Adrenal diseases are associated with an increased risk of osteopenia/osteoporosis and fragility fractures. Understand how to evaluate skeletal fragility and how it may be possible to improve bone health outcomes.
miRNAs have a key role in regulating the balance between adipogenesis and osteogenesis. Could miRNA-based interventions address the altered bone metabolism and adipose tissue dynamics in obesity and osteoporosis?
What are the key considerations for managing osteoporosis and osteoarthritis in the oldest old (≥80 years), in the context of multimorbidity, physical and mental disability, and polypharmacy?
The monoclonal antibody romosozumab has a transient but robust bone anabolic effect. Find out what is currently known about its clinical efficacy and safety for the treatment of primary and secondary osteoporosis.
Diabetes is one clinical manifestation of Werner syndrome, a rare hereditary autosomal recessive disorder. Poor glucose control was the main complaint for the patient in this case study, who was found to have a novel WRN p.I223fs mutation.
Osteoporosis is defined as a systemic skeletal disease, that not only leads to susceptibility to fracture, but is also associated with some complications after spinal surgery [ 1 – 4 ]. Cage subsidence and pedicle screw loosening are two common …
A growing role for the skeleton in human health and longevity emerged recently. However, knowledge regarding the effects of new risk factors, linked to modern life, for bone diseases is not documented satisfactorily. Micro- and nanoplastics (MPs) …
Vertebral fragility fractures (VFFs) are one of the most common fractures among individuals with osteoporosis [ 1 ], with approximately 20% of the older population expected to sustain a VFF [ 2 ]. Reported VFF incidence varies, in part, reflecting …
Osteoporosis is a metabolic bone disease characterized by decreased bone density and damage to bone microstructure, leading to increased bone fragility and a significantly elevated risk of fracture. Since early symptoms of osteoporosis are not …
In people aged over 50 years, a fracture sustained following a fall from standing height or less (termed fragility fracture) is often indicative of osteoporosis [ 1 ]. Osteoporosis is a common chronic condition of compromised bone quality and …
One in three women over the age of 50 and one in five men are likely to experience an osteoporotic (fragility) fracture in their lifetime, with the risk of fracture increasing with age [ 1 , 2 ]. Vertebral fragility fractures (VFF) are most common …
Colorectal cancer (CRC) is the third most prevalent malignancy worldwide [ 1 ]. Although the prognosis of patients with metastatic CRC (mCRC) is generally poor, recent developments in novel chemotherapeutic agents have increased the overall …
Osteoporosis is a chronic metabolic bone disorder characterized by low bone mass, microarchitectural deterioration of bone tissue, and an increased risk of fractures [ 1 , 2 ]. It is the leading cause of fractures in the elderly population [ 3 , 4 …
