Issue 1/2026
Content (27 Articles)
Epithelial WNT secretion drives niche escape of developing gastric cancer
- Open Access
- Research
Jaehun Lee, Soomin Kim, Youngchul Oh, Stephan R. Jahn, Jihoon Kim, Yeongjun Kim, Tim Schmäche, Sang-Min Kim, Isaree Teriyapirom, Thomas Groß, Ohbin Kwon, Jungmin Kim, Somi Kim, Anne-Marlen Ada, Andrea Català-Bordes, Youngwon Cho, Jinho Kim, Amanda Andersson-Rolf, Sebastian R. Merker, Joo Yeon Lim, Ji-Yeon Park, Thomas M. Klompstra, Ki-Jun Yoon, Dae-Sik Lim, Ho-Seok Lee, Jong Kyoung Kim, Eunyoung Choi, James R. Goldenring, Jae-Ho Cheong, Hyunki Kim, Daniel E. Stange, Heetak Lee, Bon-Kyoung Koo, Ji-Hyun Lee
Lactate: elucidating its indispensable role in human health
- Open Access
- Epigenetics
- Review
Shengxin Zhang, Jie Wang, Ziyu Xu, Ziyang Cheng, Bin Shao, Jiayun Yu
Integrating single cell- and spatial- resolved transcriptomics unravels the inter-tumor heterogeneity and immunosuppressive landscape in HBV- and Clonorchis sinensis-associated hepatocellular carcinoma
- Open Access
- Hepatocellular Carcinoma
- Research
Jiayun Chen, Wenmin Lu, Yanni Lou, Jing Liu, Xiwen Liao, Yunmeng Bai, Guangqing Cheng, Guangzhi Zhu, Ji Feng, Junqi Liu, Zhaoji Liu, Liqun Jia, Jing Zhou, Tao Peng, Guo-Dong Lu, Jigang Wang
Retraction Note: Circular RNA circDCUN1D4 suppresses hepatocellular carcinoma development via targeting the miR-590-5p/ TIMP3 axis
- Open Access
- Hepatocellular Carcinoma
- Retraction Note
Hongyu Li, Bing Su, Yan Jiang, Boyang Zhang, Rulong Du, Can Song, Bin Hou, Kun Xu, Lida Wu, Yuchun Gu
BRRIAR lncRNA alters breast cancer risk by modulating interferon signaling in cis and in trans
- Open Access
- Breast Cancer
- Research
Haran Sivakumaran, Sneha Nair, Mainá Bitar, Xue Lu, Lu Wang, Ji Liu, Deshapriya S. Karunarathne, P. Prakrithi, Sebastien Jacquelin, Isela Sarahi Rivera, Kristine M. Hillman, Susanne Kaufmann, Rebekah Ziegman, Wei Shi, Sarah Alexandrou, C. Elizabeth Caldon, Rakesh N. Veedu, Quan H. Nguyen, Jonathan Beesley, Michelle N. Wykes, Juliet D. French, Stacey L. Edwards
Multi-omic profiling provides insights into the heterogeneity, microenvironmental features, and biomarker landscape of small-cell lung cancer
- Open Access
- Research
Mingchao Xie, Miljenka Vuko, Shashank Saran, Siyu Liu, Andrew G. Chambers, Hana Baakza, Helen K. Angell, Felicia Ng, Carl M. Gay, Robert J. Cardnell, Felix J. Segerer, Alma Andoni, Jaime Rodriguez-Canales, Paul M. Waring, Markus Schick, J. Carl Barrett, Lauren A. Byers, Giulia Fabbri
Development and validation of a small extracellular vesicle-derived RNA signature for early diagnosis of lung adenocarcinoma and prognosis in advanced stages
- Open Access
- Research
Rui Meng, Yanjun Gao, Zheng Peng, Hua Chen, Yida Li, Yu Liu, Lanxiao Shen, Huanle Pan, Liangcheng Zheng, Dezhi Cheng, Xiaoming Lin, Wenjie Sun, Congying Xie
Gut microbial metabolites in cancer immunomodulation
- Open Access
- Review
Hengshuo Liu, Xingyu Xiong, Weizhen Zhu, Sheng Wang, Weichao Huang, Guoqing Zhu, Hang Xu, Lu Yang
Synergistic innate-adaptive immunity by NKG2D-specific CAR-macrophages drives durable remission in hepatocellular carcinoma
- Open Access
- Research
Zihao Zhao, Wenjing Zheng, Yang He, Han Zhang, Lingling Zhang, Yi Huo, Junwei Jiang, Chen Zhang, Haohan Lyu, Weiwei Qin, Chen Liu, Feng Chang, Lequn Shan, Tao Wang, Wenjie Song
Extracellular vesicles cargo orchestration in colorectal cancer: immune evasion, stromal remodeling, and therapeutic frontiers
- Open Access
- Review
Yukang Lu, Xiulan Liu, Tingting Zhang, Meijin Liu, Xiaoyan Liu, Jinyou Qiu, Linghan Zhang, Zhenzhen Wen
Correction: Loss of the tumour suppressor LKB1/STK11 uncovers a leptin-mediated sensitivity mechanism to mitochondrial uncouplers for targeted cancer therapy
- Open Access
- Cancer Therapy
- Correction
Andriani Angelopoulou, Giorgos Theocharous, Dimitrios Valakos, Aikaterini Polyzou, Sophia Magkouta, Vassilios Myrianthopoulos, Sophia Havaki, Marco Fiorillo, Ioanna Tremi, Konstantinos Vachlas, Theodoros Nisotakis, Dimitris-Foivos Thanos, Anastasia Pantazaki, Dimitris Kletsas, Jiri Bartek, Russell Petty, Dimitris Thanos, Rory J McCrimmon, Angelos Papaspyropoulos, Vassilis G Gorgoulis
Correction: YC-1 enhances the anti-tumor activity of sorafenib through inhibition of signal transducer and activator of transcription 3 (STAT3) in hepatocellular carcinoma
- Open Access
- Sorafenib
- Correction
Jian Kong, Fandong Kong, Jun Gao, Qiangbo Zhang, Shuying Dong, Fang Gu, Shan Ke, Bing Pan, Qiang Shen, Huichuan Sun, Lemin Zheng, Wenbing Sun
CircRNF10 sequestrates β-catenin by a dual regulatory circuit of direct degradation and a miR-1275/DKK3-mediated inhibition in driver gene- negative lung adenocarcinoma
- Open Access
- Research
Xiaohua Situ, Xinwei Wang, Xiting Liao, Xiaoxuan Zhang, Sicheng Chen, Fei Fang, Lihong Wei, Peng Wu, Zhiyu Liu, Honglei Chen, Kejing Tang, Lihong Bai, Zunfu Ke
Targeting OxLDL-mediated CD36 + CAF reprogramming potentiates PD-1 immunotherapy in osteosarcoma
- Open Access
- Research
Anyu Zeng, Hongmin Chen, Tianqi Luo, Weiqing Chen, Yihui Song, Yanyang Xu, Zhihao Chen, Qinglian Tang, Xiaojun Zhu, Chuangzhong Deng, Huaiyuan Xu, Anqi Wang, Hao Wu, Guohui Song, Jinchang Lu, Jin Wang
Sitravatinib plus tislelizumab in locally recurrent or metastatic triple-negative breast cancer: a multi-cohort, single-arm, phase II clinical trial (SPARK Trial)
- Open Access
- Research
Xi-Yu Liu, Xin-Yi Sui, Ying Xu, Fan Yang, Song-Yang Wu, Xiu-Zhi Zhu, Ke Zuo, Shuo-Wen Cao, Xi Jin, Li Chen, Lin-Xiaoxi Ma, Wen-Juan Zhang, Fu-Gui Ye, Fei-Lin Qu, Ding Ma, Yi Xiao, Gen-Hong Di, Guang-Yu Liu, Ke-Da Yu, Jiong Wu, Xin Hu, Yi-Zhou Jiang, Zhong-Hua Wang, Zhi-Ming Shao, Lei Fan
c-Rel drives pancreatic cancer metastasis through fibronectin-integrin signaling-induced isolation stress resistance and EMT
- Open Access
- Research
D. Bakırdöğen, K. Görgülü, J. Xin, L. Richter, S. Alcalá, L. Ruiz-Cañas, C. Dai, K. J. Frank, N. Wu, K. N. Diakopoulos, H. Ozturk, D. Demircioğlu, K. Peschke, R. Ranjan, F. Fusco, J. Martinez-Useros, M. J. Fernandez-Aceñero, N. F. Chhabra, J. C. López-Gil, J. Ai, D. A. Ruess, E. Kaya-Aksoy, F. Schmidt, L. Kohlmann, A. Berninger, H. Yang, F. Schicktanz, K. Steiger, I. E. Demir, R. M. Schmid, M. Reichert, M. Adli, M. Lesina, B. Sainz Jr., H. Algül
Local metastatic expansion versus secondary intra-organ dissemination: two causes of neurological death explained by fundamentally different metastatic colonization patterns
- Open Access
- Research
Dorde Komljenovic, Tobias Bäuerle, Jessica Alves-de-Lima, Laura Trigueros, Cara Dietz, Zoltan Winter, Tommaso Araceli, Quirin Strotzer, Christina Wendl, Matthias Brendel, Martin A. Proescholdt, Patrick N. Harter, Katja Evert, Tobias Pukrop, Raquel Blazquez
Platinum-based functional nanomaterials: mechanisms and therapeutic strategies in cancer radiotherapy sensitization
- Open Access
- Radiotherapy
- Review
Yuanchao Cheng, Yakui Mou, Hanrui Wang, Hui Shen, Yue Hu, Xiaoyu Song, Mingjun Zhang, Yao Wang, Wanchen Liu, Ting Yang, Chao Ren, Miao Yan, Xicheng Song
Cancer-associated fibroblasts in the tumor microenvironment: heterogeneity, crosstalk mechanisms, and therapeutic implications
- Open Access
- Review
Ziyue Huang, Jie Chen, Tianyu Zhu, Jinxin Li, Ho Yin Ng, Yixiong Zhou, Xiang Gu, Shiqiong Xu, Renbing Jia
Next-generation CAR-T cells design: leveraging tumor features for enhanced efficacy
- Open Access
- Review
Yanna Lei, Ning Liu, Diyuan Qin, Ming Liu, Yongsheng Wang
Selective genome editing of amplified oncogenes triggers immunogenic cell death and tumor remodeling
- Open Access
- Research
A. Nieto-Sanchez, M. Martinez-Lage, P. Puig-Serra, S. Carpintero, A. Alonso-Yanez, P. Ojeda-Walczuk, M. Ibañez-Navarro, G. Pita, FJ. Moya, C. Moreno, MC. Martin, R. Alonso, R. Nuñez-Torres, VJ. Sanchez-Arevalo Lobo, L. Alonso-Guirado, N. Malats, A. Gonzalez-Neira, L. Fernandez, P. Roda-Navarro, R. Torres-Ruiz, S. Rodriguez-Perales
The METTL3-YTHDC1 axis mediates architectural RNA m6A modification to modulate the integrity of chromatin TADs in MLLr + AML genome
- Open Access
- Research
Ruishuang Fu, Wenjuan Yu, Rongjie Zhao, Huimin Yang, Beibei Cao, Chunfei Dai, Haoyue Qianjiang, Yujun Xia, Lubo Wang, Jianrong Lu, Ruiqing Zhou, Aiqin Shi, Hanmei Lou, Xiang Zhang, Huacheng Luo
Histone lysine demethylases in breast cancer: molecular mechanisms, biological functions, and therapeutic intervention
- Open Access
- Review
Anqi Wang, Dianjun Qi, Yi Ma, Mozhi Wang, Haoran Dong, Chenxin Wang, Yingfan Zhang, Zheyuan Zhang, Lingwei Li, Jiayi Xu, Litong Yao, Yingying Xu
A pan-cancer single cell landscape reveals heterogeneity and functional diversity of double-negative T cells
- Open Access
- Research
Qing Hao, Tao Zhou, Huayun Yan, Zhixiang Ren, Wei Mao, Li-Bin Huang, Yue-yun Chen, Yuelan Wang, Minqin Xiao, Yajiao He, Xuyang Xia, Jing Wu, Wei-Han Zhang, Hai-Ning Chen, Maoxiang Qian, Feng Zhang, Li Yang, Lunzhi Dai, Huiyuan Zhang, Canhua Huang, Yang Shu, Yu Xu, Yang Luo, Yong Peng, Heng Xu
Metabolic characteristics in hepatocellular carcinoma: amino acid metabolic reprogramming
- Open Access
- Review
Ran Zhou, Yuejun Li, Guanghui Li, Yan Li, Lie Luo, Bin Wang, Liping Wang
Correction: Histone demethylase KDM4D promotes gastrointestinal stromal tumor progression through HIF1β/VEGFA signalling
- Open Access
- Correction
Fuqing Hu, Haijie Li, Lu Liu, Feng Xu, Senyan Lai, Xuelai Luo, Junbo Hu, Xi Yang
Correction: The chromosome 11q13.3 amplification associated lymph node metastasis is driven by miR-548k through modulating tumor microenvironment
- Open Access
- Correction
Weimin Zhang, Ruoxi Hong, Lin Li, Yan Wang, Peina Du, Yunwei Ou, Zitong Zhao, Xuefeng Liu, Wenchang Xiao, Dezuo Dong, Qingnan Wu, Jie Chen, Yongmei Song, Qimin Zhan
