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07-11-2024 | Mycobacterium Tuberculosis | Review

The cGAS-STING pathway in HIV-1 and Mycobacterium tuberculosis coinfection

Authors: Xiaoxu Han, Xiuwen Wang, Fangping Han, Hongxia Yan, Jin Sun, Xin Zhang, Christiane Moog, Conggang Zhang, Bin Su

Published in: Infection

Abstract

Mycobacterium tuberculosis (M. tuberculosis) infection is the most common opportunistic infection in human immunodeficiency virus-1 (HIV-1)-infected individuals, and the mutual reinforcement of these two pathogens may accelerate disease progression and lead to rapid mortality. Therefore, HIV-1/M. tuberculosis coinfection is one of the major global public health concerns. HIV-1 infection is the greatest risk factor for M. tuberculosis infection and increases the likelihood of endogenous relapse and exogenous reinfection with M. tuberculosis. Moreover, M. tuberculosis further increases HIV-1 replication and the occurrence of chronic immune activation, accelerating the progression of HIV-1 disease. Exploring the pathogenesis of HIV-1/M. tuberculosis coinfections is essential for the development of novel treatments to reduce the global burden of tuberculosis. Innate immunity, which is the first line of host immune defense, plays a critical role in resisting HIV-1 and M. tuberculosis infections. The role of the cyclic guanosine monophosphate–adenosine monophosphate synthase (cGAS)-stimulator of interferon genes (STING) signaling pathway, which is a major DNA-sensing innate immune signaling pathway, in HIV-1 infection and M. tuberculosis infection has been intensively studied. This paper reviews the role of the cGAS-STING signaling pathway in HIV-1 infection and M. tuberculosis infection and discusses the possible role of this pathway in HIV-1/M. tuberculosis coinfection to provide new insight into the pathogenesis of HIV-1/M. tuberculosis coinfection and the development of novel therapeutic strategies.

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Title: The cGAS-STING pathway in HIV-1 and Mycobacterium tuberculosis coinfection
Authors: Xiaoxu Han
Xiuwen Wang
Fangping Han
Hongxia Yan
Jin Sun
Xin Zhang
Christiane Moog
Conggang Zhang
Bin Su
Publication date: 07-11-2024
Publisher: Springer Berlin Heidelberg
Keywords: Mycobacterium Tuberculosis
Human Immunodeficiency Virus
Interferon
Tuberculosis
Tuberculosis
Published in: Infection
Print ISSN: 0300-8126
Electronic ISSN: 1439-0973
DOI: https://doi.org/10.1007/s15010-024-02429-0

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