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Osteoporosis(1)

Rare complication of methotrexate in RA

A case series describing four women with rheumatoid arthritis who presented with stress fractures and showed rapid clinical improvement after discontinuation of methotrexate.

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Editor's Choice

Updates on the role of DXA in osteoporosis

Dual X-ray absorptiometry is a valuable tool for assessing bone density and fracture risk. But it is essential to be familiar with the guidelines, limitations, and pitfalls to optimize the interpretation of results and guide clinical decisions.

Vitamin D and bone health

Understand the significance of vitamin D for bone health, especially its mechanism of action and clinical significance in bone destruction diseases such as osteoarthritis, osteoporosis, rheumatoid arthritis, and bone tuberculosis.

Epileptic seizures associated with denosumab

Denosumab is known to be associated with adverse reactions such as hypocalcemia but this is the first reported case of epileptic seizures, underscoring the need for vigilance regarding such rare side effects.

Remote bone health service beneficial for older men

A centralized, remote bone health service could significantly increase rates of osteoporosis screening, treatment, and medication adherence in older men at risk for fracture.

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Case Studies

Rare complication of methotrexate in RA

A case series describing four women with rheumatoid arthritis who presented with stress fractures and showed rapid clinical improvement after discontinuation of methotrexate.

Epileptic seizures associated with denosumab

Denosumab is known to be associated with adverse reactions such as hypocalcemia but this is the first reported case of epileptic seizures, underscoring the need for vigilance regarding such rare side effects.

Current Reviews

A meta-analysis of smoking and fracture risk to update the FRAX® tool

Smoking remains an epidemic, with approximately 1.14 billion people worldwide being current smokers in 2019; in that year, more than 7 trillion cigarette-equivalents of tobacco were consumed [ 1 ]. Smoking accounted for more than 7.5 million deaths …

Effectiveness of virtual reality-based rehabilitation for lower limb function in osteoporosis: a systematic review

The World Health Organization (WHO) defines osteoporosis as a progressive, systemic skeletal disease characterized by a reduction in bone mass, deterioration of bone microarchitecture, and an increased susceptibility to fragility fractures [ 1 ].

The impact of Tai Chi on osteoporosis and osteopenia in middle-aged and elderly adults: a systematic review and meta-analysis of randomized controlled trial

Osteoporosis is a systemic skeletal disease characterized by low bone mass, microarchitectural deterioration, increased bone fragility, and heightened susceptibility to fractures [ 1 ]. Epidemiological studies estimate that approximately 200 …

Exercise improves quality of life, mental health and pain in people living with osteoporosis: a systematic review and meta-analysis

Osteoporosis is a progressive, age-related condition, which may be associated with poor physical and mental health, increased pain and decreased quality of life [ 1 ]. The World Health Organisation diagnostic criterion for osteoporosis (OP) is a …

Further Reading

Keeping Patients on Their Feet: How Fall Prevention Clinics Can Be More Effective

Falls are leading causes of injury, hospitalization, and mortality among adults aged 65 and older. 1 , 2 Approximately one in three older adults in the community report at least one fall each year, sometimes with consequences ranging from fractures …

Diagnostic accuracy of deep learning vs. human raters for detecting osteoporotic vertebral compression fractures in routine CT scans

Osteoporosis is a systemic skeletal disorder characterized by decreased bone mass and deterioration of bone tissue, leading to increased bone fragility and susceptibility to fractures. Fragility fractures are a major public health issue …

Development and evaluation of a simple CT-based DXA triage score for osteoporosis in candidates for lumbar spine surgery

Osteoporosis is common in older adults and is a major and potentially modifiable determinant of perioperative and long-term outcomes in spine surgery [ 1 ]. Low bone mineral density (BMD) has been associated with implant-related complications such …

Exercise improves quality of life, mental health and pain in people living with osteoporosis: a systematic review and meta-analysis

Osteoporosis is a progressive, age-related condition, which may be associated with poor physical and mental health, increased pain and decreased quality of life [ 1 ]. The World Health Organisation diagnostic criterion for osteoporosis (OP) is a …

Image Credits
MRI of foot of rheumatoid arthritis patient treated with methotrexate/© 2025, Olga Dorota Lotkowska et al, under exclusive licence to Springer-Verlag GmbH Germany, part of Springer Nature, Rheumatol Int, Woman having a bone density scan/© fotodelux / Getty Images / iStock (symbolic image with models), Vitamin D capsules/© NiseriN / Getty Images / iStock, Close-up of subcutaneous injection syringe/© Laures / Getty Images / iStock, Man on a video call on a tablet/© andreswd / Getty Images / iStock (symbolic image with model), Woman with a broken arm/© VadimGuzhva / stock.adobe.com (symbolic image with model), Older woman on crutches walking/© zinkevych / Stock.adobe.com (symbolic image with model), Older man using a walking frame/© Nigel Downer / Science Photo Library (symbolic image with models)