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Current Cardiology Reports

Updates in Diagnosis and Treatment of Immune Checkpoint Inhibitor Myocarditis

  • 01-12-2025
  • Myocarditis
  • Myocardial Disease (A Abbate and M Merlo, Section Editors)
Published in:
Authors
Anthony M. Hachem
Aditya Desai
Noah Beinart
Keila C. Ostos-Mendoza
Ana Sofia Lopez Rodriguez
Regina Diaz de Leon Derby
Sara Ebrahimi
Nicolas L. Palaskas
Published in
Current Cardiology Reports | Issue 1/2025

Abstract

Purpose of Review

To provide an update on the literature regarding diagnosis and management of immune checkpoint inhibitor myocarditis.

Recent Findings

The diagnosis of immune checkpoint inhibitor myocarditis has evolved to include more reliance on performing endomyocardial biopsy to clarify the diagnosis in selected cases. Additionally, there is recognition of a spectrum of disease both clinically and on endomyocardial biopsy suggesting that there is a range of severity from mild to fulminant. The treatment of immune checkpoint inhibitor myocarditis is shifting towards increased use of additional immunosuppressive medications as steroid sparing agents. There are increased studies including two randomized controlled trials evaluating abatacept in the treatment of immune checkpoint inhibitor myocarditis.

Summary

This review summarizes the latest literature regarding diagnosis and management of immune checkpoint inhibitor myocarditis and provides our experience and approach to this rare but potentially fatal condition.
Title
Updates in Diagnosis and Treatment of Immune Checkpoint Inhibitor Myocarditis
Authors
Anthony M. Hachem
Aditya Desai
Noah Beinart
Keila C. Ostos-Mendoza
Ana Sofia Lopez Rodriguez
Regina Diaz de Leon Derby
Sara Ebrahimi
Nicolas L. Palaskas
Publication date
01-12-2025
Publisher
Springer US
Published in
Current Cardiology Reports / Issue 1/2025
Print ISSN: 1523-3782
Electronic ISSN: 1534-3170
DOI
https://doi.org/10.1007/s11886-025-02232-9
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This content is intended for healthcare professionals outside of the UK.

Independent Medical Education Grant:
  • Bayer HealthCare Pharmaceuticals Inc.
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Abstract graphic of layered, concentric circular shapes in bright green, pink, blue, and purple on a dark blue background. The rings and segments form a complex radial pattern without text/© Springer Health+ IME