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ICI-associated thyroiditis: mechanisms and outcomes

Thyroid dysfunction is the most common endocrine immune-related adverse event triggered by immune checkpoint inhibitors. Learn about the clinical features, proposed mechanisms, and association with improved survival.

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Editor's Choice

Association of type 1 stiff-person syndrome and insulinoma

A man given clonazepam for type 1 SPS experienced episodes of confusion that persisted after dose reduction. Transient symptom improvement occurred after an insulinoma was found and removed.

Extrarenal Wilms tumor in the retroperitoneum

A 6-year-old with abdominal pain and swelling was diagnosed with an extrarenal Wilms tumor located in the retroperitoneal space. ERWT should be considered in the differential diagnosis of abdominal pain, particularly in young children.

BCMA-targeted therapies in multiple myeloma

Three main classes of BCMA-targeted therapies have shown promise in multiple myeloma. Take a deep dive into the latest developments to better understand their role in the evolving treatment landscape.

Novel ICI–TKI combination outplays sorafenib in HCC

First-line treatment with anlotinib plus penpulimab significantly improves the outcomes of patients with unresectable hepatocellular carcinoma relative to sorafenib.

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Women’s health knowledge hub

Elevate your patient care with our comprehensive, evidence-based medical education on women's health. Designed to help you provide exceptional care for your female patients at every stage of life, we provide expert insights into topics such as reproductive health, menopause, breast cancer and sex-specific health risks and precision medicine.

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Incorporating comprehensive genomic profiling into the standard-of-care for NSCLC and thyroid cancer

In this interactive webinar, experts Dr. Subbiah, Dr. Drilon, and Dr. Williams discuss best pathological practices within NSCLC and thyroid cancer, as well as how genomic testing can improve outcomes in clinical practice, using patient case studies as illustrations.

This content is intended only for US-based healthcare providers.

Supported by:
  • Illumina, Inc., and Eli Lilly and Company
Dr. Vivek Subbiah
Dr. Alexander Drilon
Dr. Michelle Williams
Developed by: Springer Healthcare
Watch now
Video

Case Studies

Association of type 1 stiff-person syndrome and insulinoma

A man given clonazepam for type 1 SPS experienced episodes of confusion that persisted after dose reduction. Transient symptom improvement occurred after an insulinoma was found and removed.

Extrarenal Wilms tumor in the retroperitoneum

A 6-year-old with abdominal pain and swelling was diagnosed with an extrarenal Wilms tumor located in the retroperitoneal space. ERWT should be considered in the differential diagnosis of abdominal pain, particularly in young children.

Pulmonary manifestation of hepatitis B virus

A nodule was found in the left lung of a patient with a history of liver resection for HCC. Serological tests found no evidence of active HBV replication, however, mNGS of the lung issue detected HBV DNA.

At a glance: The DESTINY-Breast trials

The antibody–drug conjugate trastuzumab deruxtecan is being investigated in the DESTINY-Breast trials for the treatment of breast cancer.

Developed by: Springer Medicine
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Current Reviews

Stem-Cell-Assisted Lipotransfer and Platelet-Rich Plasma in Breast Reconstruction: A Literature Review

Autologous fat transplantation is a popular technique for repairing volume defects from breast cancer surgery, breastfeeding, aging, and several congenital anomalies [ 1 ]. Its popularity in plastic surgery is due to its minimally invasive nature …

Embracing cancer immunotherapy with manganese particles

A substance integral to the sustenance and functionality of virtually all forms of life is manganese (Mn), classified as an essential trace metal. Its significance lies in its pivotal role in facilitating metabolic processes crucial for survival.

Olaparib Monotherapy or in Combination with Abiraterone for the Treatment of Patients with Metastatic Castration-Resistant Prostate Cancer (mCRPC) and a BRCA Mutation

Treatment strategies to improve outcomes in patients with metastatic castration-resistant prostate cancer (mCRPC) are evolving. Of particular interest are therapies that target DNA damage responses in tumor cells by inhibiting poly(ADP-ribose) …

Radiosurgery for central nervous system ependymomas: a systematic review and meta-analysis

Ependymomas are rare malignant lesions of the central nervous system (CNS) primarily arising from ependymal cells of the ventricular system [ 1 ]. They constitute 2% to 6% of all primary CNS lesions [ 2 ]. Intracranial ependymomas typically …

Elevate your expertise in aplastic anemia (Link opens in a new window)

Transform the way you care for your patients with aplastic anemia with our 3-module series using real-world case studies and expert insights. Discover why early diagnosis matters, explore the benefits and risks of current treatments, and develop tailored approaches for complex cases. 

Supported by:
  • Pfizer
Developed by: Springer Healthcare IME
Learn more

CME & eLearning

Webinar

In this interactive webinar, experts discuss best pathological practices within NSCLC and thyroid cancer, as well as how genomic testing can improve outcomes in clinical practice, using patient case studies as illustrations. 

This content is intended only for US-based healthcare providers.

Supported by:
  • Illumina, Inc., and Eli Lilly and Company
Developed by: Springer Healthcare

eLearning (Link opens in a new window)

Transform the way you care for your patients with aplastic anemia with our 3-module series using real-world case studies and expert insights. Discover why early diagnosis matters, explore the benefits and risks of current treatments, and develop tailored approaches for complex cases. 

Supported by:
  • Pfizer
Developed by: Springer Healthcare IME

eLearning | Interviews | Digital Treatment Map | Patient Cases (Link opens in a new window)

0.75 AMA PRA Category 1 Credit(s)

Expert-led, multiformat program which will address the individualized management of NSCLC, through education on the detection of NTRK gene fusions, current evidence-based guidelines, and new and emerging therapies. Will also include guidance on integrating shared decision making into your clinical practice, drawing on insights from a patient on how best to communicate.

Supported by:
  • Bayer HealthCare Pharmaceuticals Inc.
Developed by: Springer Healthcare IME

Further Reading

Stem-Cell-Assisted Lipotransfer and Platelet-Rich Plasma in Breast Reconstruction: A Literature Review

Autologous fat transplantation is a popular technique for repairing volume defects from breast cancer surgery, breastfeeding, aging, and several congenital anomalies [ 1 ]. Its popularity in plastic surgery is due to its minimally invasive nature …

Embracing cancer immunotherapy with manganese particles

A substance integral to the sustenance and functionality of virtually all forms of life is manganese (Mn), classified as an essential trace metal. Its significance lies in its pivotal role in facilitating metabolic processes crucial for survival.

Fanconi anemia patients with head and neck squamous cell carcinoma - a multi-center study

  • Open Access
  • Anemia
  • Head and Neck

Fanconi anemia (FA) is a rare genetic disorder characterized by impaired correction of DNA damage, leading to a spectrum of clinical manifestations, including bone marrow failures, congenital malformations, and predisposition to malignancies [ 1 ].

Influence of resection distance on vulvar cancer relapse: a retrospective analysis

Vulvar cancer is characterized by the malignant transformation of the vulvar epithelium. It is the fourth most common gynecological cancer worldwide, with an annual incidence exceeding 47,000 cases and a mortality rate surpassing 18,000 deaths in …

Related topics

BCMA-targeted therapies in multiple myeloma

Three main classes of BCMA-targeted therapies have shown promise in multiple myeloma. Take a deep dive into the latest developments to better understand their role in the evolving treatment landscape.

Read more

Association of type 1 stiff-person syndrome and insulinoma

A man given clonazepam for type 1 SPS experienced episodes of confusion that persisted after dose reduction. Transient symptom improvement occurred after an insulinoma was found and removed.

Read more