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Neuroimaging Biomarkers of Caloric Restriction on Brain Metabolic and Vascular Functions

  • 01-03-2017
  • Neurological Disease and Cognitive Function (G Logroscino, Section Editor)
Published in:

Abstract

Purpose of Review

Non-invasive neuroimaging methods have been developed as powerful tools for identifying in vivo brain functions for studies in humans and animals. Here, we review the imaging biomarkers that are being used to determine the changes within brain metabolic and vascular functions induced by caloric restriction (CR) and their potential usefulness for future studies with dietary interventions in humans.

Recent Findings

CR causes an early shift in brain metabolism of glucose to ketone bodies and enhances ATP production, neuronal activity, and cerebral blood flow (CBF). With age, CR preserves mitochondrial activity, neurotransmission, CBF, and spatial memory. CR also reduces anxiety in aging mice. Neuroimaging studies in humans show that CR restores abnormal brain activity in the amygdala of women with obesity and enhances brain connectivity in old adults.

Summary

Neuroimaging methods have excellent translational values and can be widely applied in future studies to identify dietary effects on brain functions in humans.
Title
Neuroimaging Biomarkers of Caloric Restriction on Brain Metabolic and Vascular Functions
Authors
Ai-Ling Lin
Ishita Parikh
Jared D. Hoffman
David Ma
Publication date
01-03-2017
Publisher
Springer US
Published in
Current Nutrition Reports / Issue 1/2017
Electronic ISSN: 2161-3311
DOI
https://doi.org/10.1007/s13668-017-0187-9
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