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Current Diabetes Reports

A Review Article: The Relationship Between Obesity and Colorectal Cancer

  • Open Access
  • 02-12-2024
  • Obesity
  • REVIEW
Published in:
Authors
Lily Nguyen
Skandan Shanmugan
Published in
Current Diabetes Reports | Issue 1/2025

Abstract

Purpose of Review

This article aims to review the recent literature assessing the relationship between obesity and colorectal carcinogenesis, the effect of obesity on the treatment of colorectal cancer (CRC), tools available to help augment the increased risk, and outcomes for patients who are affected by both obesity and colorectal cancer.

Recent Findings

The biochemical mechanisms contributing to CRC carcinogenesis are not well understood but are suspected to be related to adipose tissue leading to a pro-inflammatory state and changes in the gut microbiome. Individuals with obesity are at higher risk for CRC development, worse oncologic outcomes, and increased rates of post-operative complications. Bariatric surgery decreases CRC risk but results with GLP-1 agonists are heterogeneous. Prehabilitation is the only weight loss method that has been demonstrated to decrease risks of post-operative morbidity in this population.

Summary

Obesity augments CRC risk and outcomes. There are persistent knowledge gaps in etiology and epidemiology for the increased CRC risk in obese patients and more research is required to identify the therapeutic advantage of weight loss on CRC risk.
Title
A Review Article: The Relationship Between Obesity and Colorectal Cancer
Authors
Lily Nguyen
Skandan Shanmugan
Publication date
02-12-2024
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Identity with Diabetes: Unpacking an Overlooked but Essential Dimension of the Diabetes Experience

A Scoping Review on Community-based Diabetes Screening Interventions: Paving the Pathway to Early Care and Prevention of Diabetes

The Effects of Obesity and Weight Loss Interventions on Bone Health: A Narrative Review

Optimizing Bone Health in Diabetes: Strategies for Fracture Risk Reduction in Public Healthcare

Impact of Weight Loss on Metabolic Dysfunction Associated Steatohepatitis and Hepatic Fibrosis

Implementation Strategies to Address Cardiometabolic Disparities in Black Men: Lessons from Existing Research and Future Directions

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  • REVIEW

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Supported by:
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Prof. Chantal Mathieu
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Image Credits
Colon cancer concept image/© Kateryna_Kon / stock.adobe.com, Woman monitoring glucose level with sensor and an app on her phone while training at swimming pool/© (M) Goffkein, stock.adobe.com (symbolic image with model), Abstract low poly wireframe illustration of the liver/© (M) Yevhen Lahunov / iStock / Getty Images Plus