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Journal of Orofacial Orthopedics / Fortschritte der Kieferorthopädie

Open Access 28-06-2023 | Orthopantomogram | Original Article

Association between craniofacial patterns and third molar agenesis in orthodontic patients

Authors: Dr. Eva Paddenberg, Dr. Alice Correa Silva-Souza, Dr. Ariane Beatriz Blancato, Prof. Dr. César Penazzo Lepri, Prof. Dr. Dr. Peter Proff, Prof. Dr. Erika Calvano Küchler, Priv.-Doz. Dr. Dr. Christian Kirschneck

Published in: Journal of Orofacial Orthopedics / Fortschritte der Kieferorthopädie

Abstract

Purpose

Third molar agenesis (TMA) is the most common craniofacial anomaly and has been associated with craniofacial patterns in different populations. Therefore, the aim of this retrospective cross-sectional study was to assess a possible association between craniofacial patterns and TMA in German orthodontic patients.

Methods

Patients undergoing orthodontic treatment with dental records including anamnesis, pretreatment lateral cephalograms and orthopantomograms were evaluated. Cephalometric analyses were conducted digitally and lines, angles and proportions were measured to investigate craniofacial morphology. Skeletal classes were determined by the individualised Wits appraisal and ANB angle. The TMA was identified with the help of orthopantomograms. Patients showing agenesis of at least one third molar were included in the TMA group. Statistical analysis was performed to assess the association between TMA and craniofacial patterns (α of p ≤ 0.05).

Results

A total of 148 patients were included, 40 (27.0%) presented at least one missing tooth (TMA group) and 108 (73.0%) showed full dentition (control group). Skeletal class determined by the individualised Wits appraisal revealed statistical significance between the TMA and control groups (p = 0.022), in which TMA patients were 11 times more likely to present with an individualised skeletal class III (odds ratio 11.3, 95% confidence interval 1.7–139.5). Skeletal cephalometric analysis revealed no statistical differences between TMA and control groups for any further angular, linear and proportional parameters.

Conclusion

Third molar agenesis was associated with skeletal class III determined by the individualised Wits appraisal.

Carter K, Worthington S (2015) Morphologic and demographic predictors of third molar agenesis: a systematic review and meta-analysis. J Dent Res 94:886–894. https://doi.org/10.1177/0022034515581644 CrossRefPubMed

Celikoglu M, Kamak H (2011) Patterns of third-molar agenesis in an orthodontic patient population with different skeletal malocclusions. Angle Orthod 82:165–169. https://doi.org/10.2319/041911-274.1 CrossRefPubMedPubMedCentral

Chung CJ, Han JH, Kim KH (2008) The pattern and prevalence of hypodontia in Koreans. Oral Dis 14:620–625. https://doi.org/10.1111/j.1601-0825.2007.01434.x CrossRefPubMed

Endo S, Sanpei S, Ishida R, Sanpei S, Abe R, Endo T (2015) Association between third molar agenesis patterns and agenesis of other teeth in a Japanese orthodontic population. Odontology 103:89–96. https://doi.org/10.1007/s10266-013-0134-1 CrossRefPubMed

Enlow DH, Moyers RE, Hunter WS, McNamara J Jr (1969) An equivalent-balance concept—An equivalent-balance concept. Am J Orthod 56:6–23 CrossRefPubMed

Gómez de Diego R, Montero J, López-Valverde N, de Nieves IJ, Prados-Frutos JC, López-Valverde A (2017) Epidemiological survey on third molar agenesis and facial pattern among adolescents requiring orthodontic treatment. J Clin Exp Dent 9:e1088–e1095. https://doi.org/10.4317/jced.53947 CrossRefPubMedPubMedCentral

Huang Y, Yan Y, Cao J, Xie B, Xiao X, Luo M, Bai D, Han X (2017) Zusammenhang zwischen Nichtanlage des dritten Molaren und kraniofazialen Abweichungen (Obeservations on association between third molar agenesis and craniofacial morphology). J Orofac Orthop 78:504–510. https://doi.org/10.1007/s00056-017-0109-x CrossRefPubMed

Jacobson A (1975) The “Wits” appraisal of jaw disharmony. Am J Orthod 67:125–138. https://doi.org/10.1016/0002-9416(75)90065-2 CrossRefPubMed

Jarabak JR, Fizzel JA (1972) Light-Wire EdgewiseAppliance. Mosby, St.Louis

10.

Järvinen S (1985) An analysis of the variation of the ANB angle: a statistical appraisal. Am J Orthod 87:144–146. https://doi.org/10.1016/0002-9416(85)90024-7 CrossRefPubMed

11.

Järvinen S (1988) Relation of the wits appraisal to the ANB angle: a statistical appraisal. Am J Orthod Dentofacial Orthop 94:432–435. https://doi.org/10.1016/0889-5406(88)90134-5 CrossRefPubMed

12.

John J, Nambiar P, Mani SA, Mohamed NH, Murad NFA, Murad NA (2012) Third molar agenesis among children and youths from three major races of Malaysians. J Dent Sci 7:211–217. https://doi.org/10.1016/j.jds.2012.05.002 CrossRef

13.

Jung YH, Cho BH (2014) Radiographic evaluation of third molar development in 6‑ to 24-year-olds. Imaging Sci Dent 44:185–191. https://doi.org/10.5624/isd.2014.44.3.185 CrossRefPubMedPubMedCentral

14.

Kajii TS, Sato Y, Kajii S, Sugawara Y, Iida J (2004) Agenesis of third molar germs depends on sagittal maxillary jaw dimensions in orthodontic patients in Japan. Angle Orthod 74:337–342. https://doi.org/10.22334/jbhost.v6i2.217.s47 CrossRefPubMed

15.

Kirschneck M, Zbidat N, Paddenberg E, Reis CLB, Madalena IR, de Menezes-Oliveira MAH, Lepri CP, Proff P, Kirschneck C, Küchler EC (2022) Transforming growth factor beta receptor 2 (TGFBR2) promoter region polymorphisms may be involved in mandibular retrognathism. Biomed Res Int 2022:1503052. https://doi.org/10.1155/2022/1503052 CrossRefPubMedPubMedCentral

16.

Küchler EC, de Risso PA, Costa MC, Modesto A, Vieira AR (2008) Assessing the proposed association between tooth agenesis and taurodontism in 975 paediatric subjects. Int J Paediatr Dent 18:231–234. https://doi.org/10.1111/j.1365-263X.2007.00876.x CrossRef

17.

Küchler EC, Risso PA, Costa MC, Modesto A, Vieira AR (2008) Studies of dental anomalies in a large group of school children. Arch Oral Biol 53:941–946. https://doi.org/10.1016/j.archoralbio.2008.04.003 CrossRefPubMed

18.

Küchler EC, da Motta LG, Vieira AR, Granjeiro JM (2011) Side of dental anomalies and taurodontism as potential clinical markers for cleft subphenotypes. Cleft Palate Craniofac J J 48:103–108. https://doi.org/10.1597/09-159 CrossRef

19.

Medina MCG, Bastos RTDRM, Mecenas P, Pinheiro JJV, Normando D (2021) Association between tooth agenesis and cancer: a systematic review. J Appl Oral Sci 29:1–11. https://doi.org/10.1590/1678-7757-2020-0955 CrossRef

20.

Meza RS (2003) Radiographic assessment of congenitally missing teeth in orthodontic patients. Int J Paediatr Dent 13:112–116. https://doi.org/10.1046/j.1365-263x.2003.00436.x CrossRef

21.

Moghadam MG, Etemadi F, Akbari N (2018) The relationship between agenesis of third molar and craniofacial morphology in orthodontic patients. J Int Soc Prev Community Dent 8:304–308. https://doi.org/10.4103/jispcd.JISPCD_110_18 CrossRefPubMed

22.

Paddenberg E, Proff P, Kirschneck C (2021) Floating norms for individualising the ANB angle and the WITS appraisal in orthodontic cephalometric analysis based on guiding variables. J Orofac Orthop. https://doi.org/10.1007/s00056-021-00322-1 CrossRefPubMedPubMedCentral

23.

Panagiotidis G, Witt E (1977) Der individualisierte ANB-Winkel. Fortschr Kieferorthop 38:408–416. https://doi.org/10.1007/BF02163219 CrossRef

24.

Ramiro-Verdugo J, de Vicente-Corominas E, Montiel-Company JM, Gandía-Franco JL, Bellot-Arcís C (2015) Association between third molar agenesis and craniofacial structure development. Am J Orthod Dentofacial Orthop 148:799–804. https://doi.org/10.1016/j.ajodo.2015.05.025 CrossRefPubMed

25.

Ricketts RM (1961) Cephalometric analysis and synthesis. Angle Orthod 31:141–156

26.

Riedel RA (1952) The relation of maxillary structures to cranium in malocclusion and in normal occlusion. Angle Orthod 22:142–145

27.

Roald KL, Wisth PJ, Bøe OE (1982) Changes in cranio-facial morphology of individuals with hypodontia between the ages of 9 and 16. Acta Odontol Scand 40:65–74. https://doi.org/10.3109/00016358209041117 CrossRefPubMed

28.

Rodrigues AS, Antunes LS, Pinheiro LHM, Guimarães LS, Calansans-Maia JA, Küchler EC, Antunes LAA (2020) Is dental agenesis associated with craniofacial morphology pattern? A systematic review and meta-analysis. Eur J Orthod 42:534–543. https://doi.org/10.1093/ejo/cjz087 CrossRefPubMed

29.

Sánchez MJ, Vicente A, Bravo LA (2009) Third molar agenesis and craniofacial morphology. Angle Orthod 79:473–478. https://doi.org/10.2319/052008-276.1 CrossRefPubMed

30.

Segner D, Hasund A (2003) Individualisierte Kephalometrie. Segner, Hamburg

31.

Steiner CC (1960) The use of cephalometrics as an aid to planning and assessing orthodontic treatment. Am J Orthod 46:721–735. https://doi.org/10.1016/0002-9416(60)90145-7 CrossRef

32.

Schultz C, Nötzel F (2008) Leitfaden der kieferorthopädischen Diagnostik Analysen und Tabellen für die Praxis. Deutscher Aerzte Verlag

33.

Tavajohi-Kermani H, Kapur R, Sciote JJ (2002) Tooth agenesis and craniofacial morphology in an orthodontic population. Am J Orthod Dentofacial Orthop 122:39–47. https://doi.org/10.1067/mod.2002.123948 CrossRefPubMed

34.

von Elm E, Altman DG, Egger M, Pocock SJ, Gøtzsche PC, Vandenbroucke JP (2008) STROBE Initiative. The Strengthening the Reporting of Observational Studies in Epidemiology (STROBE) statement: guidelines for reporting observational studies. J Clin Epidemiol 61:344–349. https://doi.org/10.1016/j.jclinepi.2007.11.008 CrossRef

35.

Yüksel S, Uçem T (1997) The effect of tooth agenesis on dentofacial structures. Eur J Orthod 19:71–78. https://doi.org/10.1093/ejo/19.1.71 CrossRefPubMed

Title: Association between craniofacial patterns and third molar agenesis in orthodontic patients
Authors: Dr. Eva Paddenberg
Dr. Alice Correa Silva-Souza
Dr. Ariane Beatriz Blancato
Prof. Dr. César Penazzo Lepri
Prof. Dr. Dr. Peter Proff
Prof. Dr. Erika Calvano Küchler
Priv.-Doz. Dr. Dr. Christian Kirschneck
Publication date: 28-06-2023
Publisher: Springer Medizin
Keyword: Orthopantomogram
Published in: Journal of Orofacial Orthopedics / Fortschritte der Kieferorthopädie
Print ISSN: 1434-5293
Electronic ISSN: 1615-6714
DOI: https://doi.org/10.1007/s00056-023-00484-0

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Association between craniofacial patterns and third molar agenesis in orthodontic patients

Abstract

Purpose

Methods

Results

Conclusion

Keynote Webinar | Spotlight on Diet and Diabetes

Springer Medicine

Abstract

Purpose

Methods

Results

Conclusion

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