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Indian Journal of Hematology and Blood Transfusion

13-11-2024 | CORRESPONDENCE

NPM1 Mutation Detected: Does Blast Count Matter?

Authors: M. Kumar Nikhil, Nathany Shrinidhi, Swaminathan Anusha, Yadav Chitresh, Gupta Aastha, Kothari Akriti, Garg Paritosh, Panda Rastogi Neha, Dua Vikas, Danewa Arun, Bhargava Rahul

Published in: Indian Journal of Hematology and Blood Transfusion

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Khoury JD, Solary E, Abla O, Akkari Y, Alaggio R, Apperley JF et al (2022) The 5th edition of the world health organization classification of haematolymphoid tumours: myeloid and histiocytic/dendritic neoplasms. Leukemia 36:1703–1719CrossRefPubMedPubMedCentral

Arber DA, Orazi A, Hasserjian RP, Borowitz MJ, Calvo KR, Kvasnicka HM et al (2022) International consensus classification of myeloid neoplasms and acute leukemias: integrating morphologic, clinical, and genomic data. Blood 15(140):1200–1228CrossRef

Falini B, Brunetti L, Sportoletti P, Martelli MP (2020) NPM1-mutated acute myeloid leukemia: from bench to bedside. Blood 8(136):1707–1721CrossRef

Hwang SM, Kim SM, Nam Y, Kim J, Kim S, Ahn YO et al (2019) Targeted sequencing aids in identifying clonality in chronic myelomonocytic leukemia. Leuk Res 84:106190CrossRefPubMed

Montalban-Bravo G, Kanagal-Shamanna R, Sasaki K, Patel K, Ganan-Gomez I, Jabbour E et al (2019) NPM1 mutations define a specific subgroup of MDS and MDS/MPN patients with favorable outcomes with intensive chemotherapy. Blood Adv 26(3):922–933CrossRef

Forghieri F, Nasillo V, Paolini A, Bettelli F, Pioli V, Giusti D et al (2020) NPM1-mutated myeloid neoplasms with <20% blasts: a really distinct clinico-pathologic entity? Int J Mol Sci 26(21):8975CrossRef

Fenaux P, Mufti GJ, Hellstrom-Lindberg E, Santini V, Finelli C, Giagounidis A et al (2009) Efficacy of azacitidine compared with that of conventional care regimens in the treatment of higher-risk myelodysplastic syndromes: a randomised, open-label, phase III study. Lancet Oncol 10:223–232CrossRefPubMedPubMedCentral

Title: NPM1 Mutation Detected: Does Blast Count Matter?
Authors: M. Kumar Nikhil
Nathany Shrinidhi
Swaminathan Anusha
Yadav Chitresh
Gupta Aastha
Kothari Akriti
Garg Paritosh
Panda Rastogi Neha
Dua Vikas
Danewa Arun
Bhargava Rahul
Publication date: 13-11-2024
Publisher: Springer India
Published in: Indian Journal of Hematology and Blood Transfusion
Print ISSN: 0971-4502
Electronic ISSN: 0974-0449
DOI: https://doi.org/10.1007/s12288-024-01918-4

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NPM1 Mutation Detected: Does Blast Count Matter?

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Recent advances in the use of CAR T-cell therapies in relapsed/refractory diffuse large B-cell lymphoma and follicular lymphoma