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Open Access 06-09-2024 | Multiple Myeloma | Original Research Article

Healthcare Resource Utilization and Associated Costs During the First 5 Years After Diagnosis and at the End of Life: A Nationwide Cohort Study of Patients with Multiple Myeloma in Finland

Authors: Mikko Kosunen, Jarno Ruotsalainen, Alvar Kallio, Roope Metsä, Paavo Raittinen, Leena Lehmus, Maarit J. Korhonen, Timo Purmonen

Published in: PharmacoEconomics - Open

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Abstract

Background

The burden associated with the treatment of patients with multiple myeloma (MM) is expected to increase due to the aging population. Thus, policymakers and clinicians need a holistic view of the healthcare resource use (HCRU) and costs associated with MM and its treatment for informed decision making. However, nationwide information on HCRU and costs due to MM is scarce in Finland. The aim of this study was to determine healthcare resource utilization, patterns of service use and associated costs among Finnish patients with MM during the first 5 years from their first diagnosis and at end of life.

Methods

Data on patients newly diagnosed with MM and receiving treatment for it in Finland in 2015–2019 was sourced from comprehensive nationwide registers. Data on all-cause and MM-specific HCRU including inpatient stays, outpatient visits and contacts, emergency care visits and home care were obtained separately from specialized and primary care registers. HCRU costs were assessed by multiplying the numbers of primary and specialized care contacts by respective national unit costs. For reimbursed outpatient medication and reimbursed sick leave, data on actual costs were collected. All registry data were linked via unique personal identifiers, and follow-up time was up to 5 years.

Results

Altogether, 1615 patients were included in the analyses. In the 5-year follow-up period, patients had on average 96 healthcare contacts per patient-year (PPY) and the mean all-cause healthcare costs were €46,000 PPY. Around 47% of these costs originated from reimbursed outpatient medication and the rest from healthcare contacts. Over half (60%) of the contacts occurred in primary care but most of the costs were associated with specialized care. Additionally, 29% of contacts were MM-specific, but they were responsible for 58% of the costs. The HCRU was highest during the first year after diagnosis, levelled off during the follow-up and then increased significantly during the last year of patients’ lives. The number of all-cause healthcare contacts PPY was approximately 53% higher, and the respective costs were 5% higher during the last year of a patient’s life when compared with the first year after diagnosis. During the last 12 months (N = 417) and 6 months (N = 505) of life and during palliative care (N = 145), the most common healthcare contact was home care.

Conclusions

During active treatment, MM is primarily treated in the specialized care setting, with outpatient medication and visits to specialized care being the main cost drivers. These results can be utilized to estimate the need for care and expected costs over time due to MM and in health economic evaluations concerning MM.
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Literature
7.
go back to reference Bessou A, Colin X, De Nascimento J, et al. Assessing the treatment pattern, health care resource utilisation, and economic burden of multiple myeloma in France using the Système National des Données de Santé (SNDS) database: a retrospective cohort study. Eur J Health Econ. 2023;24(3):321–33. https://doi.org/10.1007/s10198-022-01463-9.CrossRefPubMed Bessou A, Colin X, De Nascimento J, et al. Assessing the treatment pattern, health care resource utilisation, and economic burden of multiple myeloma in France using the Système National des Données de Santé (SNDS) database: a retrospective cohort study. Eur J Health Econ. 2023;24(3):321–33. https://​doi.​org/​10.​1007/​s10198-022-01463-9.CrossRefPubMed
8.
go back to reference Hannig LH, Nielsen LK, Ibsen R, Arnheim-Dahlström L, Kjellberg J, Abildgaard N. The impact of changed treatment patterns in multiple myeloma on health-care utilisation and costs, myeloma complications, and survival: a population-based comparison between two time periods in Denmark. Eur J Haematol. 2021;107(1):63–73. https://doi.org/10.1111/EJH.13615.CrossRefPubMed Hannig LH, Nielsen LK, Ibsen R, Arnheim-Dahlström L, Kjellberg J, Abildgaard N. The impact of changed treatment patterns in multiple myeloma on health-care utilisation and costs, myeloma complications, and survival: a population-based comparison between two time periods in Denmark. Eur J Haematol. 2021;107(1):63–73. https://​doi.​org/​10.​1111/​EJH.​13615.CrossRefPubMed
Metadata
Title
Healthcare Resource Utilization and Associated Costs During the First 5 Years After Diagnosis and at the End of Life: A Nationwide Cohort Study of Patients with Multiple Myeloma in Finland
Authors
Mikko Kosunen
Jarno Ruotsalainen
Alvar Kallio
Roope Metsä
Paavo Raittinen
Leena Lehmus
Maarit J. Korhonen
Timo Purmonen
Publication date
06-09-2024
Publisher
Springer International Publishing
Published in
PharmacoEconomics - Open
Print ISSN: 2509-4262
Electronic ISSN: 2509-4254
DOI
https://doi.org/10.1007/s41669-024-00524-4