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Current Obesity Reports

Role of Protein Lysine Acetylation in the Pathogenesis and Treatment of Obesity and Metabolic Syndrome

  • Open Access
  • 01-12-2025
  • Obesity
  • Review
Published in:
Authors
Zhaopeng Li
Yancheng Song
Zhao Li
Shuguang Liu
Song Yi
Zhuoli Zhang
Tao Yu
Yu Li
Published in
Current Obesity Reports | Issue 1/2025

Abstract

Purpose of Review

This review aimed to highlight the known role of histone deacetylases (HDACs) and lysine acetyltransferases (KATs) in individuals with obesity, better understand the role of HDACs and KATs enzymes in obesity and related metabolic disorders.

Recent Findings

Numerous cellular activities, including DNA replication, DNA repair, cell cycle regulation, RNA splicing, signal transmission, metabolic function, protein stability, transportation, and transcriptional regulation, are influenced by lysine acetylation. Protein lysine acetylation serves several purposes, which not only contribute to the development of metabolic disorders linked to obesity but also hold promise for therapeutic approaches. The current study demonstrates that HDACs and KATs control lysine acetylation.

Summary

This review details the advancements made in the study of obesity, related metabolic diseases, and protein lysine acetylation. It contributes to our understanding of the function and mechanism of protein lysine acetylation in obesity and MS and offers a fresh method for treating these diseases.
Title
Role of Protein Lysine Acetylation in the Pathogenesis and Treatment of Obesity and Metabolic Syndrome
Authors
Zhaopeng Li
Yancheng Song
Zhao Li
Shuguang Liu
Song Yi
Zhuoli Zhang
Tao Yu
Yu Li
Publication date
01-12-2025
Publisher
Springer US
Published in
Current Obesity Reports / Issue 1/2025
Electronic ISSN: 2162-4968
DOI
https://doi.org/10.1007/s13679-025-00615-1
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