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Open Access 07-11-2024 | Myocarditis | Original Paper

Deep learning automatically distinguishes myocarditis patients from normal subjects based on MRI

Authors: Cosmin-Andrei Hatfaludi, Aurelian Roșca, Andreea Bianca Popescu, Teodora Chitiboi, Puneet Sharma, Theodora Benedek, Lucian Mihai Itu

Published in: The International Journal of Cardiovascular Imaging | Issue 12/2024

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Abstract

Myocarditis, characterized by inflammation of the myocardial tissue, presents substantial risks to cardiovascular functionality, potentially precipitating critical outcomes including heart failure and arrhythmias. This investigation primarily aims to identify the optimal cardiovascular magnetic resonance imaging (CMRI) views for distinguishing between normal and myocarditis cases, using deep learning (DL) methodologies. Analyzing CMRI data from a cohort of 269 individuals, with 231 confirmed myocarditis cases and 38 as control participants, we implemented an innovative DL framework to facilitate the automated detection of myocarditis. Our approach was divided into single-frame and multi-frame analyses to evaluate different views and types of acquisitions for optimal diagnostic accuracy. The results demonstrated a weighted accuracy of 96.9%, with the highest accuracy achieved using the late gadolinium enhancement (LGE) 2-chamber view, underscoring the potential of DL in distinguishing myocarditis from normal cases on CMRI data.
Literature
2.
go back to reference Kytö V, Saukko P, Lignitz E, Schwesinger G, Henn V, Saraste A et al (2005) Diagnosis and presentation of fatal myocarditis. Hum Pathol 36(9):1003–1007CrossRefPubMed Kytö V, Saukko P, Lignitz E, Schwesinger G, Henn V, Saraste A et al (2005) Diagnosis and presentation of fatal myocarditis. Hum Pathol 36(9):1003–1007CrossRefPubMed
3.
go back to reference Sharifrazi D, Alizadehsani R, Joloudari JH, Shamshirband S, Hussain S, Sani ZA et al (2020) CNN-KCL: automatic myocarditis diagnosis using convolutional neural network combined with k-means clustering Sharifrazi D, Alizadehsani R, Joloudari JH, Shamshirband S, Hussain S, Sani ZA et al (2020) CNN-KCL: automatic myocarditis diagnosis using convolutional neural network combined with k-means clustering
4.
go back to reference Asher A (2017) A review of endomyocardial biopsy and current practice in England: out of date or underutilised. Br J Cardiol 24(3):108–112 Asher A (2017) A review of endomyocardial biopsy and current practice in England: out of date or underutilised. Br J Cardiol 24(3):108–112
5.
go back to reference Ammirati E, Frigerio M, Adler ED, Basso C, Birnie DH, Brambatti M et al (2020) Management of acute myocarditis and chronic inflammatory cardiomyopathy: an expert consensus document. Circ Heart Fail 13(11):e007405CrossRefPubMedPubMedCentral Ammirati E, Frigerio M, Adler ED, Basso C, Birnie DH, Brambatti M et al (2020) Management of acute myocarditis and chronic inflammatory cardiomyopathy: an expert consensus document. Circ Heart Fail 13(11):e007405CrossRefPubMedPubMedCentral
6.
go back to reference Katti G, Ara SA, Shireen A (2011) Magnetic resonance imaging (MRI)–a review. Int J Dent Clin 3(1):65–70 Katti G, Ara SA, Shireen A (2011) Magnetic resonance imaging (MRI)–a review. Int J Dent Clin 3(1):65–70
7.
go back to reference Gannon MP, Schaub E, Grines CL, Saba SG (2019) State of the art: evaluation and prognostication of myocarditis using cardiac MRI. J Magnet Reson Imaging 49(7):e122–e131CrossRef Gannon MP, Schaub E, Grines CL, Saba SG (2019) State of the art: evaluation and prognostication of myocarditis using cardiac MRI. J Magnet Reson Imaging 49(7):e122–e131CrossRef
8.
go back to reference Abdar M, Nasarian E, Zhou X, Bargshady G, Wijayaningrum VN, Hussain S (2019) Performance improvement of decision trees for diagnosis of coronary artery disease using multi filtering approach. In: 2019 IEEE 4th International Conference on Computer and Communication Systems (ICCCS): IEEE; pp. 26–30 Abdar M, Nasarian E, Zhou X, Bargshady G, Wijayaningrum VN, Hussain S (2019) Performance improvement of decision trees for diagnosis of coronary artery disease using multi filtering approach. In: 2019 IEEE 4th International Conference on Computer and Communication Systems (ICCCS): IEEE; pp. 26–30
9.
go back to reference Deng L, Yu D (2014) Deep learning: methods and applications. Found Trends® Signal Process 7(3–4):197–387CrossRef Deng L, Yu D (2014) Deep learning: methods and applications. Found Trends® Signal Process 7(3–4):197–387CrossRef
10.
go back to reference Snell J, Swersky K, Zemel R (2017) Prototypical networks for few-shot learning. Adv Neural Inf Process Syst ;30 Snell J, Swersky K, Zemel R (2017) Prototypical networks for few-shot learning. Adv Neural Inf Process Syst ;30
11.
go back to reference Shoeibi A, Ghassemi N, Heras J, Rezaei M, Gorriz JM (2022) Automatic diagnosis of myocarditis in cardiac magnetic images using CycleGAN and deep PreTrained models. International work-conference on the interplay between natural and artificial computation: Springer; pp. 145–155 Shoeibi A, Ghassemi N, Heras J, Rezaei M, Gorriz JM (2022) Automatic diagnosis of myocarditis in cardiac magnetic images using CycleGAN and deep PreTrained models. International work-conference on the interplay between natural and artificial computation: Springer; pp. 145–155
12.
go back to reference Moravvej SV, Alizadehsani R, Khanam S, Sobhaninia Z, Shoeibi A, Khozeimeh F et al (2022) RLMD-PA: a reinforcement learning-based myocarditis diagnosis combined with a population-based algorithm for pretraining weights. Contrast Media & Molecular Imaging Moravvej SV, Alizadehsani R, Khanam S, Sobhaninia Z, Shoeibi A, Khozeimeh F et al (2022) RLMD-PA: a reinforcement learning-based myocarditis diagnosis combined with a population-based algorithm for pretraining weights. Contrast Media & Molecular Imaging
13.
go back to reference Patro S, Sahu KK (2015) Normalization: a preprocessing stage. arXiv Preprint arXiv :150306462 Patro S, Sahu KK (2015) Normalization: a preprocessing stage. arXiv Preprint arXiv :150306462
14.
go back to reference Zeng X, Wong DF, Chao LS (2014) Constructing better classifier ensemble based on weighted accuracy and diversity measure. Sci World J Zeng X, Wong DF, Chao LS (2014) Constructing better classifier ensemble based on weighted accuracy and diversity measure. Sci World J
15.
go back to reference Hoo ZH, Candlish J, Teare D (2017) What is an ROC curve? BMJ Publishing Group Ltd and the British Association for Accident Hoo ZH, Candlish J, Teare D (2017) What is an ROC curve? BMJ Publishing Group Ltd and the British Association for Accident
16.
go back to reference Lobo JM, Jiménez-Valverde A, Real R (2008) AUC: a misleading measure of the performance of predictive distribution models. Global Ecol Biogeogr 17(2):145–151CrossRef Lobo JM, Jiménez-Valverde A, Real R (2008) AUC: a misleading measure of the performance of predictive distribution models. Global Ecol Biogeogr 17(2):145–151CrossRef
17.
go back to reference Unal I (2017) Defining an optimal cut-point value in ROC analysis: an alternative approach. Computational and mathematical methods in medicine Unal I (2017) Defining an optimal cut-point value in ROC analysis: an alternative approach. Computational and mathematical methods in medicine
18.
go back to reference Wong HB, Lim GH (2011) Measures of diagnostic accuracy: sensitivity, specificity, PPV and NPV. Proc Singap Healthc 20(4):316–318CrossRef Wong HB, Lim GH (2011) Measures of diagnostic accuracy: sensitivity, specificity, PPV and NPV. Proc Singap Healthc 20(4):316–318CrossRef
20.
go back to reference Imambi S, Prakash KB, Kanagachidambaresan G (2021) PyTorch. Programming with Tensor Flow: solution for edge computing applications. pp. 87–104 Imambi S, Prakash KB, Kanagachidambaresan G (2021) PyTorch. Programming with Tensor Flow: solution for edge computing applications. pp. 87–104
21.
go back to reference Kumari R, Srivastava SK (2017) Machine learning: a review on binary classification. Int J Comput Appl ;160(7) Kumari R, Srivastava SK (2017) Machine learning: a review on binary classification. Int J Comput Appl ;160(7)
22.
go back to reference Pratiwi H, Windarto AP, Susliansyah S, Aria RR, Susilowati S, Rahayu LK et al (2020) Sigmoid activation function in selecting the best model of artificial neural networks. J Phys: Conf Ser p. 012010 Pratiwi H, Windarto AP, Susliansyah S, Aria RR, Susilowati S, Rahayu LK et al (2020) Sigmoid activation function in selecting the best model of artificial neural networks. J Phys: Conf Ser p. 012010
23.
go back to reference Fushiki T (2011) Estimation of prediction error by using K-fold cross-validation. Stat Comput 21:137–146CrossRef Fushiki T (2011) Estimation of prediction error by using K-fold cross-validation. Stat Comput 21:137–146CrossRef
24.
go back to reference Zhang Y, Xia Z, Joishi C, Rajan S (2018) Design and Demonstration of (AlxGal-x) 2 O 3/Ga 2 O 3 Double Heterostructure Field Effect Transistor (DHFET). In: 2018 76th Device Research Conference (DRC): IEEE; pp. 1–2 Zhang Y, Xia Z, Joishi C, Rajan S (2018) Design and Demonstration of (AlxGal-x) 2 O 3/Ga 2 O 3 Double Heterostructure Field Effect Transistor (DHFET). In: 2018 76th Device Research Conference (DRC): IEEE; pp. 1–2
25.
go back to reference Ruby U, Yendapalli V (2020) Binary cross entropy with deep learning technique for image classification. Int J Adv Trends Comput Sci Eng. ;9(10) Ruby U, Yendapalli V (2020) Binary cross entropy with deep learning technique for image classification. Int J Adv Trends Comput Sci Eng. ;9(10)
26.
go back to reference Simonyan K, Vedaldi A, Zisserman A (2013) Deep inside convolutional networks: visualising image classification models and saliency maps. arXiv Preprint arXiv :13126034 Simonyan K, Vedaldi A, Zisserman A (2013) Deep inside convolutional networks: visualising image classification models and saliency maps. arXiv Preprint arXiv :13126034
27.
go back to reference Sabouri M, Hajianfar G, Hosseini Z, Amini M, Mohebi M, Ghaedian T et al (2023) Myocardial perfusion SPECT imaging radiomic features and machine learning algorithms for cardiac contractile pattern recognition. J Digit Imag 36(2):497–509CrossRef Sabouri M, Hajianfar G, Hosseini Z, Amini M, Mohebi M, Ghaedian T et al (2023) Myocardial perfusion SPECT imaging radiomic features and machine learning algorithms for cardiac contractile pattern recognition. J Digit Imag 36(2):497–509CrossRef
28.
go back to reference Hajianfar G, Sabouri M, Salimi Y, Amini M, Bagheri S, Jenabi E et al (2024) Artificial intelligence-based analysis of whole-body bone scintigraphy: the quest for the optimal deep learning algorithm and comparison with human observer performance. Z Medizin Phys 34(2):242–257CrossRef Hajianfar G, Sabouri M, Salimi Y, Amini M, Bagheri S, Jenabi E et al (2024) Artificial intelligence-based analysis of whole-body bone scintigraphy: the quest for the optimal deep learning algorithm and comparison with human observer performance. Z Medizin Phys 34(2):242–257CrossRef
29.
go back to reference Sun X, Yin Y, Yang Q, Huo T (2023) Artificial intelligence in cardiovascular diseases: diagnostic and therapeutic perspectives. Eur J Med Res 28(1):242CrossRefPubMedPubMedCentral Sun X, Yin Y, Yang Q, Huo T (2023) Artificial intelligence in cardiovascular diseases: diagnostic and therapeutic perspectives. Eur J Med Res 28(1):242CrossRefPubMedPubMedCentral
30.
go back to reference Liu R, Wang M, Zheng T, Zhang R, Li N, Chen Z et al (2022) An artificial intelligence-based risk prediction model of myocardial infarction. BMC Bioinform 23(1):217CrossRef Liu R, Wang M, Zheng T, Zhang R, Li N, Chen Z et al (2022) An artificial intelligence-based risk prediction model of myocardial infarction. BMC Bioinform 23(1):217CrossRef
31.
go back to reference El Kaid A, Baïna K (2023) A systematic review of recent deep learning approaches for 3D human pose estimation. J Imag 9(12):275CrossRef El Kaid A, Baïna K (2023) A systematic review of recent deep learning approaches for 3D human pose estimation. J Imag 9(12):275CrossRef
Metadata
Title
Deep learning automatically distinguishes myocarditis patients from normal subjects based on MRI
Authors
Cosmin-Andrei Hatfaludi
Aurelian Roșca
Andreea Bianca Popescu
Teodora Chitiboi
Puneet Sharma
Theodora Benedek
Lucian Mihai Itu
Publication date
07-11-2024
Publisher
Springer Netherlands
Keyword
Myocarditis
Published in
The International Journal of Cardiovascular Imaging / Issue 12/2024
Print ISSN: 1569-5794
Electronic ISSN: 1875-8312
DOI
https://doi.org/10.1007/s10554-024-03284-8

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