The overwhelming rise in obesity and its comorbidities requires new therapeutic interventions. This review examines the intricate interplay between chronic inflammation of adipose tissue and the hypothalamus, and the development of obesity.
Obese sarcopenia develops more quickly and is more severe than sarcopenia alone. This review discusses the development of obesity myasthenia gravis from a mitochondrial perspective and the potential for targeting mitochondrial dynamics.
Polycystic ovary syndrome (PCOS) is one of the most common endocrinopathies affecting individuals of reproductive age with an estimated prevalence of 5–16% [ 1 ]. PCOS is characterized by hyperandrogenism, ovulatory dysfunction with anovulation and …
A new generation of anti-obesity medications (AOMs), inaugurated in 2021 with the US Food and Drug Administration’s (FDA) approval of semaglutide 2.4 mg, holds real promise of transforming the management of obesity [ 1 ••]. These novel nutrient …
Several epidemiological, clinical and experimental studies in recent decades have shown the relationship between exposure to stressors during development and health outcomes later in life. The characterization of these susceptible phases, such as …
Obesity is a major public health problem that has been increasing worldwide [ 1 ]. This multifactorial disease is associated with an increased risk of developing several medical conditions, such as insulin resistance, hypertension, dyslipidaemia …
Over the past three decades, the incidence of obesity has grown worldwide; surprisingly, it has also increased in low- and middle-income nations as a result of shifting dietary habit from traditional to westernized diet [ 1 ]. Lifestyle therapies …
Simultaneous bilateral quadriceps tendon rupture (QTR) is very rare [ 1 ], particularly among young individuals with no prior medical history. Patients with QTR experience difficulty walking due to impaired active extension of the knee and have …
A unique, reversible diabetes subtype, suggestive of an autoimmune origin, in a 14-year-old girl with obesity and SLE, who presented with ketoacidosis, elevated HbA1c and positive anti-insulin antibodies.
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During the last decades, cardiovascular disease (CVD) risk is increased in obese patients with diabetes mellitus (DM) [ 1 ]. However, nowadays, there is an increasing prevalence of type 2 DM (T2DM) with lean/normal body mass index (BMI), which was …
A new generation of anti-obesity medications (AOMs), inaugurated in 2021 with the US Food and Drug Administration’s (FDA) approval of semaglutide 2.4 mg, holds real promise of transforming the management of obesity [ 1 ••]. These novel nutrient …
In the USA, one in three adults are obese, defined as having a body mass index (BMI) ≥ 30 kg/m 2 [ 1 ]. In a worsening trend, 31 states have obesity rates ≥ 30% and none are below 20% [ 2 ]. From 2008 to 2018, the USA saw a year-over-year increase …
Caffeine (3,7-dihydro-13,7-trimethyl-1H-purine-2,6-dione), is the most studied pharmacologically active substance in coffee, tea and soft drinks, cola, chocolate and cocoa [ 1 ]. From the caffeine dietary sources, coffee, is the most important …
