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Molecular Imaging and Biology
Published in:

Open Access 26-12-2023 | Special Topic

New Horizons in Hyperpolarized 13C MRI

Authors: Myriam M. Chaumeil, James A. Bankson, Kevin M. Brindle, Shdema Epstein, Ferdia A. Gallagher, Martin Grashei, Caroline Guglielmetti, Joshua D. Kaggie, Kayvan R. Keshari, Stephan Knecht, Christoffer Laustsen, Andreas B. Schmidt, Daniel Vigneron, Yi-Fen Yen, Franz Schilling

Published in: Molecular Imaging and Biology | Issue 2/2024

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Abstract

Hyperpolarization techniques significantly enhance the sensitivity of magnetic resonance (MR) and thus present fascinating new directions for research and applications with in vivo MR imaging and spectroscopy (MRI/S). Hyperpolarized 13C MRI/S, in particular, enables real-time non-invasive assessment of metabolic processes and holds great promise for a diverse range of clinical applications spanning fields like oncology, neurology, and cardiology, with a potential for improving early diagnosis of disease, patient stratification, and therapy response assessment. Despite its potential, technical challenges remain for achieving clinical translation. This paper provides an overview of the discussions that took place at the international workshop “New Horizons in Hyperpolarized 13C MRI,” in March 2023 at the Bavarian Academy of Sciences and Humanities, Munich, Germany. The workshop covered new developments, as well as future directions, in topics including polarization techniques (particularly focusing on parahydrogen-based methods), novel probes, considerations related to data acquisition and analysis, and emerging clinical applications in oncology and other fields.
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Metadata
Title
New Horizons in Hyperpolarized 13C MRI
Authors
Myriam M. Chaumeil
James A. Bankson
Kevin M. Brindle
Shdema Epstein
Ferdia A. Gallagher
Martin Grashei
Caroline Guglielmetti
Joshua D. Kaggie
Kayvan R. Keshari
Stephan Knecht
Christoffer Laustsen
Andreas B. Schmidt
Daniel Vigneron
Yi-Fen Yen
Franz Schilling
Publication date
26-12-2023
Publisher
Springer International Publishing
Published in
Molecular Imaging and Biology / Issue 2/2024
Print ISSN: 1536-1632
Electronic ISSN: 1860-2002
DOI
https://doi.org/10.1007/s11307-023-01888-5

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