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Open Access 06-11-2024 | Neuropathic Pain | REVIEW

Mechanisms and Therapeutic Potential of GPX4 in Pain Modulation

Authors: Shiwen Fan, Kaixin Wang, Tianhao Zhang, Daling Deng, Jiwei Shen, Bowen Zhao, Daan Fu, Xiangdong Chen

Abstract

Pain, a complex symptom encompassing both sensory and emotional dimensions, constitutes a significant global public health issue. Oxidative stress is a pivotal factor in the complex pathophysiology of pain, with glutathione peroxidase 4 (GPX4) recognized as a crucial antioxidant enzyme involved in both antioxidant defense mechanisms and ferroptosis pathways. This review systematically explores GPX4’s functions across various pain models, including neuropathic, inflammatory, low back, and cancer-related pain. Specifically, the focus includes GPX4’s physiological roles, antioxidant defense mechanisms, regulation of ferroptosis, involvement in signal transduction pathways, and metabolic regulation. By summarizing current research, we highlight the potential of GPX4-targeted therapies in pain management.

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Title: Mechanisms and Therapeutic Potential of GPX4 in Pain Modulation
Authors: Shiwen Fan
Kaixin Wang
Tianhao Zhang
Daling Deng
Jiwei Shen
Bowen Zhao
Daan Fu
Xiangdong Chen
Publication date: 06-11-2024
Publisher: Springer Healthcare
Keywords: Neuropathic Pain
Osteoarthrosis
Osteoarthrosis
Published in: Pain and Therapy
Print ISSN: 2193-8237
Electronic ISSN: 2193-651X
DOI: https://doi.org/10.1007/s40122-024-00673-8

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