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Recurrent CRS during bispecific antibody therapy

An unusual pattern of recurrent cytokine release syndrome occurring during bispecific antibody therapy for multiple myeloma. Recognition of this phenomenon is essential to avoid misdiagnosis as infection.

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Editor's Choice

Metabolic and bariatric surgery: evolving indications

MBS has evolved from a last-resort intervention to an effective, evidence-based therapeutic modality for obesity and its related medical conditions. The contraindications of the past are the indications of the future.

Aspirin in CRC: who to treat, when, and why

The use of aspirin in colorectal cancer should be targeted rather than routine. This algorithm integrates crucial factors such as absolute CRC risk, PI3K/PIK3CA status, and bleeding risk to maximize benefit while reducing harm.

Robot-assisted esophagectomy noninferior to thoracoscopic surgery for SCC

Comparable long-term survival for patients undergoing robot-assisted or thoracoscopic esophagectomy for resectable esophageal squamous cell carcinoma, suggests the RAMIE trial.

Diagnostics in cardio-oncology: a focus on anthracyclines

The dose-dependent cardiotoxicities of anthracyclines require careful cardiovascular monitoring. Discover how the latest diagnostic advances in imaging modalities, biomarkers, and genetic screening are refining patient care.

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Keynote webinar | Spotlight on progress in colorectal cancer

CRC remains a major global health burden, but advances in screening, treatment, and lifestyle-based prevention continue to reshape clinical practice. Gain insights into how the latest research can be leveraged to optimize patient care across the CRC continuum.

Prof. Antoni Castells
Prof. Harpreet Wasan
Prof. Edward Giovannucci
Watch now
Video
COMMISSIONED

How-to guide for healthcare professionals: understanding genomic reports

This educational activity was initiated, funded and co-developed by Boehringer Ingelheim and is intended for healthcare professionals in the UK and Ireland only. 

Genomic testing helps inform cancer diagnosis, prognosis, and treatment. A genomic report is generated by the laboratory carrying out next-generation sequencing to analyze biopsy samples. Access this educational microsite to learn more about typical genomic report content and how to interpret test results for patients with cancer.

NP-GB-106631 | Jan 2026

Commissioned by:
  • Boehringer Ingelheim
Learn more

Case Studies

Recurrent CRS during bispecific antibody therapy

An unusual pattern of recurrent cytokine release syndrome occurring during bispecific antibody therapy for multiple myeloma. Recognition of this phenomenon is essential to avoid misdiagnosis as infection.

Successful treatment of von Willebrand syndrome in CLL

Acquired von Willebrand syndrome represents a rare but significant complication of chronic lymphocytic leukemia. This patient achieved remission after treatment with venetoclax plus obinutuzumab.

Colonic metastasis from breast cancer

Although colonic metastases from breast cancer are extremely rare, it is important for patients with a history of breast cancer who present with GI symptoms to undergo prompt endoscopic evaluation.

Episode 25: Therapeutic cancer vaccines

The next frontier in cancer treatment?

Recently there has been a renewed interest in the prospect of therapeutic cancer vaccines. But what exactly does it mean to vaccinate against cancer, where are vaccines showing the most promise, and what are the challenges of making such vaccines a reality?

Dr. Elias Sayour answers these questions and more in this episode.

Dr. Elias Sayour
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Podcast

Current Reviews

Chimeric antigen receptor macrophage (CAR-M) immunotherapy in autoimmune inflammatory rheumatic diseases

Chronic autoimmune inflammatory rheumatic diseases (AIRD), such as rheumatoid arthritis (RA), systemic lupus erythematosus (SLE), juvenile idiopathic arthritis, systemic sclerosis (SSc), psoriatic arthritis (PsA), and ankylosing spondylitis (AS) …

Revisiting the Role of Gemtuzumab Ozogamicin in Core-Binding Factor Acute Myeloid Leukemia: An Urgent Priority for India

Core-binding factor acute myeloid leukemia (CBF-AML) is traditionally classified as a favorable-risk subtype; however, outcomes in the Indian context have not mirrored this biological advantage. Relapse rates approaching 40% in both pediatric and …

Potential of CAR-T cell immunotherapy in rheumatoid arthritis

Rheumatoid arthritis (RA) is a chronic autoimmune disease characterized by inflammation and joint destruction. Despite the availability of various treatment options, many patients remain refractory to conventional therapies. Recent advancements in …

A narrative review: key evidence from meta-analyses in nuclear medicine

Recent progress in nuclear medicine has been driven by continuous advances in radiotracers, imaging technologies, and radiopharmaceutical therapies, leading to an expansion of clinical applications supported by an increasing body of evidence. In …

Case simulations: Biomarker-driven management of NSCLC (Link opens in a new window)

Do you want to assess your biomarker testing skills and management decisions? Use these simulation-based case studies based on realistic NSCLC scenarios to do so in a practical and secure environment.

Independent Medical Education Grant:
  • Bayer HealthCare Pharmaceuticals Inc.
Learn more Link opens in a new window

CME & eLearning

COMMISSIONED

How-to guide for healthcare professionals: understanding genomic reports

This educational activity was initiated, funded and co-developed by Boehringer Ingelheim and is intended for healthcare professionals in the UK and Ireland only.

Genomic testing helps inform cancer diagnosis, prognosis, and treatment. Access this educational microsite to learn more about typical genomic report content and how to interpret test results for patients with cancer.

NP-GB-106631 | Jan 2026

Commissioned by:
  • Boehringer Ingelheim
Video
SPONSORED

Masterclass webinar: Expert review of CAR T-cell therapy patient cases in R/R DLBCL or R/R FL

Professor Joy Ho and a panel of Asia-Pacific-based experts will examine real-life patient cases in this Masterclass, exchanging insights into their clinical experiences of using CAR T-cell therapy to treat patients with R/R DLBCL or R/R FL.

This educational activity is not intended for healthcare professionals based in the UK, US, or off-label Asia-Pacific countries.

Sponsor:
  • Novartis Pharma AG
SPONSORED

CAR T-cell therapy medical education hub

This hub presents a curated selection of educational materials focused on the latest clinically relevant topics related to the use of chimeric antigen receptor (CAR) T‑cell therapy for the treatment of relapsed/refractory (R/R) diffuse large B-cell lymphoma (DLBCL) and R/R follicular lymphoma (FL).

This content has been developed in collaboration with and funded by the sponsor Novartis Pharma AG and is not intended for healthcare professionals based in the UK and US.

Sponsor:
  • Novartis Pharma AG

Further Reading

Economic Burden of Recurrence in Early-Stage Hepatocellular Carcinoma Treated with Surgical Resection or Local Ablation in the United States: A Retrospective Analysis of Surveillance, Epidemiology and End Results–Medicare Data

Liver cancer was the third leading cause of cancer-related mortality in 2022 and ranks among the most prevalent cancers worldwide [ 1 ]. Hepatocellular carcinoma (HCC) is the most common primary liver cancer, representing 75–85% of all cases …

Noninvasive risk stratification of liver nodule development in Fontan-associated liver disease using liver stiffness measurement

Fontan surgery is a well-established palliative procedure for patients with complex congenital heart defects resulting in a single functional ventricle [ 1 ]. It is designed to separate the pulmonary and systemic circulations by connecting the …

Related topics

Recurrent CRS during bispecific antibody therapy

An unusual pattern of recurrent cytokine release syndrome occurring during bispecific antibody therapy for multiple myeloma. Recognition of this phenomenon is essential to avoid misdiagnosis as infection.

Read more

Metabolic and bariatric surgery: evolving indications

MBS has evolved from a last-resort intervention to an effective, evidence-based therapeutic modality for obesity and its related medical conditions. The contraindications of the past are the indications of the future.

Read more
Image Credits
3D render of bispecific antibodies/© huenstructurebio.com / stock.adobe.com, Bariatric surgery/© subway84 / Stock.adobe.com, Aspirin dissolving in water/© Victor Moussa / Stock.adobe.com, Surgeon at surgical robot terminal/© MoMo Productions / DigitalVision / Getty (symbolic image with model), Holographic image of heart/© Yuichiro Chino / Moment / Getty, Colon cancer illustration/© (M) KATERYNA KON / SCIENCE PHOTO LIBRARY / Getty Images, 3D illustration of the pancreas/© Rasi Bhadramani / Getty Images / iStock, Nurse or doctor holding syringe/© Olga Ihnatsyeva / Getty Imges / iStock, DNA / genetic testing concept illustration/© piyaset / iStock / Getty Images Plus, Incretin mimetic injectors/© aprott / Getty Images / iStock, 3D illustration of a bone tumor/© Mohammed Haneefa Nizamudeen / Getty Images / iStock, DNA double helix structure on a purple background/© 2025 Adobe, Nurse checking IV drip bag/© Gorodenkoff / Stock.adobe.com (symbolic image with model), Abdominal CT of breast cancer patient with colonic metastasis/© 2026, Matteo Matteucci et al, Int J Colorectal Dis, Medicine Matters Podcast promo image/© Springer Medizin GmbH, Biomarker-driven management of NSCLC logo/© Springer Health+ IME, Dart hitting center of target/© Ramita / Generated with AI / Stock.adobe.com, CAR T cells attacking cancer cells illustration/© Artur / stock.adobe.com, CAR T-cell attacking cancer cells/© LoveLive/stock.adobe.com, T-cell expressing chimeric antigen receptor (CAR) in the cell membrane; DNA is exposed from the T-cell to highlight the genetic engineering involved in creating CAR T-cells/© LoveLive/stock.adobe.com, Thyroid gland 3D illustration/© Rasi Bhadramani / Getty Images / iStock, IV drip in hospital/© Kwangmoozaa / stock.adobe.com, IV drip/© Trsakaoe / stock.adobe.com, Hormone replacement therapy/© RFBSIP / stock.adobe.com (symbolic image with model)