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Editor's Choice

How does chronic inflammation contribute to obesity?

Open Access Obesity Review

The overwhelming rise in obesity and its comorbidities requires new therapeutic interventions. This review examines the intricate interplay between chronic inflammation of adipose tissue and the hypothalamus, and the development of obesity.

Mitochondrial disorders and development of obese sarcopenia

Open Access Obesity Review

Obese sarcopenia develops more quickly and is more severe than sarcopenia alone. This review discusses the development of obesity myasthenia gravis from a mitochondrial perspective and the potential for targeting mitochondrial dynamics.

Tirzepatide approved for chronic obesity by FDA, MHRA 

14-11-2023 Obesity News

Once-weekly tirzepatide may be used alongside diet and exercise to treat chronic obesity, regulatory bodies in the USA and UK have announced.

Current Reviews

Polycystic Ovarian Syndrome: a Risk Factor for Cardiovascular Disease

Polycystic ovary syndrome (PCOS) is one of the most common endocrinopathies affecting individuals of reproductive age with an estimated prevalence of 5–16% [ 1 ]. PCOS is characterized by hyperandrogenism, ovulatory dysfunction with anovulation and …

The Role of Lifestyle Modification with Second-Generation Anti-obesity Medications: Comparisons, Questions, and Clinical Opportunities

Open Access Semaglutide REVIEW

A new generation of anti-obesity medications (AOMs), inaugurated in 2021 with the US Food and Drug Administration’s (FDA) approval of semaglutide 2.4 mg, holds real promise of transforming the management of obesity [ 1 ••]. These novel nutrient …

Epigenetic programming for obesity and noncommunicable disease: From womb to tomb

Several epidemiological, clinical and experimental studies in recent decades have shown the relationship between exposure to stressors during development and health outcomes later in life. The characterization of these susceptible phases, such as …

Mechanisms linking bariatric surgery to adipose tissue, glucose metabolism, fatty liver disease and gut microbiota

Open Access Obesity Review Article

Obesity is a major public health problem that has been increasing worldwide [ 1 ]. This multifactorial disease is associated with an increased risk of developing several medical conditions, such as insulin resistance, hypertension, dyslipidaemia …

Case Studies

Acute post sleeve surgery bleeding as rare cause of acute renal failure: a case report

Open Access Bariatric Surgery Case Study

Over the past three decades, the incidence of obesity has grown worldwide; surprisingly, it has also increased in low- and middle-income nations as a result of shifting dietary habit from traditional to westernized diet [ 1 ]. Lifestyle therapies …

Simultaneous bilateral quadriceps tendon rupture in a healthy young male: a case report

Open Access Obesity Case Study

Simultaneous bilateral quadriceps tendon rupture (QTR) is very rare [ 1 ], particularly among young individuals with no prior medical history. Patients with QTR experience difficulty walking due to impaired active extension of the knee and have …

Spontaneous remission of diabetes in a girl with systemic lupus erythematosus

Open Access Diabetes Case Study

A unique, reversible diabetes subtype, suggestive of an autoimmune origin, in a 14-year-old girl with obesity and SLE, who presented with ketoacidosis, elevated HbA1c and positive anti-insulin antibodies.

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Further Reading

Metabolically ‘extremely unhealthy’ obese and non-obese patients with diabetes and the risk of cardiovascular events: a French nationwide cohort study

Open Access Diabetes Original Paper

During the last decades, cardiovascular disease (CVD) risk is increased in obese patients with diabetes mellitus (DM) [ 1 ]. However, nowadays, there is an increasing prevalence of type 2 DM (T2DM) with lean/normal body mass index (BMI), which was …

The Role of Lifestyle Modification with Second-Generation Anti-obesity Medications: Comparisons, Questions, and Clinical Opportunities

Open Access Semaglutide REVIEW

A new generation of anti-obesity medications (AOMs), inaugurated in 2021 with the US Food and Drug Administration’s (FDA) approval of semaglutide 2.4 mg, holds real promise of transforming the management of obesity [ 1 ••]. These novel nutrient …

Bilateral Subdiaphragmatic Vagal Nerve Stimulation Using a Novel Waveform Decreases Body Weight, Food Consumption, Adiposity, and Activity in Obesity-Prone Rats

Open Access Obesity Original Contributions

In the USA, one in three adults are obese, defined as having a body mass index (BMI) ≥ 30 kg/m 2 [ 1 ]. In a worsening trend, 31 states have obesity rates ≥ 30% and none are below 20% [ 2 ]. From 2008 to 2018, the USA saw a year-over-year increase …

Dietary caffeine intake is associated with favorable metabolic profile among apparently healthy overweight and obese individuals

Open Access Overweight Research

Caffeine (3,7-dihydro-13,7-trimethyl-1H-purine-2,6-dione), is the most studied pharmacologically active substance in coffee, tea and soft drinks, cola, chocolate and cocoa [ 1 ]. From the caffeine dietary sources, coffee, is the most important …