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Open Access 17-09-2024 | Obesity | Review

Debating Weight Loss vs. Weight Neutral Strategies for Improvements of Health

Authors: Berit L. Heitmann, Rasmus Køster-Rasmussen, Lene B. Meyer, Sofus C. Larsen, Fanney Thorsteinsdottir, Catharina T. Sandholdt, Kirstine N. Bojsen-Møller, Gritt Overbeck, Frans B. Waldorff, Marius B. Kousgaard, Ina O. Specht, Carsten Dirksen

Published in: Current Obesity Reports

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Abstract

Purpose of Review

Despite decades of development and testing of weight-loss interventions, the adult populations worldwide have witnessed a continuous rise in body weight. There is an ongoing debate about how to move forward. Some argue that this rise calls for more intensive and possibly life-long treatments, including the new effective GLP1 weight loss medications, while others have called for a fundamental shift away from weight and on to a broader understanding of health. The two strategies are represented as a weight-centric health strategy and a weight neutral health strategy. This paper debates the benefits and potential harms related to the use of these two strategies.

Recent Findings

While major weight loss may have substantial health benefits, many individuals will need intensive treatment including weight loss medication to achieve it, as generally few are able to sustain a lifestyle induced weight loss in the long term.

Summary

Both the weight loss and the weight-neutral health strategies have advantages and limitations emphasizing the need for further research comparing the two strategies. Currently, not everyone is offered, can afford, will tolerate or even desire treatment with weight loss medication, and weight neutral health strategies may be a desirable alternative intervention offering a more holistic approach to health and addressing psychological and social issues including the burden of experienced and internalized weight stigma. However, this method still needs to be tested for effectiveness with regards to both physical and long-term psychological benefits.
Literature
1.
go back to reference Rubino F, Puhl RM, Cummings DE, Eckel RH, Ryan DH, Mechanick JI, et al. Joint international consensus statement for ending stigma of obesity. Nat Med. 2020;26(4):485–97.PubMedPubMedCentralCrossRef Rubino F, Puhl RM, Cummings DE, Eckel RH, Ryan DH, Mechanick JI, et al. Joint international consensus statement for ending stigma of obesity. Nat Med. 2020;26(4):485–97.PubMedPubMedCentralCrossRef
2.
go back to reference Madigan CD, Graham HE, Sturgiss E, Kettle VE, Gokal K, Biddle G, et al. Effectiveness of weight management interventions for adults delivered in primary care: systematic review and meta-analysis of randomised controlled trials. BMJ. 2022;377:e069719.PubMedPubMedCentralCrossRef Madigan CD, Graham HE, Sturgiss E, Kettle VE, Gokal K, Biddle G, et al. Effectiveness of weight management interventions for adults delivered in primary care: systematic review and meta-analysis of randomised controlled trials. BMJ. 2022;377:e069719.PubMedPubMedCentralCrossRef
3.
go back to reference Stubbs RJ, Duarte C, O’Driscoll R, Turicchi J, Kwasnicka D, Sniehotta FF, et al. The H2020 NoHoW Project: A position Statement on behavioural approaches to longer-term Weight Management. Obes Facts. 2021;14(2):246–58.PubMedPubMedCentralCrossRef Stubbs RJ, Duarte C, O’Driscoll R, Turicchi J, Kwasnicka D, Sniehotta FF, et al. The H2020 NoHoW Project: A position Statement on behavioural approaches to longer-term Weight Management. Obes Facts. 2021;14(2):246–58.PubMedPubMedCentralCrossRef
4.
5.
go back to reference Adams TD, Davidson LE, Litwin SE, Kim J, Kolotkin RL, Nanjee MN, et al. Weight and metabolic outcomes 12 years after gastric bypass. N Engl J Med. 2017;377(12):1143–55.PubMedPubMedCentralCrossRef Adams TD, Davidson LE, Litwin SE, Kim J, Kolotkin RL, Nanjee MN, et al. Weight and metabolic outcomes 12 years after gastric bypass. N Engl J Med. 2017;377(12):1143–55.PubMedPubMedCentralCrossRef
6.
go back to reference Lincoff AM, Brown-Frandsen K, Colhoun HM, Deanfield J, Emerson SS, Esbjerg S, et al. Semaglutide and Cardiovascular outcomes in obesity without diabetes. N Engl J Med. 2023;389(24):2221–32.PubMedCrossRef Lincoff AM, Brown-Frandsen K, Colhoun HM, Deanfield J, Emerson SS, Esbjerg S, et al. Semaglutide and Cardiovascular outcomes in obesity without diabetes. N Engl J Med. 2023;389(24):2221–32.PubMedCrossRef
7.
go back to reference Lean ME, Leslie WS, Barnes AC, Brosnahan N, Thom G, McCombie L, et al. 5-year follow-up of the randomised diabetes remission clinical trial (DiRECT) of continued support for weight loss maintenance in the UK: an extension study. Lancet Diabetes Endocrinol. 2024;12(4):233–46.PubMedCrossRef Lean ME, Leslie WS, Barnes AC, Brosnahan N, Thom G, McCombie L, et al. 5-year follow-up of the randomised diabetes remission clinical trial (DiRECT) of continued support for weight loss maintenance in the UK: an extension study. Lancet Diabetes Endocrinol. 2024;12(4):233–46.PubMedCrossRef
9.
go back to reference Alkhezi OS, Alahmed AA, Alfayez OM, Alzuman OA, Almutairi AR, Almohammed OA. Comparative effectiveness of glucagon-like peptide-1 receptor agonists for the management of obesity in adults without diabetes: a network meta-analysis of randomized clinical trials. Obes Rev. 2023;24(3):e13543.PubMedCrossRef Alkhezi OS, Alahmed AA, Alfayez OM, Alzuman OA, Almutairi AR, Almohammed OA. Comparative effectiveness of glucagon-like peptide-1 receptor agonists for the management of obesity in adults without diabetes: a network meta-analysis of randomized clinical trials. Obes Rev. 2023;24(3):e13543.PubMedCrossRef
12.
go back to reference Semlitsch T, Stigler FL, Jeitler K, Horvath K, Siebenhofer A. Management of overweight and obesity in primary care-A systematic overview of international evidence-based guidelines. Obes Rev. 2019;20(9):1218–30.PubMedPubMedCentralCrossRef Semlitsch T, Stigler FL, Jeitler K, Horvath K, Siebenhofer A. Management of overweight and obesity in primary care-A systematic overview of international evidence-based guidelines. Obes Rev. 2019;20(9):1218–30.PubMedPubMedCentralCrossRef
13.
go back to reference Wharton S, Lau DCW, Vallis M, Sharma AM, Biertho L, Campbell-Scherer D, et al. Obesity in adults: a clinical practice guideline. Can Med Assoc J. 2020;192(31):E875–91.CrossRef Wharton S, Lau DCW, Vallis M, Sharma AM, Biertho L, Campbell-Scherer D, et al. Obesity in adults: a clinical practice guideline. Can Med Assoc J. 2020;192(31):E875–91.CrossRef
14.
go back to reference Wing RR, Bolin P, Brancati FL, Bray GA, Clark JM, Coday M, et al. Cardiovascular effects of intensive lifestyle intervention in type 2 diabetes. N Engl J Med. 2013;369(2):145–54.PubMedCrossRef Wing RR, Bolin P, Brancati FL, Bray GA, Clark JM, Coday M, et al. Cardiovascular effects of intensive lifestyle intervention in type 2 diabetes. N Engl J Med. 2013;369(2):145–54.PubMedCrossRef
15.
go back to reference Wing RR. Does Lifestyle Intervention Improve Health of Adults with Overweight/Obesity and type 2 diabetes? Findings from the look AHEAD randomized Trial. Obes (Silver Spring). 2021;29(8):1246–58.CrossRef Wing RR. Does Lifestyle Intervention Improve Health of Adults with Overweight/Obesity and type 2 diabetes? Findings from the look AHEAD randomized Trial. Obes (Silver Spring). 2021;29(8):1246–58.CrossRef
16.
go back to reference Lindström J, Ilanne-Parikka P, Peltonen M, Aunola S, Eriksson JG, Hemiö K, et al. Sustained reduction in the incidence of type 2 diabetes by lifestyle intervention: follow-up of the Finnish diabetes Prevention Study. Lancet. 2006;368(9548):1673–9.PubMedCrossRef Lindström J, Ilanne-Parikka P, Peltonen M, Aunola S, Eriksson JG, Hemiö K, et al. Sustained reduction in the incidence of type 2 diabetes by lifestyle intervention: follow-up of the Finnish diabetes Prevention Study. Lancet. 2006;368(9548):1673–9.PubMedCrossRef
17.
go back to reference Pan XR, Li GW, Hu YH, Wang JX, Yang WY, An ZX, et al. Effects of diet and exercise in preventing NIDDM in people with impaired glucose tolerance. The Da Qing IGT and Diabetes Study. Diabetes Care. 1997;20(4):537–44.PubMedCrossRef Pan XR, Li GW, Hu YH, Wang JX, Yang WY, An ZX, et al. Effects of diet and exercise in preventing NIDDM in people with impaired glucose tolerance. The Da Qing IGT and Diabetes Study. Diabetes Care. 1997;20(4):537–44.PubMedCrossRef
18.
go back to reference Knowler WC, Fowler SE, Hamman RF, Christophi CA, Hoffman HJ, Brenneman AT, et al. 10-year follow-up of diabetes incidence and weight loss in the diabetes Prevention Program outcomes Study. Lancet. 2009;374(9702):1677–86.PubMedCrossRef Knowler WC, Fowler SE, Hamman RF, Christophi CA, Hoffman HJ, Brenneman AT, et al. 10-year follow-up of diabetes incidence and weight loss in the diabetes Prevention Program outcomes Study. Lancet. 2009;374(9702):1677–86.PubMedCrossRef
19.
go back to reference Zucatti KP, Teixeira PP, Wayerbacher LF, Piccoli GF, Correia PE, Fonseca NKO, et al. Long-term effect of Lifestyle interventions on the Cardiovascular and all-cause mortality of subjects with prediabetes and Type 2 diabetes: a systematic review and Meta-analysis. Diabetes Care. 2022;45(11):2787–95.PubMedCrossRef Zucatti KP, Teixeira PP, Wayerbacher LF, Piccoli GF, Correia PE, Fonseca NKO, et al. Long-term effect of Lifestyle interventions on the Cardiovascular and all-cause mortality of subjects with prediabetes and Type 2 diabetes: a systematic review and Meta-analysis. Diabetes Care. 2022;45(11):2787–95.PubMedCrossRef
20.
go back to reference Johnson KC, Bray GA, Cheskin LJ, Clark JM, Egan CM, Foreyt JP, et al. The Effect of Intentional Weight loss on fracture risk in persons with diabetes: results from the look AHEAD randomized clinical trial. J Bone Min Res. 2017;32(11):2278–87.CrossRef Johnson KC, Bray GA, Cheskin LJ, Clark JM, Egan CM, Foreyt JP, et al. The Effect of Intentional Weight loss on fracture risk in persons with diabetes: results from the look AHEAD randomized clinical trial. J Bone Min Res. 2017;32(11):2278–87.CrossRef
21.
go back to reference Seimon RV, Wild-Taylor AL, Keating SE, McClintock S, Harper C, Gibson AA, et al. Effect of weight loss via severe vs Moderate Energy Restriction on lean Mass and Body Composition among Postmenopausal Women with obesity: the TEMPO Diet Randomized Clinical Trial. JAMA Netw Open. 2019;2(10):e1913733.PubMedPubMedCentralCrossRef Seimon RV, Wild-Taylor AL, Keating SE, McClintock S, Harper C, Gibson AA, et al. Effect of weight loss via severe vs Moderate Energy Restriction on lean Mass and Body Composition among Postmenopausal Women with obesity: the TEMPO Diet Randomized Clinical Trial. JAMA Netw Open. 2019;2(10):e1913733.PubMedPubMedCentralCrossRef
22.
go back to reference Parretti HM, Jebb SA, Johns DJ, Lewis AL, Christian-Brown AM, Aveyard P. Clinical effectiveness of very-low-energy diets in the management of weight loss: a systematic review and meta-analysis of randomized controlled trials. Obes Rev. 2016;17(3):225–34.PubMedCrossRef Parretti HM, Jebb SA, Johns DJ, Lewis AL, Christian-Brown AM, Aveyard P. Clinical effectiveness of very-low-energy diets in the management of weight loss: a systematic review and meta-analysis of randomized controlled trials. Obes Rev. 2016;17(3):225–34.PubMedCrossRef
23.
go back to reference Astbury NM, Aveyard P, Nickless A, Hood K, Corfield K, Lowe R, et al. Doctor referral of overweight people to low energy total diet replacement treatment (DROPLET): pragmatic randomised controlled trial. BMJ. 2018;362:k3760.PubMedPubMedCentralCrossRef Astbury NM, Aveyard P, Nickless A, Hood K, Corfield K, Lowe R, et al. Doctor referral of overweight people to low energy total diet replacement treatment (DROPLET): pragmatic randomised controlled trial. BMJ. 2018;362:k3760.PubMedPubMedCentralCrossRef
24.
go back to reference Lean MEJ, Leslie WS, Barnes AC, Brosnahan N, Thom G, McCombie L, et al. Durability of a primary care-led weight-management intervention for remission of type 2 diabetes: 2-year results of the DiRECT open-label, cluster-randomised trial. Lancet Diabetes Endocrinol. 2019;7(5):344–55.PubMedCrossRef Lean MEJ, Leslie WS, Barnes AC, Brosnahan N, Thom G, McCombie L, et al. Durability of a primary care-led weight-management intervention for remission of type 2 diabetes: 2-year results of the DiRECT open-label, cluster-randomised trial. Lancet Diabetes Endocrinol. 2019;7(5):344–55.PubMedCrossRef
25.
go back to reference Taheri S, Zaghloul H, Chagoury O, Elhadad S, Ahmed SH, El Khatib N, et al. Effect of intensive lifestyle intervention on bodyweight and glycaemia in early type 2 diabetes (DIADEM-I): an open-label, parallel-group, randomised controlled trial. Lancet Diabetes Endocrinol. 2020;8(6):477–89.PubMedCrossRef Taheri S, Zaghloul H, Chagoury O, Elhadad S, Ahmed SH, El Khatib N, et al. Effect of intensive lifestyle intervention on bodyweight and glycaemia in early type 2 diabetes (DIADEM-I): an open-label, parallel-group, randomised controlled trial. Lancet Diabetes Endocrinol. 2020;8(6):477–89.PubMedCrossRef
26.
go back to reference Larsen TM, Dalskov S-M, Mv B, Jebb SA, Papadaki A, Pfeiffer AFH, et al. Diets with high or low protein content and glycemic index for weight-loss maintenance. N Engl J Med. 2010;363(22):2102–13.PubMedPubMedCentralCrossRef Larsen TM, Dalskov S-M, Mv B, Jebb SA, Papadaki A, Pfeiffer AFH, et al. Diets with high or low protein content and glycemic index for weight-loss maintenance. N Engl J Med. 2010;363(22):2102–13.PubMedPubMedCentralCrossRef
27.
go back to reference Lundgren JR, Janus C, Jensen SBK, Juhl CR, Olsen LM, Christensen RM, et al. Healthy Weight Loss Maintenance with Exercise, Liraglutide, or both combined. N Engl J Med. 2021;384(18):1719–30.PubMedCrossRef Lundgren JR, Janus C, Jensen SBK, Juhl CR, Olsen LM, Christensen RM, et al. Healthy Weight Loss Maintenance with Exercise, Liraglutide, or both combined. N Engl J Med. 2021;384(18):1719–30.PubMedCrossRef
28.
go back to reference Khera R, Murad MH, Chandar AK, Dulai PS, Wang Z, Prokop LJ, et al. Association of Pharmacological Treatments for Obesity with Weight Loss and adverse events: a systematic review and Meta-analysis. JAMA. 2016;315(22):2424–34.PubMedPubMedCentralCrossRef Khera R, Murad MH, Chandar AK, Dulai PS, Wang Z, Prokop LJ, et al. Association of Pharmacological Treatments for Obesity with Weight Loss and adverse events: a systematic review and Meta-analysis. JAMA. 2016;315(22):2424–34.PubMedPubMedCentralCrossRef
29.
go back to reference le Roux CW, Astrup A, Fujioka K, Greenway F, Lau DCW, Van Gaal L, et al. 3 years of liraglutide versus placebo for type 2 diabetes risk reduction and weight management in individuals with prediabetes: a randomised, double-blind trial. Lancet. 2017;389(10077):1399–409.PubMedCrossRef le Roux CW, Astrup A, Fujioka K, Greenway F, Lau DCW, Van Gaal L, et al. 3 years of liraglutide versus placebo for type 2 diabetes risk reduction and weight management in individuals with prediabetes: a randomised, double-blind trial. Lancet. 2017;389(10077):1399–409.PubMedCrossRef
30.
go back to reference Garvey WT, Batterham RL, Bhatta M, Buscemi S, Christensen LN, Frias JP, et al. Two-year effects of semaglutide in adults with overweight or obesity: the STEP 5 trial. Nat Med. 2022;28(10):2083–91.PubMedPubMedCentralCrossRef Garvey WT, Batterham RL, Bhatta M, Buscemi S, Christensen LN, Frias JP, et al. Two-year effects of semaglutide in adults with overweight or obesity: the STEP 5 trial. Nat Med. 2022;28(10):2083–91.PubMedPubMedCentralCrossRef
31.
go back to reference Kaneko S, Tirzepatide. A Novel, once-weekly dual GIP and GLP-1 receptor agonist for the treatment of type 2 diabetes. touchREV Endocrinol. 2022;18(1):10–9.PubMedPubMedCentralCrossRef Kaneko S, Tirzepatide. A Novel, once-weekly dual GIP and GLP-1 receptor agonist for the treatment of type 2 diabetes. touchREV Endocrinol. 2022;18(1):10–9.PubMedPubMedCentralCrossRef
32.
go back to reference Delgado-Lista J, Alcala-Diaz JF, Torres-Peña JD, Quintana-Navarro GM, Fuentes F, Garcia-Rios A, et al. Long-term secondary prevention of cardiovascular disease with a Mediterranean diet and a low-fat diet (CORDIOPREV): a randomised controlled trial. Lancet. 2022;399(10338):1876–85.PubMedCrossRef Delgado-Lista J, Alcala-Diaz JF, Torres-Peña JD, Quintana-Navarro GM, Fuentes F, Garcia-Rios A, et al. Long-term secondary prevention of cardiovascular disease with a Mediterranean diet and a low-fat diet (CORDIOPREV): a randomised controlled trial. Lancet. 2022;399(10338):1876–85.PubMedCrossRef
33.
go back to reference Skou ST, Roos EM. Good life with osteoArthritis in Denmark (GLA:D™): evidence-based education and supervised neuromuscular exercise delivered by certified physiotherapists nationwide. BMC Musculoskelet Disord. 2017;18(1):72.PubMedPubMedCentralCrossRef Skou ST, Roos EM. Good life with osteoArthritis in Denmark (GLA:D™): evidence-based education and supervised neuromuscular exercise delivered by certified physiotherapists nationwide. BMC Musculoskelet Disord. 2017;18(1):72.PubMedPubMedCentralCrossRef
35.
go back to reference Linardon J, Tylka TL, Fuller-Tyszkiewicz M. Intuitive eating and its psychological correlates: a meta-analysis. Int J Eat Disord. 2021;54(7):1073–98.PubMedCrossRef Linardon J, Tylka TL, Fuller-Tyszkiewicz M. Intuitive eating and its psychological correlates: a meta-analysis. Int J Eat Disord. 2021;54(7):1073–98.PubMedCrossRef
36.
go back to reference Hazzard VM, Telke SE, Simone M, Anderson LM, Larson NI, Neumark-Sztainer D. Intuitive eating longitudinally predicts better psychological health and lower use of disordered eating behaviors: findings from EAT 2010–2018. Eat Weight Disord. 2021;26(1):287–94.PubMedCrossRef Hazzard VM, Telke SE, Simone M, Anderson LM, Larson NI, Neumark-Sztainer D. Intuitive eating longitudinally predicts better psychological health and lower use of disordered eating behaviors: findings from EAT 2010–2018. Eat Weight Disord. 2021;26(1):287–94.PubMedCrossRef
37.
go back to reference Carlucci C, Kardachi J, Bradley SM, Prager J, Wyka K, Jayasinghe N. Evaluation of a community-based program that Integrates Joyful Movement into Fall Prevention for Older Adults. Gerontol Geriatr Med. 2018;4:2333721418776789.PubMedPubMedCentralCrossRef Carlucci C, Kardachi J, Bradley SM, Prager J, Wyka K, Jayasinghe N. Evaluation of a community-based program that Integrates Joyful Movement into Fall Prevention for Older Adults. Gerontol Geriatr Med. 2018;4:2333721418776789.PubMedPubMedCentralCrossRef
38.
go back to reference Alleva JM, Tylka TL, Martijn C, Waldén MI, Webb JB, Piran N. I’ll never sacrifice my well-being again: the journey from negative to positive body image among women who perceive their body to deviate from societal norms. Body Image. 2023;45:153–71.PubMedCrossRef Alleva JM, Tylka TL, Martijn C, Waldén MI, Webb JB, Piran N. I’ll never sacrifice my well-being again: the journey from negative to positive body image among women who perceive their body to deviate from societal norms. Body Image. 2023;45:153–71.PubMedCrossRef
39.
go back to reference Bidstrup H, Brennan L, Kaufmann L, de la Piedad Garcia X. Internalised weight stigma as a mediator of the relationship between experienced/perceived weight stigma and biopsychosocial outcomes: a systematic review. Int J Obes (Lond). 2022;46(1):1–9.PubMedCrossRef Bidstrup H, Brennan L, Kaufmann L, de la Piedad Garcia X. Internalised weight stigma as a mediator of the relationship between experienced/perceived weight stigma and biopsychosocial outcomes: a systematic review. Int J Obes (Lond). 2022;46(1):1–9.PubMedCrossRef
40.
go back to reference Potts S, Krafft J, Levin ME. A Pilot Randomized Controlled Trial of Acceptance and Commitment Therapy guided self-help for overweight and obese adults high in Weight Self-Stigma. Behav Modif. 2022;46(1):178–201.PubMedCrossRef Potts S, Krafft J, Levin ME. A Pilot Randomized Controlled Trial of Acceptance and Commitment Therapy guided self-help for overweight and obese adults high in Weight Self-Stigma. Behav Modif. 2022;46(1):178–201.PubMedCrossRef
41.
go back to reference Palmeira L, Cunha M, Pinto-Gouveia J. Processes of change in quality of life, weight self-stigma, body mass index and emotional eating after an acceptance-, mindfulness- and compassion-based group intervention (Kg-Free) for women with overweight and obesity. J Health Psychol. 2019;24(8):1056–69.PubMedCrossRef Palmeira L, Cunha M, Pinto-Gouveia J. Processes of change in quality of life, weight self-stigma, body mass index and emotional eating after an acceptance-, mindfulness- and compassion-based group intervention (Kg-Free) for women with overweight and obesity. J Health Psychol. 2019;24(8):1056–69.PubMedCrossRef
42.
go back to reference Palmeira L, Pinto-Gouveia J, Cunha M. Exploring the efficacy of an acceptance, mindfulness & compassionate-based group intervention for women struggling with their weight (Kg-Free): a randomized controlled trial. Appetite. 2017;112:107–16.PubMedCrossRef Palmeira L, Pinto-Gouveia J, Cunha M. Exploring the efficacy of an acceptance, mindfulness & compassionate-based group intervention for women struggling with their weight (Kg-Free): a randomized controlled trial. Appetite. 2017;112:107–16.PubMedCrossRef
43.
go back to reference Ramos Salas X, Forhan M, Caulfield T, Sharma AM, Raine KD. Addressing internalized Weight Bias and changing damaged Social identities for people living with obesity. Front Psychol. 2019;10:1409.PubMedPubMedCentralCrossRef Ramos Salas X, Forhan M, Caulfield T, Sharma AM, Raine KD. Addressing internalized Weight Bias and changing damaged Social identities for people living with obesity. Front Psychol. 2019;10:1409.PubMedPubMedCentralCrossRef
44.
go back to reference Essayli JH, Murakami JM, Wilson RE, Latner JD. The impact of Weight labels on Body Image, Internalized Weight Stigma, affect, Perceived Health, and intended weight loss behaviors in normal-weight and overweight College women. Am J Health Promot. 2017;31(6):484–90.PubMedCrossRef Essayli JH, Murakami JM, Wilson RE, Latner JD. The impact of Weight labels on Body Image, Internalized Weight Stigma, affect, Perceived Health, and intended weight loss behaviors in normal-weight and overweight College women. Am J Health Promot. 2017;31(6):484–90.PubMedCrossRef
45.
go back to reference Levin ME, Krafft J, Twohig MP. An overview of Research on Acceptance and Commitment Therapy. Psychiatr Clin North Am. 2024;47(2):419–31.PubMedCrossRef Levin ME, Krafft J, Twohig MP. An overview of Research on Acceptance and Commitment Therapy. Psychiatr Clin North Am. 2024;47(2):419–31.PubMedCrossRef
46.
go back to reference Khasteganan N, Lycett D, Furze G, Turner AP. Health, not weight loss, focused programmes versus conventional weight loss programmes for cardiovascular risk factors: a systematic review and meta-analysis. Syst Rev. 2019;8(1):200.PubMedPubMedCentralCrossRef Khasteganan N, Lycett D, Furze G, Turner AP. Health, not weight loss, focused programmes versus conventional weight loss programmes for cardiovascular risk factors: a systematic review and meta-analysis. Syst Rev. 2019;8(1):200.PubMedPubMedCentralCrossRef
47.
go back to reference Dugmore JA, Winten CG, Niven HE, Bauer J. Effects of weight-neutral approaches compared with traditional weight-loss approaches on behavioral, physical, and psychological health outcomes: a systematic review and meta-analysis. Nutr Rev. 2020;78(1):39–55.PubMedCrossRef Dugmore JA, Winten CG, Niven HE, Bauer J. Effects of weight-neutral approaches compared with traditional weight-loss approaches on behavioral, physical, and psychological health outcomes: a systematic review and meta-analysis. Nutr Rev. 2020;78(1):39–55.PubMedCrossRef
48.
go back to reference Fuentes Artiles R, Staub K, Aldakak L, Eppenberger P, Rühli F, Bender N. Mindful eating and common diet programs lower body weight similarly: systematic review and meta-analysis. Obes Rev. 2019;20(11):1619–27.PubMedCrossRef Fuentes Artiles R, Staub K, Aldakak L, Eppenberger P, Rühli F, Bender N. Mindful eating and common diet programs lower body weight similarly: systematic review and meta-analysis. Obes Rev. 2019;20(11):1619–27.PubMedCrossRef
49.
go back to reference Babbott KM, Cavadino A, Brenton-Peters J, Consedine NS, Roberts M. Outcomes of intuitive eating interventions: a systematic review and meta-analysis. Eat Disord. 2023;31(1):33–63.PubMedCrossRef Babbott KM, Cavadino A, Brenton-Peters J, Consedine NS, Roberts M. Outcomes of intuitive eating interventions: a systematic review and meta-analysis. Eat Disord. 2023;31(1):33–63.PubMedCrossRef
50.
go back to reference Hensley-Hackett K, Bosker J, Keefe A, Reidlinger D, Warner M, D’Arcy A, et al. Intuitive eating intervention and Diet Quality in adults: a systematic literature review. J Nutr Educ Behav. 2022;54(12):1099–115.PubMedCrossRef Hensley-Hackett K, Bosker J, Keefe A, Reidlinger D, Warner M, D’Arcy A, et al. Intuitive eating intervention and Diet Quality in adults: a systematic literature review. J Nutr Educ Behav. 2022;54(12):1099–115.PubMedCrossRef
51.
go back to reference Ulian MD, Aburad L, da Silva Oliveira MS, Poppe ACM, Sabatini F, Perez I, et al. Effects of health at every size® interventions on health-related outcomes of people with overweight and obesity: a systematic review. Obes Rev. 2018;19(12):1659–66.PubMedCrossRef Ulian MD, Aburad L, da Silva Oliveira MS, Poppe ACM, Sabatini F, Perez I, et al. Effects of health at every size® interventions on health-related outcomes of people with overweight and obesity: a systematic review. Obes Rev. 2018;19(12):1659–66.PubMedCrossRef
52.
go back to reference Hoare JK, Lister NB, Garnett SP, Baur LA, Jebeile H. Weight-neutral interventions in young people with high body mass index: a systematic review. Nutr Diet. 2023;80(1):8–20.PubMedCrossRef Hoare JK, Lister NB, Garnett SP, Baur LA, Jebeile H. Weight-neutral interventions in young people with high body mass index: a systematic review. Nutr Diet. 2023;80(1):8–20.PubMedCrossRef
53.
go back to reference Grider HS, Douglas SM, Raynor HA. The influence of mindful eating and/or intuitive eating approaches on Dietary Intake: a systematic review. J Acad Nutr Diet. 2021;121(4):709–e271.PubMedCrossRef Grider HS, Douglas SM, Raynor HA. The influence of mindful eating and/or intuitive eating approaches on Dietary Intake: a systematic review. J Acad Nutr Diet. 2021;121(4):709–e271.PubMedCrossRef
54.
go back to reference Guest E, Costa B, Williamson H, Meyrick J, Halliwell E, Harcourt D. The effectiveness of interventions aiming to promote positive body image in adults: a systematic review. Body Image. 2019;30:10–25.PubMedCrossRef Guest E, Costa B, Williamson H, Meyrick J, Halliwell E, Harcourt D. The effectiveness of interventions aiming to promote positive body image in adults: a systematic review. Body Image. 2019;30:10–25.PubMedCrossRef
55.
go back to reference Pearl RL, Hopkins CH, Berkowitz RI, Wadden TA. Group cognitive-behavioral treatment for internalized weight stigma: a pilot study. Eat Weight Disord. 2018;23(3):357–62.PubMedCrossRef Pearl RL, Hopkins CH, Berkowitz RI, Wadden TA. Group cognitive-behavioral treatment for internalized weight stigma: a pilot study. Eat Weight Disord. 2018;23(3):357–62.PubMedCrossRef
56.
go back to reference Al Oweidat K, Toubasi AA, Tawileh RBA, Tawileh HBA, Hasuneh MM. Bariatric surgery and obstructive sleep apnea: a systematic review and meta-analysis. Sleep Breath. 2023;27(6):2283–94.PubMedCrossRef Al Oweidat K, Toubasi AA, Tawileh RBA, Tawileh HBA, Hasuneh MM. Bariatric surgery and obstructive sleep apnea: a systematic review and meta-analysis. Sleep Breath. 2023;27(6):2283–94.PubMedCrossRef
57.
go back to reference Lindekilde N, Gladstone BP, Lübeck M, Nielsen J, Clausen L, Vach W, et al. The impact of bariatric surgery on quality of life: a systematic review and meta-analysis. Obes Rev. 2015;16(8):639–51.PubMedCrossRef Lindekilde N, Gladstone BP, Lübeck M, Nielsen J, Clausen L, Vach W, et al. The impact of bariatric surgery on quality of life: a systematic review and meta-analysis. Obes Rev. 2015;16(8):639–51.PubMedCrossRef
58.
go back to reference Sanaya N, Janusaite M, Dalamaga M, Magkos F. The physiological effects of Weight-Cycling: a review of current evidence. Curr Obes Rep. 2024;13(1):35–50.PubMedCrossRef Sanaya N, Janusaite M, Dalamaga M, Magkos F. The physiological effects of Weight-Cycling: a review of current evidence. Curr Obes Rep. 2024;13(1):35–50.PubMedCrossRef
59.
go back to reference Castaneda D, Popov VB, Wander P, Thompson CC. Risk of suicide and self-harm is increased after bariatric Surgery-a systematic review and Meta-analysis. Obes Surg. 2019;29(1):322–33.PubMedCrossRef Castaneda D, Popov VB, Wander P, Thompson CC. Risk of suicide and self-harm is increased after bariatric Surgery-a systematic review and Meta-analysis. Obes Surg. 2019;29(1):322–33.PubMedCrossRef
60.
go back to reference Wilding JPH, Batterham RL, Davies M, Van Gaal LF, Kandler K, Konakli K, et al. Weight regain and cardiometabolic effects after withdrawal of semaglutide: the STEP 1 trial extension. Diabetes Obes Metab. 2022;24(8):1553–64.PubMedPubMedCentralCrossRef Wilding JPH, Batterham RL, Davies M, Van Gaal LF, Kandler K, Konakli K, et al. Weight regain and cardiometabolic effects after withdrawal of semaglutide: the STEP 1 trial extension. Diabetes Obes Metab. 2022;24(8):1553–64.PubMedPubMedCentralCrossRef
61.
go back to reference Weghuber D, Barrett T, Barrientos-Pérez M, Gies I, Hesse D, Jeppesen OK, et al. Once-weekly semaglutide in adolescents with obesity. N Engl J Med. 2022;387(24):2245–57.PubMedPubMedCentralCrossRef Weghuber D, Barrett T, Barrientos-Pérez M, Gies I, Hesse D, Jeppesen OK, et al. Once-weekly semaglutide in adolescents with obesity. N Engl J Med. 2022;387(24):2245–57.PubMedPubMedCentralCrossRef
62.
go back to reference Batterham RL. Weight stigma in healthcare settings is detrimental to health and must be eradicated. Nat Reviews Endocrinol. 2022;18(7):387–8.CrossRef Batterham RL. Weight stigma in healthcare settings is detrimental to health and must be eradicated. Nat Reviews Endocrinol. 2022;18(7):387–8.CrossRef
63.
go back to reference Sutin AR, Stephan Y, Terracciano A. Weight discrimination and risk of Mortality. Psychol Sci. 2015;26(11):1803–11.PubMedCrossRef Sutin AR, Stephan Y, Terracciano A. Weight discrimination and risk of Mortality. Psychol Sci. 2015;26(11):1803–11.PubMedCrossRef
Metadata
Title
Debating Weight Loss vs. Weight Neutral Strategies for Improvements of Health
Authors
Berit L. Heitmann
Rasmus Køster-Rasmussen
Lene B. Meyer
Sofus C. Larsen
Fanney Thorsteinsdottir
Catharina T. Sandholdt
Kirstine N. Bojsen-Møller
Gritt Overbeck
Frans B. Waldorff
Marius B. Kousgaard
Ina O. Specht
Carsten Dirksen
Publication date
17-09-2024
Publisher
Springer US
Published in
Current Obesity Reports
Electronic ISSN: 2162-4968
DOI
https://doi.org/10.1007/s13679-024-00587-8

At a glance: The STEP trials

A round-up of the STEP phase 3 clinical trials evaluating semaglutide for weight loss in people with overweight or obesity.

Developed by: Springer Medicine
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