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Current Oncology Reports

Risk Stratification Strategies and Implementation of Exercise Training in Patients with Multiple Myeloma

Authors
Sung-Soo Park
Eui-Soon Kim
Jong-Chan Youn
Mi-Hyang Jung
Jihye Park
Kyung Eun Nam
Chang-Ki Min
Saro H. Armenian
Kyuwan Lee
Published in
Current Oncology Reports

Abstract

Purpose of Review

This review aims to explore key clinical considerations for prescribing exercise in individuals with multiple myeloma (MM) and to evaluate current evidence to develop exercise regimens that prioritize both safety and efficacy.

Recent Findings

MM is a hematological cancer characterized by complex complications, including unstable bone lesions, cardiac amyloidosis, peripheral neuropathy, and cytopenia, which collectively impair patients' health and quality of life. Exercise training has emerged as a critical component of supportive care in MM; however, the complexity of the disease and its associated comorbidities pose challenges to designing safe and effective interventions. Recent evidence underscores the potential benefits of aerobic and resistance training, yet there is no consensus on optimal exercise protocols. Tools such as cardiopulmonary exercise testing, fracture risk assessment, and blood biomarker monitoring have shown promise in personalizing exercise prescriptions.

Summary

Although the feasibility and short-term benefits of exercise interventions for MM are well-established, significant gaps in knowledge persist regarding their long-term effects on disease progression, survival, and quality of life. Future research is needed to address these gaps and refine evidence-based exercise guidelines for this unique patient population.

Graphical Abstract

Title
Risk Stratification Strategies and Implementation of Exercise Training in Patients with Multiple Myeloma
Authors
Sung-Soo Park
Eui-Soon Kim
Jong-Chan Youn
Mi-Hyang Jung
Jihye Park
Kyung Eun Nam
Chang-Ki Min
Saro H. Armenian
Kyuwan Lee
Publication date
03-11-2025
Publisher
Springer US
Published in
Current Oncology Reports
Print ISSN: 1523-3790
Electronic ISSN: 1534-6269
DOI
https://doi.org/10.1007/s11912-025-01719-6
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Video
Image Credits
Senior man using a resistance band in an exercise class/© Drazen Zigic / Getty Images (symbolic image with models), Colon cancer illustration/© (M) KATERYNA KON / SCIENCE PHOTO LIBRARY / Getty Images, CAR T-cell attacking cancer cells/© LoveLive/stock.adobe.com