCrossRef
79.
go back to reference Langsetmo L, Shikany JM, Cawthon PM, Cauley JA, Taylor BC, Vo TN, et al. The Association Between Protein Intake by Source and Osteoporotic Fracture in Older Men: A Prospective Cohort Study. J Bone Miner Res Off J Am Soc Bone Miner Res. 2017;32(3):592–600.CrossRef Langsetmo L, Shikany JM, Cawthon PM, Cauley JA, Taylor BC, Vo TN, et al. The Association Between Protein Intake by Source and Osteoporotic Fracture in Older Men: A Prospective Cohort Study. J Bone Miner Res Off J Am Soc Bone Miner Res. 2017;32(3):592–600.CrossRef
80.
go back to reference Langsetmo L, Barr SI, Berger C, Kreiger N, Rahme E, Adachi JD, et al. Associations of Protein Intake and Protein Source with Bone Mineral Density and Fracture Risk: A Population-Based Cohort Study. J Nutr Health Aging. 2015;19(8):861–8.PubMedPubMedCentralCrossRef Langsetmo L, Barr SI, Berger C, Kreiger N, Rahme E, Adachi JD, et al. Associations of Protein Intake and Protein Source with Bone Mineral Density and Fracture Risk: A Population-Based Cohort Study. J Nutr Health Aging. 2015;19(8):861–8.PubMedPubMedCentralCrossRef
81.
go back to reference Weaver AA, Tooze JA, Cauley JA, Bauer DC, Tylavsky FA, Kritchevsky SB, et al. Effect of Dietary Protein Intake on Bone Mineral Density and Fracture Incidence in Older Adults in the Health, Aging, and Body Composition Study. J Gerontol A Biol Sci Med Sci. 2021;76(12):2213–22.PubMedPubMedCentralCrossRef Weaver AA, Tooze JA, Cauley JA, Bauer DC, Tylavsky FA, Kritchevsky SB, et al. Effect of Dietary Protein Intake on Bone Mineral Density and Fracture Incidence in Older Adults in the Health, Aging, and Body Composition Study. J Gerontol A Biol Sci Med Sci. 2021;76(12):2213–22.PubMedPubMedCentralCrossRef
82.
go back to reference Groenendijk I, den Boeft L, van Loon LJC, de Groot LCPGM. High Versus low Dietary Protein Intake and Bone Health in Older Adults: a Systematic Review and Meta-Analysis. Comput Struct Biotechnol J. 2019;17:1101–12.PubMedPubMedCentralCrossRef Groenendijk I, den Boeft L, van Loon LJC, de Groot LCPGM. High Versus low Dietary Protein Intake and Bone Health in Older Adults: a Systematic Review and Meta-Analysis. Comput Struct Biotechnol J. 2019;17:1101–12.PubMedPubMedCentralCrossRef
83.
go back to reference Iuliano S, Poon S, Robbins J, Bui M, Wang X, De Groot L, et al. Effect of dietary sources of calcium and protein on hip fractures and falls in older adults in residential care: cluster randomised controlled trial. BMJ. 2021;20:n2364.CrossRef Iuliano S, Poon S, Robbins J, Bui M, Wang X, De Groot L, et al. Effect of dietary sources of calcium and protein on hip fractures and falls in older adults in residential care: cluster randomised controlled trial. BMJ. 2021;20:n2364.CrossRef
84.
go back to reference Khanna A. Effect of resistance exercise on bone health of old aged individuals: Review. Sci Sports. 2023;38(4):323–36.CrossRef Khanna A. Effect of resistance exercise on bone health of old aged individuals: Review. Sci Sports. 2023;38(4):323–36.CrossRef
85.
go back to reference Xu J, Lombardi G, Jiao W, Banfi G. Effects of Exercise on Bone Status in Female Subjects, from Young Girls to Postmenopausal Women: An Overview of Systematic Reviews and Meta-Analyses. Sports Med. 2016;46(8):1165–82.PubMedCrossRef Xu J, Lombardi G, Jiao W, Banfi G. Effects of Exercise on Bone Status in Female Subjects, from Young Girls to Postmenopausal Women: An Overview of Systematic Reviews and Meta-Analyses. Sports Med. 2016;46(8):1165–82.PubMedCrossRef
86.
go back to reference Bolam KA, Van Uffelen JGZ, Taaffe DR. The effect of physical exercise on bone density in middle-aged and older men: A systematic review. Osteoporos Int. 2013;24(11):2749–62.PubMedCrossRef Bolam KA, Van Uffelen JGZ, Taaffe DR. The effect of physical exercise on bone density in middle-aged and older men: A systematic review. Osteoporos Int. 2013;24(11):2749–62.PubMedCrossRef
87.
go back to reference Lu X, Wei J, Liu Y, Lu Y. Effects of exercise on bone mineral density in middle-aged and older men: A comprehensive meta-analysis. Arch Osteoporos. 2023;18(1):108.PubMedCrossRef Lu X, Wei J, Liu Y, Lu Y. Effects of exercise on bone mineral density in middle-aged and older men: A comprehensive meta-analysis. Arch Osteoporos. 2023;18(1):108.PubMedCrossRef
88.
go back to reference Wallace BA, Cumming RG. Systematic Review of Randomized Trials of the Effect of Exercise on Bone Mass in Pre- and Postmenopausal Women. Calcif Tissue Int. 2000;67(1):10–8.PubMedCrossRef Wallace BA, Cumming RG. Systematic Review of Randomized Trials of the Effect of Exercise on Bone Mass in Pre- and Postmenopausal Women. Calcif Tissue Int. 2000;67(1):10–8.PubMedCrossRef
89.
go back to reference Hong AR, Kim SW. Effects of Resistance Exercise on Bone Health. Endocrinol Metab. 2018;33(4):435.CrossRef Hong AR, Kim SW. Effects of Resistance Exercise on Bone Health. Endocrinol Metab. 2018;33(4):435.CrossRef
90.
go back to reference Kottaras S, Stoikos J, McKinlay BJ, Ludwa IA, Josse AR, Falk B, et al. Bone Turnover Markers and Osteokines in Adolescent Female Athletes of High- and Low-Impact Sports Compared With Nonathletic Controls. Pediatr Exerc Sci. 2023;35(1):41–7.PubMed Kottaras S, Stoikos J, McKinlay BJ, Ludwa IA, Josse AR, Falk B, et al. Bone Turnover Markers and Osteokines in Adolescent Female Athletes of High- and Low-Impact Sports Compared With Nonathletic Controls. Pediatr Exerc Sci. 2023;35(1):41–7.PubMed
93.
go back to reference Turner CH, Robling AG. Mechanisms by which exercise improves bone strength. J Bone Miner Metab. 2005;23(S1):16–22.PubMedCrossRef Turner CH, Robling AG. Mechanisms by which exercise improves bone strength. J Bone Miner Metab. 2005;23(S1):16–22.PubMedCrossRef
94.
go back to reference Devries MC, Giangregorio L. Using the specificity and overload principles to prevent sarcopenia, falls and fractures with exercise. Bone. 2023;1(166):116573.CrossRef Devries MC, Giangregorio L. Using the specificity and overload principles to prevent sarcopenia, falls and fractures with exercise. Bone. 2023;1(166):116573.CrossRef
95.
go back to reference Winters-Stone KM, Snow CM. Site-specific response of bone to exercise in premenopausal women. Bone. 2006;39(6):1203–9.PubMedCrossRef Winters-Stone KM, Snow CM. Site-specific response of bone to exercise in premenopausal women. Bone. 2006;39(6):1203–9.PubMedCrossRef
96.
go back to reference Schoenfeld BJ, Grgic J, Ogborn D, Krieger JW. Strength and Hypertrophy Adaptations Between Low- vs. High-Load Resistance Training: A Systematic Review and Meta-analysis. J Strength Cond Res. 2017;31(12):3508–23.PubMedCrossRef Schoenfeld BJ, Grgic J, Ogborn D, Krieger JW. Strength and Hypertrophy Adaptations Between Low- vs. High-Load Resistance Training: A Systematic Review and Meta-analysis. J Strength Cond Res. 2017;31(12):3508–23.PubMedCrossRef
97.
go back to reference Morin SN, Feldman S, Funnell L, Giangregorio L, Kim S, McDonald-Blumer H, et al. Clinical practice guideline for management of osteoporosis and fracture prevention in Canada: 2023 update. Can Med Assoc J. 2023;195(39):E1333–48.CrossRef Morin SN, Feldman S, Funnell L, Giangregorio L, Kim S, McDonald-Blumer H, et al. Clinical practice guideline for management of osteoporosis and fracture prevention in Canada: 2023 update. Can Med Assoc J. 2023;195(39):E1333–48.CrossRef
98.
go back to reference Zernicke R, MacKay C, Lorincz C. Mechanisms of bone remodeling during weight-bearing exercise. Appl Physiol Nutr Metab Physiol Appl Nutr Metab. 2006;31(6):655–60.CrossRef Zernicke R, MacKay C, Lorincz C. Mechanisms of bone remodeling during weight-bearing exercise. Appl Physiol Nutr Metab Physiol Appl Nutr Metab. 2006;31(6):655–60.CrossRef
99.
go back to reference Volek JS, Gómez AL, Scheett TP, Sharman MJ, French DN, Rubin MR, et al. Increasing fluid milk favorably affects bone mineral density responses to resistance training in adolescent boys. J Am Diet Assoc. 2003;103(10):1353–6.PubMedCrossRef Volek JS, Gómez AL, Scheett TP, Sharman MJ, French DN, Rubin MR, et al. Increasing fluid milk favorably affects bone mineral density responses to resistance training in adolescent boys. J Am Diet Assoc. 2003;103(10):1353–6.PubMedCrossRef
100.
go back to reference Hemayattalab R. Effects of physical training and calcium intake on bone mineral density of students with mental retardation. Res Dev Disabil. 2010;31(3):784–9.PubMedCrossRef Hemayattalab R. Effects of physical training and calcium intake on bone mineral density of students with mental retardation. Res Dev Disabil. 2010;31(3):784–9.PubMedCrossRef
101.
go back to reference Arab Ameri E, Dehkhoda MR, Hemayattalab R. Bone mineral density changes after physical training and calcium intake in students with attention deficit and hyper activity disorders. Res Dev Disabil. 2012;33(2):594–9.PubMedCrossRef Arab Ameri E, Dehkhoda MR, Hemayattalab R. Bone mineral density changes after physical training and calcium intake in students with attention deficit and hyper activity disorders. Res Dev Disabil. 2012;33(2):594–9.PubMedCrossRef
102.
go back to reference Goodarzi M, Hemayattalab R. Bone mineral density accrual in students with autism spectrum disorders: Effects of calcium intake and physical training. Res Autism Spectr Disord. 2012;6(2):690–5.CrossRef Goodarzi M, Hemayattalab R. Bone mineral density accrual in students with autism spectrum disorders: Effects of calcium intake and physical training. Res Autism Spectr Disord. 2012;6(2):690–5.CrossRef
103.
go back to reference Reza SM, Rasool H, Mansour S, Abdollah H. Effects of calcium and training on the development of bone density in children with Down syndrome. Res Dev Disabil. 2013;34(12):4304–9.PubMedCrossRef Reza SM, Rasool H, Mansour S, Abdollah H. Effects of calcium and training on the development of bone density in children with Down syndrome. Res Dev Disabil. 2013;34(12):4304–9.PubMedCrossRef
104.
go back to reference Cohen TR, Hazell TJ, Vanstone CA, Rodd C, Weiler HA. Bone Health is Maintained, While Fat Mass is Reduced in Pre-pubertal Children with Obesity Participating in a 1-Year Family-Centered Lifestyle Intervention. Calcif Tissue Int. 2017;101(6):612–22.PubMedCrossRef Cohen TR, Hazell TJ, Vanstone CA, Rodd C, Weiler HA. Bone Health is Maintained, While Fat Mass is Reduced in Pre-pubertal Children with Obesity Participating in a 1-Year Family-Centered Lifestyle Intervention. Calcif Tissue Int. 2017;101(6):612–22.PubMedCrossRef
105.
go back to reference Josse A, Ludwa I, Kouvelioti R, Calleja M, Falk B, Ward W, et al. Dairy product intake decreases bone resorption following a 12-week diet and exercise intervention in overweight and obese adolescent girls. Pediatr Res. 2020;16:88. Josse A, Ludwa I, Kouvelioti R, Calleja M, Falk B, Ward W, et al. Dairy product intake decreases bone resorption following a 12-week diet and exercise intervention in overweight and obese adolescent girls. Pediatr Res. 2020;16:88.
106.
go back to reference Gómez AL, Kraemer WJ, Maresh CM, Lee EC, Szivak TK, Caldwell LK, et al. Resistance Training and Milk-Substitution Enhance Body Composition and Bone Health in Adolescent Girls. J Am Coll Nutr. 2021;40(3):193–210.PubMedCrossRef Gómez AL, Kraemer WJ, Maresh CM, Lee EC, Szivak TK, Caldwell LK, et al. Resistance Training and Milk-Substitution Enhance Body Composition and Bone Health in Adolescent Girls. J Am Coll Nutr. 2021;40(3):193–210.PubMedCrossRef
107.
go back to reference Klentrou P, McKee K, McKinlay BJ, Kurgan N, Roy BD, Falk B. Circulating Levels of Bone Markers after Short-Term Intense Training with Increased Dairy Consumption in Adolescent Female Athletes. Children. 2021;8(11):961.PubMedPubMedCentralCrossRef Klentrou P, McKee K, McKinlay BJ, Kurgan N, Roy BD, Falk B. Circulating Levels of Bone Markers after Short-Term Intense Training with Increased Dairy Consumption in Adolescent Female Athletes. Children. 2021;8(11):961.PubMedPubMedCentralCrossRef
108.
go back to reference Wagner G, Kindrick S, Hertzler S, DiSilvestro RA. Effects of Various Forms of Calcium on Body Weight and Bone Turnover Markers in Women Participating in a Weight Loss Program. J Am Coll Nutr. 2007;26(5):456–61.PubMedCrossRef Wagner G, Kindrick S, Hertzler S, DiSilvestro RA. Effects of Various Forms of Calcium on Body Weight and Bone Turnover Markers in Women Participating in a Weight Loss Program. J Am Coll Nutr. 2007;26(5):456–61.PubMedCrossRef
109.
go back to reference Josse AR, Tang JE, Tarnopolsky MA, Phillips SM. Body Composition and Strength Changes in Women with Milk and Resistance Exercise. Med Sci Sports Exerc. 2010;42(6):1122.PubMedCrossRef Josse AR, Tang JE, Tarnopolsky MA, Phillips SM. Body Composition and Strength Changes in Women with Milk and Resistance Exercise. Med Sci Sports Exerc. 2010;42(6):1122.PubMedCrossRef
110.
go back to reference Thomas DT, Wideman L, Lovelady CA. Effects of Calcium and Resistance Exercise on Body Composition in Overweight Premenopausal Women. J Am Coll Nutr. 2010;29(6):604–11.PubMedCrossRef Thomas DT, Wideman L, Lovelady CA. Effects of Calcium and Resistance Exercise on Body Composition in Overweight Premenopausal Women. J Am Coll Nutr. 2010;29(6):604–11.PubMedCrossRef
111.
go back to reference Josse AR, Atkinson SA, Tarnopolsky MA, Phillips SM. Diets Higher in Dairy Foods and Dietary Protein Support Bone Health during Diet- and Exercise-Induced Weight Loss in Overweight and Obese Premenopausal Women. J Clin Endocrinol Metab. 2012;97(1):251–60.PubMedCrossRef Josse AR, Atkinson SA, Tarnopolsky MA, Phillips SM. Diets Higher in Dairy Foods and Dietary Protein Support Bone Health during Diet- and Exercise-Induced Weight Loss in Overweight and Obese Premenopausal Women. J Clin Endocrinol Metab. 2012;97(1):251–60.PubMedCrossRef
112.
go back to reference Arazi H, Samadpour M, Eghbali E. The effects of concurrent training (aerobic-resistance) and milk consumption on some markers of bone mineral density in women with osteoporosis. BMC Womens Health. 2018;18(1):202.PubMedPubMedCentralCrossRef Arazi H, Samadpour M, Eghbali E. The effects of concurrent training (aerobic-resistance) and milk consumption on some markers of bone mineral density in women with osteoporosis. BMC Womens Health. 2018;18(1):202.PubMedPubMedCentralCrossRef
113.
go back to reference Bridge AD, Brown J, Snider H, Ward WE, Roy BD, Josse AR. Consumption of Greek yogurt during 12 weeks of high-impact loading exercise increases bone formation in young, adult males – a secondary analysis from a randomized trial. Appl Physiol Nutr Metab. 2020;45(1):91–100.PubMedCrossRef Bridge AD, Brown J, Snider H, Ward WE, Roy BD, Josse AR. Consumption of Greek yogurt during 12 weeks of high-impact loading exercise increases bone formation in young, adult males – a secondary analysis from a randomized trial. Appl Physiol Nutr Metab. 2020;45(1):91–100.PubMedCrossRef
114.
go back to reference Kukuljan S, Nowson CA, Sanders KM, Nicholson GC, Seibel MJ, Salmon J, et al. Independent and Combined Effects of Calcium-Vitamin D3 and Exercise on Bone Structure and Strength in Older Men: An 18-Month Factorial Design Randomized Controlled Trial. J Clin Endocrinol Metab. 2011;96(4):955–63.PubMedCrossRef Kukuljan S, Nowson CA, Sanders KM, Nicholson GC, Seibel MJ, Salmon J, et al. Independent and Combined Effects of Calcium-Vitamin D3 and Exercise on Bone Structure and Strength in Older Men: An 18-Month Factorial Design Randomized Controlled Trial. J Clin Endocrinol Metab. 2011;96(4):955–63.PubMedCrossRef
115.
go back to reference Lee SM, Kim S, Lim CG. The effects of milk intake and whole-body vibration exercise on bone mineral density in elderly women in nursing homes. J Phys Ther Sci. 2017;29(7):1125–8.PubMedPubMedCentralCrossRef Lee SM, Kim S, Lim CG. The effects of milk intake and whole-body vibration exercise on bone mineral density in elderly women in nursing homes. J Phys Ther Sci. 2017;29(7):1125–8.PubMedPubMedCentralCrossRef
116.
go back to reference Huschtscha Z, Parr A, Porter J, Costa RJS. The Effects of a High-Protein Dairy Milk Beverage With or Without Progressive Resistance Training on Fat-Free Mass, Skeletal Muscle Strength and Power, and Functional Performance in Healthy Active Older Adults: A 12-Week Randomized Controlled Trial. Front Nutr. 2021;17(8):644865.CrossRef Huschtscha Z, Parr A, Porter J, Costa RJS. The Effects of a High-Protein Dairy Milk Beverage With or Without Progressive Resistance Training on Fat-Free Mass, Skeletal Muscle Strength and Power, and Functional Performance in Healthy Active Older Adults: A 12-Week Randomized Controlled Trial. Front Nutr. 2021;17(8):644865.CrossRef
117.
go back to reference Vergnaud P, Garnero P, Meunier PJ, Bréart G, Kamihagi K, Delmas PD. Undercarboxylated Osteocalcin Measured with a Specific Immunoassay Predicts Hip Fracture in Elderly Women: The EPIDOS Study1. J Clin Endocrinol Metab. 1997;82(3):719–24.PubMed Vergnaud P, Garnero P, Meunier PJ, Bréart G, Kamihagi K, Delmas PD. Undercarboxylated Osteocalcin Measured with a Specific Immunoassay Predicts Hip Fracture in Elderly Women: The EPIDOS Study1. J Clin Endocrinol Metab. 1997;82(3):719–24.PubMed
118.
go back to reference Iuliano-Burns S, Saxon L, Naughton G, Gibbons K, Bass SL. Regional specificity of exercise and calcium during skeletal growth in girls: a randomized controlled trial. J Bone Miner Res Off J Am Soc Bone Miner Res. 2003;18(1):156–62.CrossRef Iuliano-Burns S, Saxon L, Naughton G, Gibbons K, Bass SL. Regional specificity of exercise and calcium during skeletal growth in girls: a randomized controlled trial. J Bone Miner Res Off J Am Soc Bone Miner Res. 2003;18(1):156–62.CrossRef
119.
go back to reference Bass SL, Naughton G, Saxon L, Iuliano-Burns S, Daly R, Briganti EM, et al. Exercise and calcium combined results in a greater osteogenic effect than either factor alone: a blinded randomized placebo-controlled trial in boys. J Bone Miner Res Off J Am Soc Bone Miner Res. 2007;22(3):458–64.CrossRef Bass SL, Naughton G, Saxon L, Iuliano-Burns S, Daly R, Briganti EM, et al. Exercise and calcium combined results in a greater osteogenic effect than either factor alone: a blinded randomized placebo-controlled trial in boys. J Bone Miner Res Off J Am Soc Bone Miner Res. 2007;22(3):458–64.CrossRef
120.
go back to reference Gruneisen E, Kremer R, Duque G. Fat as a Friend or Foe of the Bone. Curr Osteoporos Rep. 2024;22(2):245–56.PubMedCrossRef Gruneisen E, Kremer R, Duque G. Fat as a Friend or Foe of the Bone. Curr Osteoporos Rep. 2024;22(2):245–56.PubMedCrossRef
121.
go back to reference Mohammad Rahimi GR, Smart NA, Liang MTC, Bijeh N, Albanaqi AL, Fathi M, et al. The Impact of Different Modes of Exercise Training on Bone Mineral Density in Older Postmenopausal Women: A Systematic Review and Meta-analysis Research. Calcif Tissue Int. 2020;106(6):577–90.PubMedCrossRef Mohammad Rahimi GR, Smart NA, Liang MTC, Bijeh N, Albanaqi AL, Fathi M, et al. The Impact of Different Modes of Exercise Training on Bone Mineral Density in Older Postmenopausal Women: A Systematic Review and Meta-analysis Research. Calcif Tissue Int. 2020;106(6):577–90.PubMedCrossRef
122.
go back to reference Fulgoni VL, Keast DR, Auestad N, Quann EE. Nutrients from dairy foods are difficult to replace in diets of Americans: food pattern modeling and an analyses of the National Health and Nutrition Examination Survey 2003–2006. Nutr Res. 2011;31(10):759–65.PubMedCrossRef Fulgoni VL, Keast DR, Auestad N, Quann EE. Nutrients from dairy foods are difficult to replace in diets of Americans: food pattern modeling and an analyses of the National Health and Nutrition Examination Survey 2003–2006. Nutr Res. 2011;31(10):759–65.PubMedCrossRef
124.
go back to reference Trommelen J, van Loon LJC. Pre-Sleep Protein Ingestion to Improve the Skeletal Muscle Adaptive Response to Exercise Training. Nutrients. 2016;8(12):763.PubMedPubMedCentralCrossRef Trommelen J, van Loon LJC. Pre-Sleep Protein Ingestion to Improve the Skeletal Muscle Adaptive Response to Exercise Training. Nutrients. 2016;8(12):763.PubMedPubMedCentralCrossRef
125.
go back to reference Snijders T, Trommelen J, Kouw IWK, Holwerda AM, Verdijk LB, van Loon LJC. The Impact of Pre-sleep Protein Ingestion on the Skeletal Muscle Adaptive Response to Exercise in Humans: An Update. Front Nutr. 2019;6(6):17.PubMedPubMedCentralCrossRef Snijders T, Trommelen J, Kouw IWK, Holwerda AM, Verdijk LB, van Loon LJC. The Impact of Pre-sleep Protein Ingestion on the Skeletal Muscle Adaptive Response to Exercise in Humans: An Update. Front Nutr. 2019;6(6):17.PubMedPubMedCentralCrossRef
126.
go back to reference Weijzen MEG, Kohlen M, Monsegue A, Houtvast DCJ, Nyakayiru J, Beijer S, et al. Access to a pre-sleep protein snack increases daily energy and protein intake in surgical hospitalized patients. Clin Nutr Edinb Scotl. 2024;43(5):1073–8. Weijzen MEG, Kohlen M, Monsegue A, Houtvast DCJ, Nyakayiru J, Beijer S, et al. Access to a pre-sleep protein snack increases daily energy and protein intake in surgical hospitalized patients. Clin Nutr Edinb Scotl. 2024;43(5):1073–8.
127.
go back to reference Karagounis LG, Volterman KA, Breuillé D, Offord EA, Emady-Azar S, Moore DR. Protein Intake at Breakfast Promotes a Positive Whole-Body Protein Balance in a Dose-Response Manner in Healthy Children: A Randomized Trial. J Nutr. 2018;148(5):729–37.PubMedCrossRef Karagounis LG, Volterman KA, Breuillé D, Offord EA, Emady-Azar S, Moore DR. Protein Intake at Breakfast Promotes a Positive Whole-Body Protein Balance in a Dose-Response Manner in Healthy Children: A Randomized Trial. J Nutr. 2018;148(5):729–37.PubMedCrossRef
128.
go back to reference Mamerow MM, Mettler JA, English KL, Casperson SL, Arentson-Lantz E, Sheffield-Moore M, et al. Dietary protein distribution positively influences 24-h muscle protein synthesis in healthy adults. J Nutr. 2014;144(6):876–80.PubMedPubMedCentralCrossRef Mamerow MM, Mettler JA, English KL, Casperson SL, Arentson-Lantz E, Sheffield-Moore M, et al. Dietary protein distribution positively influences 24-h muscle protein synthesis in healthy adults. J Nutr. 2014;144(6):876–80.PubMedPubMedCentralCrossRef
129.
go back to reference Turgeon SL, Rioux LE. Food matrix impact on macronutrients nutritional properties. Food Hydrocoll. 2011;25(8):1915–24.CrossRef Turgeon SL, Rioux LE. Food matrix impact on macronutrients nutritional properties. Food Hydrocoll. 2011;25(8):1915–24.CrossRef
130.
go back to reference Cheng S, Lyytikäinen A, Kröger H, Lamberg-Allardt C, Alén M, Koistinen A, et al. Effects of calcium, dairy product, and vitamin D supplementation on bone mass accrual and body composition in 10–12-y-old girls: a 2-y randomized trial2. Am J Clin Nutr. 2005;82(5):1115–26.PubMedCrossRef Cheng S, Lyytikäinen A, Kröger H, Lamberg-Allardt C, Alén M, Koistinen A, et al. Effects of calcium, dairy product, and vitamin D supplementation on bone mass accrual and body composition in 10–12-y-old girls: a 2-y randomized trial2. Am J Clin Nutr. 2005;82(5):1115–26.PubMedCrossRef
131.
go back to reference van Vliet S, Shy EL, AbouSawan S, Beals JW, West DW, Skinner SK, et al. Consumption of whole eggs promotes greater stimulation of postexercise muscle protein synthesis than consumption of isonitrogenous amounts of egg whites in young men†. Am J Clin Nutr. 2017;106(6):1401–12.PubMedCrossRef van Vliet S, Shy EL, AbouSawan S, Beals JW, West DW, Skinner SK, et al. Consumption of whole eggs promotes greater stimulation of postexercise muscle protein synthesis than consumption of isonitrogenous amounts of egg whites in young men†. Am J Clin Nutr. 2017;106(6):1401–12.PubMedCrossRef
132.
go back to reference Paulussen KJM, Barnes TM, Askow AT, Salvador AF, McKenna CF, Scaroni SE, et al. Underpinning the Food Matrix Regulation of Postexercise Myofibrillar Protein Synthesis by Comparing Salmon Ingestion With the Sum of Its Isolated Nutrients in Healthy Young Adults. J Nutr. 2023;153(5):1359–72.PubMedCrossRef Paulussen KJM, Barnes TM, Askow AT, Salvador AF, McKenna CF, Scaroni SE, et al. Underpinning the Food Matrix Regulation of Postexercise Myofibrillar Protein Synthesis by Comparing Salmon Ingestion With the Sum of Its Isolated Nutrients in Healthy Young Adults. J Nutr. 2023;153(5):1359–72.PubMedCrossRef
Metadata
Title
Dairy and Exercise for Bone Health: Evidence from Randomized Controlled Trials and Recommendations for Future Research
Authors
Nicholas Cheng
Andrea R. Josse
Publication date
13-09-2024
Publisher
Springer US
Published in
Current Osteoporosis Reports
Print ISSN: 1544-1873
Electronic ISSN: 1544-2241
DOI
https://doi.org/10.1007/s11914-024-00882-2