Skip to main content

Exercise training in patients with multiple myeloma

Despite well-documented benefits, exercise interventions are often underutilized in the multiple myeloma population. This review provides evidence-based strategies for developing safe and effective exercise programs for these patients.

Read more

Editor's Choice

Live webinar: Biomarker-driven management of NSCLC (Link opens in a new window)

  • NSCLC
  • Independent Medical Education

Join our experts for a discussion- and case-based webinar exploring the latest in NTRK fusion-positive non-small-cell lung cancer and equip yourself to best manage this subset of patients.

Supported by:
  • Bayer HealthCare Pharmaceuticals Inc.

Who benefits from treatment intensification in NSCLC?

  • Open Access
  • NSCLC
  • Review

Recent trials have shown survival benefits of intensified regimens in EGFR-mutant NSCLC, but they come at the cost of increased toxicity and treatment burden. So which patients should receive up-front intensification?

Managing dual primary liver metastases

The treatment strategy for liver metastases is predominantly determined by the primary cancer site, which made this patient with metastases from breast and colorectal cancer quite challenging to manage.

Neurotoxicity in CNS tumors treated with CAR T-cell therapy

CAR T-cell therapy for central nervous system tumors in children and adults induces unique neurotoxicities. Learn about the underlying mechanisms, clinical implications, and management approaches.

Our tailored content service will keep you up to date…

Receive newsletters curated for the busy specialist by our expert editorial team

Episode 22: Celebrating 25 years of TKIs in CML

Marking a major milestone in chronic myeloid leukemia treatment

Tyrosine kinase inhibitors have transformed the treatment of chronic myeloid leukemia, a condition that had limited therapeutic options before.

In this 25th year since the first phase 2 trials of the first TKI, we speak to a researcher and clinician who has been involved since the early days. Dr. Jorge Cortes shares his experience and talks about the impact of these drugs, not only in the treatment of CML but also more widely.

Dr. Jorge Cortes
Listen now
Podcast

Are you up to date on targeted therapies for relapsed/refractory AML? 

Join Prof. Amer Zeidan and his expert guests to hear about innovations in molecular testing, emerging therapies, and IDH-targeted treatments, and get practical advice for improving your patient care.

Supported by: independent educational grant from Rigel

Find out more
SPONSORED

Masterclass webinar: Expert review of CAR T-cell therapy patient cases in R/R DLBCL or R/R FL

Join Professor Joy Ho as she leads a panel of Asia-Pacific-based experts, discussing real-life patient cases and their experiences with CAR T-cell therapy for the treatment of R/R DLBCL or R/R FL. Learn about how to identify appropriate patients for CAR T-cell therapy and how to optimize outcomes with this treatment modality. Gain insights into essential aspects of pre- and post-infusion management, as well as important considerations for treatment sequencing.

This educational activity is not intended for healthcare professionals based in the UK, US, or off-label Asia-Pacific countries.

Sponsored by:
  • Novartis Pharma AG
Prof. Joy Ho
Prof. William Hwang
Dr. Kentaro Fukushima
Prof. Dok Hyun Yoon
Prof. Miki Ando
Developed by: Springer Health+
Learn more

Case Studies

Managing dual primary liver metastases

The treatment strategy for liver metastases is predominantly determined by the primary cancer site, which made this patient with metastases from breast and colorectal cancer quite challenging to manage.

Pulmonary toxicity induced by carfilzomib

Carfilzomib is mostly associated with gastrointestinal or cardiovascular side effects, but this patient with relapsed multiple myeloma developed pulmonary complications, which resolved once the drug was discontinued.

Iris pigment epithelial cysts in leukemia

Bilateral IPE cysts in a 3-year-old triggered investigations that revealed acute lymphoblastic leukemia. Chemotherapy reduced the cysts, supporting a possible link between IPE cysts and hematologic malignancies.

2025 ESMO Congress hub

Unlock your free and exclusive access to expert interviews, news, and more from the annual congress of the European Society for Medical Oncology.

Read more

Current Reviews

Sunvozertinib: a Promising Oral EGFR Inhibitor Approved for NSCLC with EGFR Ex20ins Mutations

Lung cancer continues to be a significant health burden in the United States, with 2025 estimates indicating approximately 226,650 new cases and 124,730 deaths. NSCLC is the predominant histological subtype of lung cancer, representing …

Optimizing the use of melflufen (melphalan flufenamide) in relapsed or refractory multiple myeloma: recommendations for clinical practice

In this report, a panel of multiple myeloma experts assesses the role of melflufen (melphalan flufenamide) in the treatment of patients with relapsed or refractory multiple myeloma (RRMM). Based on available data, recommendations for …

The cure hit a nerve: a case of immune checkpoint inhibitor-induced mononeuritis multiplex

A 74-year-old gentleman with a background of early stage melanoma presented with subacute onset of asymmetric sensorimotor symptoms, involving all four limbs. This had progressed over the preceding three-months - he had become severely debilitated …

Computed tomography and magnetic resonance imaging features of adnexal and leiomyoma torsion: correlation with laparoscopic findings

Adnexal torsion and pedunculated subserosal leiomyoma torsion are significant gynecological emergencies requiring prompt recognition and surgical intervention. Although ultrasound remains the primary imaging modality, cross-sectional imaging with …

Women’s health knowledge hub

Elevate your patient care with our comprehensive, evidence-based medical education on women's health. Designed to help you provide exceptional care for your female patients at every stage of life, we provide expert insights into topics such as reproductive health, menopause, breast cancer and sex-specific health risks and precision medicine.

Read more

CME & eLearning

SPONSORED

Masterclass webinar: Expert review of CAR T-cell therapy patient cases in R/R DLBCL or R/R FL

Professor Joy Ho and a panel of Asia-Pacific-based experts will examine real-life patient cases in this Masterclass, exchanging insights into their clinical experiences of using CAR T-cell therapy to treat patients with R/R DLBCL or R/R FL.

This educational activity is not intended for healthcare professionals based in the UK, US, or off-label Asia-Pacific countries.

Sponsored by:
  • Novartis Pharma AG
Developed by: Springer Health+
SPONSORED

CAR T-cell therapy medical education hub

This hub presents a curated selection of educational materials focused on the latest clinically relevant topics related to the use of chimeric antigen receptor (CAR) T‑cell therapy for the treatment of relapsed/refractory (R/R) diffuse large B-cell lymphoma (DLBCL) and R/R follicular lymphoma (FL).

This content has been developed in collaboration with and funded by the sponsor Novartis Pharma AG and is not intended for healthcare professionals based in the UK and US.

Sponsored by:
  • Novartis Pharma AG

The AML expert series

Hear directly from experts in acute myeloid leukemia about innovations in molecular testing, emerging therapies, and targeted treatments, and get practical advice for improving the care of your patients with relapsed or refractory disease.

Supported by:
  • Rigel Pharmaceuticals, Inc.
Developed by: Springer Health+ IME

Further Reading

Role of primary chemoradiotherapy in the management of advanced stage vulvar cancer

Vulvar cancer is a rare disease with an age standardized rate of about 0.9/100,000 women worldwide in 2020 (about 45,000 cases worldwide) [ 1 ]. Regions with the highest incidence rates are Western and Northern Europe, Northern America, Australia …

A phase 2, open-label, single-arm study evaluating the combination of pembrolizumab, lenvatinib, carboplatin and pemetrexed in patients with metastatic non-small cell lung cancer harbouring targetable genomic alterations who progressed on standard tyrosine kinase inhibitors

Patients with metastatic non-small cell lung cancer (NSCLC) harbouring targetable genomic alterations who progressed on standard tyrosine kinase inhibitors (TKIs) have limited treatment options, with platinum-based chemotherapy offering modest …

Unraveling the miR-144-3p/PUMA pathway: a novel regulator of FDX1-mediated cuproptosis in colorectal cancer

Colorectal cancer (CRC) is the third most common malignant tumor globally exhibiting a rising incidence rate-particularly among younger populations under 50, where rates increased annually in recent years [ 1 ]. According to the World Health …

Clinical features of varicella-zoster virus meningitis diagnosed by polymerase chain reaction without abnormal routine cerebrospinal fluid analysis

This study aimed to investigate the clinical features of varicella-zoster virus (VZV) meningitis cases diagnosed by polymerase chain reaction (PCR) despite normal routine cerebrospinal fluid (CSF) testing. A retrospective review was performed on …

Related topics

Exercise training in patients with multiple myeloma

Despite well-documented benefits, exercise interventions are often underutilized in the multiple myeloma population. This review provides evidence-based strategies for developing safe and effective exercise programs for these patients.

Read more

Who benefits from treatment intensification in NSCLC?

  • Open Access
  • NSCLC
  • Review

Recent trials have shown survival benefits of intensified regimens in EGFR-mutant NSCLC, but they come at the cost of increased toxicity and treatment burden. So which patients should receive up-front intensification?

Read more
Image Credits
Senior man using a resistance band in an exercise class/© Drazen Zigic / Getty Images (symbolic image with models), Biomarker-driven management of NSCLC/© Springer Health+ IME, Yellow question mark in front of a row of wooden figures/© Abu Hanifah / Getty Images / iStock, 3D reconstruction of liver metastases from breast and colorectal cancer/© 2025, Ryota Ito et al, under exclusive licence to Japanese Society of Gastroenterology, Clin J Gastroenterol, Glowing neuron network in brain/© ChaoticMind / stock.adobe.com / Generated with AI, Medicine Matters Podcast promo image/© Springer Medizin GmbH, Woman receiving an intravenous infusion/© FatCamera / Getty Images / iStock (symbolic image with model), Lymph nodes concept/© Artur / stock.adobe.com, CAR T-cell attacking cancer cells/© LoveLive/stock.adobe.com, Doctor examining a chest x-ray/© Minerva Studio / stock.adobe.com (symbolic image with model), Iris pigment epithelial cysts in acute lymphoblastic leukemia/© 2025, Kar Yong Chong et al, BMC Ophthalmol, Cancer cell screening and treatment concept/© artacet / iStock / Getty Images Plus, Stylized collage of women/© (M) VictoriaBar / Getty Images / iStock, T-cell expressing chimeric antigen receptor (CAR) in the cell membrane; DNA is exposed from the T-cell to highlight the genetic engineering involved in creating CAR T-cells/© LoveLive/stock.adobe.com, Leukemia background in bright colors, including white and red blood cells in realistic style/© Double Brain/Shutterstock.com, Imaging of patient with multiple myeloma and spinal infiltration/© 2025, Fondazione Società Italiana di Neurologia, Neurol Sci (used with permission), Syringe, vial and white pills/© Alexander / Stock.adobe.com, Electrocardiogram and pills/© Horacio Selva / stock.adobe.com, Syringe and multicolored pills on red background/© VlaDee / Getty Images / iStock