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26-06-2023 | Note

New nitric oxide production inhibitors from Syzygium bullockii

Authors: Bui Huu Tai, Bui Hai Ninh, Pham Hai Yen, Duong Thi Dung, Nguyen Huy Hoang, Nguyen Xuan Nhiem, Nguyen Van Tuyen, Le Tuan Anh, Phan Van Kiem

Published in: Journal of Natural Medicines | Issue 4/2023

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Abstract

Three undescribed triterpene glycosides syzybullosides A-C (13) along with fourteen known compounds were isolated from the leaves of Syzygium bullockii (Hance) Merr.& L.M. Perry, including six triterpene glycosides (16), four phenolics (79, 17), four megastigmanes (10–13), and three flavonoids (14–16). The structures of 117 were elucidated by extensive spectroscopic analysis, including IR, HR-ESI–MS, 1D and 2D NMR spectra. Compounds 110 and 12–17 inhibited nitric oxide (NO) production in lipopolysaccharide activated RAW264.7 cells with IC50 values ranging from 1.30 to 13.70 µM, lower than that of the positive control compound, L-NMMA (IC50 = 33.8 µM).

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Metadata
Title
New nitric oxide production inhibitors from Syzygium bullockii
Authors
Bui Huu Tai
Bui Hai Ninh
Pham Hai Yen
Duong Thi Dung
Nguyen Huy Hoang
Nguyen Xuan Nhiem
Nguyen Van Tuyen
Le Tuan Anh
Phan Van Kiem
Publication date
26-06-2023
Publisher
Springer Nature Singapore
Published in
Journal of Natural Medicines / Issue 4/2023
Print ISSN: 1340-3443
Electronic ISSN: 1861-0293
DOI
https://doi.org/10.1007/s11418-023-01725-7

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