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PPIs tied to inferior survival in glioblastoma

Use of potent ALDH1A1-activating proton pump inhibitors is associated with worse survival outcomes in people with newly diagnosed glioblastoma.

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Editor's Choice

Pediatric CRC: a rare diagnosis

Colorectal cancer is very rare in children and adolescents. And due to the generally highly aggressive nature and a low index of suspicion in this population, diagnosis can be delayed and lead to a very poor prognosis.

Current surgical management of acral melanoma

Review the available evidence on surgical management for acral melanoma, and explore future perspectives and challenges for optimizing treatment strategies for this distinct melanoma subtype.

CASSANDRA supports neoadjuvant PAXG for pancreatic cancer

Preoperative treatment with the PAXG chemotherapy regimen significantly improves the event-free survival of patients with resectable or borderline resectable pancreatic cancer versus mFOLFIRINOX.

Treatment choices for tumor-related epilepsy

Which strategies integrate antiseizure medications, surgery, chemotherapy, radiation, and targeted therapies to improve seizure control while minimizing drug interactions and preserving quality of life?

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Keynote webinar | Spotlight on progress in colorectal cancer

  • Live
  • Webinar | 11-12-2025 | 18:00 (CET)

CRC remains a major global health burden, but advances in screening, treatment, and lifestyle-based prevention continue to reshape clinical practice. Gain insights into how the latest research can be leveraged to optimize patient care across the CRC continuum.

Watch it live: Thursday 11 December 2025, 18:00-19:30 (CET)

Prof. Antoni Castells
Prof. Edward Giovannucci
Prof. Harpreet Wasan
Join the webinar
Webinar

Are you up to date on targeted therapies for relapsed/refractory AML? 

Join Prof. Amer Zeidan and his expert guests to hear about innovations in molecular testing, emerging therapies, and IDH-targeted treatments, and get practical advice for improving your patient care.

Supported by: independent educational grant from Rigel

Find out more
SPONSORED

Masterclass webinar: Expert review of CAR T-cell therapy patient cases in R/R DLBCL or R/R FL

Join Professor Joy Ho as she leads a panel of Asia-Pacific-based experts, discussing real-life patient cases and their experiences with CAR T-cell therapy for the treatment of R/R DLBCL or R/R FL. Learn about how to identify appropriate patients for CAR T-cell therapy and how to optimize outcomes with this treatment modality. Gain insights into essential aspects of pre- and post-infusion management, as well as important considerations for treatment sequencing.

This educational activity is not intended for healthcare professionals based in the UK, US, or off-label Asia-Pacific countries.

Sponsored by:
  • Novartis Pharma AG
Prof. Joy Ho
Prof. William Hwang
Dr. Kentaro Fukushima
Prof. Dok Hyun Yoon
Prof. Miki Ando
Developed by: Springer Health+
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Video

Case Studies

Pediatric CRC: a rare diagnosis

Colorectal cancer is very rare in children and adolescents. And due to the generally highly aggressive nature and a low index of suspicion in this population, diagnosis can be delayed and lead to a very poor prognosis.

ICI-associated hypothyroidism, macular rash, and adrenal insufficiency

A complex case of hypothyroidism, macular rash, and adrenal insufficiency that developed in an older man several months after he received sintilimab for the treatment of esophageal carcinoma.

Intralesional IL-2 for periocular cSCC

This first case series shows intralesional IL-2 therapy is a promising non-surgical option for locally advanced periocular cutaneous squamous cell carcinoma.

Episode 22: Celebrating 25 years of TKIs in CML

Marking a major milestone in chronic myeloid leukemia treatment

Tyrosine kinase inhibitors have transformed the treatment of chronic myeloid leukemia, a condition that had limited therapeutic options before.

In this 25th year since the first phase 2 trials of the first TKI, we speak to a researcher and clinician who has been involved since the early days. Dr. Jorge Cortes shares his experience and talks about the impact of these drugs, not only in the treatment of CML but also more widely.

Dr. Jorge Cortes
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Podcast

Current Reviews

Artificial intelligence and multi-omics integration in liquid biopsy for genitourinary cancers: a systematic scoping review

Genitourinary (GU) cancers—including prostate, bladder, kidney, and testicular malignancies—remain a major global health challenge, with high morbidity and mortality driven by late detection, tumor heterogeneity, and limited tools for real-time …

Comparative Economic Evaluations of CAR-T Therapies for Relapsed or Refractory Diffuse Large B-Cell Lymphoma: A Systematic Review

Diffuse large B-cell lymphoma (DLBCL) is a group of lymphoid malignancies characterized by highly heterogenous pathological, clinical, and molecular features [ 1 ]. Diffuse large B-cell lymphoma is the most common type of non-Hodgkin lymphoma …

Management of squamous cell carcinoma of unknown primary in the head and neck: current evidence-based diagnostic and treatment strategies

Cancer of unknown primary (CUP) encompasses a heterogeneous group of histologically confirmed metastatic cancers where the primary site remains unknown despite standardized diagnostic workup [ 1 ]. In the head and neck region, cervical CUP accounts …

Diagnostic accuracy of artificial intelligence-assisted 18f-fdg pet/ct for predicting pathological complete response to neoadjuvant chemotherapy in breast cancer: a systematic review and meta-analysis

We conducted a systematic review and meta-analysis to assess the diagnostic accuracy of artificial intelligence (AI)-assisted 18 F-FDG PET/CT for predicting pathological complete response (pCR) to neoadjuvant chemotherapy (NAC) in breast cancer. A …

Women’s health knowledge hub

Elevate your patient care with our comprehensive, evidence-based medical education on women's health. Designed to help you provide exceptional care for your female patients at every stage of life, we provide expert insights into topics such as reproductive health, menopause, breast cancer and sex-specific health risks and precision medicine.

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CME & eLearning

SPONSORED

Masterclass webinar: Expert review of CAR T-cell therapy patient cases in R/R DLBCL or R/R FL

Professor Joy Ho and a panel of Asia-Pacific-based experts will examine real-life patient cases in this Masterclass, exchanging insights into their clinical experiences of using CAR T-cell therapy to treat patients with R/R DLBCL or R/R FL.

This educational activity is not intended for healthcare professionals based in the UK, US, or off-label Asia-Pacific countries.

Sponsored by:
  • Novartis Pharma AG
SPONSORED

CAR T-cell therapy medical education hub

This hub presents a curated selection of educational materials focused on the latest clinically relevant topics related to the use of chimeric antigen receptor (CAR) T‑cell therapy for the treatment of relapsed/refractory (R/R) diffuse large B-cell lymphoma (DLBCL) and R/R follicular lymphoma (FL).

This content has been developed in collaboration with and funded by the sponsor Novartis Pharma AG and is not intended for healthcare professionals based in the UK and US.

Sponsored by:
  • Novartis Pharma AG

The AML expert series

Hear directly from experts in acute myeloid leukemia about innovations in molecular testing, emerging therapies, and targeted treatments, and get practical advice for improving the care of your patients with relapsed or refractory disease.

Supported by:
  • Rigel Pharmaceuticals, Inc.
Developed by: Springer Health+ IME

Further Reading

Glioblastoma survival prediction through MRI and clinical data integration with transfer learning

Glioblastoma multiforme (GBM) is the most prevalent and aggressive primary brain tumor, characterized by rapid progression and poor prognosis. Standard treatment involves maximal safe surgical resection, radiotherapy, and temozolomide …

Effectiveness of Tofacitinib in Patients with Psoriatic Arthritis Initiating Monotherapy Versus Combination Therapy: Results from the CorEvitas Psoriatic Arthritis/Spondyloarthritis Registry

Psoriatic arthritis (PsA) is a chronic, immune-mediated inflammatory disease characterized by heterogenous manifestations including peripheral arthritis, enthesitis, dactylitis, axial disease, and skin psoriasis (PsO) [ 1 ]. It is common for …

Qualitative Interviews on the Experience of Orally vs. Intramuscularly Administered Endocrine Therapy for Advanced Breast Cancer: Patient and Healthcare Provider Perspectives

Breast cancer (BC) is the leading cause of cancer-related mortality among women globally [ 1 ] and among women aged 20–59 years in the USA [ 2 ]. In the USA, it is estimated that more than 169,000 female individuals will be living with metastatic …

Multidimensional impact of fixed-dose subcutaneous trastuzumab-pertuzumab on oncology workflow and patient time burden in a real-world study

Breast Cancer remains the most commonly diagnosed malignancy among women worldwide, and its incidence continues to rise. Approximately 20% of cases are classified as human epidermal growth factor receptor 2 (HER2)-positive, a subtype associated …

Related topics

Transforming the treatment of ALL

Learn how emerging therapeutic strategies such as CAR T-cell therapy, antibody–drug conjugates, and bispecific antibodies are improving the outcomes of people with B-cell acute lymphoblastic leukemia.

Read more

PPIs tied to inferior survival in glioblastoma

Use of potent ALDH1A1-activating proton pump inhibitors is associated with worse survival outcomes in people with newly diagnosed glioblastoma.

Read more
Image Credits
Pills on background of brain MRI scan/© Ildar Imashev / Getty Images / iStock, Laparoscopy of child with colorectal adenocarcinoma/© 2025, Riccardo Guanà et al, Int J Colorectal Dis, Representative cases of acral melanoma/© 2025, Shigeru Koizumi et al, Curr Treat Options Oncol, Close-up of woman with IV drip in arm/© Seventyfour / stock.adobe.com, Doctors discussing brain scans and treatment decisions/© dragana991 / Getty Images (symbolic image with models), Colon cancer illustration/© (M) KATERYNA KON / SCIENCE PHOTO LIBRARY / Getty Images, Downward arrows/© (M) Kulpreya Chaichatpornsuk / Getty Images / iStock, Heap of blue, white, and beige pills and capsules/© AlexRaths / Getty Images / iStock, CAR T-cell attacking cancer cells/© LoveLive/stock.adobe.com, ECG in a patient with hypothyroidism, macular rash, and adrenal crisis following ICI treatment/© 2025, Zhong-qing Mou et al, BMC Endocr Disord, Patient presenting with periocular cutaneous squamous cell carcinoma/© 2025, Sorayya Seddigh et al, Ophthalmol Ther, Medicine Matters Podcast promo image/© Springer Medizin GmbH, Stylized collage of women/© (M) VictoriaBar / Getty Images / iStock, T-cell expressing chimeric antigen receptor (CAR) in the cell membrane; DNA is exposed from the T-cell to highlight the genetic engineering involved in creating CAR T-cells/© LoveLive/stock.adobe.com, Leukemia background in bright colors, including white and red blood cells in realistic style/© Double Brain/Shutterstock.com, Acute lymphoblastic leukemia cytology/© Arif Biswas / stock.adobe.com, Senior man using a resistance band in an exercise class/© Drazen Zigic / Getty Images (symbolic image with models), Doctor examining a chest x-ray/© Minerva Studio / stock.adobe.com (symbolic image with model), Iris pigment epithelial cysts in acute lymphoblastic leukemia/© 2025, Kar Yong Chong et al, BMC Ophthalmol, Imaging of patient with multiple myeloma and spinal infiltration/© 2025, Fondazione Società Italiana di Neurologia, Neurol Sci (used with permission), Syringe, vial and white pills/© Alexander / Stock.adobe.com