Can blood-based markers predict RECIST progression in non-small cell lung cancer treated with immunotherapy?
- Open Access
- 01-06-2024
- NSCLC
- Research
Published in:
- Authors
- Melda Yeghaian
- Teresa M. Tareco Bucho
- Melissa de Bruin
- Alexander Schmitz
- Zuhir Bodalal
- Egbert F. Smit
- Regina G. H. Beets-Tan
- Daan van den Broek
- Stefano Trebeschi
- Published in
- Journal of Cancer Research and Clinical Oncology | Issue 6/2024
Abstract
Purpose
In this study, we aimed to evaluate the potential of routine blood markers, serum tumour markers and their combination in predicting RECIST-defined progression in patients with stage IV non-small cell lung cancer (NSCLC) undergoing treatment with immune checkpoint inhibitors.
Methods
We employed time-varying statistical models and machine learning classifiers in a Monte Carlo cross-validation approach to investigate the association between RECIST-defined progression and blood markers, serum tumour markers and their combination, in a retrospective cohort of 164 patients with NSCLC.
Results
The performance of the routine blood markers in the prediction of progression free survival was moderate. Serum tumour markers and their combination with routine blood markers generally improved performance compared to routine blood markers alone. Elevated levels of C-reactive protein (CRP) and alkaline phosphatase (ALP) ranked as the top predictive routine blood markers, and CYFRA 21.1 was consistently among the most predictive serum tumour markers. Using these classifiers to predict overall survival yielded moderate to high performance, even when cases of death-defined progression were excluded. Performance varied across the treatment journey.
Conclusion
Routine blood tests, especially when combined with serum tumour markers, show moderate predictive value of RECIST-defined progression in NSCLC patients receiving immune checkpoint inhibitors. The relationship between overall survival and RECIST-defined progression may be influenced by confounding factors.
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- Title
- Can blood-based markers predict RECIST progression in non-small cell lung cancer treated with immunotherapy?
- Authors
-
Melda Yeghaian
Teresa M. Tareco Bucho
Melissa de Bruin
Alexander Schmitz
Zuhir Bodalal
Egbert F. Smit
Regina G. H. Beets-Tan
Daan van den Broek
Stefano Trebeschi
- Publication date
- 01-06-2024
- Publisher
- Springer Berlin Heidelberg
- Published in
-
Journal of Cancer Research and Clinical Oncology / Issue 6/2024
Print ISSN: 0171-5216
Electronic ISSN: 1432-1335 - DOI
- https://doi.org/10.1007/s00432-024-05814-2
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