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Published in: European Journal of Nutrition 6/2022

Open Access 21-03-2022 | Obesity | Original Contribution

Associations between dietary patterns, FTO genotype and obesity in adults from seven European countries

Authors: Katherine M. Livingstone, Barbara Brayner, Carlos Celis-Morales, George Moschonis, Yannis Manios, Iwona Traczyk, Christian A. Drevon, Hannelore Daniel, Wim H. M. Saris, Julie A. Lovegrove, Mike Gibney, Eileen R. Gibney, Lorraine Brennan, J. Alfredo Martinez, John C. Mathers

Published in: European Journal of Nutrition | Issue 6/2022

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Abstract

Purpose

High-fat and low-fibre discretionary food intake and FTO genotype are each associated independently with higher risk of obesity. However, few studies have investigated links between obesity and dietary patterns based on discretionary food intake, and the interaction effect of FTO genotype are unknown. Thus, this study aimed to derive dietary patterns based on intake of discretionary foods, saturated fatty acids (SFA) and fibre, and examine cross-sectional associations with BMI and waist circumference (WC), and interaction effects of FTO genotype.

Methods

Baseline data on 1280 adults from seven European countries were included (the Food4Me study). Dietary intake was estimated from a Food Frequency Questionnaire. Reduced rank regression was used to derive three dietary patterns using response variables of discretionary foods, SFA and fibre density. DNA was extracted from buccal swabs. Anthropometrics were self-measured. Linear regression analyses were used to examine associations between dietary patterns and BMI and WC, with an interaction for FTO genotype.

Results

Dietary pattern 1 (positively correlated with discretionary foods and SFA, and inversely correlated with fibre) was associated with higher BMI (β:0.64; 95% CI 0.44, 0.84) and WC (β:1.58; 95% CI 1.08, 2.07). There was limited evidence dietary pattern 2 (positively correlated with discretionary foods and SFA) and dietary pattern 3 (positively correlated with SFA and fibre) were associated with anthropometrics. FTO risk genotype was associated with higher BMI and WC, with no evidence of a dietary interaction.

Conclusions

Consuming a dietary pattern low in discretionary foods and high-SFA and low-fibre foods is likely to be important for maintaining a healthy weight, regardless of FTO predisposition to obesity.

Trial registration

Clinicaltrials.gov NCT01530139. Registered 9 February 2012 https://​clinicaltrials.​gov/​ct2/​show/​NCT01530139
Appendix
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Metadata
Title
Associations between dietary patterns, FTO genotype and obesity in adults from seven European countries
Authors
Katherine M. Livingstone
Barbara Brayner
Carlos Celis-Morales
George Moschonis
Yannis Manios
Iwona Traczyk
Christian A. Drevon
Hannelore Daniel
Wim H. M. Saris
Julie A. Lovegrove
Mike Gibney
Eileen R. Gibney
Lorraine Brennan
J. Alfredo Martinez
John C. Mathers
Publication date
21-03-2022
Publisher
Springer Berlin Heidelberg
Keywords
Obesity
Obesity
Published in
European Journal of Nutrition / Issue 6/2022
Print ISSN: 1436-6207
Electronic ISSN: 1436-6215
DOI
https://doi.org/10.1007/s00394-022-02858-3

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