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Orforglipron may offer superior efficacy over oral semaglutide

The novel oral GLP-1 receptor agonist orforglipron shows noninferior and potentially superior glycemic control versus oral semaglutide in type 2 diabetes, but with more gastrointestinal adverse events.

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Editor's Choice

Cardiorenal and metabolic dimensions of cardiomyopathies

Metabolic and renal dysfunctions can influence the disease trajectory, treatment response, and prognosis of cardiomyopathies. A holistic and multidisciplinary approach is key to identifying the appropriate therapies.

Prebiotics, probiotics, and postbiotics: an emerging approach to MetS

Biotics have the potential to improve metabolic syndrome by reducing weight gain, insulin resistance, dyslipidemia, inflammation, and improving glycemic control and gut barrier function.

Moving on from cardiovascular-kidney-metabolic syndrome

Given the association of MASLD with cardiovascular, renal, and endocrine metabolic disorders, should cardiovascular-kidney-metabolic syndrome evolve to metabolic-associated liver-cardiovascular-kidney syndrome?

Obesity linked to increased risk for severe infections

Adult obesity is associated with a significantly increased risk for infection-related hospitalization and death.

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Keynote webinar | Spotlight on addressing alcohol-associated liver disease

The global burden of ALD is growing and compounded by frequent late-stage diagnosis and undertreatment. Get the latest insights and advances in alcohol-associated liver disease, from patient risk and identification to treatment and management, plus the arrival of MetALD and what it means for patient care.

Prof. Helena Cortez-Pinto
Prof. Mark Thursz
Dr. Juan Pablo Arab
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Video

Raising the standard: ensuring patient safety through minimum requirements for CGM performance

Prof. Chantal Mathieu highlights how the absence of rigorous performance standards for continuous glucose monitors in Europe contributes to wide variability in device accuracy, raising important concerns about patient safety.

Supported by:
  • Abbott Diabetes Care
Prof. Chantal Mathieu
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Video

Case Studies

Co-occurrence of syndromic and monogenic obesity?

A 6-year-old girl with early onset, severe obesity fulfilling the criteria for ROHHAD syndrome was found to have variants in PLXNA3 and PCSK1, genes involved in the leptin‒melanocortin pathway and associated with monogenic obesity.

Giant RCA aneurysm mistaken for mediastinal mass

Coronary aneurysms may present with nonspecific symptoms, delaying appropriate management. A suspected cardiac tumor in this patient was revealed to be a giant right coronary artery aneurysm, which was successfully managed with aneurysmectomy and CABG.

Gastrectomy after heart transplant: a viable strategy?

Laparoscopic sleeve gastrectomy was performed on a heart-transplant recipient to manage post-transplant weight gain and mitigate rejection risks. Improvements in cardiac function, metabolic parameters, and liver and kidney function suggest the procedure might benefit these high-risk patients

Episode 19: GLP-1 medicines - past, present, and future

From diabetes to obesity and beyond

In 2005 the US FDA approved the first GLP-1 medicine for type 2 diabetes, marking the start of a remarkable journey that goes beyond the stimulation of insulin secretion.

Prof. Daniel Drucker gives us a fascinating insight into the early work on GLP-1 and discusses how these medicines are impacting the lives of people with diabetes and obesity. He covers what's known about how they work, treatment duration, side effects, and the role of bariatric surgery, plus what's in the pipeline in terms of drug development and the indications that GLP-1 medicines may be used to treat in the future.

Prof. Daniel Drucker
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Podcast

Current Reviews

Efficacy of different types of intermittent fasting in improving glycemic control in adults with overweight or obesity: a systematic review and network meta-analysis

Intermittent fasting (IF) aids the management of obesity and impaired glucose homeostasis, although the comparative efficacy of different modes of IF on glycemic control remains unclear. The current review therefore aimed to investigate the …

Atypical diabetes subtypes in Black African populations

Atypical diabetes subtypes and presentations are disproportionately prevalent in populations of African and Asian ancestry. This review discusses the epidemiology, clinical presentation, aetiopathogenesis and management of four atypical diabetes …

Gut Microbiota and Metabolic Health: From Dysbiosis to Therapeutics

The gut microbiota (GM) is a pivotal regulator of host metabolism and a contributor to the pathophysiology of obesity, type 2 diabetes (T2D), and metabolic syndrome (MS). Disruptions in GM composition and function are collectively termed …

Same-day Discharge Metabolic and Bariatric Surgery: a GRADE-based International Federation for the Surgery and Other Therapies for Obesity (IFSO) Position Statement

Metabolic and Bariatric Surgery (MBS) is an established treatment for obesity and its associated metabolic conditions. As obesity prevalence has risen globally over the past two decades, so too has MBS utilization, spurring interest in same-day …

Keynote series | Spotlight on managing health in obesity

Obesity is a major contributor to cardiorenal metabolic disease, but its impact extends throughout the body. Understand how obesity can affect other organ systems and impact treatment, and whether weight-loss measures improve outcomes.

Prof. Eva L. Feldman
Prof. Jonette Keri
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Video

CME & eLearning

Paediatric endocrinology (Link opens in a new window)

Treating children with hormone disorders is complex and requires tailored management. To help you provide the most effective care, we deliver news, cases and expert reviews covering adrenal, thyroid, pituitary, growth, and puberty disorders, obesity, and diabetes.

Independent Medical Education Grant:
  • Merck Healthcare KGaA, Darmstadt, Germany

Further Reading

Analysis of Factors Influencing Extended Post Anesthesia Care Unit Length of Stay (PACU-LOS) in Obese Patients Undergoing Laparoscopic Sleeve Gastrectomy

Obesity has emerged as a significant national and global health challenge. Data indicate the global prevalence of overweight and obesity has rose markedly from 1990 to 2021, with a 155.1% increase in men and a 104.9% increase in women. By 2050, it …

Long-Term Outcomes of Pouch Resizing with Ring Augmentation for Dumping Syndrome and Weight Trajectory after Roux-en-Y Gastric Bypass: A Single-Center Experience

Metabolic bariatric surgery (MBS) is the most effective treatment option for achieving sustained weight loss in patients with obesity, while also improving obesity associated medical problems [ 1 , 2 ]. Among the various surgical options, Roux-en-Y …

Hyaluronan and Associated Biomarkers: A Longitudinal Cohort Study in Patients with Obesity Following Gastric Bypass Surgery

Obesity is a global health issue that leads to an increase in morbidity but also in all-cause mortality. Today, metabolic and bariatric surgery (MBS) is commonly provided as an effective procedure for weight loss that also has beneficial secondary …

Ring-augmented Metabolic Bariatric Surgery Procedures GRADE-based International Federation for the Surgery of Obesity and Metabolic Disorders (IFSO) Position Statement

In this position statement, the International Federation for the Surgery of Obesity and Metabolic Disorders (IFSO) highlights the evaluation of ring-augmented procedures in Metabolic Bariatric Surgery (MBS). A GRADE-based systematic review and …

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