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Open Access 08-07-2024 | Obesity | REVIEW

Mitochondrial Adaptation in Skeletal Muscle: Impact of Obesity, Caloric Restriction, and Dietary Compounds

Authors: Lauren Jun, Ya-Xiong Tao, Thangiah Geetha, Jeganathan Ramesh Babu

Published in: Current Nutrition Reports

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Abstract

Purpose of Review

The global obesity epidemic has become a major public health concern, necessitating comprehensive research into its adverse effects on various tissues within the human body. Among these tissues, skeletal muscle has gained attention due to its susceptibility to obesity-related alterations. Mitochondria are primary source of energy production in the skeletal muscle. Healthy skeletal muscle maintains constant mitochondrial content through continuous cycle of synthesis and degradation. However, obesity has been shown to disrupt this intricate balance. This review summarizes recent findings on the impact of obesity on skeletal muscle mitochondria structure and function. In addition, we summarize the molecular mechanism of mitochondrial quality control systems and how obesity impacts these systems.

Recent Findings

Recent findings show various interventions aimed at mitigating mitochondrial dysfunction in obese model, encompassing strategies including caloric restriction and various dietary compounds.

Summary

Obesity has deleterious effect on skeletal muscle mitochondria by disrupting mitochondrial biogenesis and dynamics. Caloric restriction, omega-3 fatty acids, resveratrol, and other dietary compounds enhance mitochondrial function and present promising therapeutic opportunities.
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Metadata
Title
Mitochondrial Adaptation in Skeletal Muscle: Impact of Obesity, Caloric Restriction, and Dietary Compounds
Authors
Lauren Jun
Ya-Xiong Tao
Thangiah Geetha
Jeganathan Ramesh Babu
Publication date
08-07-2024
Publisher
Springer US
Published in
Current Nutrition Reports
Electronic ISSN: 2161-3311
DOI
https://doi.org/10.1007/s13668-024-00555-7
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