Plexiform neurofibroma in the salivary glands is a rare condition, comprising only 0.4% of all salivary gland tumors. This benign but locally invasive tumor, commonly associated with neurofibromatosis type 1 (NF-1), arises from Schwann cells of the peripheral nerve sheath. In this report, we present a case of a 20-year-old male with a massive plexiform neurofibroma involving both the left parotid and submandibular glands. The patient had a painless swelling in the left preauricular region since 2 years, which had gradually enlarged over the last one year. Imaging revealed extensive involvement of the tumor, extending into the parapharyngeal space and infratemporal fossa. A surgical excision was performed, and a histopathological examination confirmed the diagnosis. The extensive size and involvement of multiple salivary glands posed significant challenges in management, emphasizing the need for careful surgical planning and thorough clinical evaluation. This case highlights the rare occurrence of large plexiform neurofibromas in the salivary glands and underscores the complexities involved in treating such extensive tumors.
