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YKL-40 linked to GI cancer risk in type 2 diabetes

Raised YKL-40 levels are associated with an increased risk for obesity-related and gastrointestinal cancers, particularly liver cancer, in people with type 2 diabetes.

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Editor's Choice

The threat of childhood obesity

Childhood obesity is a growing global health concern, but how should obesity be defined and measured in children, and how does it impact health in the short and long term?

Colonic ischemia associated with a GLP-1 RA

Although it seems to be a rare complication, there should be a high index of suspicion for colonic ischemia in patients taking a GLP-1 receptor agonist who present with abdominal pain.

The promise of incretin-based therapies for MASH

Discover the growing evidence for incretin-based therapies in metabolic dysfunction-associated steatohepatitis, the potential mechanisms involved, common side effects, and what’s needed to finesse their use.

Metabolic accelerator associated with weight loss in people with obesity and HFpEF

The metabolic accelerator HU6 leads to modest but significant weight loss in adults who have obesity and heart failure with preserved ejection fraction.

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Keynote series | Spotlight on managing health in obesity

Obesity is a major contributor to cardiorenal metabolic disease, but its impact extends throughout the body. Understand how obesity can affect other organ systems and impact treatment, and whether weight-loss measures improve outcomes.

Prof. Eva L. Feldman
Prof. Jonette Keri
Developed by: Springer Medicine
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Video

Case Studies

Colonic ischemia associated with a GLP-1 RA

Although it seems to be a rare complication, there should be a high index of suspicion for colonic ischemia in patients taking a GLP-1 receptor agonist who present with abdominal pain.

Semaglutide for comorbid obesity and cocaine use disorder

Semaglutide therapy achieved weight loss and reduced cocaine craving in a man with obesity and chronic cocaine abuse. Could this be a new strategy to address substance craving in patients with comorbid obesity?

Do GNB1 gene variants have a role in obesity?

Two rare cases that expand the list of pathogenic GNB1 variants. GNB1 may have value as a candidate gene for severe early-onset obesity, hyperphagia, and neurodevelopmental delay or other metabolic and endocrine disorders.

At a glance: The STEP trials

A round-up of the STEP phase 3 clinical trials evaluating semaglutide for weight loss in people with overweight or obesity.

Developed by: Springer Medicine
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Current Reviews

Gastro-Oesophageal Reflux Disease Outcomes Following Roux-en-Y Gastric Bypass Surgery in Patients with Obesity: A Systematic Review and Meta-analysis

We aimed to investigate the effect of primary Roux-en-Y gastric bypass (RYGB) on gastro-oesophageal reflux disease (GORD) in patients with obesity. A systematic review was performed using MEDLINE, Embase, Emcare, and CINAHL databases for studies …

Advancing Cardiovascular, Kidney, and Metabolic Medicine: A Narrative Review of Insights and Innovations for the Future

Cardiovascular, kidney and metabolic (CKM) conditions are interrelated, significantly contributing to morbidity, mortality and healthcare burden. Despite therapeutic advances, traditional disease-specific approaches often fail to address their …

The Impact of Bias and Stigma on Patient Referral for Metabolic/Bariatric Surgery: An Algerian Experience

Obesity is a chronic disease causing a major public health challenge, particularly in Algeria, yet in patient referrals for metabolic/bariatric surgery (MBS), the most effective treatment remain low. This study aims to analyze the factors …

Gaps and challenges in the management of pediatric steatotic liver diseases: a narrative review

A recent international multi-society Delphi consensus statement on fatty liver disease nomenclature has established “steatotic liver disease” (SLD) as the term for disorders characterized by hepatic lipid accumulation [ 1 ]. Pediatric SLD includes …

Keynote webinar | Spotlight on diet and diabetes

  • On-demand Webinar

An expert-led symposium exploring the prevention and management of type 2 diabetes through dietary interventions. Highlights include discussion of the recent EASD guidelines, therapeutic diets, food types and processing, plus psychological factors that influence patient success, and the drivers of healthy eating and diabetes control.

Prof. Mike Lean
Prof. Falko Sniehotta
Developed by: Springer Medicine
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CME & eLearning

Expert Interviews | Videos (Link opens in a new window)

With adolescent obesity at an all-time high, greater understanding of the individual cost and societal burden is crucial. Discover the unique challenges faced by adolescents with obesity, and learn effective strategies to help young people to overcome this disease.

This program is not available to users in the UK and US.

Supported by:
  • Novo Nordisk A/S
Developed by: Springer Healthcare IME

News | Expert Reviews | Cases (Link opens in a new window)

Treating children with hormone disorders is complex and requires tailored management. To help you provide the most effective care, we deliver resources covering adrenal, thyroid, pituitary, growth, and puberty disorders, obesity, and diabetes.

Supported by:
  • Merck Healthcare KGaA, Darmstadt, Germany
Developed by: Springer Healthcare IME

Further Reading

Gastro-Oesophageal Reflux Disease Outcomes Following Roux-en-Y Gastric Bypass Surgery in Patients with Obesity: A Systematic Review and Meta-analysis

We aimed to investigate the effect of primary Roux-en-Y gastric bypass (RYGB) on gastro-oesophageal reflux disease (GORD) in patients with obesity. A systematic review was performed using MEDLINE, Embase, Emcare, and CINAHL databases for studies …

Perceptions and Beliefs About Obesity and Bariatric and Metabolic Surgery Among Black and White Men

Metabolic and bariatric surgery (MBS) is a safe and effective treatment option for patients not responding to non-surgical treatments [ 1 – 3 ]. Despite its effectiveness, utilization of MBS among eligible patients with severe obesity (BMI ≥ 40) …

Analysis of Tirzepatide Acquisition Costs and Weight Reduction Outcomes in the United Kingdom: Insights from the SURMOUNT-1 Study

Obesity is a highly prevalent chronic disease in the UK, with nearly two-thirds of adults (63%) affected by either overweight or obesity [ 1 ]. Obesity challenges economic growth, costing approximately £27 billion yearly, which includes direct …

Obesity Is Associated with Inferior Clinical Treatment Outcomes in Inflammatory Bowel Disease: A Nationwide Dutch Registry Study

Inflammatory Bowel Disease (IBD), mainly consisting of ulcerative colitis (UC) and Crohn’s disease (CD), are chronic immune-mediated inflammatory diseases affecting the gastrointestinal tract. The etiology of IBD is multifactorial, involving a …