Skip to main content

Advanced Search

Projected result for your current search:: 0

Search Operators:

You can use operators in your search query to narrow down your results even more. Click on the search operator to see an explanation of how it works.
Finds documents with exactly this word group, in exactly this word order and spelling (e.g. "employer branding").
Finds documents with both search terms (e.g. sales AND bonus).
Finds documents with one or the other search term (e.g. porsche OR volkswagen).
Finds documents with all search terms. Blank space is understood as AND (e.g. man robot production).
Finds documents with no appearance of the word behind NOT (e.g. ford NOT "harrison ford").
Finds documents where the search term is mentioned at least "n" times."n" may be any number (e.g. COUNT(gear)>8).
Finds documents with both search terms in any word order, permitting "n" words as a maximum distance between them. Best choose between 15 and 30 (e.g. NEAR(recruit, professionals, 20)).
Finds documents with the search term in word versions or composites. The asterisk * marks whether you wish them BEFORE, BEHIND, or BEFORE and BEHIND the search term (e.g. lightweight*, *lightweight, *lightweight*).
Finds documents with the search term in different spellings. "?" allows only one character (e.g. organi?ation).
Special characters are understood as AND (e.g. Miller Bros. & Sons).
 Log in
Top
Lasers in Medical Science

The effects of green light-emitting diode irradiation and inducer factors on the differentiation of human adipose tissue-derived mesenchymal cells into myocardial-like cells

Published in:
Authors
Elahe Mousanejad
Massood Ezzatabadipour
Masoumeh Baghalishahi
Mohammad Shojaei
Shayan Vafaei
Ali Afgar
Seyed Noureddin Nematollahi-Mahani
Published in
Lasers in Medical Science | Issue 1/2025

Abstract

Physical factors like LED light can influence cell behavior, impacting stem cell proliferation and differentiation. Stem cell-based therapies offer a promising alternative to heart transplantation for cardiac conditions like myocardial infarction. This study evaluated the effects of green LED light (530 nm) and a biochemical inducer cocktail (oxytocin and ascorbic acid) on human adipose tissue-derived mesenchymal stem cells (hAD-MSCs) differentiation into cardiomyocyte-like cells. hAD-MSCs were treated with LED, the cocktail, and their combination. Cardiomyogenic markers NKX2.5, GATA4, cTnI, and CX43 were assessed via real-time PCR and western blotting. LED and the cocktail enhanced cardiac gene expression and protein synthesis, but their combination showed significantly higher effects, especially on day 7. This study demonstrates for the first time that green LED light combined with oxytocin and ascorbic acid can enhance hAD-MSC cardiac differentiation, supporting its potential in regenerative therapies following human studies.
Title
The effects of green light-emitting diode irradiation and inducer factors on the differentiation of human adipose tissue-derived mesenchymal cells into myocardial-like cells
Authors
Elahe Mousanejad
Massood Ezzatabadipour
Masoumeh Baghalishahi
Mohammad Shojaei
Shayan Vafaei
Ali Afgar
Seyed Noureddin Nematollahi-Mahani
Publication date
01-12-2025
Publisher
Springer London
Published in
Lasers in Medical Science / Issue 1/2025
Print ISSN: 0268-8921
Electronic ISSN: 1435-604X
DOI
https://doi.org/10.1007/s10103-025-04471-2
This content is only visible if you are logged in and have the appropriate permissions.
This content is only visible if you are logged in and have the appropriate permissions.

Other articles of this Issue 1/2025

Tattoo fading using Nd: YAG ns laser pulses by water cavitation bubbles and jet formation: (case study)

High-intensity versus low-level laser therapy in treatment of patients with subacromial impingement syndrome: a randomized, double-blind, controlled trial

Violet photobiomodulation: biological effects and health implications

Label-free diagnostic procedure for hirschsprung’s disease to detect intestinal mucosal characteristics of aganglionosis by Raman spectroscopy with optimized decision algorithms

  • Open Access
  • Research

The application of low-level laser in the treatment of periodontal Intra-bony defects: systematic review and meta-analysis

  • Open Access
  • Laser
  • Review

Computational modeling and histologic analysis of 6.78- and 2-MHz monopolar radiofrequency-induced thermal reactions