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Pain and Therapy

Open Access 28-09-2024 | Neuropathic Pain | REVIEW

Peripheral Nerve Stimulation for Neuropathic Pain Management: A Narrative Review

Authors: Zhangyan Mao, Jing Lv, Yan Sun, Jiwei Shen, Yafen Gao, Shujun Sun, Dong Yang

Published in: Pain and Therapy

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Abstract

This narrative review examines the therapeutic efficacy of peripheral nerve stimulation (PNS) in the treatment of neuropathic pain (NP), a type of pain arising from lesions or diseases of the somatosensory system with a global prevalence ranging from 6.90% to 10.00%. Traditional pharmacological interventions often fall short for many persons, highlighting the need for alternative treatments such as PNS, which has demonstrated significant promise with minimal side effects. The review summarizes the effectiveness of PNS in various NP conditions, including trigeminal neuralgia and postherpetic neuralgia, and underscores the need for further research to refine treatment approaches. The mechanism of PNS is discussed, involving the activation of non-nociceptive Aβ fibers and modulation of neurotransmitters, and offering pain relief through both peripheral and central pathways. Despite the proven efficacy of PNS, challenges remain, including the need for randomized controlled trials and the optimization of stimulation parameters. The review concludes that PNS is a promising treatment modality for NP, warranting additional high-quality trials to solidify its role in clinical practice.
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Metadata
Title
Peripheral Nerve Stimulation for Neuropathic Pain Management: A Narrative Review
Authors
Zhangyan Mao
Jing Lv
Yan Sun
Jiwei Shen
Yafen Gao
Shujun Sun
Dong Yang
Publication date
28-09-2024
Publisher
Springer Healthcare
Published in
Pain and Therapy
Print ISSN: 2193-8237
Electronic ISSN: 2193-651X
DOI
https://doi.org/10.1007/s40122-024-00659-6

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