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Conjunctival tumors show promising response to imiquimod ointment

Early data show imiquimod compounded ointment may have potential as a treatment for diffuse conjunctival melanoma in situ and ocular surface squamous neoplasia, but further research is needed.

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Editor's Choice

Complex K. pneumoniae infection in patient with relapsed AML

An elderly patient with relapsed AML developed cavitary pneumonia and bacteremia. Whole-genome sequencing revealed two distinct K. pneumoniae strains with divergent AMR and virulence profiles, highlighting the importance of genomic diagnostics in guiding treatment decisions.

PPIs tied to inferior survival in glioblastoma

Use of potent ALDH1A1-activating proton pump inhibitors is associated with worse survival outcomes in people with newly diagnosed glioblastoma.

Pediatric CRC: a rare diagnosis

Colorectal cancer is very rare in children and adolescents. And due to the generally highly aggressive nature and a low index of suspicion in this population, diagnosis can be delayed and lead to a very poor prognosis.

Current surgical management of acral melanoma

Review the available evidence on surgical management for acral melanoma, and explore future perspectives and challenges for optimizing treatment strategies for this distinct melanoma subtype.

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2025 ASH Congress hub

Catch up on all the latest news, guidance and expert opinion from the 2025 ASH annual meeting, including updates in sickle cell disease, multiple myeloma, lymphoma, transplants.

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Are you up to date on targeted therapies for relapsed/refractory AML? 

Join Prof. Amer Zeidan and his expert guests to hear about innovations in molecular testing, emerging therapies, and IDH-targeted treatments, and get practical advice for improving your patient care.

Supported by: independent educational grant from Rigel

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SPONSORED

Masterclass webinar: Expert review of CAR T-cell therapy patient cases in R/R DLBCL or R/R FL

Join Professor Joy Ho as she leads a panel of Asia-Pacific-based experts, discussing real-life patient cases and their experiences with CAR T-cell therapy for the treatment of R/R DLBCL or R/R FL. Learn about how to identify appropriate patients for CAR T-cell therapy and how to optimize outcomes with this treatment modality. Gain insights into essential aspects of pre- and post-infusion management, as well as important considerations for treatment sequencing.

This educational activity is not intended for healthcare professionals based in the UK, US, or off-label Asia-Pacific countries.

Sponsored by:
  • Novartis Pharma AG
Prof. Joy Ho
Prof. William Hwang
Dr. Kentaro Fukushima
Prof. Dok Hyun Yoon
Prof. Miki Ando
Developed by: Springer Health+
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Case Studies

Complex K. pneumoniae infection in patient with relapsed AML

An elderly patient with relapsed AML developed cavitary pneumonia and bacteremia. Whole-genome sequencing revealed two distinct K. pneumoniae strains with divergent AMR and virulence profiles, highlighting the importance of genomic diagnostics in guiding treatment decisions.

Pediatric CRC: a rare diagnosis

Colorectal cancer is very rare in children and adolescents. And due to the generally highly aggressive nature and a low index of suspicion in this population, diagnosis can be delayed and lead to a very poor prognosis.

ICI-associated hypothyroidism, macular rash, and adrenal insufficiency

A complex case of hypothyroidism, macular rash, and adrenal insufficiency that developed in an older man several months after he received sintilimab for the treatment of esophageal carcinoma.

Keynote webinar | Spotlight on progress in colorectal cancer

  • Xy
  • On-demand Webinar

On-demand video coming soon

CRC remains a major global health burden, but advances in screening, treatment, and lifestyle-based prevention continue to reshape clinical practice. Gain insights into how the latest research can be leveraged to optimize patient care across the CRC continuum.

Prof. Antoni Castells
Prof. Edward Giovannucci
Prof. Harpreet Wasan
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Current Reviews

Recent advances in the diagnosis and treatment of refractory ocular inflammatory diseases: focus on uveitic macular edema, acute retinal necrosis, and vitreoretinal lymphoma

  • Open Access
  • Uveitis
  • Forefront Review

Refractory inflammatory ocular diseases—uveitic macular edema (UME), acute retinal necrosis (ARN), and vitreoretinal lymphoma (VRL)—pose significant diagnostic and therapeutic challenges due to their vision- or life-threatening nature and limited …

Classic Hodgkin lymphoma in a patient with Behçet’s disease: a case report and review of the literature

Behçet’s disease (BD) is a chronic, relapsing, multisystem inflammatory vasculitis characterized by recurrent oral and genital ulcers, skin lesions, and ocular involvement, with potential for vascular, neurologic, and gastrointestinal …

Intramedullary melanocytoma: a systematic review

Primary spinal cord tumors are rare. They are categorized based on their location: extradural, intradural-extramedullary, and rarely intradural-intramedullary (5% to 10%) [ 1 ].

Episode 22: Celebrating 25 years of TKIs in CML

Marking a major milestone in chronic myeloid leukemia treatment

Tyrosine kinase inhibitors have transformed the treatment of chronic myeloid leukemia, a condition that had limited therapeutic options before.

In this 25th year since the first phase 2 trials of the first TKI, we speak to a researcher and clinician who has been involved since the early days. Dr. Jorge Cortes shares his experience and talks about the impact of these drugs, not only in the treatment of CML but also more widely.

Dr. Jorge Cortes
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Podcast

CME & eLearning

SPONSORED

Masterclass webinar: Expert review of CAR T-cell therapy patient cases in R/R DLBCL or R/R FL

Professor Joy Ho and a panel of Asia-Pacific-based experts will examine real-life patient cases in this Masterclass, exchanging insights into their clinical experiences of using CAR T-cell therapy to treat patients with R/R DLBCL or R/R FL.

This educational activity is not intended for healthcare professionals based in the UK, US, or off-label Asia-Pacific countries.

Sponsored by:
  • Novartis Pharma AG
SPONSORED

CAR T-cell therapy medical education hub

This hub presents a curated selection of educational materials focused on the latest clinically relevant topics related to the use of chimeric antigen receptor (CAR) T‑cell therapy for the treatment of relapsed/refractory (R/R) diffuse large B-cell lymphoma (DLBCL) and R/R follicular lymphoma (FL).

This content has been developed in collaboration with and funded by the sponsor Novartis Pharma AG and is not intended for healthcare professionals based in the UK and US.

Sponsored by:
  • Novartis Pharma AG

The AML expert series

Hear directly from experts in acute myeloid leukemia about innovations in molecular testing, emerging therapies, and targeted treatments, and get practical advice for improving the care of your patients with relapsed or refractory disease.

Supported by:
  • Rigel Pharmaceuticals, Inc.
Developed by: Springer Health+ IME

Further Reading

Recent advances in the diagnosis and treatment of refractory ocular inflammatory diseases: focus on uveitic macular edema, acute retinal necrosis, and vitreoretinal lymphoma

  • Open Access
  • Uveitis
  • Forefront Review

Refractory inflammatory ocular diseases—uveitic macular edema (UME), acute retinal necrosis (ARN), and vitreoretinal lymphoma (VRL)—pose significant diagnostic and therapeutic challenges due to their vision- or life-threatening nature and limited …

Intraperitoneal nivolumab for malignant ascites in patients with advanced gastrointestinal or pancreaticobiliary tract cancer

  • Open Access
  • Ascites
  • Original Article

Malignant ascites develop in 10–15% of patients with gastrointestinal cancers at some stage of the disease [ 1 ], including 8–18.3% of patients with gastric cancer [ 2 , 3 ], 15–21% of those with advanced pancreaticobiliary cancers [ 3 , 4 ], and …

Evaluating the metabolic effects of neoadjuvant treatment in clear cell renal cell carcinoma using hyperpolarized [1-13 C]pyruvate MRI

Renal cell carcinoma (RCC) is the most common kidney malignancy with an increasing incidence globally, but with no decline in mortality rates [ 1 ]. Surgery with curative intent is the treatment of choice for clinically-fit patients whose disease …

Association of skill and errors with outcomes in robotic rectal cancer surgery

VAMIS is a national multicentre study (protocol on ClinicalTrials.gov NCT05279287) which gained Health Research Authority and Health and Care Research Wales (HCRW) approval with local Research Ethics Committee (REC) approval for national …

Related topics

Complex K. pneumoniae infection in patient with relapsed AML

An elderly patient with relapsed AML developed cavitary pneumonia and bacteremia. Whole-genome sequencing revealed two distinct K. pneumoniae strains with divergent AMR and virulence profiles, highlighting the importance of genomic diagnostics in guiding treatment decisions.

Read more

Conjunctival tumors show promising response to imiquimod ointment

Early data show imiquimod compounded ointment may have potential as a treatment for diffuse conjunctival melanoma in situ and ocular surface squamous neoplasia, but further research is needed.

Read more
Image Credits
Ocular surface squamous neoplasia/© 2021, Randy C. Bowen et al, under exclusive licence to The Royal College of Ophthalmologists, Eye, Chest x-ray showing patchy infiltrates with internal lucency suggestive of cavitation/© 2025, Akela Ghazawi et al, BMC Infect Dis, Pills on background of brain MRI scan/© Ildar Imashev / Getty Images / iStock, Laparoscopy of child with colorectal adenocarcinoma/© 2025, Riccardo Guanà et al, Int J Colorectal Dis, Representative cases of acral melanoma/© 2025, Shigeru Koizumi et al, Curr Treat Options Oncol, Blood cells in abstract design/© zketch / Stock.adobe.com, CAR T-cell attacking cancer cells/© LoveLive/stock.adobe.com, ECG in a patient with hypothyroidism, macular rash, and adrenal crisis following ICI treatment/© 2025, Zhong-qing Mou et al, BMC Endocr Disord, Colon cancer illustration/© (M) KATERYNA KON / SCIENCE PHOTO LIBRARY / Getty Images, Medicine Matters Podcast promo image/© Springer Medizin GmbH, T-cell expressing chimeric antigen receptor (CAR) in the cell membrane; DNA is exposed from the T-cell to highlight the genetic engineering involved in creating CAR T-cells/© LoveLive/stock.adobe.com, Leukemia background in bright colors, including white and red blood cells in realistic style/© Double Brain/Shutterstock.com, Acute lymphoblastic leukemia cytology/© Arif Biswas / stock.adobe.com, Senior man using a resistance band in an exercise class/© Drazen Zigic / Getty Images (symbolic image with models), Doctor examining a chest x-ray/© Minerva Studio / stock.adobe.com (symbolic image with model), Iris pigment epithelial cysts in acute lymphoblastic leukemia/© 2025, Kar Yong Chong et al, BMC Ophthalmol, Imaging of patient with multiple myeloma and spinal infiltration/© 2025, Fondazione Società Italiana di Neurologia, Neurol Sci (used with permission), Close-up of woman with IV drip in arm/© Seventyfour / stock.adobe.com, Doctors discussing brain scans and treatment decisions/© dragana991 / Getty Images (symbolic image with models)