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Extrarenal Wilms tumor in the retroperitoneum

A 6-year-old with abdominal pain and swelling was diagnosed with an extrarenal Wilms tumor located in the retroperitoneal space. ERWT should be considered in the differential diagnosis of abdominal pain, particularly in young children.

Read more

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BCMA-targeted therapies in multiple myeloma

Three main classes of BCMA-targeted therapies – CAR T-cell therapies, bispecific antibodies, and antibody–drug conjugates – have shown promise in multiple myeloma. Take a deep dive into the latest developments to better understand their role in the evolving treatment landscape.

Novel ICI–TKI combination outplays sorafenib in HCC

First-line treatment with anlotinib plus penpulimab significantly improves the outcomes of patients with unresectable hepatocellular carcinoma relative to sorafenib.

How useful is liquid biopsy in brain tumors?

Liquid biopsies have emerged as a promising candidate for minimally invasive, accurate, and affordable monitoring of disease progression and treatment response in gliomas and brain metastases.

Pulmonary manifestation of hepatitis B virus

A nodule was found in the left lung of a patient with a history of liver resection for HCC. Serological tests found no evidence of active HBV replication, however, mNGS of the lung issue detected HBV DNA.

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Women’s health knowledge hub

Elevate your patient care with our comprehensive, evidence-based medical education on women's health. Designed to help you provide exceptional care for your female patients at every stage of life, we provide expert insights into topics such as reproductive health, menopause, breast cancer and sex-specific health risks and precision medicine.

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Incorporating comprehensive genomic profiling into the standard-of-care for NSCLC and thyroid cancer

In this interactive webinar, experts Dr. Subbiah, Dr. Drilon, and Dr. Williams discuss best pathological practices within NSCLC and thyroid cancer, as well as how genomic testing can improve outcomes in clinical practice, using patient case studies as illustrations.

This content is intended only for US-based healthcare providers.

Supported by:
  • Illumina, Inc., and Eli Lilly and Company
Dr. Vivek Subbiah
Dr. Alexander Drilon
Dr. Michelle Williams
Developed by: Springer Healthcare
Watch now
Video

Case Studies

Extrarenal Wilms tumor in the retroperitoneum

A 6-year-old with abdominal pain and swelling was diagnosed with an extrarenal Wilms tumor located in the retroperitoneal space. ERWT should be considered in the differential diagnosis of abdominal pain, particularly in young children.

Pulmonary manifestation of hepatitis B virus

A nodule was found in the left lung of a patient with a history of liver resection for HCC. Serological tests found no evidence of active HBV replication, however, mNGS of the lung issue detected HBV DNA.

Ocular complications of treating Krukenberg tumor

This case highlights the potential for severe bilateral optic neuropathy associated with FOLFOX plus nivolumab treatment, leading to irreversible vision loss.

At a glance: The DESTINY-Breast trials

The antibody–drug conjugate trastuzumab deruxtecan is being investigated in the DESTINY-Breast trials for the treatment of breast cancer.

Developed by: Springer Medicine
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Current Reviews

Imiquimod for Anal High Grade Intraepithelial Neoplasia: A Systematic Review

Anal high-grade squamous intraepithelial lesion is the precursor of anal squamous cell carcinoma (ASCC). Anal cancer progresses similarly to cervical cancer, with reported incidence rates markedly increasing to 2–3 cases per 100.000 people/year …

Impact of chronic alcohol consumption on inflammatory response and periapical bone resorption in induced apical periodontitis: a systematic review of animal studies

Alcohol consumption is linked to reduced bone mass and strength due to an imbalance in bone remodeling, characterized by decreased bone formation and an increased inflammatory response. Apical periodontitis affects the tissues surrounding the …

Impact of laparoscopic and open surgery on stoma formation and postoperative outcomes in elderly patients with obstructive colorectal cancer following self-expandable metallic stent placement: a systematic review and meta-analysis

Colorectal cancer (CRC) is a leading cause of cancer-related mortality, particularly in elderly patients. Obstructive CRC, often treated with self-expandable metallic stents (SEMS) as a bridge to surgery, requires careful consideration of the …

Tirbanibulin ointment 1% in actinic keratosis: a profile of its use in the USA

Tirbanibulin ointment 1% (KLISYRI®) is an effective and well-tolerated topical treatment option for actinic keratosis (AK) in an area of up to 100 cm2 on the face or scalp of adults. Tirbanibulin is a first-in-class drug that inhibits keratinocyte …

Elevate your expertise in aplastic anemia (Link opens in a new window)

Transform the way you care for your patients with aplastic anemia with our 3-module series using real-world case studies and expert insights. Discover why early diagnosis matters, explore the benefits and risks of current treatments, and develop tailored approaches for complex cases. 

Supported by:
  • Pfizer
Developed by: Springer Healthcare IME
Learn more

CME & eLearning

Webinar

In this interactive webinar, experts discuss best pathological practices within NSCLC and thyroid cancer, as well as how genomic testing can improve outcomes in clinical practice, using patient case studies as illustrations. 

This content is intended only for US-based healthcare providers.

Supported by:
  • Illumina, Inc., and Eli Lilly and Company
Developed by: Springer Healthcare

eLearning (Link opens in a new window)

Transform the way you care for your patients with aplastic anemia with our 3-module series using real-world case studies and expert insights. Discover why early diagnosis matters, explore the benefits and risks of current treatments, and develop tailored approaches for complex cases. 

Supported by:
  • Pfizer
Developed by: Springer Healthcare IME

eLearning | Interviews | Digital Treatment Map | Patient Cases (Link opens in a new window)

0.75 AMA PRA Category 1 Credit(s)

Expert-led, multiformat program which will address the individualized management of NSCLC, through education on the detection of NTRK gene fusions, current evidence-based guidelines, and new and emerging therapies. Will also include guidance on integrating shared decision making into your clinical practice, drawing on insights from a patient on how best to communicate.

Supported by:
  • Bayer HealthCare Pharmaceuticals Inc.
Developed by: Springer Healthcare IME

Further Reading

Dermatomyofibromas harbor PDGFRB mutations – another tyrosine kinase-driven neoplasm

Platelet-derived growth factor receptor beta (PDGFRB) is one of the numerous members of the receptor tyrosine kinase protein family. When altered, it is known to be the driver mutation in different mesenchymal neoplasms, such as pericytic tumors …

Oncological outcomes of breast cancer patients after planned IORT boost with low-kV x-rays—results of the TARGIT BQR prospective phase IV trial

Breast cancer is still the most common malignant cancer in women worldwide and ranks second in terms of cancer-related deaths after lung cancer [ 1 ]. Although global mortality is declining due to better treatment options, the incidence is also …

Critical Aspects into Surgical Management, Classification, and Therapeutic Guidelines for Incidental GISTs During Bariatric Surgeries

Incidental gastrointestinal stromal tumors (GISTs) discovered during bariatric surgeries present unique diagnostic and management challenges. In response to Khan et al.’s report on a sleeve-preserving approach to GIST resection, we highlight …

Imiquimod for Anal High Grade Intraepithelial Neoplasia: A Systematic Review

Anal high-grade squamous intraepithelial lesion is the precursor of anal squamous cell carcinoma (ASCC). Anal cancer progresses similarly to cervical cancer, with reported incidence rates markedly increasing to 2–3 cases per 100.000 people/year …

Related topics

BCMA-targeted therapies in multiple myeloma

Three main classes of BCMA-targeted therapies – CAR T-cell therapies, bispecific antibodies, and antibody–drug conjugates – have shown promise in multiple myeloma. Take a deep dive into the latest developments to better understand their role in the evolving treatment landscape.

Read more

Extrarenal Wilms tumor in the retroperitoneum

A 6-year-old with abdominal pain and swelling was diagnosed with an extrarenal Wilms tumor located in the retroperitoneal space. ERWT should be considered in the differential diagnosis of abdominal pain, particularly in young children.

Read more