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Current Cardiology Reports

Chagas Cardiomyopathy and Myocardial Sympathetic Denervation

  • 24-04-2024
  • Neurotomy
  • Nuclear Cardiology (V Dilsizian, Section Editor)
Published in:
Authors
Leonardo Pippa Gadioli
André Schmidt
Benedito Carlos Maciel
Gustavo Jardim Volpe
Marcus Vinicius Simões
José Antonio Marin-Neto
Published in
Current Cardiology Reports | Issue 6/2024

Abstract

Purpose of Review

More than a century since its discovery, the pathogenesis of Chagas heart disease (CHD) remains incompletely understood. The role of derangements in the autonomic control of the heart in triggering malignant arrhythmia before the appearance of contractile ventricular impairment was reviewed.

Recent Findings

Although previous investigations had demonstrated the anatomical and functional consequences of parasympathetic dysautonomia upon the heart rate control, only recently, coronary microvascular disturbances and sympathetic denervation at the ventricular level have been reported in patients and experimental models of CHD, exploring with nuclear medicine methods their impact on the progression of myocardial dysfunction and cardiac arrhythmias.

Summary

More important than parasympathetic impaired sinus node regulation, recent evidence indicates that myocardial sympathetic denervation associated with coronary microvascular derangements is causally related to myocardial injury and arrhythmia in CHD. Additionally, 123I-MIBG imaging is a promising tool for risk stratification of progression of ventricular dysfunction and sudden death.
Title
Chagas Cardiomyopathy and Myocardial Sympathetic Denervation
Authors
Leonardo Pippa Gadioli
André Schmidt
Benedito Carlos Maciel
Gustavo Jardim Volpe
Marcus Vinicius Simões
José Antonio Marin-Neto
Publication date
24-04-2024
Publisher
Springer US
Published in
Current Cardiology Reports / Issue 6/2024
Print ISSN: 1523-3782
Electronic ISSN: 1534-3170
DOI
https://doi.org/10.1007/s11886-024-02057-y
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This content is intended for healthcare professionals outside of the UK.

Independent Medical Education Grant:
  • Bayer HealthCare Pharmaceuticals Inc.
Learn more Link opens in a new window
Image Credits
Abstract graphic of layered, concentric circular shapes in bright green, pink, blue, and purple on a dark blue background. The rings and segments form a complex radial pattern without text/© Springer Health+ IME