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23-09-2024 | NSCLC | Thoracic Oncology

Wedge or Segmentectomy for Early-Stage Non-Small Cell Lung Cancer? The Dilemma Remains Unresolved

Author: Alessandro Brunelli, MD

Published in: Annals of Surgical Oncology | Issue 2/2025

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Excerpt

Many retrospective series have shown that wedge resections are oncologically inferior to anatomic lung resections (including segmentectomy).13 This concept held true until publication of the post hoc analysis of the Cancer and Leukemia Group B (CALGB) 140503 trial, which did not find any differences between wedges, segmentectomies, and lobectomies in terms of overall survival, disease-free survival, and locoregional recurrence rate in patients with peripheral non-small cell lung cancer (NSCLC) ≤2 cm and with a solid component.4
Literature
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go back to reference Shi Y, Wu S, Ma S, Lyu Y, Xu H, Deng L, Chen X. Comparison between wedge resection and lobectomy/segmentectomy for early-stage non-small cell lung cancer: a Bayesian meta-analysis and systematic review. Ann Surg Oncol. 2022;29(3):1868–79.CrossRefPubMed Shi Y, Wu S, Ma S, Lyu Y, Xu H, Deng L, Chen X. Comparison between wedge resection and lobectomy/segmentectomy for early-stage non-small cell lung cancer: a Bayesian meta-analysis and systematic review. Ann Surg Oncol. 2022;29(3):1868–79.CrossRefPubMed
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go back to reference Hou B, Deng XF, Zhou D, Liu QX, Dai JG. Segmentectomy versus wedge resection for the treatment of high-risk operable patients with stage I non-small cell lung cancer: a meta-analysis. Ther Adv Respir Dis. 2016;10(5):435–43.CrossRefPubMedPubMedCentral Hou B, Deng XF, Zhou D, Liu QX, Dai JG. Segmentectomy versus wedge resection for the treatment of high-risk operable patients with stage I non-small cell lung cancer: a meta-analysis. Ther Adv Respir Dis. 2016;10(5):435–43.CrossRefPubMedPubMedCentral
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go back to reference Dai C, Shen J, Ren Y, Zhong S, Zheng H, He J, et al. Choice of surgical procedure for patients with non-small-cell lung cancer ≤ 1 cm or > 1 to 2 cm among lobectomy, segmentectomy, and wedge resection: a population-based study. J Clin Oncol. 2016;34(26):3175–82.CrossRefPubMed Dai C, Shen J, Ren Y, Zhong S, Zheng H, He J, et al. Choice of surgical procedure for patients with non-small-cell lung cancer ≤ 1 cm or > 1 to 2 cm among lobectomy, segmentectomy, and wedge resection: a population-based study. J Clin Oncol. 2016;34(26):3175–82.CrossRefPubMed
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go back to reference Altorki N, Wang X, Damman B, Mentlick J, Landreneau R, Wigle D, et al. Lobectomy, segmentectomy, or wedge resection for peripheral clinical T1aN0 non-small cell lung cancer: a post hoc analysis of CALGB 140503 (Alliance). J Thorac Cardiovasc Surg. 2024;167(1):338–47.CrossRefPubMed Altorki N, Wang X, Damman B, Mentlick J, Landreneau R, Wigle D, et al. Lobectomy, segmentectomy, or wedge resection for peripheral clinical T1aN0 non-small cell lung cancer: a post hoc analysis of CALGB 140503 (Alliance). J Thorac Cardiovasc Surg. 2024;167(1):338–47.CrossRefPubMed
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go back to reference Thomas PA, Seguin-Givelet A, Pages PB, Alifano M, Brouchet L, Falcoz PE, et al., EPITHOR working group. Real-world outcomes of lobectomy, segmentectomy and wedge resection for the treatment of stage c-IA lung carcinoma. Eur J Cardiothorac Surg. 2024;66(1):ezae251 Thomas PA, Seguin-Givelet A, Pages PB, Alifano M, Brouchet L, Falcoz PE, et al., EPITHOR working group. Real-world outcomes of lobectomy, segmentectomy and wedge resection for the treatment of stage c-IA lung carcinoma. Eur J Cardiothorac Surg. 2024;66(1):ezae251
Metadata
Title
Wedge or Segmentectomy for Early-Stage Non-Small Cell Lung Cancer? The Dilemma Remains Unresolved
Author
Alessandro Brunelli, MD
Publication date
23-09-2024
Publisher
Springer International Publishing
Published in
Annals of Surgical Oncology / Issue 2/2025
Print ISSN: 1068-9265
Electronic ISSN: 1534-4681
DOI
https://doi.org/10.1245/s10434-024-16257-x
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