Butyrate: More Than a Short Chain Fatty Acid
- 10-02-2023
- Nutrition
- INVITED COMMENTARY
Published in:
- Authors
- Osman Mohamed Elfadil
- Manpreet S. Mundi
- Marwa G. Abdelmagid
- Ankitaben Patel
- Nishant Patel
- Robert Martindale
- Published in
- Current Nutrition Reports | Issue 2/2023
Abstract
Purpose of Review
The mechanistic understanding of the importance and the potential benefits of the gut microbiome has exploded in potential roles in human health and disease. Short chain fatty acids (SCFAs), including butyrate, are one of the key metabolic end products that has been a major focus of microbiome understanding. This brief review aims to describe butyrate’s relation to certain biological concepts and their clinical application.
Recent Findings
Butyrate has reportedly been described as a potent pro-resolution molecule that has a significant role in maintaining gut immunity, supporting gut barrier function, regulation of histone deacetylase (HDAC), and numerous systemic roles. Further research is needed to explore potential benefits of adding SCFAs for patients receiving total parenteral nutrition.
Summary
Butyrate plays several biological roles in intestinal epithelium anti-inflammatory pathways with clear benefits in numerous acute and chronic disease states and overall human health helping to maintain homeostasis.
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- Title
- Butyrate: More Than a Short Chain Fatty Acid
- Authors
-
Osman Mohamed Elfadil
Manpreet S. Mundi
Marwa G. Abdelmagid
Ankitaben Patel
Nishant Patel
Robert Martindale
- Publication date
- 10-02-2023
- Publisher
- Springer US
- Keyword
- Nutrition
- Published in
-
Current Nutrition Reports / Issue 2/2023
Electronic ISSN: 2161-3311 - DOI
- https://doi.org/10.1007/s13668-023-00461-4
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