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Infrapatellar fat pad glucocorticoid injections were no better than placebo for reducing knee osteoarthritis pain or inflammation in a randomized controlled trial.
Transcutaneous auricular vagus nerve stimulation does not significantly improve hand pain relative to sham stimulation in people with erosive hand osteoarthritis, but may benefit certain subgroups.
Understand the significance of vitamin D for bone health, especially its mechanism of action and clinical significance in bone destruction diseases such as osteoarthritis, osteoporosis, rheumatoid arthritis, and bone tuberculosis.
An overview of the evidence for weight-loss treatments in people with obesity and rheumatic diseases, highlighting the practical considerations and potential pleiotropic benefits
In adults with hip osteoarthritis and overweight or obesity, adhering to a very-low-calorie diet in addition to exercising does not significantly improve hip pain compared with exercising alone.
Why are disease-modifying treatments for osteoarthritis such a difficult proposition?
Despite multiple attempts, no DMOAD is yet approved for clinical use. Prof. Ali Mobasheri takes us through the main challenges, the work being done to make these so-called utopia drugs a reality, and discusses other advances that offer hope in the meantime.
The first reported case of heterotopic ossification following total wrist arthroplasty. Revision surgery was performed to remove ossifications and no further signs have been reported, but the patient's range of motion remains reduced.
The subchondral bone is an integral structural component of the knee with key roles in shock absorption and load distribution. Injuries to the subchondral bone, which may occur secondary to various etiologies including trauma, degenerative …
An untreated scapholunate interosseous ligament injury or scaphoid nonunion leads to progressive post-traumatic periscaphoid osteoarthritis and carpal collapse. Symptomatic forms, known as scapholunate advanced collapse (SLAC) or scaphoid nonunion …
The renin–angiotensin system (RAS), traditionally regarded as a hormonal cascade regulating cardiovascular and renal homeostasis, is increasingly recognized as a locally active, tissue-specific network within joint structures. Accumulating …
Osteoarthritis is one of the major contributors to pain and disability worldwide, significantly impacting quality of life of affected individuals due to limitations in activities of daily living [ 1 ]. With an estimated prevalence of approximately …
To evaluate the capacity of the RA MRI Score (RAMRIS) in distinguishing rheumatoid arthritis (RA) and hand osteoarthritis (HOA). Patients with RA and HOA were retrospectively matched in pairs. Inflammatory and degenerative changes in MRI scans of …
Lumbar spine degeneration affects the intervertebral discs, vertebrae, muscles, and facet joints, and is considered a natural consequence of the ageing process [ 1 , 2 ]. While generally occurring over decades, degeneration progresses at different …
Thumb carpometacarpal joint (CMC1) osteoarthritis (OA) is the second most common and the most symptomatic form of hand OA [ 1 ]. Of the different risk factors, the most well-known are age and female sex. Above the age of 50 years, the prevalence of …
The implantation of hip prostheses is a widely adopted surgical intervention aimed at restoring mobility and alleviating pain in individuals with advanced hip joint pathology [ 1 ]. While the primary goal is mechanical correction, recent literature …