Unveiling the Role of the Cellular Tumor Microenvironment and the Therapeutic Targets it Provides in Cutaneous T-Cell Lymphoma
- Open Access
- 08-03-2025
- Mycosis Fungoides
- Review
Published in:
- Authors
- Nikolaos A. Chinas
- Stella Kaliampou
- Vasiliki Nikolaou
- Published in
- Current Oncology Reports | Issue 4/2025
Abstract
Purpose of Review
Cutaneous T-Cell Lymphoma (CTCL) poses challenges both in diagnosis and prognosis. The purpose of this review is to address the role of profiling immune and non-immune cells in the tumor microenvironment (TME) as it provides information for better diagnosis, prognosis, biomarker discovery, and personalized treatment strategies.
Recent Findings
Recent evidence suggests that the progression of CTCL is closely linked to the Tumor Microenvironment (TME) which comprises various cell types including immune cells, stromal cells, blood vessels, and the extracellular matrix. Cell profiling within the TME demonstrates the perplexity of intracellular communication of the different cell fates and their mediators as the disease progresses.
Summary
CTCL as a rare form of non-Hodgkin lymphoma often misdiagnosed due to its similarity to other skin conditions. It encompasses diseases like Mycosis fungoides (MF) and Sézary Syndrome (SS), with the latter being more severe. Advances in studying the TME have shown its pivotal role in CTCL progression, highlighting the need for comprehensive cell profiling to enhance diagnosis, prognosis, and treatment personalization.
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- Title
- Unveiling the Role of the Cellular Tumor Microenvironment and the Therapeutic Targets it Provides in Cutaneous T-Cell Lymphoma
- Authors
-
Nikolaos A. Chinas
Stella Kaliampou
Vasiliki Nikolaou
- Publication date
- 08-03-2025
- Publisher
- Springer US
- Keywords
-
Mycosis Fungoides
Sézary Syndrome
Lymphoma - Published in
-
Current Oncology Reports / Issue 4/2025
Print ISSN: 1523-3790
Electronic ISSN: 1534-6269 - DOI
- https://doi.org/10.1007/s11912-025-01646-6
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