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ALS in a patient with CLL and drug-related SLR

A man presenting with a skin rash and left leg weakness was diagnosed with sarcoid-like reaction due to treatment for chronic lymphocytic leukemia, and ultimately also amyotrophic lateral sclerosis when the motor symptoms progressed.

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Editor's Choice

Managing neuroendocrine tumors and diabetes

  • Free for a limited time
  • Diabetes
  • Review

Diabetes and NET can adversely affect each other’s prognosis, but what impact do NET therapies have on diabetes and vice versa? And how should radiological and functional procedures be managed in patients with NET and diabetes?

Melanoma risk doubled in childhood cancer survivors

Compared with the general population, childhood cancer survivors have a twofold increased risk for melanoma, with substantially worse survival for those who develop invasive melanoma.

Asciminib discontinuation feasible in CML

There are minimal data concerning treatment-free remission after discontinuation of the novel TKI asciminib in people with chronic myeloid leukemia. These two cases provide proof of principle that sustained TFR is possible in selected patients.

Spondyloarthritis and cancer risk

The risk for malignancy in people with spondyloarthritis remains a controversial issue. What is the current evidence for the impact of the disease and its treatment with biologic and targeted synthetic DMARDs?

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Episode 15: Breastfeeding after breast cancer

POSITIVEly reassuring results from a clinical trial

The POSITIVE trial previously showed that women with breast cancer can safely interrupt endocrine therapy in order to become pregnant. But what about breastfeeding - is that possible and safe for the mother and baby?

Women can take heart from the latest findings, says Dr. Cristina Saura, as she takes us through these important clinical updates.

Dr. Cristina Saura
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SPONSORED

Recent advances in the use of CAR T-cell therapies in relapsed/refractory diffuse large B-cell lymphoma and follicular lymphoma

In this webinar, Professor Martin Dreyling and an esteemed international panel of CAR T-cell therapy experts discuss the latest data on the safety, efficacy, and clinical impact of CAR T-cell therapies in the treatment of r/r DLBCL and r/r FL.

Please note, this webinar is not intended for healthcare professionals based in the US and UK.

Sponsored by:
  • Novartis Pharma AG
Chaired by: Prof. Martin Dreyling
Developed by: Springer Healthcare
Watch now

Case Studies

ALS in a patient with CLL and drug-related SLR

A man presenting with a skin rash and left leg weakness was diagnosed with sarcoid-like reaction due to treatment for chronic lymphocytic leukemia, and ultimately also amyotrophic lateral sclerosis when the motor symptoms progressed.

Asciminib discontinuation feasible in CML

There are minimal data concerning treatment-free remission after discontinuation of the novel TKI asciminib in people with chronic myeloid leukemia. These two cases provide proof of principle that sustained TFR is possible in selected patients.

Primary vitreoretinal lymphoma mimics fungal endophthalmitis

PVRL is a life-threatening neoplasm. It can be mistaken for non-infectious uveitis, as it often presents with vitritis that responds to corticosteroids, but this case shows that it can also mimic infectious uveitis.

ASH 2024 Annual Meeting Coverage

inMIND supports tafasitamab addition in follicular lymphoma

Combining tafasitamab with lenalidomide and rituximab significantly improves progression-free survival for patients with relapsed or refractory follicular lymphoma.

Featuring the official presentation video

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Current Reviews

Diagnostic accuracy of preoperative MRI in assessing macrotrabecular-massive subtype of hepatocellular carcinoma: a systematic review and meta-analysis

Primary liver cancers, mainly hepatocellular carcinomas (HCCs), are the third-leading cause of cancer-related deaths globally, posing a significant threat to public health [ 1 , 2 ]. HCC shows strong genomic, molecular, and histologic heterogeneity …

“Update on pediatric primary liver tumors”

Liver masses are common in children, however primary malignant neoplasms are rare, representing only 1% of all pediatric cancers. Hepatocellular neoplasms are the most common primary liver malignancies and hepatoblastoma (HB) is the most …

Implementation of the 9th TNM for lung cancer: practical insights for radiologists

Lung cancer is the most incident cancer in the world, accounting for 2,480,675 new cases in both sexes and at all stages, as well as the most lethal, with 1,817,469 deaths in both sexes at all ages in 2022 [ 1 ].

Genetic alterations and their prognostic impact in marginal zone lymphoma: a meta-analysis

This meta-analysis aimed to assess the impact of genetic mutations, particularly in the NOTCH2 and TNFAIP3 genes, on the prognostic outcomes of Marginal Zone Lymphoma (MZL) patients. Databases, including PubMed, Embase, and Cochrane Library, were …

At a glance: The KEYNOTE lung cancer trials

A quick guide to the KEYNOTE trials investigating the anti-PD-1 agent pembrolizumab in non-small-cell and small-cell lung cancer.

Developed by: Springer Medicine
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CME & eLearning

SPONSORED

Webinar

1.5 European CME credits (ECMEC®s)

A series of patient cases underpin this interactive webinar that aims to provide practical guidance on a multidisciplinary approach to managing patients with cutaneous T-cell lymphoma.

Sponsored by:
  • Kyowa Kirin
Developed by: Springer Healthcare

Symposium (Link opens in a new window)

An independent symposium at the 10th COMy World Congress focusing on BCMA-targeting strategies for the treatment of multiple myeloma. Gain insights into the latest clinical data and the implications for clinical practice.

Supported by:
  • GlaxoSmithKline
Developed by: Springer Healthcare IME

eLearning (Link opens in a new window)

The evolving landscape of metastatic urothelial carcinoma brings with it many challenges, such as optimally sequencing therapies and managing adverse events. Navigate your way through these with the Ultimate mUC challenge game and expert-to-expert interviews.

Supported by:
  • Merck Healthcare KGaA, Darmstadt, Germany and Astellas
Developed by: Springer Healthcare IME

Further Reading

Evaluation of MRI characterisation of histopathologically matched lymph nodes and other mesorectal nodal structures in rectal cancer

Pelvic magnetic resonance imaging (MRI) is considered the standard of care for rectal cancer staging. Nevertheless, MRI regional metastatic lymph node assessment (N staging) is still associated with limited sensitivity and specificity [ 1 ].

Prognostic value of CT-based skeletal muscle and adipose tissue mass and quality parameters in patients with liver metastases and intrahepatic cholangiocarcinoma undergoing Yttrium-90 radioembolization

Sarcopenia is characterized as a progressive loss of skeletal muscle mass and function, which leads to serious adverse effects on quality of life and survival [ 1 , 2 ]. The incidence of sarcopenia is associated with multiple factors such as cancer …

Immunohistochemical analysis of 147 cases of low-grade endometrial stromal sarcoma: refining the immunohistochemical profile of LG-ESS on a large, molecularly confirmed series

  • Open Access
  • Sarcoma
  • ORIGINAL ARTICLE

Low-grade endometrial stromal sarcoma (LG-ESS) can present diagnostic challenges, due to its overlapping morphological features with other uterine mesenchymal tumors. Misdiagnosis rates remain significant, and immunohistochemical data for LG-ESS …

Spleen volume assessment in Ph-negative chronic myeloproliferative neoplasms: a real-life study comparing ultrasonography vs. magnetic resonance imaging scans

Splenomegaly is a quite common clinical feature of Philadelphia (Ph) negative chronic myeloproliferative neoplasms (MPNs) and its presence may, in some cases, drives treatment decision. Most importantly, palpable splenomegaly is a minor criterion …

Related topics

ALS in a patient with CLL and drug-related SLR

A man presenting with a skin rash and left leg weakness was diagnosed with sarcoid-like reaction due to treatment for chronic lymphocytic leukemia, and ultimately also amyotrophic lateral sclerosis when the motor symptoms progressed.

Read more

Managing neuroendocrine tumors and diabetes

  • Free for a limited time
  • Diabetes
  • Review

Diabetes and NET can adversely affect each other’s prognosis, but what impact do NET therapies have on diabetes and vice versa? And how should radiological and functional procedures be managed in patients with NET and diabetes?

Read more