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Neurological Sciences

Issue 4/2026

Content (80 Articles)

Brain morphometry and cognition in late-onset glutaric aciduria type 1: scoping review and novel insights from a case report

  • Open Access
  • Review Article

Laura Veronelli, Anna Commone, Mara Botti, Paolo Remida, Eleonora Grande, Giuseppe Vallar, Rossella Parini

A meta-analysis of the effect of non-invasive neuromodulation techniques on improving cognitive function in patients with Alzheimer's disease

Jiarong Wen, Mei Li, Junpeng Xu, Yuxiang Sun, Xianchuang Chen, Zhiqi Mao

Effect of co-morbid anxiety and depression history on multidomain concussion clinical outcomes and recovery time

Eli J. Anish, Garrett Thomas, Aaron J. Zynda, Jonathan French, Michael W. Collins, Alicia M. Trbovich, Anthony P. Kontos

Regulatory, clinical, and post-marketing challenges of lecanemab for Alzheimer’s disease: insights from real-world data

  • Open Access
  • Original Article

Giuseppe Marano, Roberto Da Cas, Ilaria Ippoliti, Paolo Caffarra, Nicoletta Locuratolo, Nicola Vanacore, Antonio Ancidoni

Anti-myeloperoxidase-ANCA-associated vasculitis presenting with sudden sensorineural hearing loss: a case report

Byungseok Kim, Seunghee Na, In-Uk Song

Fibromyalgia: the Italian survey by the ministry of health

Alice Giordano, Davide Sasssos, Roberto Fancellu, Massimo Del Sette, Luca Boni, Alberto Sulli

Neurosyphilis presenting as ocular motor nerve palsy: two cases and a systematic literature review

Won Jeong Son, Eunjin Kwon, Seong-Hae Jeong, Hyun Sung Kim, Su-Jin Kim, Seo Young Choi, Kwang-Dong Choi, Jae-Hwan Choi

Headache associated with adverse cognitive trajectories in Chinese aging cohort: a group-based trajectory modeling study

Hong Wang, Weisheng Deng, Wei Qiu

Clinical, laboratory, and radiological features influencing admission DWI-ASPECTS in stroke patients with middle cerebral artery occlusion undergoing mechanical thrombectomy

  • Open Access
  • Stroke
  • Original Article

Carmelo Tiberio Currò, Antonio Ciacciarelli, Giulia Fiume, Davide Vicari, Anna Gardin, Concetto Fabio Vecchio, Alessandra Coglitore, Mirta Longo, Giuseppe Trimarchi, Cristina Dell’Aera, Masina Cotroneo, Rosa Fortunata Musolino, Antonio Toscano, Sergio Lucio Vinci, Enricomaria Mormina, Paolino La Spina, Agostino Tessitore

Intraoperative ultrasonography in the surgical management of Chiari I malformation: A systematic review and meta-analysis of outcomes and applications

Bardia Hajikarimloo, Ibrahim Mohammadzadeh, Mohammad Amin Habibi, Salem M. Tos, Haris Yaseen, Nathan Chisvo, Mohammadmahdi Sabahi, Qais Alrashidi, Badih Adada, Hamid Borghei-Razavi

Comprehensive analysis of the potential role of Ferroptosis-related genes in glioblastoma multiforme

Xin Guo, Li Sun, Hengxing Jiao, Li Liu, Haibing Xiong, Zhijie Tian, Shi Zeng, Jianhong Huo

Unraveling amyotrophic lateral sclerosis: a novel peripherin mutation in a young male with sporadic onset

Manoj Manyem, Saranya B. Gomathy, Vishnu K. Subramanian, Shamir Sugan, Ramkumar Sugumaran, Sunil K. Narayan

First pediatric migraine with transient hypoperfusion, venous abnormalities and EEG slowing

Luca Prosperini, Margherita Federici, Alessandro Stasolla, Maurizio Zucco, Enrica De Luca, Mauro Calvani

Validation of the brief assessment of impaired cognition (BASIC) and brief assessment of impaired cognition questionnaire (BASIC-Q) in Italy

Marco Canevelli, Simone Pomati, Emanuela Salati, Giorgia Maestri, Giulia Sarti, Clara Calia, Chiara Pecorari, Sara Marchetti, Ilaria Cova, T. Rune Nielsen, Kasper Jørgensen, Daniel Kjaergaard, Francesco Sciancalepore, Filippo Nuti, Marco Toccaceli Blasi, Leonardo Pantoni, Nicola Vanacore, Giuseppe Bruno

Commentary on “Is gaitrite system sensitive in discriminating gait pattern of subjects affected by Charcot Marie tooth? A pilot study”

Arnaud Gouelle

Response on “Commentary on “Is gaitrite system sensitive in discriminating gait pattern of subjects affected by Charcot Marie tooth? A pilot study””

Cristina Schenone, Marta Ponzano, Laura Mori

Efficacy and safety of deferiprone for Parkinson’s disease: a systematic review and meta-analysis of motor function and overall disease severity

Ismail A. Ibrahim, Mandy Elewa, Israa A. Solah, Moaz Ezz-Alarab, Rawan Gameel Hekal, Menna Ehab, Amro K. AlQurm, Rahma M. Almetwaly, Ayham R. A. Zidat

Poliomyelitis, the years before vaccination. A reading through art

Mariano Martini, Francesco Brigo, Carola Minet, Davide Orsini

BDNF Val66Met polymorphism modulates early TMS–EEG plasticity and rTMS efficacy in patients with anterior circulation ischemic stroke

Jingyuan Lin

Downregulation of dual-specificity phosphatase 1 (DUSP1) in post-mortem brain white matter in progressive multiple sclerosis

Martí Oró-Nolla, Melody Cui Sun, Thomas Reilly, Julia Anandarajah, Almudena Otálora-Alcaraz, Lisa Costelloe, Hugh Kearney, Richard Magee, Yvonne M. Nolan, Eric J. Downer

Retro-cerebellar arachnoid cyst in a patient with a novel SPG7

Khaled I Dweik, Sotiris G Mitropanopoulos, Mayowa A Osundiji

The association between prescribed hormonal contraception and multiple sclerosis risk: a systematic review and meta-analysis

Jessica McDonald, Priya Sharma, Christopher Tench, Ruth Dobson, Radu Tanasescu, Sonia Gran, Bruno Gran

Machine learning -driven discovery of Parkinsonian-like phenotypes in idiopathic REM sleep behavior disorder

D. L. Giardino, C. Huck-Iriart, P. M. Gonzalez, P. A. Aguirre, J. P. Fededa, C. Peralta, S. M. Valiensi, A. Garay

p. His110Asn: confirmation of pathological ATTRv variant

Maria Ausilia Sciarrone, Francesca Vitali, Maria Chiara Meucci, Francesca Graziani, Marco Luigetti

MRI-morphometric characterization of Chiari malformation types 0 and 1 with syringomyelia: implications for diagnosis and pathogenesis

Enver I. Bogdanov, Aisylu T. Faizutdinova, John D. Heiss

Efficacy of digital health technologies as adjunctive functional training in occupational therapy for stroke rehabilitation: a meta-analysis

Yangzi Zhang, Chenshu Ge, Congwei Li, Fang Liu

Early anti-C5 therapy in NMOSD: rationale and clinical evidence

Haruka Kido, Satoru Morimoto, Mikiaki Matsuoka

Neurosarcoidosis-like reaction under TNF-α inhibitors: a case report and literature review of a paradoxical immune phenomenon

Gianvito Barbella, Pietro Antenucci, Marta Rosa, Andrea Gozzi, Marina Padroni

Mechanisms of acupuncture-regulated cortical plasticity after stroke based on TMS-EEG-MEP integration

Chuanfeng Qiu

Suicidality in Parkinson’s disease: a controlled study and review of literature

Koray Yarız, Muhittin Cenk Akbostancı, Damla Sayar Akaslan, Turan Ayidaga, Ece Bayram, Rezzak Yılmaz

Assessment of cognitive function in patients with heart failure: impact of clinical and sociodemographic factors

Refika Reva Ciftcioglu, Zeliha Tulek

Neuro-behcet’s syndrome: epidemiology, mechanisms, and emerging strategies in diagnosis and treatment

Emine Rabia Koc, Sanja Gluscevic, Abdulkadir Tunc, Meral Seferoglu, Christos Bakirtzis, Sara Samadzadeh, Krzysztof Selmaj, Hans-Peter Hartung, Xavier Montalban, Aksel Siva

Immunotherapy-induced vitiligo and demyelinating plaques: a case report suggesting a neurocutaneous mechanism

Demet Ersivri, Eda Hayber, Ufuk Yazar, Ahmet Uyar, Yusuf Acıkgoz

Effect of surface electromyographic biofeedback on post-stroke dysphagia: a meta-analysis

Yongying Zhang, Bin Zhang, Tingting Huang, Honghua Zhuang, Yushan Yin

Italian recommendations for the diagnosis and treatment of myasthenia gravis

Laura Fionda, Paolo Emilio Alboini, Carlo Antozzi, Domenico Marco Bonifati, Valentina Damato, Francesco Habetswallner, Maurizio Inghilleri, Raffaele Iorio, Rocco Liguori, Michelangelo Maestri Tassoni, Lorenzo Maggi, Renato Mantegazza, Roberto Massa, Elena Pegoraro, Carmelo Rodolico, Mariangela Pino, Giovanni Antonini, Amelia Evoli

Can virtual reality interventions reduce falls in Parkinson’s disease? A systematic review and meta-analysis of randomized trials

Gabriel Dimitrov, Katrin Maystorska, Stefka Mantarova-Valkova

Blood-based biomarkers for Alzheimer’s disease diagnosis: a joint position paper from the Italian Societies of Neurology (SIN) and of Clinical Biochemistry and Clinical Molecular Biology - Laboratory Medicine(SIBioC) and from the Autonomous Association affiliated with SIN for dementia (SINdem)

Lorenzo Gaetani, Luisa Agnello, Andrea Pilotto, Alberto Benussi, Annachiara Cagnin, Lucilla Parnetti, Marco Bozzali, Alessandro Padovani, Marcello Ciaccio, Marco Canevelli, Giordano Cecchetti, Giuseppe Di Fede, Giulia Giacomucci, Guido Maria Giuffrè, Piergiorgio Grillo, Daniele Imperiale, Camillo Marra, Alessandro Martorana, Federico Massa, Benedetta Nacmias, Federico Paolini Paoletti, Piero Parchi, Tommaso Piccoli, Domenico Plantone, Elisa Rubino, Martina Valletta, Gianluigi Zanusso, Laura Bonanni, Giulia Musso, Giulia Sancesario

Letter to the editor concerning “The burden and management of emergency room neurological consultation in hub and spoke Italian hospitals: the nationwide surveys of the Italian Association for Emergency Neurology (ANEU)”

Matin Sarshivi, Ali Mohseni, Nima Masoudi

Molecular mirror: reflecting the complexity of Parkinson’s disease

Shahin Siddik, Upashana Patgiri, Piyong Sola

Association between the newly introduced Diet Index for Gut Microbiota (DI-GM) and stroke prevalence: potential indirect associations via phenotypic age and body mass index (BMI)

Li Ke, Ying Li, Wenli Xing, Sili Jiang, Lei Zhao

Monoallelic ATP7B variants in adult-onset cerebellar ataxia

Yoon Seob Kim, Don Gueu Park, Joo-Yeon Lee, Jung Han Yoon

Teaching NeuroImage: an imaging clue for neuronal intranuclear inclusion disease

Jianhua Yang, Qing Liu, Xianghong Liu

N200 and P300 as neurophysiological markers of the cognitive continuum in Parkinson’s disease: insights from an inhibitory control task

Hui Xu, Yijing Guo

Bell’s palsy as the first manifestation of neurosyphilis in an immunocompetent and HIV-negative patient: a challenging diagnosis

Marco Bisquoli, Massimo Bondavalli, Claudia Lazzaretti, Manuela Napoli, Letizia Caprari, Pedro Fraiman, Sergio Mezzadri, Sara Montepietra, Francesco Cavallieri

Neurological complications as a predictor of in-hospital mortality in infective endocarditis: 11 years’ experience of tertiary center

Zeynep Yıldız, Özlem Yıldırımtürk, Aydın İşletme, Melek Süzer Aslan

Uncoupling of apnea-hypopnea index and oxygen desaturation in als: characterization and diagnostic implications of an “AHI-SpO₂ dissociation” phenotype

Xueming Li, Weijiang Ding, Enwang Xu

Early-onset Parkinson’s disease: clinical findings and progression

Didem Tezen, Furkan Sefa Bayır, Cihan İşler, Hülya Apaydın, Ayşegül Gündüz

Vincenzo Neri and the visual culture of wartime neuropsychiatry (1914–1918)

  • History of Neurology

Tamara Sandrin, Lorenzo Lorusso, Francesco Brigo

Revascularization treatments within 4.5 h after onset in acute ischemic stroke with isolated extracranial artery occlusion

Manuel Cappellari, Ettore Nicolini, Valentina Saia, Giovanni Pracucci, Ludovica Guido, Ilaria Casetta, Enrico Fainardi, Sandra Bracco, Rossana Tassi, Antonio Laiso, Patrizia Nencini, Maria Ruggiero, Marco Longoni, Andrea Saletti, Alessandro De Vito, Nicola Cavasin, Adriana Critelli, Roberto Menozzi, Alessandro Pezzini, Mauro Bergui, Giovanni Bosco, Alessio Comai, Enrica Franchini, Claudia Rolla Bigliani, Tiziana Benzi Markushi, Emilio Lozupone, Sabino D’Agostino, Stefano Vallone, Guido Bigliardi, Andrea Boghi, Andrea Naldi, Ivan Gallesio, Alessandro Canessa, Michele Besana, Alessia Giossi, Luigi Simonetti, Andrea Zini, Valerio Da Ros, Giordano Lacidogna, Nicola Burdi, Angelica Tinelli, Sergio Lucio Vinci, Paolino La Spina, Mauro Plebani, Francesco Valletta, Manuela De Michele, Antonio Ciacciarelli, Andrea Romi, Alessandra Persico, Guido Andrea Lazzarotti, Gaia Mignani, Marco Perri, Federica De Santis, Antioco Sanna, Elena Coco, Gianluca Galvano, Eleonora Saracco, Matteo Alberti, Paolo Invernizzi, Massimiliano Allegritti, Stefano Caproni, Luigi Chiumarulo, Marco Petruzzellis, Giuseppe Carità, Monia Russo, Edoardo Puglielli, Alfonsina Casalena, Ahmed Niaz, Salvatore Mangiafico, Danilo Toni

Two cases with overlapping features of multiple sclerosis and neuromyelitis optica spectrum disorder

Asli Buyukkurt, Elias S. Sotirchos

Efgartigimod Alfa as a novel rescue therapy for severe NMOSD: a case report

Yundi Wei, Cuilan Wang, Xiangqing Xu, Hengye Zhao, Dingwen Yu, He Li, Tong Wu

An updated italian normative data for a short version of the stroop colour word test

Simona Luzzi, Veronica Cherubini, Pamela Rosettani, Sara Baldinelli, Chiara Fiori, Mauro Silvestrini, Michele Scandola

Global, regional, and national burden of Early-onset Parkinson’s disease: A comprehensive analysis and forecast, 1990–2021

Qing Shen, Fengrui Zheng, Yun Dong, Hongping Yang, Jie Zhu, Shun Chen, Zujuan Shan

TSPO-PET highlights an atypical mitochondrial encephalomyopathy with lactic acidosis and stroke-like episodes (MELAS) phenotype

Yang Zeng, Yingxue Yang, Wei Wang, Qing Peng, Yuye Bai, Xiaoling Yu, Shen Yang, Liankun Ren

Probable tirzepatide-associated limbic encephalitis with status epilepticus in a patient with extreme obesity: a case report

Andrea Mazzeo, Valerio Alaimo, Luigi M. Grimaldi

Metabolome Wide Mendelian Randomization Assessing the Causal Relationship Between Serum Metabolites, Cerebrospinal Metabolites, and Aneurysmal Subarachnoid Hemorrhage

Bingyi Song, Youjia Qiu, Minjia Xie, Yuchen Tao, Ziqian Yin, Menghan Wang, Na Ji, Xinlin Tang, Zhouqing Chen, Zhong Wang

Quiz Case: Late-onset Cbl C Deficiency Presenting As Isolated Subacute Combined Degeneration

  • Quiz Cases

Miao Wu¹, Zhiyong Zhang

Correction to: Head to head comparison between arterial spin labelling MRI and [18F]FDG-PET in presurgical evaluation of epilepsy in children: the role of voxel-based asymmetry index analysis

Pietro Mattioli, Giulia Nobile, Matteo Cataldi, Luca Bosisio, Francesco Famà, Andrea Rossi, Alessandro Consales, Stefano Raffa, Flavio Villani, Silvia Morbelli, Dario Arnaldi, Lino Nobili, Domenico Tortora, Alessandra , Ferrari Stefano Francione, Thea Giacomini, Laura Giorgetti, Mattia Losa, Maria Margherita Margherita, Valentina Marazzotta, Elisa Micalizzi, Mattia Pacetti, Irene Pappalardo, Costanza Parodi, Giulia Prato, Mariasavina Severino, Laura Siri, Andrea Michele Wolfler

A GRASS-guided phased progressive brain-computer interface approach for post-infarction hand motor recovery

Guidi Zou, Liyi Chen, Huihong Tan, Feixiang Zeng, Anqin Dong, Gufeng Li, Jianghong Fu, Kewei Yu, Liang Du, Qiang Liu, Xiaokai Chen, Hewei Wang

Relapse in Tolosa-Hunt syndrome: pooled recurrence rates and associated factors from a meta-analysis of 456 cases

  • Open Access
  • DBS
  • Review Article

Bernardo Leite Pondé da Luz, Guilherme Diogo Silva

Motor fatigue and fatigability in early multiple sclerosis patients: an analysis of clinical, radiological and psychological underpinnings

  • Open Access
  • Fatigue
  • Original Article

Matteo Betti, C. Masciulli, I. Addazio, C. Ballerini, R. Bonacchi, A. Caporali, F. Chiappetta, E. De Meo, C. Fabbiani, F. Gerli, U. Kihlbom, C. Niccolai, G. Pasquini, L. Pastò, V. Penati, K. Scholin Bywall, Jennifer Viberg Johansson, E. Fainardi, S. Martin, E. Portaccio, MP. Amato

Bilateral fornix bodies and posterolateral thalamus ischemia, septum pellucidum cyst

Monique Boukobza, Augustin Gaudemer, Elisa Ouin, Philippa Lavallée, Jean-Pierre Laissy

Validation of the Arabic version of the composite autonomic symptom score 31 questionnaire in diabetic autonomic neuropathy

  • Open Access
  • Original Article

Ahmed S. Alkotami, Asmaa Aboelfath, Aya E. Zhran, Amro M. Stino, Ahmed M. Eldokla

Clinical and immunological features of auto-immune nodopathies

Meng Dong, Xiaozhen Gao, ChaoYi Yu, Zaiqiang Zhang

Atypical subacute sclerosing panencephalitis mimicking mitochondrial encephalopathy, lactic acidosis and stroke-like episodes

Madhu S. Gaddigoudar, Ritansh Khera, Ratan Gupta, Arvinder Wander

Needs, experiences, and knowledge of people with primary progressive multiple sclerosis: a scoping review

Andrea Giordano, Giulia Di Domenico, Julia Hickstein, Lorenz Rasev, Miguel Angel Robles-Sanchez, Ingrid Galán, Edwin Roger Meza Murillo, Klara Novotna, Markus Wiemann, Rieke Schnakenberg, Sinéad M. Hynes, Alessandra Solari, Christoph Heesen, Anne Christin Rahn

Sudoscan® and QSART in the composite autonomic severity scale: complementary approaches to sudomotor assessment in multiple sclerosis

Katarina Tešija, Mašan Sredanović, Katy Jerčinović, Magdalena Krbot Skorić, Mario Habek

Genotype-guided switch from ravulizumab to satralizumab in aquaporin-4–IgG–positive neuromyelitis optica spectrum disorder: a case of C5 polymorphism-associated ravulizumab resistance

Hiroyuki Naito, Takamichi Sugimoto, Yu Yamazaki, Hirofumi Maruyama

Association between lesion location and symptoms of restless leg syndrome (RLS) among patients with multiple sclerosis (MS)

Salman Aljarallah, Saleh Husam Aldeligan, Ahmed Almarshed, Omar A. Aldosari, Manal Alosaimi, Alaa M. Albishi, Ahmed Bahammam, Nuha M. Alkhawajah

Peripheral inflammation predicts motor, cognitive, and disease progression in Parkinson’s disease: A 4-year longitudinal study from the PPMI cohorts

Zonghui Chen, Lijuan Xie, Qingwen Jin, Mingchao Shi

The value of venous outflow assessment based on multiphase CTA in predicting the prognosis of endovascular therapy for acute ischemic stroke patients

Tong Zhang, Yan Zhang, Chengxin Yan

Dystonia induced by anticholinesterase drugs: case report and literature review

Hortensia Alonso-Navarro, Silvina Espada-Rubio, Miguel Ángel Martín-Gómez, Paula Salgado-Cámara, Margarita Arroyo-Solera, Alba Cárcamo Fonfría, Félix Javier Jiménez-Jiménez

Clarifications to “Congenital myasthenia syndrome with demyelinating sensorimotor neuropathy responsive to salbutamol monotherapy: a novel clinical phenotype of CHRNE mutation”: the usefulness of single-fiber electromyography (SFEMG)

Moisés León-Ruiz, Ritwik Ghosh, Souvik Dubey, Carlos Castañeda-Cabrero, Julián Benito-León

Heterogeneity of monogenic epilepsy in loci, phenotypes, and treatment approaches

Ali K. Saad, Nadia Akawi

Blood pressure variability in the ATACH2 study: evaluating a target range

Kendall Huntt, Aric Shadler, Abigail Leonhard, Rachael Scott, Justin F. Fraser, Jessica Lee, Melissa Nestor, Adnan Qureshi, Aaron M. Cook

Patent foramen ovale closure versus medical therapy alone in elderly patients with cryptogenic stroke: a systematic review and meta-analysis

Ocilio de Deus, Gabriel Caruso Novaes Tudella, Maria Antonia Oliveira Machado Pereira, Giovana Menegucci, Augusto Utida Klostermann, Anderson Matheus Pereira da Silva, Lucas Pari Mitre, Luca Scarcia, Ahmet Günkan, Thanh Nguyen

MERRF/MELAS overlap syndrome mimicking paradoxical cerebral embolism due to patent foramen ovale

Akira Machida, Kentaro Shirai, Jun Oyama, Eisuke Usui, Tsunekazu Kakuta

Prolonged episodic ataxia associated with a SCN2A variant: intrafamilial phenotypic heterogeneity and adult vestibulo-cerebellar presentation

Halil Onder, Mehmet Eranil, Serdar Ceylaner

Successful treatment with efgartigimod as rescue therapy in acute attack of MOGAD: a case report

  • MOGAD
  • Brief Communication

Yi-Xiao Li, Rui-Yun Wang, Ming-Qiu Wang, Yan-Lei Hao

Rehabilitation after diagnosis of hydrocephalus in severe acquired brain injury: the unmet need for evidence-based guidelines

Giulio Verrienti

Mar 26
Issue: 3/2026
May 26
Issue: 5/2026

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Case challenge: neuroimaging in Alzheimer disease (Link opens in a new window)

Put your decision-making and interpretation skills into practice with these six cases focusing on different presentations. Can you choose the optimal PET tracer, accurately interpret the results, and advise on next steps?

This content is intended for healthcare professionals outside of the UK.

Independent Medical Education Grant:
  • Lilly
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Navigating neuroimaging in Alzheimer’s care: Practical applications and strategies for integration/© Springer Health+ IME