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Current Nutrition Reports

Nutritional Ketosis for Weight Management and Reversal of Metabolic Syndrome

  • 01-09-2018
  • Gastroenterology, Critical Care, and Lifestyle Medicine (SA McClave, Section Editor)
Published in:
Authors
Victoria M. Gershuni
Stephanie L. Yan
Valentina Medici
Published in
Current Nutrition Reports | Issue 3/2018

Abstract

Purpose of Review

The goal of this paper is to review current literature on nutritional ketosis within the context of weight management and metabolic syndrome, namely, insulin resistance, lipid profile, cardiovascular disease risk, and development of non-alcoholic fatty liver disease. We provide background on the mechanism of ketogenesis and describe nutritional ketosis.

Recent Findings

Nutritional ketosis has been found to improve metabolic and inflammatory markers, including lipids, HbA1c, high-sensitivity CRP, fasting insulin and glucose levels, and aid in weight management. We discuss these findings and elaborate on potential mechanisms of ketones for promoting weight loss, decreasing hunger, and increasing satiety.

Summary

Humans have evolved with the capacity for metabolic flexibility and the ability to use ketones for fuel. During states of low dietary carbohydrate intake, insulin levels remain low and ketogenesis takes place. These conditions promote breakdown of excess fat stores, sparing of lean muscle, and improvement in insulin sensitivity.
Title
Nutritional Ketosis for Weight Management and Reversal of Metabolic Syndrome
Authors
Victoria M. Gershuni
Stephanie L. Yan
Valentina Medici
Publication date
01-09-2018
Publisher
Springer New York
Published in
Current Nutrition Reports / Issue 3/2018
Electronic ISSN: 2161-3311
DOI
https://doi.org/10.1007/s13668-018-0235-0
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