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08-07-2024 | Nerve Injury

Dental Pulp Derived Stem Cells for Facial Nerve Regeneration and Functional Repair: A Systematic Review of Animal Studies

Authors: Sunnypriyatham Tirupathi, Lamea Afnan

Published in: Current Oral Health Reports

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Abstract

Purpose of Review

Facial nerve damage can occur due to multitude of reasons such as trauma, iatrogenic reasons. The aim of this systematic review is to evaluate the effect of Dental pulp derived stem cells in regeneration, repair and functional recovery of facial nerve.

Recent Findings

PubMed, Scopus, Cochrane were searched from inception to 1 March 2024 2023. PICO criteria was applied and articles were selected based on pre-specified inclusion and exclusion criteria. Prospero registered. The search queries have identified 137 titles, from three databases (PubMed, Cochrane and Web of Science), after application of filters for exclusion of systematic reviews and meta-analysis, duplicate exclusion (n = 12) and removal of irrelevant titles led to the final inclusion of 12 articles for full text screening. Out of these 12 studies, only 7 studies qualified for the final inclusion.

Summary

Seven articles sustained the rigorous search, were subjected to final qualitative data analysis. Within the limits of the available studies, there is low quality evidence suggesting positive potential of dental pulp derived stem cells (DPSC, SHED) with growth factors such as SCF, Neuregulin-1, VGEF on enhanced regeneration and thereby promoting repair of facial nerve in the animal facial nerve trauma model.
Literature
2.
go back to reference Odebode TO, Ologe FE. Facial Nerve Palsy After Head Injury: Case Incidence, Causes, Clinical Profile and Outcome. J Trauma. 2006;61(2):388–91.CrossRefPubMed Odebode TO, Ologe FE. Facial Nerve Palsy After Head Injury: Case Incidence, Causes, Clinical Profile and Outcome. J Trauma. 2006;61(2):388–91.CrossRefPubMed
3.
go back to reference Hohman MH, Hadlock TA. Etiology, diagnosis, and management of facial palsy: 2000 patients at a facial nerve center. Laryngoscope. 2014;124(7):E283–93.CrossRefPubMed Hohman MH, Hadlock TA. Etiology, diagnosis, and management of facial palsy: 2000 patients at a facial nerve center. Laryngoscope. 2014;124(7):E283–93.CrossRefPubMed
4.
go back to reference Gordin E, Lee TS, Ducic Y, Arnaoutakis D. Facial nerve trauma: evaluation and considerations in management. Craniomaxillofac Trauma Reconstr. 2015;8(1):1–13.CrossRefPubMed Gordin E, Lee TS, Ducic Y, Arnaoutakis D. Facial nerve trauma: evaluation and considerations in management. Craniomaxillofac Trauma Reconstr. 2015;8(1):1–13.CrossRefPubMed
5.
go back to reference Sun J, Wang R, Chen X, Wang J, Liu D, Sai N, et al. Surgical management and the prognosis of iatrogenic facial nerve injury in middle ear surgery: a 20-year experience. Head Face Med. 2023;19(1):31.CrossRefPubMedPubMedCentral Sun J, Wang R, Chen X, Wang J, Liu D, Sai N, et al. Surgical management and the prognosis of iatrogenic facial nerve injury in middle ear surgery: a 20-year experience. Head Face Med. 2023;19(1):31.CrossRefPubMedPubMedCentral
8.
go back to reference Ray WZ, Mackinnon SE. Management of nerve gaps: Autografts, allografts, nerve transfers, and end-to-side neurorrhaphy. Exp Neurol. 2010;223(1):77–85.CrossRefPubMed Ray WZ, Mackinnon SE. Management of nerve gaps: Autografts, allografts, nerve transfers, and end-to-side neurorrhaphy. Exp Neurol. 2010;223(1):77–85.CrossRefPubMed
9.
go back to reference Okano H. Identification of neural stem cells in adult human brain: its implication in the strategy for repairing the damaged central nervous system]. Rinsho Shinkeigaku. 2005;45(11):871–3.PubMed Okano H. Identification of neural stem cells in adult human brain: its implication in the strategy for repairing the damaged central nervous system]. Rinsho Shinkeigaku. 2005;45(11):871–3.PubMed
11.
go back to reference Matos Cruz AJ, Hohman MH, De Jesus O. Facial Nerve Repair. 2023 Aug 23. In: StatPearls [Internet]. Treasure Island (FL): StatPearls Publishing; 2024 Matos Cruz AJ, Hohman MH, De Jesus O. Facial Nerve Repair. 2023 Aug 23. In: StatPearls [Internet]. Treasure Island (FL): StatPearls Publishing; 2024
12.
go back to reference Xing WB, Wu ST, Wang XX, Li FY, Wang RX, He JH, et al. Potential of dental pulp stem cells and their products in promoting peripheral nerve regeneration and their future applications. World J Stem Cells. 2023;15(10):960–78.CrossRefPubMedPubMedCentral Xing WB, Wu ST, Wang XX, Li FY, Wang RX, He JH, et al. Potential of dental pulp stem cells and their products in promoting peripheral nerve regeneration and their future applications. World J Stem Cells. 2023;15(10):960–78.CrossRefPubMedPubMedCentral
13.
go back to reference Sasaki R, Watanabe Y, Yamato M, Okamoto T. Tissue-engineered nerve guides with mesenchymal stem cells in the facial nerve regeneration. Neurochem Int. 2021;148:105062.CrossRefPubMed Sasaki R, Watanabe Y, Yamato M, Okamoto T. Tissue-engineered nerve guides with mesenchymal stem cells in the facial nerve regeneration. Neurochem Int. 2021;148:105062.CrossRefPubMed
14.
go back to reference Carnevale G, Pisciotta A, Riccio M, Bertoni L, De Biasi S, Gibellini L, et al. Human dental pulp stem cells expressing STRO-1, c-kit and CD34 markers in peripheral nerve regeneration. J Tissue Eng Regen Med. 2018;12(2):e774–85.CrossRefPubMed Carnevale G, Pisciotta A, Riccio M, Bertoni L, De Biasi S, Gibellini L, et al. Human dental pulp stem cells expressing STRO-1, c-kit and CD34 markers in peripheral nerve regeneration. J Tissue Eng Regen Med. 2018;12(2):e774–85.CrossRefPubMed
15.
go back to reference Euler de Souza Lucena E, Guzen FP, Lopes de PaivaCavalcanti JR, GalvãoBarboza CA, Silva do NascimentoJúnior E, Cavalcante de JS. Experimental considerations concerning the use of stem cells and tissue engineering for facial nerve regeneration: a systematic review. J Oral Maxillofac Surg. 2014;72(5):1001–12.CrossRefPubMed Euler de Souza Lucena E, Guzen FP, Lopes de PaivaCavalcanti JR, GalvãoBarboza CA, Silva do NascimentoJúnior E, Cavalcante de JS. Experimental considerations concerning the use of stem cells and tissue engineering for facial nerve regeneration: a systematic review. J Oral Maxillofac Surg. 2014;72(5):1001–12.CrossRefPubMed
16.
go back to reference Mu X, Liu H, Yang S, Li Y, Xiang L, Hu M, et al. Chitosan Tubes Inoculated with Dental Pulp Stem Cells and Stem Cell Factor Enhance Facial Nerve-Vascularized Regeneration in Rabbits. ACS Omega. 2022;7(22):18509–20.CrossRefPubMedPubMedCentral Mu X, Liu H, Yang S, Li Y, Xiang L, Hu M, et al. Chitosan Tubes Inoculated with Dental Pulp Stem Cells and Stem Cell Factor Enhance Facial Nerve-Vascularized Regeneration in Rabbits. ACS Omega. 2022;7(22):18509–20.CrossRefPubMedPubMedCentral
17.
go back to reference Saez DM, Sasaki RT, Martins de DO, Chacur M, Kerkis I, da Silva MCP. Rat Facial Nerve Regeneration with Human Immature Dental Pulp Stem Cells. Cell Transplant. 2019;28(12):1573–84.CrossRefPubMedPubMedCentral Saez DM, Sasaki RT, Martins de DO, Chacur M, Kerkis I, da Silva MCP. Rat Facial Nerve Regeneration with Human Immature Dental Pulp Stem Cells. Cell Transplant. 2019;28(12):1573–84.CrossRefPubMedPubMedCentral
18.
go back to reference Sasaki R, Aoki S, Yamato M, Uchiyama H, Wada K, Ogiuchi H, et al. PLGA artificial nerve conduits with dental pulp cells promote facial nerve regeneration. J Tissue Eng Regen Med. 2011;5(10):823–30.CrossRefPubMed Sasaki R, Aoki S, Yamato M, Uchiyama H, Wada K, Ogiuchi H, et al. PLGA artificial nerve conduits with dental pulp cells promote facial nerve regeneration. J Tissue Eng Regen Med. 2011;5(10):823–30.CrossRefPubMed
19.
go back to reference Ahmed MN, Shi D, Dailey MT, Rothermund K, Drewry MD, Calabrese TC, et al. Dental Pulp Cell Sheets Enhance Facial Nerve Regeneration via Local Neurotrophic Factor Delivery. Tissue Eng Part A. 2021;27(17–18):1128–39.CrossRefPubMedPubMedCentral Ahmed MN, Shi D, Dailey MT, Rothermund K, Drewry MD, Calabrese TC, et al. Dental Pulp Cell Sheets Enhance Facial Nerve Regeneration via Local Neurotrophic Factor Delivery. Tissue Eng Part A. 2021;27(17–18):1128–39.CrossRefPubMedPubMedCentral
20.
go back to reference Xu W, Xu X, Yao L, Xue B, Xi H, Cao X, et al. VEGFA-modified DPSCs combined with LC-YE-PLGA NGCs promote facial nerve injury repair in rats. Heliyon. 2023;9(4):e14626.CrossRefPubMedPubMedCentral Xu W, Xu X, Yao L, Xue B, Xi H, Cao X, et al. VEGFA-modified DPSCs combined with LC-YE-PLGA NGCs promote facial nerve injury repair in rats. Heliyon. 2023;9(4):e14626.CrossRefPubMedPubMedCentral
21.
go back to reference Yao L, Xu W, Liu L, Xu X, Xi H, Xue B, et al. The involvement of Neuregulin-1 in the process of facial nerve injury repair through the utilization of dental pulp stem cells. BMC Oral Health. 2024;24(1):238.CrossRefPubMedPubMedCentral Yao L, Xu W, Liu L, Xu X, Xi H, Xue B, et al. The involvement of Neuregulin-1 in the process of facial nerve injury repair through the utilization of dental pulp stem cells. BMC Oral Health. 2024;24(1):238.CrossRefPubMedPubMedCentral
22.
go back to reference Pereira LV, Bento RF, Cruz DB, Marchi C, Salomone R, Oiticicca J, et al. Stem Cells from Human Exfoliated Deciduous Teeth (SHED) Differentiate in vivo and Promote Facial Nerve Regeneration. Cell Transplant. 2019;28(1):55–64.CrossRefPubMed Pereira LV, Bento RF, Cruz DB, Marchi C, Salomone R, Oiticicca J, et al. Stem Cells from Human Exfoliated Deciduous Teeth (SHED) Differentiate in vivo and Promote Facial Nerve Regeneration. Cell Transplant. 2019;28(1):55–64.CrossRefPubMed
23.
go back to reference Hooijmans CR, Rovers MM, de Vries RB, Leenaars M, Ritskes-Hoitinga M, Langendam MW. SYRCLE’s risk of bias tool for animal studies. BMC Med Res Methodol. 2014;14(1):43.CrossRefPubMedPubMedCentral Hooijmans CR, Rovers MM, de Vries RB, Leenaars M, Ritskes-Hoitinga M, Langendam MW. SYRCLE’s risk of bias tool for animal studies. BMC Med Res Methodol. 2014;14(1):43.CrossRefPubMedPubMedCentral
24.
go back to reference Percie du Sert N, Hurst V, Ahluwalia A, Alam S, Avey MT, Baker M, et al. The ARRIVE guidelines 2.0: Updated guidelines for reporting animal research. BMC Vet Res. 2020;16(1):242.CrossRefPubMedPubMedCentral Percie du Sert N, Hurst V, Ahluwalia A, Alam S, Avey MT, Baker M, et al. The ARRIVE guidelines 2.0: Updated guidelines for reporting animal research. BMC Vet Res. 2020;16(1):242.CrossRefPubMedPubMedCentral
25.
go back to reference Lopes B, Sousa P, Alvites R, Branquinho M, Sousa AC, Mendonça C, et al. Peripheral Nerve Injury Treatments and Advances: One Health Perspective. Int J Mol Sci. 2022;23(2):918.CrossRefPubMedPubMedCentral Lopes B, Sousa P, Alvites R, Branquinho M, Sousa AC, Mendonça C, et al. Peripheral Nerve Injury Treatments and Advances: One Health Perspective. Int J Mol Sci. 2022;23(2):918.CrossRefPubMedPubMedCentral
26.
go back to reference Ahmed MN, Shi D, Dailey MT, Rothermund K, Drewry MD, Calabrese TC, et al. Dental Pulp Cell Sheets Enhance Facial Nerve Regeneration via Local Neurotrophic Factor Delivery. Tissue Eng Part A. 2021;27(17–18):1128–39.CrossRefPubMedPubMedCentral Ahmed MN, Shi D, Dailey MT, Rothermund K, Drewry MD, Calabrese TC, et al. Dental Pulp Cell Sheets Enhance Facial Nerve Regeneration via Local Neurotrophic Factor Delivery. Tissue Eng Part A. 2021;27(17–18):1128–39.CrossRefPubMedPubMedCentral
27.
go back to reference Ghnenis AB, Czaikowski RE, Zhang ZJ, Bushman JS. Toluidine Blue Staining of Resin-Embedded Sections for Evaluation of Peripheral Nerve Morphology. J Vis Exp. 2018;(137):58031. Ghnenis AB, Czaikowski RE, Zhang ZJ, Bushman JS. Toluidine Blue Staining of Resin-Embedded Sections for Evaluation of Peripheral Nerve Morphology. J Vis Exp. 2018;(137):58031.
28.
go back to reference Russell RC. Transmission and Scanning Electron Microscopy of Peripheral Nerves. Hand Clin. 1986;2(4):665–76.CrossRefPubMed Russell RC. Transmission and Scanning Electron Microscopy of Peripheral Nerves. Hand Clin. 1986;2(4):665–76.CrossRefPubMed
29.
go back to reference Saez DM, Sasaki RT, de Martins DO, Chacur M, Kerkis I, da Silva MCP. Rat Facial Nerve Regeneration with Human Immature Dental Pulp Stem Cells. Cell Transplant. 2019;28(12):1573–84.CrossRefPubMedPubMedCentral Saez DM, Sasaki RT, de Martins DO, Chacur M, Kerkis I, da Silva MCP. Rat Facial Nerve Regeneration with Human Immature Dental Pulp Stem Cells. Cell Transplant. 2019;28(12):1573–84.CrossRefPubMedPubMedCentral
30.
go back to reference Jones LK, Watson JC. Motor Nerve Conduction Studies. In: Clinical Neurophysiology. Oxford Univ Press. 2016;257–91. Jones LK, Watson JC. Motor Nerve Conduction Studies. In: Clinical Neurophysiology. Oxford Univ Press. 2016;257–91.
Metadata
Title
Dental Pulp Derived Stem Cells for Facial Nerve Regeneration and Functional Repair: A Systematic Review of Animal Studies
Authors
Sunnypriyatham Tirupathi
Lamea Afnan
Publication date
08-07-2024
Publisher
Springer International Publishing
Published in
Current Oral Health Reports
Electronic ISSN: 2196-3002
DOI
https://doi.org/10.1007/s40496-024-00380-5