Early trials of a new oral Factor XIa inhibitor (Milvexian) are showing promise for prevention of thrombotic events in patients with acute stroke, acute coronary syndrome, and atrial fibrillation.
PPT is an uncommon infection involving the frontal bone, often with intracranial extension and risk of serious neurological morbidity. Is immune dysfunction a predisposing factor?
Many patients with drug-resistant epilepsy who are referred for surgical evaluation can benefit from optimizing their antiseizure medications, potentially avoiding surgery. Explore expert panel recommendations for cenobamate use in these patients.
Rapid advances in stroke treatment are driving the evolution of time-critical hyperacute stroke services. Explore case studies and the elements of well-functioning systems.
Giving the recombinant shingles vaccine to adults aged 65 years or older is associated with a significantly lower risk for dementia in the 6 years after vaccination than the live alternative, which already offers some protection against the condition.
Trans-spinal magnetic stimulation combined with kinesiotherapy improved balance, walking independence, and functional mobility of a 23-year-old with spinal cord injury due to neuromyelitis optica-associated transverse myelitis.
Mild cognitive impairment, dementia, and affective disorders are the most common and debilitating non-motor symptoms in PD. Here are the DGN's recommendations on diagnosis and treatment.
Several drug and gene therapies are emerging that aim to stop, delay, or reverse the relentless trajectory of Friedreich ataxia, which is one of the most common inherited ataxias.
Spinal CSF leak from a dural tear or CSF-venous fistula are known causes of spontaneous intracranial hypotension, but this is the first case caused by a primary CSF-lymphatic fistula unrelated to vascular malformation.
Sudden unexpected death in epilepsy is responsible for most epilepsy-related deaths. How do antiseizure medications, non-epilepsy concomitant drugs, and seizure detection devices affect SUDEP risk?
Maintaining glycated hemoglobin levels within target range may reduce the risk for developing Alzheimer’s disease and related dementias in older men with diabetes.
Various types of immune-mediated cerebellar ataxias have been identified. Learn about their unique clinical manifestations and underlying autoimmune mechanisms.
An extensive history of treatment-resistant migraine was eventually found to be a superficial aneurysm after the patient developed a painless lump in the left temporal region.
Parkinsonism in people with chronic traumatic encephalopathy due to sport-related repetitive head injury is linked to substantia nigra tau pathology and neuronal loss.
What are the key considerations for managing migraine in individuals with renal, liver, and/or cardiovascular comorbidities? And how can you best use the currently available pharmacologic and non-pharmacologic options?
Updated recommendations from DGN on the diagnosis and therapeutic management of impulse control disorders, psychosis, and delirium associated with Parkinson’s disease.
Diagnosis of primary diffuse large B-cell lymphoma of the CNS is challenging and often delayed. In these three cases with varied clinical presentations and radiological findings, diagnosis was suggested by novel CSF biomarkers.
Treating epilepsy with concomitant atrial fibrillation using enzyme-inducing antiseizure medications does not compromise efficacy of concurrent DOAC use.
