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Rheumatology Osteoarthritis

Osteoarthritis

Infrapatellar steroid injections ineffective in OA

Infrapatellar fat pad glucocorticoid injections were no better than placebo for reducing knee osteoarthritis pain or inflammation in a randomized controlled trial.

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Editor's Choice

taVNS of limited benefit in erosive osteoarthritis

Transcutaneous auricular vagus nerve stimulation does not significantly improve hand pain relative to sham stimulation in people with erosive hand osteoarthritis, but may benefit certain subgroups.

Vitamin D and bone health

Understand the significance of vitamin D for bone health, especially its mechanism of action and clinical significance in bone destruction diseases such as osteoarthritis, osteoporosis, rheumatoid arthritis, and bone tuberculosis.

Weight-lowering medications and rheumatic diseases

An overview of the evidence for weight-loss treatments in people with obesity and rheumatic diseases, highlighting the practical considerations and potential pleiotropic benefits

Adding weight-loss diet to exercise fails to reduce OA hip pain

In adults with hip osteoarthritis and overweight or obesity, adhering to a very-low-calorie diet in addition to exercising does not significantly improve hip pain compared with exercising alone.

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Episode 17: Challenges of developing DMOADs

Why are disease-modifying treatments for osteoarthritis such a difficult proposition?

Despite multiple attempts, no DMOAD is yet approved for clinical use. Prof. Ali Mobasheri takes us through the main challenges, the work being done to make these so-called utopia drugs a reality, and discusses other advances that offer hope in the meantime.

Prof. Ali Mobasheri
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Podcast

Case Studies

Heterotopic ossification after wrist replacement

The first reported case of heterotopic ossification following total wrist arthroplasty. Revision surgery was performed to remove ossifications and no further signs have been reported, but the patient's range of motion remains reduced.

Current Reviews

Subchondral bone abnormalities in the knee: imaging techniques, regional anatomy, and pathology

The subchondral bone is an integral structural component of the knee with key roles in shock absorption and load distribution. Injuries to the subchondral bone, which may occur secondary to various etiologies including trauma, degenerative …

Surgical management and imaging evaluation of post-traumatic periscaphoid osteoarthritis (SLAC and SNAC wrists)

An untreated scapholunate interosseous ligament injury or scaphoid nonunion leads to progressive post-traumatic periscaphoid osteoarthritis and carpal collapse. Symptomatic forms, known as scapholunate advanced collapse (SLAC) or scaphoid nonunion …

The joint-local renin–angiotensin system in rheumatoid arthritis and osteoarthritis: mechanistic evidence, disease-specific patterns, and translational perspectives

The renin–angiotensin system (RAS), traditionally regarded as a hormonal cascade regulating cardiovascular and renal homeostasis, is increasingly recognized as a locally active, tissue-specific network within joint structures. Accumulating …

The Potential of Authorised Drugs to be Repurposed for the Treatment of Osteoarthritis: A Scoping Review of Clinical Studies

Osteoarthritis is one of the major contributors to pain and disability worldwide, significantly impacting quality of life of affected individuals due to limitations in activities of daily living [ 1 ]. With an estimated prevalence of approximately …

Further Reading

Limited discriminatory value of RAMRIS findings between RA and hand osteoarthritis: a cross-sectional MRI study

To evaluate the capacity of the RA MRI Score (RAMRIS) in distinguishing rheumatoid arthritis (RA) and hand osteoarthritis (HOA). Patients with RA and HOA were retrospectively matched in pairs. Inflammatory and degenerative changes in MRI scans of …

Data-driven classification of lumbar spine degeneration trajectories in chronic low back pain

Lumbar spine degeneration affects the intervertebral discs, vertebrae, muscles, and facet joints, and is considered a natural consequence of the ageing process [ 1 , 2 ]. While generally occurring over decades, degeneration progresses at different …

Assessing active thumb palmar and radial abduction in persons with thumb carpometacarpal osteoarthritis via intermetacarpal distance methods: an exploration of validity, reliability, and precision

Thumb carpometacarpal joint (CMC1) osteoarthritis (OA) is the second most common and the most symptomatic form of hand OA [ 1 ]. Of the different risk factors, the most well-known are age and female sex. Above the age of 50 years, the prevalence of …

Grey matter volume reduction in the cerebellum of hip osteoarthritis patients: insights from pre- and postoperative VBM analysis

The implantation of hip prostheses is a widely adopted surgical intervention aimed at restoring mobility and alleviating pain in individuals with advanced hip joint pathology [ 1 ]. While the primary goal is mechanical correction, recent literature …

Image Credits
Close-up of man with both hands on knee/© Jacob Wackerhausen / Getty Images / iStock, Close-up of person massaging their hand/© Jacob Wackerhausen / Getty Images / iStock, Vitamin D capsules/© NiseriN / Getty Images / iStock, Weighing scales and measuring tape/© Atlas / stock.adobe.com, Woman doing stretches in bedroom/© Galina Zhigalova / Getty Images / iStock (symbolic image with model), Medicine Matters Podcast promo image/© Springer Medizin GmbH, Woman taking medication/© ozgurcankaya / Getty Images / iStock (symbolic image with model), Elderly woman massaging hand/© Jacob Wackerhausen / Getty Images / iStock (symbolic image with model), 3D illustration of a hip joint implant/© Christoph Burgstedt / stock.adobe.com, X-rays of patient with heterotopic ossification after wrist replacement/© 2025, Sonja Verena Schmidt et al, J Med Case Reports