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BMC Cardiovascular Disorders
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Open Access 01-12-2023 | Myocardial Infarction | Research

The association between serum uric acid and creatine phosphokinase in the general population: NHANES 2015–2018

Authors: Xinxin Chen, Jiuhong You, Mei Zhou, Hui Ma, Cheng Huang

Published in: BMC Cardiovascular Disorders | Issue 1/2023

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Abstract

Background

The association between serum creatine phosphokinase (CPK), a standard biochemical measure of acute myocardial infarction, and serum uric acid (sUA) has not been studied. This study aimed to determine the association between sUA and CPK in the general population of the US.

Methods

Data from the National Health and Nutrition Examination Survey (NHANES) 2015–2018 were used, including a total of 8,431 subjects aged ≥ 30 years. Weighted multiple regression analysis was used to estimate the independent relationship between sUA and CPK. Fitted smoothing curves and weighted generalized additive models were also performed.

Results

We found a positive relationship between sUA and CPK after adjusting for potential confounders. In subgroup analyses stratified by sex and race/ethnicity, sUA was positively correlated with CPK in each subgroup. The association between sUA and CPK followed an inverted U-shaped curve in females (turning point: sUA = 428.3 μmol/L).

Conclusions

Our study suggested that sUA level was positively correlated with CPK in the general population of the US. However, CPK increased with sUA until the turning point (sUA = 428.3 μmol/L) in females. Fundamental research and large sample prospective studies are needed to determine the exact mechanism of the association between sUA and CPK.
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Metadata
Title
The association between serum uric acid and creatine phosphokinase in the general population: NHANES 2015–2018
Authors
Xinxin Chen
Jiuhong You
Mei Zhou
Hui Ma
Cheng Huang
Publication date
01-12-2023
Publisher
BioMed Central
Published in
BMC Cardiovascular Disorders / Issue 1/2023
Electronic ISSN: 1471-2261
DOI
https://doi.org/10.1186/s12872-023-03333-5

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