The Japanese Society for Pediatric Nephrology published the ‘‘Clinical Practice Guideline for Medical Treatment of Pediatric Idiopathic Nephrotic Syndrome (version 1.0) (in Japanese)’’ in 2005, and the ‘‘Clinical Practice Guideline for Pediatric Idiopathic Nephrotic Syndrome 2013″ [
1,
2] in 2013. Under the supervision of the Japanese Society of Pediatric Nephrology, the Research for Intractable Renal Diseases of the Ministry of Health, Labour and Welfare of Japan have revised the guideline to include important evidence from 2013 that includes rituximab therapy and have published ‘‘Clinical Practice Guideline for Pediatric Idiopathic Nephrotic Syndrome 2020 (in Japanese)” (Shindan To Chiryo Sha, Inc., Tokyo, Japan) on September 30, 2020. Subsequently, an addendum to the guidelines was prepared and published on the Society’s website (in Japanese) on August 31, 2022. The committee herein published the digest of guideline in English, with an aim to introduce it to pediatricians around the world. …