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Current Cardiology Reports

Mutual Regulation of Cardiovascular and Hematopoietic Development

  • Open Access
  • 01-12-2025
  • Regenerative Medicine (SM Wu, Section Editor)
Published in:
Authors
Norika Liu
Haruko Nakano
Atsushi Nakano
Published in
Current Cardiology Reports | Issue 1/2025

Abstract

Purpose of Review

The cardiovascular and hematopoietic systems share molecular mechanisms and regulatory interactions across species. Endocardial hematopoiesis, a debated topic in mice, is actually an evolutionarily conserved process from Drosophila. This review explores the origins and significance of endocardial hematopoiesis, highlighting its role in cardiac development and macrophage formation.

Recent Findings

Despite extensive lineage-tracing and transcriptome studies, it remained unclear until single-cell RNA sequencing (scRNA-seq) identified that endocardial cells possess an intrinsic hematopoietic program independent of known hematopoietic organs. These endocardial-derived macrophages contribute uniquely to cardiac morphogenesis, supporting valve maturation and tissue remodeling.

Summary

Endocardial hematopoiesis is an evolutionarily conserved phenomenon that is essential for developmental process. The heterogeneity of tissue-resident macrophages and their specialized functions in cardiac development have been further unraveled by single-cell analysis. This review provides an evolutionary perspective on endocardial hematopoiesis and highlights its critical contributions of hematopoietic cells to heart formation and homeostasis.
Title
Mutual Regulation of Cardiovascular and Hematopoietic Development
Authors
Norika Liu
Haruko Nakano
Atsushi Nakano
Publication date
01-12-2025
Publisher
Springer US
Published in
Current Cardiology Reports / Issue 1/2025
Print ISSN: 1523-3782
Electronic ISSN: 1534-3170
DOI
https://doi.org/10.1007/s11886-025-02236-5
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Independent Medical Education Grant:
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Image Credits
Abstract graphic of layered, concentric circular shapes in bright green, pink, blue, and purple on a dark blue background. The rings and segments form a complex radial pattern without text/© Springer Health+ IME