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Vaping and tumor metastasis

Cigarette smoking is known to promote tumor metastasis, but do e-cigarettes also have an impact? This mini review synthesizes the current literature on the topic and discusses potential public health implications.

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Editor's Choice

Novel CAR T-cell therapy shows potential for B-cell ALL

Obecabtagene autoleucel has demonstrated promising antitumor activity and safety in adults with relapsed or refractory B-cell acute lymphoblastic leukemia.

Updated guidelines for chemotherapy in glioma

Evidence-based guidelines from the Congress of Neurological Surgeons on the role of chemotherapy in patients with newly diagnosed WHO grade II diffuse glioma. Explore the latest recommendations.

CheckMate 8HW supports nivolumab–ipilimumab for metastatic CRC

Among patients with metastatic colorectal cancer and DNA repair deficiency, first-line nivolumab plus ipilimumab significantly improves progression-free survival versus chemotherapy.

Four cases of ICI-related fulminant myocarditis

Three of the four cases resulted in fatal outcomes despite aggressive treatment, emphasizing the poor prognosis of fulminant myocarditis related to immune checkpoint inhibitor therapy.

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At a glance: The KEYNOTE lung cancer trials

A quick guide to the KEYNOTE trials investigating the anti-PD-1 agent pembrolizumab in non-small-cell and small-cell lung cancer.

Developed by: Springer Medicine
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SPONSORED

Recent advances in the use of CAR T-cell therapies in relapsed/refractory diffuse large B-cell lymphoma and follicular lymphoma

In this webinar, Professor Martin Dreyling and an esteemed international panel of CAR T-cell therapy experts discuss the latest data on the safety, efficacy, and clinical impact of CAR T-cell therapies in the treatment of r/r DLBCL and r/r FL.

Please note, this webinar is not intended for healthcare professionals based in the US and UK.

Sponsored by:
  • Novartis Pharma AG
Chaired by: Prof. Martin Dreyling
Developed by: Springer Healthcare
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Case Studies

Four cases of ICI-related fulminant myocarditis

Three of the four cases resulted in fatal outcomes despite aggressive treatment, emphasizing the poor prognosis of fulminant myocarditis related to immune checkpoint inhibitor therapy.

Rare complication in a patient with seminoma

A patient treated with carboplatin for stage I seminoma developed hematuria and acute kidney injury. It is crucial to recognize this rare but serious complication and start treatment promptly to prevent further kidney damage.

Cushing disease or ectopic adrenocorticotrophic hormone syndrome?

A girl with typical signs and symptoms of hypercortisolemia experienced adrenal insufficiency while on oral ketoconazole. Ectopic ACTH syndrome due to a thymic neuroendocrine tumor was diagnosed.

Episode 9: The gut microbiome and CAR T-cell therapy

How do nutrition, supplements and antibiotics impact patient outcomes?

Recent research suggests that the gut microbiome could be an important modulator of response to CAR T-cell therapy in patients with hematologic cancers.

Prof. Marion Subklewe takes us through the latest evidence, highlighting the impact of antibiotics, nutrition, and dietary supplements, and discusses how to devise interventions to improve patient outcomes.

Prof. Marion Subklewe
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Current Reviews

Regulatory role of microRNAs in virus-mediated inflammation

Viral infections in humans often cause excessive inflammation. In some viral infections, inflammation can be serious and even fatal, while in other infections it can promote viral clearance. Viruses can escape from the host immune system via …

The anti-inflammatory properties of vinpocetine mediates its therapeutic potential in management of atherosclerosis

Atherosclerosis (AS) formation is enhanced by different mechanisms including cytokine generation, vascular smooth muscle cell proliferation, and migration. One of the recent treatments towards endothelial dysfunction and AS is Vinpocetine (VPN).

A systematic review of dentists’ knowledge, perception, practice and confidence in managing patients with cancers

Patients undergoing CTx have unique oral and dental needs as cancer and its treatment often have direct and indirect impact on oral health. Attentive dental care tailored to the needs of CPs reduces oral complications [ 1 – 3 ], improves quality of …

Health care accessibility and mobility in breast cancer: a Latin American perspective

Limited geographic access to health facilities is a major factor contributing to reduced utilization of health services, resulting in poorer health outcomes [ 1 ]. This issue is particularly critical in the context of patients with cancer, as their …

Keynote webinar | Spotlight on antibody–drug conjugates in cancer

  • Webinar | 19-02-2024 | 17:30 (CET)

Antibody–drug conjugates (ADCs) are novel agents that have shown promise across multiple tumor types. Explore the current landscape of ADCs in breast and lung cancer with our experts, and gain insights into the mechanism of action, key clinical trials data, existing challenges, and future directions.

Dr. Véronique Diéras
Prof. Fabrice Barlesi
Developed by: Springer Medicine
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CME & eLearning

SPONSORED

Webinar

1.5 European CME credits (ECMEC®s)

A series of patient cases underpin this interactive webinar that aims to provide practical guidance on a multidisciplinary approach to managing patients with cutaneous T-cell lymphoma.

Sponsored by:
  • Kyowa Kirin
Developed by: Springer Healthcare

Symposium (Link opens in a new window)

An independent symposium at the 10th COMy World Congress focusing on BCMA-targeting strategies for the treatment of multiple myeloma. Gain insights into the latest clinical data and the implications for clinical practice.

Supported by:
  • GlaxoSmithKline
Developed by: Springer Healthcare IME

eLearning (Link opens in a new window)

The evolving landscape of metastatic urothelial carcinoma brings with it many challenges, such as optimally sequencing therapies and managing adverse events. Navigate your way through these with the Ultimate mUC challenge game and expert-to-expert interviews.

Supported by:
  • Merck Healthcare KGaA, Darmstadt, Germany and Astellas
Developed by: Springer Healthcare IME

Further Reading

Regulatory role of microRNAs in virus-mediated inflammation

Viral infections in humans often cause excessive inflammation. In some viral infections, inflammation can be serious and even fatal, while in other infections it can promote viral clearance. Viruses can escape from the host immune system via …

Lipopolysaccharide pretreatment increases the sensitivity of the TRPV1 channel and promotes an anti-inflammatory phenotype of capsaicin-activated macrophages

The transient receptor potential vanilloid 1 (TRPV1) is a non-selective cation channel associated with pain signaling and neurogenic inflammation [ 1 , 2 ]. Nevertheless, accumulating evidence suggests that TRPV1 is also involved in many other …

Locomotor and gait changes in the LPS model of neuroinflammation are correlated with inflammatory cytokines in blood and brain

Lipopolysaccharide (LPS) challenge in mice has been used to identify the mechanisms and therapeutics for neuroinflammation. In this study, we aimed to comprehensively evaluate the behavioral changes including locomotion, exploration, and memory …

MAP3K8 is a potential therapeutic target in airway epithelial inflammation

Airway inflammation is one of the central characteristics of chronic respiratory diseases such as asthma and chronic obstructive pulmonary disease (COPD). MAPK transduction signalling pathways are major regulatory influence on in the airway …

Related topics

Updated guidelines for chemotherapy in glioma

Evidence-based guidelines from the Congress of Neurological Surgeons on the role of chemotherapy in patients with newly diagnosed WHO grade II diffuse glioma. Explore the latest recommendations.

Read more