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28-06-2024 | Multiple Myeloma | Review Free for a limited time

Update on kidney injury caused by multiple myeloma

Authors: Linhui Wang, Chen Liu, Haiyan Song, Jing Yuan, Yan Zha, Yiyao Deng

Published in: Annals of Hematology

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Abstract

Multiple myeloma (MM) is a form of clonal plasma cell malignancy that associates with clinical manifestations such as anemia, hypercalcemia, bone pain, and renal impairment. Approximately 20–50% of MM patients at initial diagnosis experience renal injury, a vital complication that significantly influences prognosis and quality of life. This review seeks to clarify the multifaceted mechanisms of renal injury in MM, scrutinizing the pathogenic role of monoclonal proteins, the impact of hypercalcemia, and direct renal infiltration by plasma cells. Furthermore, it evaluates current diagnostic approaches, reviews management strategies, and highlights potential avenues for future research. By incorporating the latest scientific evidence and insights, this article aims to provide a comprehensive understanding of MM-associated renal impairment, offering a valuable resource for researchers and clinicians in handling this complex complication.
Literature
27.
go back to reference Di Raimondo F et al (2000) Angiogenic factors in multiple myeloma: higher levels in bone marrow than in peripheral blood. Haematologica 85:800–805PubMed Di Raimondo F et al (2000) Angiogenic factors in multiple myeloma: higher levels in bone marrow than in peripheral blood. Haematologica 85:800–805PubMed
30.
go back to reference Gou MJ et al (2022) Contribution of capillary zone electrophoresis hyphenated with drift tube ion mobility mass spectrometry as a complementary tool to microfluidic reversed phase liquid chromatography for antigen discovery. Int J Mol Sci 23. https://doi.org/10.3390/ijms232113350 Gou MJ et al (2022) Contribution of capillary zone electrophoresis hyphenated with drift tube ion mobility mass spectrometry as a complementary tool to microfluidic reversed phase liquid chromatography for antigen discovery. Int J Mol Sci 23. https://​doi.​org/​10.​3390/​ijms232113350
49.
go back to reference Pasvolsky O, Marcoux C, Dai J, Milton DR, Tanner MR, Syed N, Bashir Q, Srour SA, Saini NY, Lin P, Ramdial J, Nieto Y, Lee HC, Patel KK, Manasanch EE, Kebriaei P, Thomas SK, Weber DM, Orlowski RZ, Shpall EJ, Champlin RE, Qazilbash MH (2023) Trends in outcomes over three decades after upfront autologous stem cell transplant for multiple myeloma at MD Anderson Cancer Center. Blood 142:4962. https://doi.org/10.1182/blood-2023-174479CrossRef Pasvolsky O, Marcoux C, Dai J, Milton DR, Tanner MR, Syed N, Bashir Q, Srour SA, Saini NY, Lin P, Ramdial J, Nieto Y, Lee HC, Patel KK, Manasanch EE, Kebriaei P, Thomas SK, Weber DM, Orlowski RZ, Shpall EJ, Champlin RE, Qazilbash MH (2023) Trends in outcomes over three decades after upfront autologous stem cell transplant for multiple myeloma at MD Anderson Cancer Center. Blood 142:4962. https://​doi.​org/​10.​1182/​blood-2023-174479CrossRef
Metadata
Title
Update on kidney injury caused by multiple myeloma
Authors
Linhui Wang
Chen Liu
Haiyan Song
Jing Yuan
Yan Zha
Yiyao Deng
Publication date
28-06-2024
Publisher
Springer Berlin Heidelberg
Published in
Annals of Hematology
Print ISSN: 0939-5555
Electronic ISSN: 1432-0584
DOI
https://doi.org/10.1007/s00277-024-05860-3