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Neurological Sciences

Issue 11/2025

Content (83 Articles)

Beyond Neuroinflammation: Microglia at the Crossroads of Amyloid, Tau, and Neurodegeneration in Alzheimer’s Disease

Rasoul Ebrahimi, Sanaz Bordbar, Ghazal Azad, Samin Davoody, MahSima Mahmoudi, Khadijeh Esmaeilpour

Role of Monoclonal Antibodies in Alzheimer’s Disease: Successes, Failures, and Future Directions

Arushi Gupta, Sonu Pahal, Vivek Kumar, Amit Chaudhary

Retinal microvascular alterations in Parkinson’s disease: visual analysis and meta-analysis

Shiyuan Qin, Lei Li, Shuang Gao, Yazhi Yang, Yu Chen, Ying Wang

Ultrasonography of the vagus nerve in Parkinson’s disease: a systematic review and meta-analysis

Yating Cui, Rui Yan, Yan Qu, Shuting Liu, Xiaohong Li

From diabetes to dopamine: Evaluating the disease-modifying potential of GLP-1 receptor agonists in Parkinson’s disease. A systematic review and meta-analysis of placebo-controlled trials

Ahmed Samy Badran, Mohamed Ibrahim Gbreel

Generalized dystonia unraveled: Molecular mechanisms, diagnostic strategies, and treatment paradigms

Fereshteh Yarahmadi, Ali Shoiebi, Mohammad Shariati, Michael Zech, Ariane Sadr-Nabavi

MicroRNA-126 as an endogenous molecule for hypoxic/ischemic tolerance in neuroprotection

Yuzhi Shao, Shaohan Zhang, Pu Zhang, Junwei Chen, Guo Shao

Cerebrovascular malformations different from AVMs in patients with hereditary hemorrhagic telangiectasia: a systematic review

Matteo Palermo, Federico Cocilovo, Giuseppe Lanzino, Alessandro Olivi, Carmelo Lucio Sturiale

Effectiveness of intermittent theta burst stimulation (iTBS) on Post-Stroke motor dysfunction: A Meta-Analysis of randomized controlled trials

Hongmei Chen, Kaimin Xiao, Xinwei Yang, Zhixue Yin, Yujie Wu, Guoshuang Fu, Yutong Xia, Bilin Liang, Ying Wang, Tianzhu Liu, Li Chen

Pediatric stiff-person syndrome and related disorders: A systematic review

H Shafeeq Ahmed, Purva Reddy Jayaram, Deepika Reddy Aluru, Rishika Das, Muskan Kotwal, Lakshmi A. K. Bhat, Niharika B. R

Anti-Kelch-like protein 11 antibody encephalitis presenting with progressive cognitive deficits in an older woman: a case report and literature review

Qin Wang, Yihua Guo, Jianli He, Linna Jiao, Haibo Su

VNS treatment in super-refractory status epilepticus: report of two cases and systematic review of literature

Luca Bosisio, Giulia Barbagallo, Lino Nobili, Gianluca Piatelli, Mattia Pacetti, Matteo Cataldi, Silvia Buratti, Maria Margherita Mancardi, Alessandro Consales

The first report of ceroid lipofuscinosis type 11 in China: a novel mutation of GRN and updated clinical review

Difang Shi, Jianjian Bao, Haohao Wu, Baogang Huang, Yan Zheng, Fengming Xu, Hanmin Wang, Jia Liu, Shaoyong Guan, Kang Du

Unexplained cerebral hemiatrophy in a case of astrocytoma, IDH-Mutant, WHO grade 3: a case report and literature review

Alice S. Juell, Brett J. Theeler

Advancing glioblastoma therapy with surface-modified nanoparticles

Giorgia De Rosa, Marco Zeppieri, Caterina Gagliano, Alessandro Tel, Daniele Tognetto, Pier Paolo Panciani, Marco Maria Fontanella, Tamara Ius, Edoardo Agosti

The remote administration of the uniform data set neuropsychological test battery (I-UDSNB) Italian version: normative data

  • Open Access
  • Original Article

Davide Quaranta, Francesca Conca, Federica L’Abbate, Valentina Esposito, Elena Gobbi, Ilaria Pagnoni, Francesca Baglio, Francesca Borgnis, Maddalena De Matteis, Michelangelo Stanzani-Maserati, Federica Piras, Giulia Caruso, Valentina Catania, Francesco Rundo, Barbara Poletti, Vincenzo Silani, Matteo Pardini, Beatrice Orso, Emanuela Inguscio, Valeria Crepaldi, Nicola Canessa, Giulia Mattavelli, Alberto Albanese, Elena Perdixi, Andrea Pace, Antonio Tanzilli, Maria Cotelli, Raffaele Lodi, Raffaele Ferri, Pietro Tiraboschi, Fabrizio Tagliavini, Sonia Di Tella, Ugo Lucca, Alessia A. Galbussera, Mauro Tettamanti, Eleonora Catricalà, Stefano F. Cappa, Camillo Marra

Effect of HD-tDCS targeting the DLPFC on cognitive ability and flight simulation performance in healthy adults

  • Original Article

Yushan Li, Yue Gong, Zhihua Guo, Rui Qiu, Xia Zhu

The impact of polygenic risk for alzheimer’s disease on neurotransmitter-related grey matter atrophy in the alzheimer continuum

Riccardo Manca, Micaela Mitolo, Maria Giulia Bacalini, Sabina Capellari, Annalena Venneri

Efficacy of Transcranial Direct Current Stimulation in Patients with Primary Progressive Aphasia: A Systematic Review and Updated Meta-analysis

Khaled Alhwaishel, Mariano Gallo Ruelas, Aisha Rizwan Ahmed, Victor Gonçalves Soares, Aishwarya Koppanatham, Jhon E. Bocanegra-Becerra, Elizabet Taylor Pimenta Weba, Anuraag Punukollu, Krish Kuhar, Gabriel de Moraes Mangas, Jéssica Sales de Oliveira, Reem Ali Aldubaisy, Brodus A. Franklin, Murilo dos Santos Mancilha, Rafael B. João

Evaluation of glymphatic system activity and lateralization by diffusion tensor imaging in Parkinson’s disease with excessive daytime sleepiness

Xinxin Miao, Zihan Li, Yongfeng Jia, Qiumei Zhang, Jun Shen, Peixian Ji, Jianwei Wang, Min Wang

Is GBA1 mutation status a game-changer for impulse control behaviour in Parkinson's disease?

Nikola Kresojević, Vladana Marković, Cveta Geratović, Milica Ječmenica Lukić, Aleksandra Tomić, Valerija Dobričić, Iva Stanković, Tanja Stojković, Nataša Dragašević, Maksim Šarčević, Milena Janković, Ana Marjanović, Ivana Novaković, Vladimir Kostić, Marina Svetel, Igor Petrović

Clinical predictors of speech changes after subthalamic neurostimulation in Parkinson’s disease

Francesco Cavallieri, Francesco Bove, Alessandro Zampogna, Anna Castrioto, Sara Meoni, Annalisa Gessani, Emmanuelle Schmitt, Pierre Pélissier, Franco Valzania, Antonio Suppa, Serge Pinto, Stephan Chabardès, Valerie Fraix, Elena Moro

Motor neuron axonal excitability changes in the clinical course of amyotrophic lateral sclerosis

Panagiotis Kokotis, Eleni Bakola, Martin Schmelz, Michalis Rentzos, Georgia Papagiannopoupou, Georgios Tsivgoulis

Association between metabolic syndrome, its individual components and progression of amyotrophic lateral sclerosis

Qirui Jiang, Qianqian Wei, Tianmi Yang, Junyu Lin, Yi Xiao, Chunyu Li, Lingyu Zhang, Yanbing Hou, Ruwei Ou, Shichan Wang, Jiyong Liu, Yan Liang, Huifang Shang

G20 stroke burden 1990–2035: trends, projections and precision health insights

Rongrong Chen, Xiangwen Li, Ruonan Zhao, Xufei Zhao, Lin Ma, Qi Miao, Rongqiang Zhang

Mobile stroke unit treatment times and transport frequency in a suburban setting

Alejandro Vargas, Rebecca Zobel, Laurel J. Cherian, Rima M. Dafer, Nicholas D. Osteraas, Sarah Y. Song, Mark E. Cichon, James J. Conners

Incidence, predictors, types and outcome of Post-Partum stroke: A population based study

Javaria Aslam, Shoaib Luqman, Umair Arif, Mazhar Faiz Alam, Khursheed Muzammil, Saima Nasreen, Muhammad Danial Khan, Ayesha Ali Khan, Amit Kumar Thakur

The essential role of multimodal magnetic resonance imaging in diagnosing vertebrobasilar artery dissection

  • Pica
  • Original Article

Yoshitaka Nakayama, Teppei Komatsu, Motohiro Okumura, Hiroyuki Kida, Ryoji Nakada, Tomomichi Kitagawa, Hiroki Takatsu, Kenichi Sakuta, Kenichiro Sakai, Hidetaka Mitsumura, Yasuyuki Iguchi

Clinical features and outcomes of intracerebral hemorrhage patients with dizziness: a multi-center cohort study

Jia-Xin Luo, Zi-zhen Meng, Zhi-bo Gao, Xiao Hu, Zi-jie Wang, Xue-yun Liu, Chu Chen, Shan-yu Zhang, Peng-ju Sun, Xin-Ni Lv, Jie Shen, Qi Li

Group-based trajectory modeling identifies distinct glycemic patterns predictive of mortality in aneurysmal subarachnoid hemorrhage

Xingyu Qiu, Xue Bai, Yu Zhang, Xing Wang, Renjie Zhang, Jialing He, Chao You, Lu Ma, Dingke Wen, Fang Fang

CT-Based deep learning platform combined with clinical parameters for predicting different discharge outcome in spontaneous intracerebral hemorrhage

Te-Chang Wu, Mao-Hsiang Chan, Kuan-Hung Lin, Chung-Feng Liu, Jeon-Hor Chen, Ruey-Feng Chang

Investigation of the subclinical atherosclerosis risk in patients with migraine

Aylin Güneşli, Ahmet Onur Keskin

Stroke risk in cancer survivors: A meta-analysis and meta regression

Francisco Cezar Aquino de Moraes, Gustavo Tadeu Freitas Uchôa Matheus, Maria Eduarda Cavalcanti Souza, Artur Menegaz de Almeida, Ocílio de Deus da Rocha Ribeiro Gonçalves, Anna Lydia Machado Silva, Lucas Bresciani Padilha, Francinny Alves Kelly, Rommel Mario Rodríguez Burbano

Long-Term outcomes of mild traumatic brain injury in veterans of the second Nagorno-Karabakh war

Javid Shafiyev, Anar İsmayılov, Azar Aliyev, Rashad Qubadov, Irfan Gahramanov

Dicer and microRNA-155 dysregulation in multiple sclerosis: biomarkers for disease progression and treatment response

Nadia M. H. Madany, Mona I. A. El-Seidi, Husam S. Mourad, Mona A. Abdelmaseeh, Hagar L. Mowafy

The associations between caregivers’ psychological characteristics and patients’ apathy symptoms in multiple sclerosis

Maria Cropano, Giacomo Lus, Mariachiara Gaita, Lidia Ammendola, Daniela Malangone, Elisabetta Signoriello, Simona Raimo

Circulating MicroRNAs as diagnostic indicators in tuberculous Meningitis-A case -control study in North Indian population

Ritika, Vineeta Singh, Varun Kumar Singh, Rameshwar Nath Chaurasia, Abhishek Pathak, Deepika Joshi, Anand Kumar, Vijay Nath Mishra

Changes in etiology, diagnostic challenges, and prognostic factors in pediatric acute encephalitis: Insights from an 18-year retrospective study

Lorna Stemberger Marić, Dominik Ljubas, Andrea Nikčević, Kristian Bodulić, Ana Tripalo Batoš, Goran Tešović

β2-Microglobulin: A potential novel prognostic indicator for neuroblastoma

Yan Lei, Jianjun Zhu, Xiaoning Liu, Yuantao Zhou, Li Li

Implications of neural integration beyond gaze-holding: translating insights from animal models to human patients

Fabio Bandini, Alexander A. Tarnutzer, Fatema F. Ghasia, Su-Chun Huang, Christian Cordano, Aasef G. Shaikh

Benign multiple sclerosis: looking beyond physical disability

Josué de Almeida David, Thomas Vieira de Paula, Alfredo Damasceno

Aripiprazole-induced reversible myopia in a patient with tourette syndrome

Andrea E. Cavanna, Elisa Capriolo, Virginia Caimi, Gabriele Arienti, Anna Riva, Renata Nacinovich, Stefano Seri

SPG7 p.A510V heterozygosity as a cause of adult-onset cerebellar ataxia without spasticity: longitudinal evidence from a sporadic case

Simone Aloisio, Martina De Riggi, Adriana Martini, Sofia Grandolfo, Daniele Birreci, Luca Angelini, Giulia Paparella, Stefano Gambardella, Matteo Bologna

Carcinomatous leptomeningitis from bladder cancer mimicking immune-related cerebellitis: A case report

Filippo Cordaro, Andrea Barresi, Francesco Bencivinni, Aurelia Banco, Massimo Gangitano, Giuseppe Salemi, Marco D’Amelio, Cesare Gagliardo

“Crab sign” in an ataxia patient with central nervous system Erdheim Chester disease: a novel neuroimaging finding with review of literature

Farsana Mustafa, Chaithra Rajanna, Archita Makharia, Divyani Garg, Ayush Agarwal, Ajay Garg, Aanchal Kakkar, Shreya Ojha, Nishikant A. Damle, Yamini Dharmashaktu, Divya M. Radhakrishnan, Achal Kumar Srivastava

Neurological and neuropsychological correlates of Klippel-Feil syndrome

  • Open Access
  • Short Paper

Sara Melchiorre, Mirella Russo, Matteo Santilli, Gaetano Polito, Consuelo Ciprietti, Dario Calisi, Valentina Panara, Loris Di Clemente, Astrid Thomas, Stefano L. Sensi

A forgotten physician, A fading sign: rediscovering Pietro Binda (1884–1967) and his shoulder phenomenon

  • History of Neurology

Valentina Martinelli, Paolo Mazzarello, Francesco Brigo, Maria Carla Garbarino

Neuroplastic adaptations in neurodegenerative and cerebrovascular diseases induced by green space activity: A pathway to optimized rehabilitation

Srishti Banerjee

Strengthening Parkinson’s disease epidemiology: refining diagnosis and survival metrics

FNU Aqsa, FNU Laraib, Aveena Lohana, Adarsh Shahani, Kashish Assaram, Noor un nisa Irshad

Letter to the editor: clinical utility of visual rating scales in detecting mild cognitive impairment in Parkinson’s disease: a focus on medial temporal and occipital atrophy

Brijesh Sathian, Syed Muhammad Ali, Javed Iqbal, Ayesha Parvaiz Malik

Critical insights on “advanced clinical stage parkinson’s disease is linked to pro inflammatory and regulatory blood cell populations.”

Maryam Amjad, Bilal Ahmad, Sameen Amjad

Artificial Intelligence-driven innovation for Non-Expert clinicians in progressive supranuclear palsy

Talha Khan, Rehman Bashir, Hasnain Wajeeh Saqib, Ayesha Tariq, Muzakkir Omer

Wilson’s disease presenting as an isolated adult-onset cervical dystonia

Niraj Kumar, Sweety Kumari, Mritunjai Kumar, Ashutosh Tiwari

Dose-dependent effects of Arimoclomol in ALS: insights from a network meta-analysis

Arkansh Sharma, Karthik NB

Multimodal imaging reveals intracranial stenosis in a young patient with cryptogenic borderzone stroke

Maria Rosaria Bagnato, Chiara Bagnato, Martina Gaia Di Donna, Dario Filoni, Giada Valente, Bruna Venturi

Reversible symmetric bilateral basal ganglia lesions in hemodialysis patients with acute movement disorders

Jie-Qiang Xia, Yan-Mei Zhu, Jian Fan, Hao Sun

Reconsidering the link between obstructive sleep apnea and intracranial collateral circulation in stroke

Muhammad Saeed Qazi, Mohammad Mujtaba Khokhar, Muhammad Raif, Tazeen Saeed Ali

Cognitive impairment and neuropsychiatric symptoms in cerebral venous congestion: a call for comprehensive multidisciplinary assessment

Polona Rus Prelog, Matija Zupan, Senta Frol

Adult-onset neuronal intranuclear inclusion disease (NIID) combined with acute ischaemic stroke: a case report

Jinyu Jia, Bing Yang, Yifan Gong, Li’an Huang

Clinical insights on “unilateral contralesional versus bilateral repetitive transcranial magnetic stimulation for patients with post-stroke dysphagia”

Ali Karim, FNU Rida, FNU Nasrullah, Nimarta Devi, Noor un nisa Irshad, Zaghum Abbas

Unilateral cavernous sinus dAVF presenting with sequential contralateral trochlear and ipsilateral abducens nerve palsies

Takenori Kanai, Ryotaro Ishii, Haruka Miyata, Misaki Nakamura, Ryosuke Fukazawa, Soo-Kyoung Kim

Intracranial hypotension syndrome manifesting as headache and oculomotor nerve palsy in a 68-Year-Old male: A case report

Sha Han, Weijun Tang, Hui Zhang

Frailty, urinary symptoms, comorbidity and multiple sclerosis

Funda Uysal Tan, Mustafa Ozgur Tan

Letter to the Editor regarding: “Long-term safety evaluation of natalizumab during pregnancy and lactation in patients with multiple sclerosis”

Humaira Ahmed, Amna Siddiqui, Syeda Laiba Sajid

Case Report: Papillary Dermal Elastolysis in a Patient Receiving Teriflunomide Therapy

Fateme Khosravani, Mina farahnejad, Maryam Payere, Mahsa Akbari Oryani, Mohammadali Nahayati

Atypical Anti-NMDAR encephalitis presenting with pharyngeal-cervical-bibrachial weakness: A rare case report

Shamir Sella Sugan, Saranya B Gomathy, Mohamed Azharudeen, Sunil K Narayan, Ramkumar Sugumaran

CNS demyelination risk in biologic-treated rheumatic disease: are we capturing the full picture?

Yuqing You, Jinyan Guo, Weifeng Yao

Response to the letter to the editor regarding ‘central nervous system demyelination associated with biological agents used in the treatment of rheumatologic diseases: A retrospective cohort study’

Doruk Arslan, Basak Sayinalp-Arslan, Umut Kalyoncu, Asli Tuncer

Possible autoimmune encephalitis in a patient with Good’s syndrome

Enis Guso, Irene Volonghi, Sara Mariotto, Davide Arici, Emanuele Olivieri, Andrea Pilotto, Alessandro Padovani

Secondary hypogammaglobulinemia and lymphocytopenia in patients with inflammatory neurological diseases on anti-CD20 therapy: risk of infection and infection-related mortality

Abdullah Farooq, Mubariz Ali, Ayesha Parvaiz Malik, Brijesh Sathian

“Secondary hypogammaglobulinemia and lymphocytopenia in patients with inflammatory neurological diseases on anti-CD20 therapy: risk of infection and infection-related mortality”

Muhammad Owais, Muhammad Huzaifa Sabir, Asma Azam, Muhammad Nouman Javed

Assessment of Binda sign in the diagnosis of tuberculous meningitis

Steven H. Yale, Halil Tekiner, Eileen S. Yale

Disseminated nocardiosis with brain abscesses in an immunocompetent patient: a case report

G. Regonesi, A. Formenti, S. Piconi, L. Lorusso

Blue-grey pigmentation associated with levetiracetam use: a rare adverse effect

Harun Yildirim, Imren Nur Cicek, Sumeyye Arslan, Ebru Aydin Yildirim

Cutaneous adverse reactions to low doses of cenobamate: don’t DRESS it up…tell the truth!

Giovanni Falcicchio, Teresa Francavilla

Catatonia and cognitive decline in a patient with bipolar disorder: a diagnostic challenge leading to neuronal ceroid lipofuscinosis type 13

Furkan Sefa Bayır, Merve Rana Altunel, Sarp Yoldaş, Damla Ökmen, Nazife Gamze Usta Sağlam, Şenol Turan, Ayşegül Gündüz

Ultrasound imaging and guidance for traumatic distal saphenous neuropathy

  • Letter to the Editor

Beytullah Yazar, Burak Tolga Başoluk, Levent Özçakar

Comment on “Efficacy of neuromodulation and rehabilitation approaches on pain relief in patients with spinal cord injury: A systematic review and meta-analysis”

Jie Hao

Fibromuscular dysplasia: Challenges for the current classification

Marialuisa Zedde, Maria Simona Stoenoiu, Alexandre Persu, Rosario Pascarella

The hidden struggles of neurofibromatosis patients: overcoming stigmatization and confronting misconceptions

Muhammad Liaquat Raza, Syed Muhammad Farzan Ali Warsi, Zainab Hasan

Unilateral change of laryngeal adductor reflex and hiccups resolution after removal of bulbar hemangioblastoma: is there a connection?

V. Fontana, G. M. Squintani, A. Badari, F. Basaldella, F. Sala, G. Pinna, B. Masotto

Blurred vision after thrombolysis

Bernat Boy, Álvaro García-Tornel, Federica Rizzo, Laura Sánchez-Vela, Carlos Molina

Swinging subclavian artery web

Zhong-Yu Cao, Fu-Liang Zhang, Baofeng Xu

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Case challenge: neuroimaging in Alzheimer disease (Link opens in a new window)

Put your decision-making and interpretation skills into practice with these six cases focusing on different presentations. Can you choose the optimal PET tracer, accurately interpret the results, and advise on next steps?

This content is intended for healthcare professionals outside of the UK.

Independent Medical Education Grant:
  • Lilly
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Navigating neuroimaging in Alzheimer’s care: Practical applications and strategies for integration/© Springer Health+ IME