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Sleep and Breathing

The effect of supplemental oxygen and continuous positive airway pressure withdrawal on endocan levels

Published in:
Authors
Chris D Turnbull
John R Stradling
Nayia Petousi
Philippe Lassalle
Published in
Sleep and Breathing | Issue 6/2024

Abstract

Purpose

Endocan is a biomarker of endothelial dysfunction, which is a precursor to cardiovascular disease. Obstructive sleep apnoea (OSA) is associated with elevated endocan levels but the effects of treatment on endocan levels in OSA are not fully established. We aimed to determine whether endocan levels could be detected by immunoassay and to determine the effect of supplemental oxygen during continuous positive airway pressure (CPAP) withdrawal on circulating endocan levels.

Methods

We conducted an exploratory analysis from a randomised controlled crossover study which included participants with OSA. Participants stopped their CPAP therapy and were randomised to receive either supplemental oxygen or sham for 14 nights before crossing over. Supplemental oxygen blocked the rise in blood pressure seen in the sham group. We analysed plasma endocan levels by immunoassay at baseline and after 14 nights of intervention in both groups.

Results

Twenty-five participants were included, with a total of 100 samples. Endocan levels were detectable at all time points in 22 participants (88%), and in 93 (93%) samples. Supplemental oxygen had no effect on endocan levels compared to sham (+ 0.52 ng/ml, 95%CI -0.21 to + 1.25, p = 0.16), and there was no significant difference in endocan levels from baseline to follow-up in either the sham (-0.30 ng/ml, 95%CI -0.89 to + 0.30, p = 0.31) or supplemental oxygen (+ 0.22 ng/ml, 95%CI 0.00 to + 0.44, p = 0.05) arm.

Conclusions

We have shown that endocan levels are detectable before and after CPAP withdrawal. However, we found no effect of supplemental oxygen following CPAP withdrawal on circulating endocan levels.

Trial registration and date

ISRCTN 17,987,510 19/02/2015.
Title
The effect of supplemental oxygen and continuous positive airway pressure withdrawal on endocan levels
Authors
Chris D Turnbull
John R Stradling
Nayia Petousi
Philippe Lassalle
Publication date
06-09-2024
Publisher
Springer International Publishing
Published in
Sleep and Breathing / Issue 6/2024
Print ISSN: 1520-9512
Electronic ISSN: 1522-1709
DOI
https://doi.org/10.1007/s11325-024-03120-2
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