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16-10-2024 | Obesity | Review

Roles of thyroid and leptin hormones and their crosstalk in male reproductive functions: an updated review

Authors: Madhumanti Barman, Nelli Giribabu, Naguib Salleh

Published in: Endocrine | Issue 3/2025

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Abstract

Purpose

This review aims to provide updated information regarding the role of thyroid and leptin hormones and their crosstalk in affecting the male reproductive function in hypothyroid and obesity conditions.

Method

A wide literature search was made using online search engines on published articles using keywords including thyroid hormone, hypothyroidism, leptin hormone, hyperleptinemia, obesity, the relationship between thyroid and leptin hormones and male reproduction, and hypothyroidism, obesity, and male reproduction.

Results

All information pertaining thyroid and leptin hormone effects on male reproduction, hypothyroidism, hyperleptinemia, and obesity effect on male fertility as well as the related molecular mechanisms are obtained.

Conclusion

Thyroid and leptin hormones individually play a significant role in male reproduction. Alterations of these hormones’ levels could adversely affect the male reproductive functions. PI3K/AKT signaling was found to be the major signaling pathway involved in mediating the effect of both hormones on male reproduction. Impaired crosstalk between the two hormones may occur in hypothyroidism with obesity which would contribute towards male reproductive dysfunction.
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Metadata
Title
Roles of thyroid and leptin hormones and their crosstalk in male reproductive functions: an updated review
Authors
Madhumanti Barman
Nelli Giribabu
Naguib Salleh
Publication date
16-10-2024
Publisher
Springer US
Published in
Endocrine / Issue 3/2025
Print ISSN: 1355-008X
Electronic ISSN: 1559-0100
DOI
https://doi.org/10.1007/s12020-024-04069-8

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