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Published in: Journal of Natural Medicines 3/2024

25-04-2024 | Obesity | Original Paper

Ameliorative effect of bofutsushosan (Fangfengtongshengsan) extract on the progression of aging-induced obesity

Authors: Takafumi Saeki, Saya Yamamoto, Junji Akaki, Takahiro Tanaka, Misaki Nakasone, Hidemasa Ikeda, Wei Wang, Makoto Inoue, Yoshiaki Manse, Kiyofumi Ninomiya, Toshio Morikawa

Published in: Journal of Natural Medicines | Issue 3/2024

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Abstract

This study aimed to compare fat accumulation in young and aged mice raised on a high-fat diet and to characterize the obesity-reducing effects of a Kampo medicine, bofutsushosan (BTS; fangfengtongshengsan in Chinese). Aged mice fed a high-fat diet containing 2% BTS extract for 28 days exhibited a significant reduction in weight gain and accumulation of visceral and subcutaneous fat, which were greater degree of reduction than those of the young mice. When the treatment period was extended to two months, the serum aspartate aminotransferase and alanine aminotransferase levels and the accumulation of fat droplets in the hepatocytes decreased. The mRNA expression of mitochondrial uncoupling protein 1 (UCP1) in the brown adipose tissue was significantly reduced in the aged mice compared to the young mice but increased by 2% in the BTS-treated aged mice. Additionally, the effect of BTS extract on oleic acid–albumin-induced triglyceride accumulation in hepatoblastoma-derived HepG2 cells was significantly inhibited in a concentration-dependent manner. Evaluation of the single crude drug extracts revealed that Forsythia Fruit, Schizonepeta Spike, and Rhubarb were the active components in BTS extract. These results suggest that BTS extract is effective against visceral, subcutaneous, and ectopic fats in the liver, which tend to accumulate with aging. Thus, BTS extract is useful in preventing and ameliorating the development of obesity and metabolic syndrome.

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Metadata
Title
Ameliorative effect of bofutsushosan (Fangfengtongshengsan) extract on the progression of aging-induced obesity
Authors
Takafumi Saeki
Saya Yamamoto
Junji Akaki
Takahiro Tanaka
Misaki Nakasone
Hidemasa Ikeda
Wei Wang
Makoto Inoue
Yoshiaki Manse
Kiyofumi Ninomiya
Toshio Morikawa
Publication date
25-04-2024
Publisher
Springer Nature Singapore
Keywords
Obesity
Obesity
Published in
Journal of Natural Medicines / Issue 3/2024
Print ISSN: 1340-3443
Electronic ISSN: 1861-0293
DOI
https://doi.org/10.1007/s11418-024-01803-4

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