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Normal Weight Central Obesity and its Impact on Type 2 Diabetes Mellitus

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Abstract

Purpose of Review

The aim of this review is to provide an updated commentary on the current literature examining the impact of normal weight obesity (NWO) and normal weight central obesity (NWCO) on type 2 diabetes mellitus in adults.

Recent Findings

Total 14 studies were included, comprising 9 cross-sectional and 5 cohort studies with 334,438 subjects. The quality of evidence was mixed. The pooled prevalence of NWO was 16.1% (95% CI: 12.7—19.4) and NWCO was 21.1% (95% CI: 12.2—30.1). The prevalence of NWO and NWCO higher in females and non-Asians. This review also showed that type 2 diabetes was significantly associated with NWO and NWCO (pooled OR: 1.82 [1.62, 2.04], p < 0.01, I2 = 64%). Subgroup analyses revealed consistent relationships between type 2 diabetes and NWO/NWCO across sex, region and definition approach.

Summary

There was a relative high prevalence of NWO and NWCO, particularly in females and non-Asian populations. There was a consistent association of NWO/NWCO with type 2 diabetes. Implications for future research to guide intervention optimization in clinical practice and public health promotion are provided.
Title
Normal Weight Central Obesity and its Impact on Type 2 Diabetes Mellitus
Authors
Jing Bai
Yifan Zhang
Li He
Yang Zhao
Publication date
01-12-2025
Publisher
Springer US
Published in
Current Diabetes Reports / Issue 1/2025
Print ISSN: 1534-4827
Electronic ISSN: 1539-0829
DOI
https://doi.org/10.1007/s11892-024-01559-x
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