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Molecular Cancer

Issue 1/2025

Content (313 Articles)

circASAP1 induces renal clear cell carcinoma ferroptosis by binding to HNRNPC and thereby regulating GPX4

Yunfei Wang, Taowei Yang, Qihao Li, Zhousan Zheng, Lican Liao, Junjie Cen, Wei Chen, Junhang Luo, Yi Xu, Mi Zhou, Jiaxing Zhang

Pan-cancer drivers of metastasis

Ryan Lusby, Engin Demirdizen, Mohammed Inayatullah, Paramita Kundu, Oscar Maiques, Ziyi Zhang, Mikkel Green Terp, Victoria Sanz-Moreno, Vijay K. Tiwari

Single cell and spatial analysis of immune-hot and immune-cold tumours identifies fibroblast subtypes associated with distinct immunological niches and positive immunotherapy response

Benjamin H. Jenkins, Ian Tracy, Maria Fernanda S. D. Rodrigues, Melanie J. L. Smith, Begoña R. Martinez, Mark Edmond, Sangeetha Mahadevan, Anjali Rao, Hailing Zong, Kai Liu, Abhishek Aggarwal, Li Li, Lauri Diehl, Emma V. King, Jamie G. Bates, Christopher J. Hanley, Gareth J. Thomas

Exosomal circ_0006896 promotes AML progression via interaction with HDAC1 and restriction of antitumor immunity

Can Can, Xinyu Yang, Hexiao Jia, Hanyang Wu, Xiaodong Guo, Yihong Wei, Ziting Jia, Wancheng Liu, Amin Zhang, Na He, Hailei Zhang, Daoxin Ma

Myeloid-derived suppressor cells (MDSCs) in the tumor microenvironment and their targeting in cancer therapy

Shuyan He, Lu Zheng, Chunjian Qi

Intra-tumoral sphingobacterium multivorum promotes triple-negative breast cancer progression by suppressing tumor immunosurveillance

Zhikai Mai, Liwu Fu, Jiyan Su, Kenneth K.W. To, Chuansheng Yang, Chenglai Xia

Tumor metabolic regulators: key drivers of metabolic reprogramming and the promising targets in cancer therapy

Kun Huang, Ying Han, Yihong Chen, Hong Shen, Shan Zeng, Changjing Cai

Commentary on “Epigenome-wide analysis across the development span of pediatric acute lymphoblastic leukemia: backtracking to birth”

Emma Raitoharju, Saara Marttila

Targeting KRAS: from metabolic regulation to cancer treatment

  • Open Access
  • NSCLC
  • Review

Yanyan Shi, Huiling Zheng, Tianzhen Wang, Shengpu Zhou, Shiqing Zhao, Mo Li, Baoshan Cao

Mir-483-5p-mediated activating of IGF2/H19 enhancer up-regulates IGF2/H19 expression via chromatin loops to promote the malignant progression of hepatocellular carcinoma

Weiwei Chen, Chutian Wu, Yuting Li, Tonghua Wang, Miaoling Huang, Min Wang, Linjing Long, Yanfang Chen, Shufen Feng, Xuyou Liu, Shaohui Tang

AXL: shapers of tumor progression and immunosuppressive microenvironments

  • Open Access
  • Review

Yihui Liu, Lei Xu, Yuanyao Dou, Yong He

Lipid nanoparticles deliver DNA-encoded biologics and induce potent protective immunity

Dafei Chai, Junhao Wang, Jing Ming Lim, Xiaohui Xie, Xinfang Yu, Dan Zhao, Perry Ayn Mayson Maza, Yifei Wang, Dana Cyril-Remirez, Ken H. Young, Yong Li

Emerging role of exosomes in cancer therapy: progress and challenges

Jiale Li, Jiachong Wang, Zigui Chen

The roles of KRAS in cancer metabolism, tumor microenvironment and clinical therapy

  • Open Access
  • NSCLC
  • Review

Qinglong Ma, Wenyang Zhang, Kongming Wu, Lei Shi

Quantitative proteomic analysis unveils a critical role of VARS1 in hepatocellular carcinoma aggressiveness through the modulation of MAGI1 expression

Natalia Hermán-Sánchez, Mercedes del Rio-Moreno, Rubén Ciria, Marina E. Sánchez-Frias, Maite G. Fernández-Barrena, Iker Uriarte, Eduardo Chicano-Galvez, Ignacio Ortea, Ángela Peralbo-Molina, Javier Briceño, Matías A. Avila, Manuel Rodríguez-Perálvarez, Raúl M. Luque, Juan L. López-Cánovas, Manuel D. Gahete

Metabolically activated and highly polyfunctional intratumoral VISTA+ regulatory B cells are associated with tumor recurrence in early-stage NSCLC

  • Open Access
  • NSCLC
  • Research

Domenico Lo Tartaro, Beatrice Aramini, Valentina Masciale, Nikolaos Paschalidis, Francesco Demetrio Lofaro, Anita Neroni, Rebecca Borella, Elena Santacroce, Alin Liviu Ciobanu, Anna Valeria Samarelli, Federica Boraldi, Daniela Quaglino, Alessandra Dubini, Michele Gaudio, Gloria Manzotti, Francesca Reggiani, Federica Torricelli, Alessia Ciarrocchi, Antonino Neri, Federica Bertolini, Massimo Dominici, Pier Luigi Filosso, Franco Stella, Lara Gibellini, Sara De Biasi, Andrea Cossarizza

Biometallic ions and derivatives: a new direction for cancer immunotherapy

Lin Zhao, Yajun Gui, Jing Cai, Xiangying Deng

The mycobiome in human cancer: analytical challenges, molecular mechanisms, and therapeutic implications

Ting Ding, Chang Liu, Zhengyu Li

ALKBH5 suppresses gastric cancer tumorigenesis and metastasis by inhibiting the translation of uncapped WRAP53 RNA isoforms in an m6A-dependent manner

Ziqi Zheng, Feizhi Lin, Baiwei Zhao, Guoming Chen, Chengzhi Wei, Xiaojiang Chen, Runcong Nie, Ruopeng Zhang, Zhoukai Zhao, Zhiwei Zhou, Yuanfang Li, Weigang Dai, Yijia Lin, Yongming Chen

Resistance mechanisms to immune checkpoint inhibitors: updated insights

Besan H. Alsaafeen, Bassam R. Ali, Eyad Elkord

Unveiling the immunomodulatory dance: endothelial cells’ function and their role in non-small cell lung cancer

  • Open Access
  • NSCLC
  • Review

Sophia Daum, Lilith Decristoforo, Mira Mousa, Stefan Salcher, Christina Plattner, Baharak Hosseinkhani, Zlatko Trajanoski, Dominik Wolf, Peter Carmeliet, Andreas Pircher

Bidirectional role of neutrophils in tumor development

  • Open Access
  • Review

Haoxin Luyang, Feng Zeng, Yan Lei, Qian He, Yanhong Zhou, Juan Xu

Ferroptosis and pyroptosis are connected through autophagy: a new perspective of overcoming drug resistance

  • Open Access
  • Review

Peng Zhao, Shuangshuang Yin, Yuling Qiu, Changgang Sun, Haiyang Yu

Neuroscience of cancer: unraveling the complex interplay between the nervous system, the tumor and the tumor immune microenvironment

  • Open Access
  • Review

Qibo Huang, Bai Hu, Ping Zhang, Ye Yuan, Shiwei Yue, Xiaoping Chen, Junnan Liang, Zhouping Tang, Bixiang Zhang

Intercellular TIMP-1-CD63 signaling directs the evolution of immune escape and metastasis in KRAS-mutated pancreatic cancer cells

Chu-An Wang, Ya-Chin Hou, Yi-Kai Hong, Yu-Jing Tai, Chieh Shen, Pei-Chi Hou, Jhao-Lin Fu, Cheng-Lin Wu, Siao Muk Cheng, Daw-Yang Hwang, Yung-Yeh Su, Yan-Shen Shan, Shaw-Jenq Tsai

Present and future of cancer nano-immunotherapy: opportunities, obstacles and challenges

Man Wang, Fei Yu, Yuan Zhang

Tailoring traditional Chinese medicine in cancer therapy

Shuiquan Li, Xi Chen, Hui Shi, Ming Yi, Bing Xiong, Tianye Li

Comprehensive single-cell atlas of colorectal neuroendocrine tumors with liver metastases: unraveling tumor microenvironment heterogeneity between primary lesions and metastases

Yiqiao Deng, Qichen Chen, Chengyao Guo, Jinghua Chen, Xin Li, Zhiyu Li, Yefan Zhang, Jianjun Zhao, Jianguo Zhou, Jianqiang Cai, Tao Yan, Xiaobing Wang, Xinyu Bi, Zhen Huang, Hong Zhao

Circular RNA circBNC2 inhibits tumorigenesis by modulating ferroptosis and acts as a nanotherapeutic target in prostate cancer

Xiang Pan, Kailai Chen, Wei Gao, Meiqi Xu, Fanlong Meng, Mengyuan Wu, Zi Qi Wang, Yun Qi Li, Wanhai Xu, Manjie Zhang, Yakun Luo

The micro(nano)plastics perspective: exploring cancer development and therapy

Xiangying Deng, Yajun Gui, Lin Zhao

Correction: LncRNA LINRIS stabilizes IGF2BP2 and promotes the aerobic glycolysis in colorectal cancer

  • Open Access
  • Correction

Yun Wang, Jia-Huan Lu, Qi-Nian Wu, Ying Jin, De-Shen Wang, Yan-Xing Chen, Jia Liu, Xiao-Jing Luo, Qi Meng, Heng-Ying Pu, Ying-Nan Wang, Pei-Shan Hu, Ze-Xian Liu, Zhao-Lei Zeng, Qi Zhao, Rong Deng, Xiao-Feng Zhu, Huai-Qiang Ju, Rui-Hua Xu

CircTTC13 promotes sorafenib resistance in hepatocellular carcinoma through the inhibition of ferroptosis by targeting the miR-513a-5p/SLC7A11 axis

Ying Zhang, Ruiwei Yao, Mingyi Li, Chongkai Fang, Kunliang Feng, Xiuru Chen, Jinan Wang, Rui Luo, Hanqian Shi, Xinqiu Chen, Xilin Zhao, Hanlin Huang, Shuwei Liu, Bing Yin, Chong Zhong

Correction: Intra-tumoral sphingobacterium multivorum promotes triple-negative breast cancer progression by suppressing tumor immunosurveillance

  • Open Access
  • Correction

Zhikai Mai, Liwu Fu, Jiyan Su, Kenneth K.W. To, Chuansheng Yang, Chenglai Xia

Sorafenib enhanced the function of myeloid-derived suppressor cells in hepatocellular carcinoma by facilitating PPARα-mediated fatty acid oxidation

Chunxiao Li, Liting Xiong, Yuhan Yang, Ping Jiang, Junjie Wang, Mengyuan Li, Shuhua Wei, Suqing Tian, Yuexuan Wang, Mi Zhang, Jie Tang

Radioresistance in rectal cancer: can nanoparticles turn the tide?

Diogo Coelho, Diogo Estêvão, Maria José Oliveira, Bruno Sarmento

CircRNF13 enhances IGF2BP1 phase separation-mediated ITGB1 mRNA stabilization in an m6A-dependent manner to promote oral cancer cisplatin chemoresistance

Xuemeng Xu, Qiu Peng, Zongyao Ren, Yaqian Han, Xianjie Jiang, Zhu Wu, Shiming Tan, Wenjuan Yang, Linda Oyang, Xia Luo, Jinguan Lin, Longzheng Xia, Mingjing Peng, Nayiyuan Wu, Yanyan Tang, Hao Tian, Yujuan Zhou, Qianjin Liao

Correction: miR-630 targets IGF1R to regulate response to HER-targeting drugs and overall cancer cell progression in HER2 over-expressing breast cancer

  • Open Access
  • Correction

Claire Corcoran, Sweta Rani, Susan Breslin, Martina Gogarty, Irene M Ghobrial, John Crown, Lorraine O’Driscoll

lncRNAs: the unexpected link between protein synthesis and cancer adaptation

  • Open Access
  • Review

Mila Gugnoni, Manoj Kumar Kashyap, Kishore K. Wary, Alessia Ciarrocchi

Correction: YTHDF2 in peritumoral hepatocytes mediates chemotherapy-induced antitumor immune responses through CX3CL1-mediated CD8+ T cell recruitment

  • Open Access
  • Correction

Zhenyun Yang, Xin Wang, Yizhen Fu, Weijie Wu, Zili Hu, Qingyang Lin, Wei Peng, Yangxun Pan, Juncheng Wang, Jinbin Chen, Dandan Hu, Zhongguo Zhou, Li Xu, Yaojun Zhang, Jiajie Hou, Minshan Chen

Cancer cells avoid ferroptosis induced by immune cells via fatty acid binding proteins

  • Open Access
  • Research

Maria Angelica Freitas-Cortez, Fatemeh Masrorpour, Hong Jiang, Iqbal Mahmud, Yue Lu, Ailing Huang, Lisa K. Duong, Qi Wang, Tiffany A. Voss, Claudia S. Kettlun Leyton, Bo Wei, Wai-Kin Chan, Kevin Lin, Jie Zhang, Efrosini Tsouko, Shonik Ganjoo, Hampartsoum B. Barsoumian, Thomas S. Riad, Yun Hu, Carola Leuschner, Nahum Puebla-Osorio, Jing Wang, Jian Hu, Michael A. Davies, Vinay K. Puduvalli, Cyrielle Billon, Thomas P. Burris, Philip L. Lorenzi, Boyi Gan, James W. Welsh

SELP+ TEC:CD8+ T cell crosstalk associates with improved radiotherapy efficacy in cervical cancer

Qingyu Huang, Wenhui Yang, Fuhao Wang, Rui Huang, Qian Wang, Xiaohui Li, Tianyu Lei, Shengqin Yue, Wenxue Zou, Qi An, Jinbo Yue, Qinyong Hu, Chao Liu

Correction: The landscape of BRAF transcript and protein variants in human cancer

  • Open Access
  • Correction

Andrea Marranci, Zhijie Jiang, Marianna Vitiello, Elena Guzzolino, Laura Comelli, Samanta Sarti, Simone Lubrano, Cinzia Franchin, Ileabett Echevarría-Vargas, Andrea Tuccoli, Alberto Mercatanti, Monica Evangelista, Paolo Sportoletti, Giorgio Cozza, Ettore Luzi, Enrico Capobianco, Jessie Villanueva, Giorgio Arrigoni, Giovanni Signore, Silvia Rocchiccioli, Letizia Pitto, Nicholas Tsinoremas, Laura Poliseno

Multimodal lung cancer theranostics via manganese phosphate/quercetin particle

  • Open Access
  • Research

Chong Qiu, Fei Xia, Qingchao Tu, Huan Tang, Yinan Liu, Hongda Liu, Chen Wang, HaiLu Yao, Linying Zhong, Yuanfeng Fu, Pengbo Guo, Weiqi Chen, Xinyu Zhou, Li Zou, Licheng Gan, Jiawei Yan, Yichong Hou, Junzhe Zhang, Huanhuan Pang, Yuqing Meng, Qiaoli Shi, Guang Han, Xijun Wang, Jigang Wang

Hijacking of the nervous system in cancer: mechanism and therapeutic targets

Yu Zhang, Qili Liao, Xuyang Wen, Jiayan Fan, Tifei Yuan, Xuemei Tong, Renbing Jia, Peiwei Chai, Xianqun Fan

Extracellular vesicles in tumor immunity: mechanisms and novel insights

  • Open Access
  • Review

Liwen Kuang, Lei Wu, Yongsheng Li

Correction: CircCD44 plays oncogenic roles in triple-negative breast cancer by modulating the miR-502–5p/KRAS and IGF2BP2/Myc axes

  • Open Access
  • Correction

Jie Li, Xinya Gao, Zhanqiang Zhang, Yuanhui Lai, Xunxun Lin, Bo Lin, Maoguang Ma, Xiaoli Liang, Xixi Li, Weiming Lv, Ying Lin, Nu Zhang

Towards understanding cancer dormancy over strategic hitching up mechanisms to technologies

Sumin Yang, Jieun Seo, Jeonghyeon Choi, Sung-Hyun Kim, Yunmin Kuk, Kyung Chan Park, Mingon Kang, Sangwon Byun, Jae-Yeol Joo

Single-cell RNA sequencing identifies molecular biomarkers predicting late progression to CDK4/6 inhibition in patients with HR+/HER2- metastatic breast cancer

Linjie Luo, Peng Yang, Sofia Mastoraki, Xiayu Rao, Yan Wang, Nicole M. Kettner, Akshara Singareeka Raghavendra, Debasish Tripathy, Senthil Damodaran, Kelly K. Hunt, Jing Wang, Ziyi Li, Khandan Keyomarsi

Correction: Deciphering a profiling based on multiple post-translational modifications functionally associated regulatory patterns and therapeutic opportunities in human hepatocellular carcinoma

  • Open Access
  • Correction

Yuanxiang Lao, Yirong Jin, Songfeng Wu, Ting Fang, Qiang Wang, Longqin Sun, Beicheng Sun

DCLK1-mediated regulation of invadopodia dynamics and matrix metalloproteinase trafficking drives invasive progression in head and neck squamous cell carcinoma

  • Open Access
  • Research

Levi Arnold, Marrion Yap, Nathan Farrokhian, Laura Jackson, Michael Barry, Thuc Ly, Pachiappan Arjunan, Angela Kaczorowski-Worthley, Carter Tews, Avisha Pandey, Austin Morrison, Michael P. Washburn, David Standing, Juan P. Gomez, Nanda Kumar Yellapu, David Johnson, Linheng Li, Shahid Umar, Shrikant Anant, Sufi Mary Thomas

Inflammation in cancer: therapeutic opportunities from new insights

Yifei Xie, Fangfang Liu, Yunfei Wu, Yuer Zhu, Yanan Jiang, Qiong Wu, Zigang Dong, Kangdong Liu

Cancer stem cells and niches: challenges in immunotherapy resistance

  • Open Access
  • Review

Yonglong Pan, Chaoyi Yuan, Chenglong Zeng, Chaoyang Sun, Limin Xia, Guihua Wang, Xiaoping Chen, Bixiang Zhang, Jianfeng Liu, Ze-yang Ding

CircAKT3 promotes prostate cancer proliferation and metastasis by enhancing the binding of RPS27A and RPL11

Xiaoming Song, Ziwei Wei, Cong Zhang, Dunsheng Han, Jinke Liu, Yufeng Song, Xuefeng Xie, Dingchang Shao, Mingkun Zhao, Fan Chao, Guoxiong Xu, Shiyu Wang, Gang Chen

Spatial transcriptomic analysis of tumor microenvironment in esophageal squamous cell carcinoma with HIV infection

Yuanli Zuo, Yang Jin, Gang Li, Yue Ming, Ting Fan, Yitong Pan, Xiaojun Yao, Yong Peng

Role of circular RNAs in cancer therapy resistance

Wenjuan Liu, Jiling Niu, Yanfei Huo, Long Zhang, Linyu Han, Nasha Zhang, Ming Yang

EIF4E-mediated biogenesis of circPHF14 promotes the growth and metastasis of pancreatic ductal adenocarcinoma via Wnt/β-catenin pathway

Zhou Fang, Zhuo Wu, Chao Yu, Qingyu Xie, Liangtang Zeng, Rufu Chen

Traditional Chinese medicine in lung cancer treatment

Zhichao Xi, Rongchen Dai, Yufei Ze, Xue Jiang, Mengfan Liu, Hongxi Xu

Glioblastoma multiforme: insights into pathogenesis, key signaling pathways, and therapeutic strategies

Ashkan Pouyan, Masoud Ghorbanlo, Masoud Eslami, Majid Jahanshahi, Ehsan Ziaei, Ali Salami, Khatere Mokhtari, Koorosh Shahpasand, Najma Farahani, Tohid Emami Meybodi, Maliheh Entezari, Afshin Taheriazam, Kiavash Hushmandi, Mehrdad Hashemi

Hsa_circ_0125356 promotes gemcitabine resistance by modulating WNT canonical and non-canonical pathways via miR-582-5p/FGF9 axis in non-small cell lung cancer

  • Open Access
  • NSCLC
  • Research

Xinyue Du, Weijie Luo, Hongwu Li, Qi Gu, Ping Huang, Cheng Wang, Na Li, Fanglan Liu, Chunhua Xia

Identification of blood-derived exosomal tumor RNA signatures as noninvasive diagnostic biomarkers for multi-cancer: a multi-phase, multi-center study

Fubo Wang, Chengbang Wang, Shaohua Chen, Chunmeng Wei, Jin Ji, Yan Liu, Leifeng Liang, Yifeng Chen, Xing Li, Lin Zhao, Xiaolei Shi, Yu Fang, Weimin Lu, Tianman Li, Zhe Liu, Wenhao Lu, Tingting Li, Xiangui Hu, Mugan Li, Fuchen Liu, Xing He, Jiannan Wen, Zuheng Wang, Wenxuan Zhou, Zehui Chen, Yonggang Hong, Shaohua Zhang, Xiao Li, Rongbin Zhou, Linjian Mo, Duobing Zhang, Tianyu Li, Qingyun Zhang, Li Wang, Xuedong Wei, Bo Yang, Shenglin Huang, Huiyong Zhang, Guijian Pang, Liu Ouyang, Zhenguang Wang, Jiwen Cheng, Bin Xu, Zengnan Mo

Lipid metabolic reprograming: the unsung hero in breast cancer progression and tumor microenvironment

Mengting Wan, Shuaikang Pan, Benjie Shan, Haizhou Diao, Hongwei Jin, Ziqi Wang, Wei Wang, Shuya Han, Wan Liu, Jiaying He, Zihan Zheng, Yueyin Pan, Xinghua Han, Jinguo Zhang

BCL-2 dependence is a favorable predictive marker of response to therapy for chronic lymphocytic leukemia

Stephen Jun Fei Chong, Junyan Lu, Rebecca Valentin, Timothy Z. Lehmberg, Jie Qing Eu, Jing Wang, Fen Zhu, Li Ren Kong, Stacey M. Fernandes, Jeremy Zhang, Charles Herbaux, Boon Cher Goh, Jennifer R. Brown, Carsten U. Niemann, Wolfgang Huber, Thorsten Zenz, Matthew S. Davids

From morphology to single-cell molecules: high-resolution 3D histology in biomedicine

  • Open Access
  • Review

Xintian Xu, Jimeng Su, Rongyi Zhu, Kailong Li, Xiaolu Zhao, Jibiao Fan, Fengbiao Mao

Distant origin of glioblastoma recurrence: neural stem cells in the subventricular zone serve as a source of tumor reconstruction after primary resection

Xue Li, Hyun Jung Kim, Jihwan Yoo, Yeonhee Lee, Chang Hyun Nam, Jonghan Park, Soon-Tae Lee, Tae Min Kim, Seung Hong Choi, Jae-Kyung Won, Sung‑Hye Park, Young Seok Ju, Jong Bae Park, Se Hoon Kim, Jong Hee Chang, Hong-Gyun Wu, Chul-Kee Park, Jeong Ho Lee, Seok-Gu Kang, Joo Ho Lee

Nanobodies targeting the tumor microenvironment and their formulation as nanomedicines

  • Open Access
  • Review

Liudmyla Maksymova, Yannick A. Pilger, Lutz Nuhn, Jo A. Van Ginderachter

The epigenetic hallmarks of immune cells in cancer

Yu Ji, Chu Xiao, Tao Fan, Ziqin Deng, Di Wang, Wenpeng Cai, Jia Li, Tianle Liao, Chunxiang Li, Jie He

Circular RNA circCLASP2 promotes nasopharyngeal carcinoma progression through binding to DHX9 to enhance PCMT1 translation

Miao Peng, Shanshan Zhang, Pan Wu, Xiangchan Hou, Dan Wang, Junshang Ge, Hongke Qu, Chunmei Fan, Yujuan Zhou, Bo Xiang, Qianjin Liao, Ming Zhou, Ming Tan, Guiyuan Li, Wei Xiong, Pan Chen, Zhaoyang Zeng, Zhaojian Gong

Engineered multifunctional nanoparticles for enhanced radiation therapy: three-in-one approach for cancer treatment

  • Open Access
  • Research

Tejaswini Appidi, Debarghya China, George-Răzvan Ștefan, Michele Moreau, Serena Mao, Esteban Velarde, Ngeh Toyang, Henry Lowe, Aravind Kumar Rengan, Kai Ding, Wilfred Ngwa

Harnessing myeloid cells in cancer

  • Open Access
  • Review

Su-Yeon Park, Ekaterina Pylaeva, Vikas Bhuria, Adriana Rosa Gambardella, Giovanna Schiavoni, Dimitrios Mougiakakos, Sung-Hoon Kim, Jadwiga Jablonska

Contract to kill: GNAS mutation

  • Open Access
  • Review

Pratima Raut, Poompozhil Mathivanan, Surinder K. Batra, Moorthy P. Ponnusamy

Bridging epigenomics and tumor immunometabolism: molecular mechanisms and therapeutic implications

  • Open Access
  • Review

Xiaowen Xie, Weici Liu, Zhiyuan Yuan, Hanqing Chen, Wenjun Mao

Small extracellular vesicles and particles (sEVPs) derived from tumor-free pre-metastatic organs promote breast cancer metastasis and support organotropism

Tasneem Cheytan, Martin Schneider, Roberto Würth, Paul Schwerd-Kleine, Ewgenija Gutjahr, Verena Thewes, Laura L. Michel, Rebecca Weber, Tim Vorberg, Sabrina Lohr, Katja Nitschke, Michelle Neßling, Peter Lichter, Andreas Schneeweiss, Karsten Richter, Dominic Helm, Martin Sprick, Andreas Trumpp

Modulating lipid metabolism by nanoparticles (NPs)-mediated ACSL3 silencing to inhibit hepatocellular carcinoma growth and metastasis

Linzhuo Huang, Rui Xu, Siyu Chen, Chunhao Lin, Wende Li, Senlin Li, Phei Er Saw, Lei Zhang, Xiaoding Xu

Reprogramming of Thyroid Cancer Metabolism: from Mechanism to Therapeutic Strategy

Yuxuan Wan, Guoqing Li, Gaoyuan Cui, Saili Duan, Shi Chang

Lymphatic system is the mainstream for breast cancer dissemination and metastasis revealed by single-cell lineage tracing

Kai Miao, Aiping Zhang, Xiaodan Yang, Yipeng Zhang, Anqi Lin, Lijian Wang, Xin Zhang, Heng Sun, Jun Xu, Jingyao Zhang, Yuzhao Feng, Fangyuan Shao, Sen Guo, Zhihui Weng, Peng Luo, Dong Wang, Shuai Gao, Xiao-Yang Zhao, Xiaoling Xu, Chu-Xia Deng

ADT-1004: a first-in-class, oral pan-RAS inhibitor with robust antitumor activity in preclinical models of pancreatic ductal adenocarcinoma

  • Open Access
  • Research

Dhana Sekhar Reddy Bandi, Ganji Purnachandra Nagaraju, Sujith Sarvesh, Julienne L. Carstens, Jeremy B. Foote, Emily C. Graff, Yu-Hua D Fang, Adam B. Keeton, Xi Chen, Jacob Valiyaveettil, Kristy L. Berry, Sejong Bae, Mehmet Akce, Greg Gorman, Karina J. Yoon, Upender Manne, Michael R. Boyd, Donald J. Buchsbaum, Asfar S. Azmi, Yulia Y. Maxuitenko, Gary A. Piazza, Bassel F. El-Rayes

Proteogenomic characterization of molecular and cellular targets for treatment-resistant subtypes in locally advanced cervical cancers

Do Young Hyeon, Dowoon Nam, Hye-Jin Shin, Juhee Jeong, Eunsoo Jung, Soo Young Cho, Dong Hoon Shin, Ja-Lok Ku, Hye Jung Baek, Chong Woo Yoo, Eun-Kyung Hong, Myong Cheol Lim, Sang-Jin Lee, Young-Ki Bae, Jong Kwang Kim, Jingi Bae, Wonyoung Choi, Su-Jin Kim, Seunghoon Back, Chaewon Kang, Inamul Hasan Madar, Hokeun Kim, Suhwan Kim, Duk Ki Kim, Jihyung Kang, Geon Woo Park, Ki Seok Park, Yourae Shin, Sang Soo Kim, Keehoon Jung, Daehee Hwang, Sang-Won Lee, Joo-Young Kim

Nanotechnology-leveraged CRISPR/Cas systems: icebreaking in trace cancer-related nucleic acids biosensing

Weipan Peng, Mengting Shi, Bin Hu, Jingyu Jia, Xinyue Li, Nan Wang, Shuli Man, Shengying Ye, Long Ma

NNMT promotes acquired EGFR-TKI resistance by forming EGR1 and lactate-mediated double positive feedback loops in non-small cell lung cancer

Jiali Dai, Xiyi Lu, Chang Zhang, Tianyu Qu, Wei Li, Jun Su, Renhua Guo, Dandan Yin, Pingping Wu, Liang Han, Erbao Zhang

IL-4 mediated TAP2 downregulation is a dominant and reversible mechanism of immune evasion and immunotherapy resistance in non-small cell lung cancer

  • Open Access
  • NSCLC
  • Research

Kishu Ranjan, Barani Kumar Rajendran, Imad Ud Deen, Adrien Costantini, Miguel Lopez de Rodas, Shruti S. Desai, Frankie Scallo, Nicole Gianino, Soldano Ferrone, Kurt A. Schalper

Shifting landscapes of gender equity in oncology journals: a decade of authorship trends

  • Open Access
  • Correspondence

Hang Yi, Mingzhong Wan, Xu Ou-Yang, Yang Wang, Yan Wang, Yinyan Gao, Qihao Leng, Shuangping Zhang, Yousheng Mao, Guochao Zhang

o8G-modified circPLCE1 inhibits lung cancer progression via chaperone-mediated autophagy

Qingyun Zhao, Dunyu Cai, Haotian Xu, Yihong Gao, Ruirui Zhang, Xiaodong Zhou, Xingcai Chen, Sixian Chen, Jiaxi Wu, Wenyi Peng, Shengyi Yuan, Deqing Li, Gang Li, Aruo Nan

Lactate accumulation induces H4K12la to activate super-enhancer-driven RAD23A expression and promote niraparib resistance in ovarian cancer

Bingfeng Lu, Shuo Chen, Xue Guan, Xi Chen, Yuping Du, Jing Yuan, Jielin Wang, Qinghua Wu, Lingfeng Zhou, Xiangchun Huang, Yang Zhao

Retraction Note: Loss of vinculin and membrane-bound β-catenin promotes metastasis and predicts poor prognosis in colorectal cancer

  • Open Access
  • Retraction Note

Ting Li, Hanqing Guo, Ying Song, Xiaodi Zhao, Yongquan Shi, Yuanyuan Lu, Sijun Hu, Yongzhan Nie, Daiming Fan, Kaichun Wu

Autophagy in tumor immune escape and immunotherapy

  • Open Access
  • NSCLC
  • Review

Huan Wang, Peng Sun, Xijing Yuan, Zhiyong Xu, Xinyuan Jiang, Mingshu Xiao, Xin Yao, Yueli Shi

Extracellular vesicles in cancer´s communication: messages we can read and how to answer

Alena Semeradtova, Michaela Liegertova, Regina Herma, Magdalena Capkova, Chiara Brignole, Genny Del Zotto

Correction: Deciphering tumor microenvironment: CXCL9 and SPP1 as crucial determinants of tumor-associated macrophage polarity and prognostic indicators

  • Open Access
  • Correction

Xinming Su, Chenhao Liang, Ruixiu Chen, Shiwei Duan

Understanding gold nanoparticles and their attributes in ovarian cancer therapy

Rishabh Aggarwal, Afsana Sheikh, Masheera Akhtar, Mohammed Ghazwani, Umme Hani, Amirhossein Sahebkar, Prashant Kesharwani

Dual role of interferon-gamma in the response of melanoma patients to immunotherapy with immune checkpoint inhibitors

Piotr Wawrzyniak, Mariusz L. Hartman

DNA damage response signatures are associated with frontline chemotherapy response and routes of tumor evolution in extensive stage small cell lung cancer

  • Open Access
  • SCLC
  • Research

Benjamin B. Morris, Simon Heeke, Yuanxin Xi, Lixia Diao, Qi Wang, Pedro Rocha, Edurne Arriola, Myung Chang Lee, Darren R. Tyson, Kyle Concannon, Kavya Ramkumar, C. Allison Stewart, Robert J. Cardnell, Runsheng Wang, Vito Quaranta, Jing Wang, John V. Heymach, Barzin Y. Nabet, David S. Shames, Carl M. Gay, Lauren A. Byers

Correction: Sorafenib enhanced the function of myeloid‑derived suppressor cells in hepatocellular carcinoma by facilitating PPARα‑mediated fatty acid oxidation

Chunxiao Li, Liting Xiong, Yuhan Yang, Ping Jiang, Junjie Wang, Mengyuan Li, Shuhua Wei, Suqing Tian, Yuexuan Wang, Mi Zhang, Jie Tang

Correction: The circROBO1/KLF5/FUS feedback loop regulates the liver metastasis of breast cancer by inhibiting the selective autophagy of afadin

  • Open Access
  • Correction

Zehao Wang, Lu Yang, Peng Wu, Xing Li, Yuhui Tang, Xueqi Ou, Yue Zhang, Xiangsheng Xiao, Jin Wang, Hailin Tang

3D tumor cultures for drug resistance and screening development in clinical applications

  • Open Access
  • Review

Zheng Peng, Xiaolan Lv, Hao Sun, Lina Zhao, Shigao Huang

EGFR-mediated local invasiveness and response to Cetuximab in head and neck cancer

Jiefu Zhou, Min He, Qiong Zhao, Enxian Shi, Hairong Wang, Vaidehi Ponkshe, Jiahang Song, Zhengquan Wu, Dongmei Ji, Gisela Kranz, Anna Tscherne, Sabina Schwenk-Zieger, Nilofer Abdul Razak, Julia Hess, Claus Belka, Horst Zitzelsberger, Iordanis Ourailidis, Fabian Stögbauer, Melanie Boxberg, Jan Budczies, Christoph A. Reichel, Martin Canis, Philipp Baumeister, Hongxia Wang, Kristian Unger, Andreas Mock, Olivier Gires

RETRACTED ARTICLE: Circular RNA circDCUN1D4 suppresses hepatocellular carcinoma development via targeting the miR-590-5p/ TIMP3 axis

Hongyu Li, Bing Su, Yan Jiang, Boyang Zhang, Rulong Du, Can Song, Bin Hou, Kun Xu, Lida Wu, Yuchun Gu

Immunomodulatory gene networks predict treatment response and survival to de-escalated, anthracycline-free neoadjuvant chemotherapy in triple-negative breast cancer in the WSG-ADAPT-TN trial

Darren Korbie, Clare Stirzaker, Oleg Gluz, Christine zu Eulenburg, Ulrike Nitz, Matthias Christgen, Sherko Kuemmel, Eva-Maria Grischke, Helmut Forstbauer, Michael Braun, Mathias Warm, John Hackmann, Christoph Uleer, Bahriye Aktas, Claudia Schumacher, Rachel Wuerstlein, Enrico Pelz, Hans Heinrich Kreipe, Susan J. Clark, Matt Trau, Monika Graeser, Nadia Harbeck

Inhibition of 6-phosphogluconate dehydrogenase suppresses esophageal squamous cell carcinoma growth and enhances the anti-tumor effects of metformin via the AMPK/mTOR pathway

Bei Wang, Zixuan Wang, Zini Zhou, Gui Liu, Zhenyuan Jiang, Mingyue Zheng, Wei Geng

Correction: CircZBTB44 promotes renal carcinoma progression by stabilizing HK3 mRNA structure

  • Open Access
  • Correction

Tushuai Li, Yue Gu, Baocai Xu, Kamil Kuca, Jie Zhang, Wenda Wu

Circulating MicroRNAs: functional biomarkers for melanoma prognosis and treatment

Su Yin Lim, Suzanah C. Boyd, Russell J. Diefenbach, Helen Rizos

Correction: SPOCK1 as a potential cancer prognostic marker promotes the proliferation and metastasis of gallbladder cancer cells by activating the PI3K/AKT pathway

Yi-Jun Shu, Hao Weng, Yuan-Yuan Ye, Yun-Ping Hu, Run-Fa Bao, Yang Cao, Xu-An Wang, Fei Zhang, Shan-Shan Xiang, Huai-Feng Li, Xiang-Song Wu, Mao-Lan Li, Lin Jiang, Wei Lu, Bao-San Han, Zhi-Gang Jie, Ying-Bin Liu

Cancer neuroscience in head and neck: interactions, modulation, and therapeutic strategies

  • Open Access
  • Review

Hanrui Wang, Xiaoyu Song, Hui Shen, Wanchen Liu, Yao Wang, Mingjun Zhang, Ting Yang, Yakui Mou, Chao Ren, Xicheng Song

C1Q+ TPP1+ macrophages promote colon cancer progression through SETD8-driven p53 methylation

Veronica Veschi, Francesco Verona, Sebastiano Di Bella, Alice Turdo, Miriam Gaggianesi, Simone Di Franco, Laura Rosa Mangiapane, Chiara Modica, Melania Lo Iacono, Paola Bianca, Ornella Roberta Brancato, Caterina D’Accardo, Gaetana Porcelli, Vincenzo Luca Lentini, Isabella Sperduti, Elisabetta Sciacca, Peter Fitzgerald, David Lopez-Perez, Pierre Martine, Kate Brown, Giuseppe Giannini, Ettore Appella, Giorgio Stassi, Matilde Todaro

Editorial expression of concern: Withanolide D induces apoptosis in leukemia by targeting the activation of neutral sphingomyelinase-ceramide cascade mediated by synergistic activation of c-Jun N-terminal kinase and p38 mitogen-activated protein kinase

  • Open Access
  • Editorial Expression of Concern

Susmita Mondal, Chandan Mandal, Rajender Sangwan, Sarmila Chandra, Chitra Mandal

Retraction Note: Tetrathiomolybdate inhibits head and neck cancer metastasis by decreasing tumor cell motility, invasiveness and by promoting tumor cell anoikis

  • Open Access
  • Retraction Note

Pawan Kumar, Arti Yadav, Samip N. Patel, Mozaffarul Islam, Quintin Pan, Sofia D. Merajver, Theodoros N. Teknos

Small open reading frame-encoded microproteins in cancer: identification, biological functions and clinical significance

  • Open Access
  • Review

Tingting Zhang, Zhang Li, Jiao Li, Yong Peng

Regulation of cellular senescence in tumor progression and therapeutic targeting: mechanisms and pathways

  • Open Access
  • Review

Bowei Liu, Zhigang Peng, Hao Zhang, Nan Zhang, Zaoqu Liu, Zhiwei Xia, Shaorong Huang, Peng Luo, Quan Cheng

Wnt signaling in cancer: from biomarkers to targeted therapies and clinical translation

Muhammad Tufail, Can-Hua Jiang, Ning Li

Editorial Expression of Concern: Alterations in candidate genes PHF2, FANCC, PTCH1 and XPA at chromosomal 9q22.3 region: Pathological significance in early- and late-onset breast carcinoma

  • Open Access
  • Editorial Expression of Concern

Satyabrata Sinha, Ratnesh K. Singh, Neyaz Alam, Anup Roy, Susanta Roychoudhury, Chinmay Kumar Panda

Caveolin-1: an ambiguous entity in breast cancer

Naveen Chintalaramulu, Dhirendra Pratap Singh, Biplov Sapkota, Dayanidhi Raman, Suresh Alahari, Joseph Francis

Multimodal sequencing of neoadjuvant nivolumab treatment in hepatocellular carcinoma reveals cellular and molecular immune landscape for drug response

Fanhong Zeng, Qingyang Zhang, Yu-Man Tsui, Huanhuan Ma, Lu Tian, Abdullah Husain, Jingyi Lu, Joyce Man-Fong Lee, Vanilla Xin Zhang, Po-Man Li, Gary Cheuk-Hang Cheung, Tan-To Cheung, Daniel Wai-Hung Ho, Irene Oi-Lin Ng

Single-cell and spatial transcriptomic analyses revealing tumor microenvironment remodeling after neoadjuvant chemoimmunotherapy in non-small cell lung cancer

  • Open Access
  • NSCLC
  • Research

Xiaolu Cui, Siyuan Liu, He Song, Jingjing Xu, Yanbin Sun

Editorial expression of concern: Yin Yang-1 suppresses invasion and metastasis of pancreatic ductal adenocarcinoma by downregulating MMP10 in a MUC4/ErbB2/p38/MEF2C-dependent mechanism

  • Open Access
  • Editorial Expression of Concern

Jing-Jing Zhang, Yi Zhu, Kun-Ling Xie, Yun-Peng Peng, Jin-Qiu Tao, Jie Tang, Zheng Li, Ze-Kuan Xu, Cun-Cai Dai, Zhu-Yin Qian, Kui-Rong Jiang, Jun-Li Wu, Wen-Tao Gao, Qing Du, Yi Miao

BIRC2 blockade facilitates immunotherapy of hepatocellular carcinoma

Lingyi Fu, Shuo Li, Jie Mei, Ziteng Li, Xia Yang, Chengyou Zheng, Nai Li, Yansong Lin, Chao Cao, Lixuan Liu, Liyun Huang, Xiujiao Shen, Yuhua Huang, Jingping Yun

KF1601, a dual inhibitor of BCR::ABL1 and FLT3, overcomes drug resistance in FLT3+ blast phase chronic myeloid leukemia

Hyun-Jin Kwon, Ji Eun Shin, Amir Khan, So Yeon Park, Jiyoung Kim, Jee-Young Lee, Doohyun Lee, Seungyeon Lee, Chun Young Im, Heegyum Moon, Ye Ri Han, Minori Tamai, Koshi Akahane, Takeshi Inukai, Wonhwa Lee, Hyelim Kim, Hong Nam Kim, Sung-Min Ahn, Hyun Woo Park, Dong-Wook Kim

Correction: CMTM6 overexpression confers trastuzumab resistance in HER2‑positive breast cancer

Fei Xing, Hongli Gao, Guanglei Chen, Lisha Sun, Jiayi Sun, Xinbo Qiao, Jinqi Xue, Caigang Liu

ADAR1-high tumor-associated macrophages induce drug resistance and are therapeutic targets in colorectal cancer

Hibiki Umeda, Kunitoshi Shigeyasu, Toshiaki Takahashi, Kazuya Moriwake, Yoshitaka Kondo, Kazuhiro Yoshida, Sho Takeda, Shuya Yano, Yuki Matsumi, Hiroyuki Kishimoto, Tomokazu Fuji, Kazuya Yasui, Hideki Yamamoto, Kosei Takagi, Masashi Kayano, Hiroyuki Michiue, Keiichiro Nakamura, Yoshiko Mori, Fuminori Teraishi, Hiroshi Tazawa, Yuzo Umeda, Shunsuke Kagawa, Ajay Goel, Toshiyoshi Fujiwara

Correction: Targeting SOST using a small‑molecule compound retards breast cancer bone metastasis

Lisha Sun, Yixiao Zhang, Guanglei Chen, Yaoting Ji, Qingtian Ma, Xinbo Qiao, Sijin Wu, Lin Zhou, Jiawen Bu, Xudong Zhu, Xiaoying Zhang, Xiaofan Jiang, Chao Liu, Xinnan Li, Yang Liu, Yongliang Yang, Caigang Liu

Lung-specific metastasis: the coevolution of tumor cells and lung microenvironment

Guixiu Xiao, Xinmin Wang, Zihan Xu, Yanyang Liu, Jing Jing

Transient intracellular expression of PD-L1 and VEGFR2 bispecific nanobody in cancer cells inspires long-term T cell activation and infiltration to combat tumor and inhibit cancer metastasis

Lei Zhang, Yunfeng Lin, Li Hu, Yanan Wang, Chaohua Hu, Xinyi Shangguan, Shuzhi Tang, Jincan Chen, Ping Hu, Zhe-Sheng Chen, Zun-Fu Ke, Zhuo Chen

Retraction Note: Dclk1, a tumor stem cell marker, regulates pro-survival signaling and self-renewal of intestinal tumor cells

  • Open Access
  • Retraction Note

Parthasarathy Chandrakesan, Jiannan Yao, Dongfeng Qu, Randal May, Nathaniel Weygant, Yang Ge, Naushad Ali, Sripathi M. Sureban, Modhi Gude, Kenneth Vega, Eddie Bannerman-Menson, Lijun Xia, Michael Bronze, Guangyu An, Courtney W. Houchen

Exploring molecular and cellular mechanisms of Pre-Metastatic niche in renal cell carcinoma

Xiao Zhou, Ruirui Li, Maode Lai, Chong Lai

LSD1 inhibition attenuates targeted therapy-induced lineage plasticity in BRAF mutant colorectal cancer

Christopher A. Ladaika, Averi Chakraborty, Ashiq Masood, Galen Hostetter, Joo Mi Yi, Heather M. O’Hagan

Emerging artificial intelligence-driven precision therapies in tumor drug resistance: recent advances, opportunities, and challenges

Yuan Mao, Dangang Shangguan, Qi Huang, Ling Xiao, Dongsheng Cao, Hui Zhou, Yi-Kun Wang

Advancing pancreatic cancer therapy by mesothelin-specific nanobody conjugation

Soyeon Yi, Kyunghee Noh, Hyeran Kim, Eunkyeong Jung, Suhyeon Kim, Jieun Lee, Kyeonghye Guk, Jinsol Choi, Eun-Kyung Lim, Seokho Kim, Hwangseo Park, Jung Hwa Lim, Cho-Rok Jung, Taejoon Kang, Juyeon Jung

The application of organoids in investigating immune evasion in the microenvironment of gastric cancer and screening novel drug candidates

Liuyue Kan, Ying Yu, Yaxue Wang, Lei Shi, Tingyuan Fan, Hui Chen, Chuanli Ren

Strategies to overcome tumour relapse caused by antigen escape after CAR T therapy

Yufei Lu, Fu Zhao

Epigenomic disorder and partial EMT impair luminal progenitor integrity in Brca1-associated breast tumorigenesis

  • Open Access
  • Research

Camille Landragin, Melissa Saichi, Marthe Laisné, Adeline Durand, Pacôme Prompsy, Renaud Leclere, Jérémy Mesple, Kyra Borgman, Amandine Trouchet, Marisa M. Faraldo, Aurélie Chiche, Anne Vincent-Salomon, Hélène Salmon, Céline Vallot

Therapy-induced senescence is a transient drug resistance mechanism in breast cancer

Eszter Bajtai, Csaba Kiss, Éva Bakos, Tamás Langó, Anna Lovrics, Éva Schád, Viktória Tisza, Károly Hegedűs, Péter Fürjes, Zoltán Szabó, Gábor E. Tusnády, Gergely Szakács, Ágnes Tantos, Sándor Spisák, József Tóvári, András Füredi

Multi‑omics analysis identifies different molecular subtypes with unique outcomes in early-stage poorly differentiated lung adenocarcinoma

  • Open Access
  • Research

Bing Liu, Wei Tao, Xuantong Zhou, Li-Di Xu, Yanrui Luo, Xin Yang, Qingjie Min, Miao Huang, Yuge Zhu, Xinrun Cui, Yaqi Wang, Tongyang Gong, Enli Zhang, Yu S. Huang, Weizhi Chen, Shi Yan, Nan Wu

Does side matter? Deciphering mechanisms that underpin side-dependent pathogenesis and therapy response in colorectal cancer

Harrison J. Boka, Rebekah M. Engel, Christine Georges, Paul J. McMurrick, Helen E. Abud

Targeting pyroptosis for cancer immunotherapy: mechanistic insights and clinical perspectives

Chen Huang, Jiayi Li, Ruiyan Wu, Yangqian Li, Chenliang Zhang

Lymph node macrophage-targeted interferon alpha boosts anticancer immune responses by regulating CD169-positive phenotype of macrophages

Ryo Fukuda, Yukio Fujiwara, Hitoshi Maeda, Cheng Pan, Yuki Minayoshi, Hiromu Yano, Yuki Mizuta, Mei Takano, Rin Yamada, Yoichi Saito, Kenshiro Hirata, Shuhei Imoto, Keishi Yamasaki, Kentaro Oniki, Junji Saruwatari, Masaki Otagiri, Hiroshi Watanabe, Yoshihiro Komohara, Toru Maruyama

Cancer-nervous system crosstalk: from biological mechanism to therapeutic opportunities

Sirui Huang, Jing Zhu, Linglu Yu, Yan Huang, Yue Hu

The anti-diabetic PPARγ agonist Pioglitazone inhibits cell proliferation and induces metabolic reprogramming in prostate cancer

Emine Atas, Kerstin Berchtold, Michaela Schlederer, Sophie Prodinger, Felix Sternberg, Perla Pucci, Christopher Steel, Jamie D. Matthews, Emily R. James, Cécile Philippe, Karolína Trachtová, Ali A. Moazzami, Nastasiia Artamonova, Felix Melchior, Torben Redmer, Gerald Timelthaler, Elena E. Pohl, Suzanne D. Turner, Isabel Heidegger, Marcus Krueger, Ulrike Resch, Lukas Kenner

A comprehensive overview of ovarian cancer stem cells: correlation with high recurrence rate, underlying mechanisms, and therapeutic opportunities

Hadi Alizadeh, Parastoo Akbarabadi, Alireza Dadfar, Mohammad Reza Tareh, Bahram Soltani

Advances in cancer immunotherapy: historical perspectives, current developments, and future directions

Meiyin Zhang, Chaojun Liu, Jing Tu, Min Tang, Milad Ashrafizadeh, Noushin Nabavi, Gautam Sethi, Peiqing Zhao, Shijian Liu

Correction: SPOP‑mediated ubiquitination and degradation of PDK1 suppresses AKT kinase activity and oncogenic functions

  • Open Access
  • Correction

Qiwei Jiang, Nana Zheng, Lang Bu, Xiaomei Zhang, Xiaoling Zhang, Yuanzhong Wu, Yaqing Su, Lei Wang, Xiaomin Zhang, Shancheng Ren, Xiangpeng Dai, Depei Wu, Wei Xie, Wenyi Wei, Yasheng Zhu, Jianping Guo

Protein lipidation in the tumor microenvironment: enzymology, signaling pathways, and therapeutics

  • Open Access
  • Review

Mengke Xu, Bo Xu

Targeting the HER2-ELF3-KRAS axis: a novel therapeutic strategy for KRASG13D colorectal cancer

Soo-Yeon Hwang, Yoojeong Seo, Seojeong Park, Seul-Ah Kim, Inhye Moon, Yi Liu, Seojeong Kim, Eun Seon Pak, Sehyun Jung, Hyeyoon Kim, Kyung-Hwa Jeon, Seung Hee Seo, Inyoung Sung, Heetak Lee, So-Yeon Park, Younghwa Na, Tae Il Kim, Youngjoo Kwon

N-glycosylation of PD-L1 modulates the efficacy of immune checkpoint blockades targeting PD-L1 and PD-1

Bar Kaufman, Muhammad Abu-Ahmad, Olga Radinsky, Eman Gharra, Tal Manko, Baisali Bhattacharya, Daniela Gologan, Nofar Erlichman, Tsipi Meshel, Yoav Nuta, Tomer Cooks, Moshe Elkabets, Adit Ben-Baruch, Angel Porgador

Profiling triple-negative breast cancer-specific super-enhancers identifies high-risk mesenchymal development subtype and BETi-Targetable vulnerabilities

Qing-shan Chen, Rui-zhao Cai, Yan Wang, Ge-hao Liang, Kai-ming Zhang, Xiao-Yu Yang, Dong Yang, De-Chang Zhao, Xiao-Feng Zhu, Rong Deng, Jun Tang

Dissecting small cell carcinoma of the esophagus ecosystem by single-cell transcriptomic analysis

  • Open Access
  • Research

Hao-Xiang Wu, Yu-Kun Chen, Ying-Nan Wang, Jia-Ying Chen, Shu-Jing Xiang, Ying Jin, Zi-Xian Wang, Chun-Yu Huang, Lu-Ping Yang, Ye He, Wen-Long Guan, Long Bai, Yan-Xing Chen, Min Wang, Chao-Ye Wang, Run-Jie Huang, Yue Huang, Jin-Ling Zhang, Zhi-Da Lv, Si-Qi Yang, Rui-Hua Xu, Qi Zhao, Feng Wang

Perioperative nivolumab and chemotherapy in locally advanced squamous cell carcinoma of the oesophagus: a randomized multicentre phase 2 study with circulating tumor DNA dynamics monitoring

Heng Jiao, Siyun Lin, Jianmin Gu, Dongxian Jiang, Peng Cui, Zhiliang Huang, Yong Fang, Hao Wang, Miao Lin, Han Tang, Tian Jiang, Guangyi Lin, Shaoyuan Zhang, Hao Yin, Fei Liang, Jingshu Wang, Xuning Fan, Fujun Qiu, Yang Yang, Zhigang Li, Bin Li, Jiaqing Xiang, Xuefeng Leng, Yongtao Han, Chengcheng Li, Luoyan Ai, Yingyong Hou, Guoqiang Wang, Zhihong Zhang, Shangli Cai, Tianshu Liu, Jun Yin, Lijie Tan

Death-ision: the link between cellular resilience and cancer resistance to treatments

Gustavo Baldassarre, Ivana L. de la Serna, François M. Vallette

SLAMF receptors: key regulators of tumor progression and emerging targets for cancer immunotherapy

Jia Li, Tao Fan, Di Wang, Chu Xiao, Ziqin Deng, Wenpeng Cai, Yu Ji, Chunxiang Li, Jie He

Correction: CircDIDO1 inhibits gastric cancer progression by encoding a novel DIDO1‑529aa protein and regulating PRDX2 protein stability

Yu Zhang, Jiajia Jiang, Jiayin Zhang, Han Shen, Maoye Wang, Zhen Guo, Xueyan Zang, Hui Shi, Jiayan Gao, Hui Cai, Xinjian Fang, Hui Qian, Wenrong Xu, Xu Zhang

Double-sided niche regulation in skin stem cell and cancer: mechanisms and clinical applications

Trang Thao Quoc Pham, Yung-Che Kuo, Wei-Ling Chang, Hao-Jui Weng, Yen-Hua Huang

Biofilm formation by the host microbiota: a protective shield against immunity and its implication in cancer

Elena Montanari, Giancarla Bernardo, Valentino Le Noci, Martina Anselmi, Serenella M. Pupa, Elda Tagliabue, Michele Sommariva, Lucia Sfondrini

LMTK3 regulation of EV biogenesis and cargo sorting promotes tumour growth by reducing monocyte infiltration and driving pro-tumourigenic macrophage polarisation in breast cancer

Mark Samuels, Christos Karakostas, Simoni Besta, Andrea Lauer Betrán, Katerina Tsilingiri, Charlotte Turner, Reza Shirazi Nia, Niloufar Poudine, Richard Goodyear, William Jones, Apostolos Klinakis, Georgios Giamas

Drug-induced tolerant persisters in tumor: mechanism, vulnerability and perspective implication for clinical treatment

Shujie Liu, Anfeng Jiang, Faqing Tang, Minghao Duan, Bin Li

GP73-dependent regulation of exosome biogenesis promotes colorectal cancer liver metastasis

Linfei Huang, Meng Wei, Huilong Li, Mingxin Yu, Luming Wan, Ruzhou Zhao, Qi Gao, Lijuan Sun, Xufeng Hou, Yunhai Mo, Qing Huang, Lan Zhen, Xiaopan Yang, Jingfei Li, Nan Wang, Chundong Zhang, Haoran Jin, Li Zhou, Yixin Xu, Haotian Lin, Xuhui Zhang, Boan Li, Yue Han, Jing Yuan, Rui Zhang, Feixiang Wu, Hui Zhong, Congwen Wei

NAP1L1 degradation by FBXW7 reduces the deubiquitination of HDGF-p62 signaling to stimulate autophagy and induce primary cisplatin chemosensitivity in nasopharyngeal carcinoma

Bin Gong, Yahui Liu, Weiwei Yan, Chao Cheng, Huiling Yang, Jiyu Huang, Qing Liu, Yuyan Liu, Jiankang Guo, Xiaojie Deng, Beixian Zhou, Dayong Zheng, Xiong Liu, Zhen Liu, Weiyi Fang

Targeting metastasis in paediatric bone sarcomas

Emma C. Bull, Archana Singh, Amy M. Harden, Kirsty Soanes, Hala Habash, Lisa Toracchio, Marianna Carrabotta, Christina Schreck, Karan M. Shah, Paulina Velasco Riestra, Margaux Chantoiseau, Maria Eugénia Marques Da Costa, Gaël Moquin-Beaudry, Pan Pantziarka, Edidiong Akanimo Essiet, Craig Gerrand, Alison Gartland, Linda Bojmar, Anna Fahlgren, Antonin Marchais, Evgenia Papakonstantinou, Eleni M. Tomazou, Didier Surdez, Dominique Heymann, Florencia Cidre-Aranaz, Olivia Fromigue, Darren W. Sexton, Nikolas Herold, Thomas G. P. Grünewald, Katia Scotlandi, Michaela Nathrath, Darrell Green

Co-targeting of epigenetic regulators and BCL-XL improves efficacy of immune checkpoint blockade therapy in multiple solid tumors

Yaiza Senent, Vicente Fresquet, Victoria Jiménez, Karmele Valencia, Francisco Exposito, Patxi San Martín-Úriz, Gracián Camps, Eva Fernández-Pierola, Borja Ruiz-Fernández de Córdoba, Marisol González-Huarriz, Ibon Tamayo, Ana Remírez, Haritz Moreno, Diego Serrano, Daniel Ajona, Marta M. Alonso, Fernando Lecanda, Antonio Pineda-Lucena, Felipe Prósper, Miguel F. Sanmamed, Alfonso Calvo, Jose A. Martinez-Climent, Ruben Pio

Nuclear receptors as novel regulators that modulate cancer radiosensitivity and normal tissue radiotoxicity

Xiaochen Meng, Xiaoqian Li, Yi Gao, Shuyu Zhang

Clinical approaches to overcome PARP inhibitor resistance

  • Open Access
  • Review

Yutian Zou, Hanqi Zhang, Pangzhou Chen, Jiayi Tang, Siwei Yang, Christophe Nicot, Ziyun Guan, Xing Li, Hailin Tang

Targeting BATF2-RGS2 axis reduces T-cell exhaustion and restores anti-tumor immunity

Xuyu Gu, Chanchan Gao, Xiangyu Su, Yaoyao Zhu, Qiyu Fang, Jia Yu, Ziming Wang, Deping Zhao, Wentian Zhang

Loss of TACC2 impairs chemokine CCL3 and CCL4 expression and reduces response to anti-PD-1 therapy in soft tissue sarcoma

Jing Yang, Xiuxia Lu, Qiyan Cai, Mengmeng Liu, Tianliang Xia, Dongchun Hong, Liyuan Le, Xinke Zhang, Xing Zhang

Current AI technologies in cancer diagnostics and treatment

Ashutosh Tiwari, Soumya Mishra, Tsung-Rong Kuo

Precision nanomedicine: navigating the tumor microenvironment for enhanced cancer immunotherapy and targeted drug delivery

Hussein Sabit, Timothy M. Pawlik, Faisal Radwan, Mohamed Abdel-Hakeem, Shaimaa Abdel-Ghany, Al-Hassan Soliman Wadan, Mokhtar Elzawahri, Ahmed El-Hashash, Borros Arneth

Reprogrammed immuno-metabolic environment of cancer: the driving force of ferroptosis resistance

  • Open Access
  • Review

Sramana Bhowmick, Saptak Banerjee, Viji Shridhar, Susmita Mondal

Establishing 3D organoid models from patient-derived conditionally reprogrammed cells to bridge preclinical and clinical insights in pancreatic cancer

Jin Su Kim, Chan Hee Park, Eunyoung Kim, Hee Seung Lee, Jinyoung Lee, Jeehoon Kim, Eun Hee Kam, Sanghee Nam, Moon Jae Chung, Jeong Youp Park, Seung Woo Park, Sangwoo Kim, Galam Leem, Seungmin Bang

GUIDE: a prospective cohort study for blood-based early detection of gastrointestinal cancers using targeted DNA methylation and fragmentomics sequencing

  • Open Access
  • Research

Ao Huang, De-Zhen Guo, Zhi-Xi Su, Yun-Shi Zhong, Liang Liu, Zhi-Guo Xiong, Dong-Li He, Bin Yan, Quan-Lin Li, Zhen Feng, Wen-Quan Wang, Pin-Xiang Lu, Meng-Jiang He, Zhi-Peng Qi, Qi Guo, Jian-Wen Cheng, Shi-Yu Zhang, Wei Guo, Qing Li, Guo-Yong Lin, Hui-Chuan Sun, Shuang-Jian Qiu, Qi-Ye He, Jia Fan, Ajay Goel, Rui Liu, Gang Jin, Xin-Rong Yang, Jian Zhou

Integrative multi-omics analysis reveals the LncRNA 60967.1–PLCD4–ATRA axis as a key regulator of colorectal cancer progression and immune response

Yiyi Chen, Ningning Zhao, Lingna Xu, Xiya Jia, Fang Liu, Jian Huang, Xuhua Li, Yunfei Wang, Chuanxi Lai, Yanbin Shen, Fei Wang, Yiming Lv, Xuefeng Huang, Fan Zhang, Hongcang Gu, Sheng Dai

The EGR1-mediated lncRNA TENM3-AS1 potentiates gastric cancer metastasis via reprogramming fatty acid metabolism

Yuhui Tang, Baiwei Zhao, Wanchuan Wang, Haoming Chen, Junsheng Zhang, Yi Xie, Yongming Chen, Feizhi Lin, Yuanfang Li, Xiaohui Zhai, Wen Zhou

Exosomes in cancer nanomedicine: biotechnological advancements and innovations

  • Open Access
  • Review

Jacky J. J. Liu, Duanrui Liu, Sally K. Y. To, Alice S. T. Wong

Epithelial-to-mesenchymal transition (EMT) and cancer metastasis: the status quo of methods and experimental models 2025

Heike Allgayer, Samikshya Mahapatra, Barnalee Mishra, Biswajit Swain, Suryendu Saha, Sinjan Khanra, Kavita Kumari, Venketesh K. Panda, Diksha Malhotra, Nitin S. Patil, Jörg H. Leupold, Gopal C. Kundu

Targeting PERP promotes anti-tumor immunity in HNSCC by regulating tumor immune microenvironment and metabolic homeostasis

  • Open Access
  • Research

Xueying Wang, Yuxi Tian, Xiaohong Wu, Yewen Zhu, Huihong Chen, Zeyao Wang, Zihan Liu, Jiaqi Tan, Zhaoyu Pan, Jiaoyan Cao, Zhenjiang Li, Xin Zhang, Zhongjie Shi, Juncheng Wang, Tong Liu

Nanomedicine in Cancer Therapeutics: Current Perspectives from Bench to Bedside

  • Open Access
  • Review

K. M. Abdullah, Gunjan Sharma, Ajay P. Singh, Jawed A. Siddiqui

CREPT is required for the metastasis of triple-negative breast cancer through a co-operational-chromatin loop-based gene regulation

Jianghua Li, Lu Xu, Jiayu Wang, Xuning Wang, Yuting Lin, Alex Yutian Zou, Fangli Ren, Yinyin Wang, Jun Li, Zhijie Chang

Wnt/β-catenin mediated signaling pathways in cancer: recent advances, and applications in cancer therapy

Xiuzhu Wu, Haiying Que, Qingfang Li, Xiawei Wei

Differential susceptibility and role for senescence in CART cells based on costimulatory domains

  • Open Access
  • Research

Ismail Can, Elizabeth L. Siegler, Olivia L. Sirpilla, Claudia Manriquez-Roman, Kun Yun, Carli M. Stewart, Jennifer M. Feigin, Makena L. Rodriguez, Omar L. Gutierrez-Ruiz, Ekene J. Ogbodo, Truc N. Huynh, Brooke L. Kimball, Long K. Mai, Mehrdad Hefazi, Lionel Kankeu Fonkoua, Hong Xia, Imene Hamaidi, Berke Alkan, Fatih Sezer, H. Atakan Ekiz, R. Leo Sakemura, Saad S. Kenderian

The tumor microenvironment in hepatocellular carcinoma: mechanistic insights and therapeutic potential of traditional Chinese medicine

Xiaojun Su, Xiuli Yan, Hui Zhang

Correction: Proteogenomic characterization of molecular and cellular targets for treatment‑resistant subtypes in locally advanced cervical cancers

Do Young Hyeon, Dowoon Nam, Hye‑Jin Shin, Juhee Jeong, Eunsoo Jung, Soo Young Cho, Dong Hoon Shin, Ja‑Lok Ku, Hye Jung Baek, Chong Woo Yoo, Eun‑Kyung Hong, Myong Cheol Lim, Sang‑Jin Lee, Young‑Ki Bae, Jong Kwang Kim, Jingi Bae, Wonyoung Choi, Su‑Jin Kim, Seunghoon Back, Chaewon Kang, Inamul Hasan Madar, Hokeun Kim, Suhwan Kim, Duk Ki Kim, Jihyung Kang, Geon Woo Park, Ki Seok Park, Yourae Shin, Sang Soo Kim, Keehoon Jung, Daehee Hwang, Sang‑Won Lee, Joo‑Young Kim

Anlotinib combined with benmelstobart as a chemo-free first-line treatment in advanced esophageal squamous cell carcinoma: an exploratory multicenter, single-arm phase II clinical trial

  • Open Access
  • Research

Xiangrui Meng, Xiuli Yang, Yonggui Hong, Wenkang Wang, Zhiye Zhang, Jin Xia, Yunfang Chen, Yue Zhou, Taiying Lu, Min Song, Zhengzheng Shan, Tao Wu, Weilong Wu, Ling Shen, Lulu Guan, Mingying Ma, Lisen Wang, Xi Luo, Dao Xin, Yihui Ma, Guozhong Jiang, Yu Qi, Binghua Jiang, Daoyu Zhang, Biao Hu, Xiaoying Wu, Zuofu Peng, Feng Wang

Enhancing radiotherapy-induced anti-tumor immunity via nanoparticle-mediated STING agonist synergy

Qian Zeng, Min Liu, Ziqi Wang, Rongrong Zhou, Kelong Ai

Single-cell transcriptome reveals the reprogramming of immune microenvironment during the transition from MASH to HCC

Yu Huang, Ying Xie, Yuqing Zhang, Zhemian Liu, Weihua Jiang, Yingying Ye, Jiale Tang, Zhenhua Li, Zhinan Yin, Xue-Jia Lin

Demystifying the cGAS-STING pathway: precision regulation in the tumor immune microenvironment

  • Open Access
  • Review

Qingyang Wang, Yang Yu, Jing Zhuang, Ruijuan Liu, Changgang Sun

Single-cell multi-omics reveals that FABP1 + renal cell carcinoma drive tumor angiogenesis through the PLG-PLAT axis under fatty acid reprogramming

Yiqiu Wang, Yingchun Liang, Min Li, Jiayi Lu, Sian Zhou, Yaoyu Yu, Changwei Yang, Xinhuang Hou

Aurora kinases signaling in cancer: from molecular perception to targeted therapies

Prerna Vats, Chainsee Saini, Bhavika Baweja, Sandeep K. Srivastava, Ashok Kumar, Atar Singh Kushwah, Rajeev Nema

Biologically targeted dual adaptive and innate nano-Immunotherapy for clear cell renal cell carcinoma treatment

Kin Man Au, Siqing Li, Tian Zhang, Andrew Z. Wang

Correction: Targeting BATF2-RGS2 axis reduces T-cell exhaustion and restores anti-tumor immunity

  • Open Access
  • Correction

Xuyu Gu, Chanchan Gao, Xiangyu Su, Yaoyao Zhu, Qiyu Fang, Jia Yu, Ziming Wang, Deping Zhao, Wentian Zhang

Extracellular vesicles: the “Trojan Horse” within breast cancer host microenvironments

Yue Kang, Ling’ao Meng, Shi Bai, Shenglong Li

Correction: THBS2 + cancer-associated fibroblasts promote EMT leading to oxaliplatin resistance via COL8A1-mediated PI3K/AKT activation in colorectal cancer

  • Open Access
  • Correction

Xing Zhou, Jiashu Han, Anning Zuo, Yuhao Ba, Shutong Liu, Hui Xu, Yuyuan Zhang, Siyuan Weng, Zhaokai Zhou, Long Liu, Peng Luo, Quan Cheng, Chuhan Zhang, Yukang Chen, Dan Shan, Benyu Liu, Shuaixi Yang, Xinwei Han, Jinhai Deng, Zaoqu Liu

CircERC1 facilitates chemoresistance through inhibiting pyroptosis and remodeling extracellular matrix in pancreatic cancer

Jian Zhang, Shengnan Lv, Xinyu Peng, Huan Liu, Jianxiong Guo, Ziyu Liu, Tongjia Chu, Han Liu, Kehang Duan, Fengxiang Lou, Yubo Chi, Bing Gao, Yan Liu, Feng Wei

STK3 is a transcriptional target of YAP1 and a hub component in the crosstalk between Hippo and Wnt signaling pathways during gastric carcinogenesis

Fuda Xie, Yang Lyu, Bonan Chen, Hoi Wing Leung, Peiyao Yu, Tiejun Feng, Canbin Fang, Alvin H.K. Cheung, Bin Zhou, Jianhui Jiang, Ge Zhang, Dazhi Xu, Liang Li, Chen Jiang, Jianwu Chen, Zhaocai Zhou, Liwei An, Bing Huang, Kangmin Zhuang, Xiaobei Luo, Kam Tong Leung, Ching Hei To, Brigette BY Ma, Chi Chun Wong, William KK Wu, Jun Yu, Ka Fai To, Wei Kang

IFITM3 enhances immunosensitivity via MHC-I regulation and is associated with the efficacy of anti-PD-1/-L1 therapy in SCLC

  • Open Access
  • SCLC
  • Research

Yanan Cui, Tianyu Qiu, Jiale Wang, Xinyu Liu, Libo Luo, Jizhong Yin, Xinxin Zhi, Wanying Wang, Gaohua Feng, Chunyan Wu, Zhikai Zhao, Hua Zhang, Fei Li, Fengying Wu, Shengxiang Ren

Non-canonical ALK7 pathways promote pancreatic cancer metastasis through β-catenin/MMP-mediated basement membrane breakdown and intravasation

Anna M. Kolarzyk, Yujin Kwon, Elizabeth Oh, Keng-Jung Lee, Su-Yeon Cho, Issahy Cano, Renhao Lu, Tae Joon Kwak, Jaehyun Lee, Gigi Wong, Andrew H. Kim, Omar Gandarilla, Manuel Hidalgo, Won Kyu Kim, Esak Lee

Targeting CD30L in B-cell non-Hodgkin lymphoma: novel peptide conjugates and their therapeutic potential

Chaowen Shi, Tianzheng Lan, Yufeng Gao, Zhiquan Liang, Yafei Zhang, Yanbei Tu, Hanqing Liu, Zhigang Tu

Promising therapeutic efficacy and safety of a novel integrin α6-targeting peptide-drug conjugate in lung adenocarcinoma

  • Open Access
  • Research

Wuyou Gao, Qiaoli Wang, Shibing Li, Wanqi Chen, Bin Luo, Kaili Xie, Huaze Liao, Leqi Zhong, Youfang Chen, Zhesheng Wen, Guokai Feng

Advancing CAR-based cell therapies for solid tumours: challenges, therapeutic strategies, and perspectives

  • Open Access
  • Review

Sarkar Sardar Azeez, Raya Kh. Yashooa, Shukur Wasman Smail, Abbas Salihi, Azhin Saber Ali, Sami Mamand, Christer Janson

M6A-Methylated circRAPGEF5 drives lung adenocarcinoma progression and metastasis via IGF2BP2/NUP160-mediated autophagy suppression

Liqun Ling, Tianqi Hu, Chenkang Zhou, Yingjie Dai, Lijuan Hu, Yuxin Chen, Zhaoting Hu, Kate Huang, Jie Chen, Yumin Wang

Post-translational modifications of cancer immune checkpoints: mechanisms and therapeutic strategies

Haiqing Jia, Lei Jiang, Xiaoyu Shen, Huinan Ye, Xinguang Li, Liwei Zhang, Yanyan Hu, Dandan Song, Hui Jia, Zhe Wang

Bridging the tumor microenvironment: the pivotal role of cancer-associated fibroblasts in tumor cachexia development

Guoming Chen, Bonan Chen, Yilin Wu, Hao Nie, Zilan Zhong, Shuyang Yang, Rui Qin, Wei Kang, Cheng Zhang, Ning Wang, Yibin Feng

The tumor microbiome in cancer progression: mechanisms and therapeutic potential

  • Open Access
  • Review

Wanting Zhang, Yuhang Xiang, He Ren, Yilin Liu, Qi Wang, Mengdi Ran, Wanting Zhou, Lu Tian, Xianhui Zheng, Cong Qiao, Yifei Liu, Meisi Yan

Chronic stress: a fourth etiology in tumorigenesis?

Asra khan, Mengqiu Song, Zigang Dong

Double vulnerability of active-NRF2 lung squamous cell carcinoma to NRF2 and TRIM24

  • Open Access
  • Research

Miriam Sánchez-Ortega, Antonio Garrido, Lorena Sanz, Rafael Torres-Pérez, Carmen Hernandez, Alvaro Gutierrez-Uzquiza, Ming Sound Tsao, Ana Clara Carrera

From preneoplastic lesion to heterogenous tumor: recent insights into hepatoblastoma biology and therapeutic opportunities

Jun Yang, Andrew M. Davidoff, Andrew J. Murphy

CircABCA1 promotes ccRCC by reprogramming cholesterol metabolism and facilitating M2 macrophage polarization through IGF2BP3-mediated stabilization of SCARB1 mRNA

  • Open Access
  • Research

Hao Ning, Yan Jiang, Binbin Li, Junwu Ren, Cong Wang, Ling Wei, Linfei Li, Ai Ran, Zuozhang Li, Jiao Li, Wei Li, Yongquan Wang, Bin Xiao

Application of photodynamic activation of prodrugs combined with phototherapy in tumor treatment

Yining Du, Jingyuan Zhao, Shuai Li, Hong Yuan

NSUN2-mediated cytosine-5 methylation of FSP1 protects acute myeloid leukemia cells from ferroptosis

Wenle Ye, Yanchun Zhao, Yutong Zhou, Jiansong Huang, Xiao He, Zhixin Ma, Xin Huang, Chao Hu, Fenglin Li, Qing Ling, Huafeng Wang, Hongyan Tong, Jie Sun, Jie Jin

An immune responsive tumor microenvironment imprints into PBMCs and predicts outcome in advanced pancreatic cancer: lessons from the PREDICT trial

Anton Lahusen, Manfred P. Lutz, Rui Fang, Martina Kirchner, Sarah Albus, Klaus Kluck, Meinolf Karthaus, Andreas Schwarzer, Gabriele Siegler, Alexander Kleger, Thomas J. Ettrich, Alexander Becher, Sabine Höfling, Jens T. Siveke, Jan Budczies, Andrea Tannapfel, Albrecht Stenzinger, Phyllis Fung-Yi Cheung, Tim Eiseler, Thomas Seufferlein

Primary and secondary metastatic dissemination: multiple routes to cancer-related death

D. Sparrer, R. Blazquez, F. Keil, S. Einhell, F. Lüke, S. Uderhardt, C. Gerner, C.H.R. Wendl, M. Proescholdt, C. Schulz, A. Kandulski, S. Haferkamp, H.J. Schlitt, T. Bäuerle, K. Franze, R. Mayr, M. Rechenmacher, P. Hau, D. Hirsch, D. Heudobler, K. Evert, T. Pukrop

Metabolic reprogramming promotes apoptosis resistance in acute lymphoblastic leukemia through CASP3 lactylation

Zhi Lin, Fei Long, Jiao Liu, Rui Kang, Daniel J. Klionsky, Guido Kroemer, Daolin Tang, Minghua Yang

PEGylated PLGA nanoparticles: unlocking advanced strategies for cancer therapy

Prashant Kesharwani, Vishal Kumar, Khang Wen Goh, Garima Gupta, Abdulrhman Alsayari, Shadma Wahab, Amirhossein Sahebkar

Hijacking homeostasis: the brain-body neural circuitry in tumor pathogenesis and emerging therapeutic frontiers

  • Open Access
  • Review

Yong-Fei Wang, Zi-Kai Dong, Wei-Lin Jin

Advances and obstacles of T cell-based immunotherapy in gynecological malignancies

Xi Zhao, Jialing Ran, Shenglong Li, Jinxin Chen

Targeting FGFR4 abrogates HNF1A-driven metastasis in pancreatic ductal adenocarcinoma

Katherine J. Crawford, Kennedy S. Humphrey, Eduardo Cortes, Jianxin Wang, Vishnu Kumarasamy, Yin Wan, Mark D. Long, Michael E. Feigin, Agnieszka K. Witkiewicz, Karen M. Mann, Erik S. Knudsen, Ethan V. Abel

Traditional Chinese medicine in the treatment of breast Cancer

Peng Song, Tongtong Liu, Yinfang Zhang, Tingting Shao, Rongkun Li, Chaoxia An, Lu-Qi Cao, Zhe-Sheng Chen, Wenjing Guo, Dongzhu Duan

Metabolic checkpoints in immune cell reprogramming: rewiring immunometabolism for cancer therapy

Yingying Lv, Zongshang Li, Shutong Liu, Zhaokai Zhou, Jinling Song, Yuhao Ba, Siyuan Weng, Anning Zuo, Hui Xu, Peng Luo, Quan Cheng, Chuhan Zhang, Jingyuan Ning, Yukang Chen, Yuyuan Zhang, Zaoqu Liu, Xinwei Han

Unraveling the glyco-immunity nexus in pancreatic cancer

Christabelle Rajesh, Richard D. Cummings, Prakash Radhakrishnan

Bispecific antibodies: unleashing a new era in oncology treatment

Lin Shui, Dan Wu, Kaixuan Yang, Chuntang Sun, Qingli Li, Rutie Yin

Cellular senescence in cancer: from mechanism paradoxes to precision therapeutics

Tiejun Feng, Fuda Xie, Leo M.Y. Lee, Zhiqiang Lin, Yifan Tu, Yang Lyu, Peiyao Yu, Jialin Wu, Bonan Chen, Ge Zhang, Gary M.K. Tse, Ka Fai To, Wei Kang

CircRNA aptamer targets IGF2BP2 to overcome acquired BETi resistance

Christophe Nicot

Integrating neuroscience and oncology: neuroimmune crosstalk in the initiation and progression of digestive system tumors

  • Open Access
  • Review

Haonan Sun, Tao Wang, Xiangyan Jiang, Mingdou Li, Xiaoe He, Yong Ma, Xiangkai Li, Weilin Jin, Zuoyi Jiao

Neurotransmitters: an emerging target for therapeutic resistance to tumor immune checkpoint inhibitors

Jiyuan Yang, Yu Wu, Xinhui Lv, Sicong Liu, Ziwen Yuan, Yafang Chen, Xiangyu Ding, Zhong Li, Xudong Wang

Jab1 regulates HRR mRNA stability to modulate PARP inhibitor sensitivity in triple-negative breast cancer

Xin Peng, Yingying Wang, Zixiang Yu, Shengfan Huang, Shaolu Zhang, Zhenxing Zhong, Yongzhe Wang, Shanshan Liu, Kailin Wang, Christophe Nicot, Francois X. Claret, Dexin Kong

CircZFR/YTHDF3 axis drives lymph node metastasis in cervical cancer via FASN translation

Mingyi Zhou, Yan Gao, Yong Zhang, Lian He, Bo Gao, Yue Zhang, Francois X. Claret, George A. Calin, Danbo Wang

Oxidative stress in cancer: from tumor and microenvironment remodeling to therapeutic frontiers

  • Open Access
  • Review

Xisong Liang, Jiadi Weng, Zhongyi You, Yang Wang, Jie Wen, Zhiwei Xia, Shaorong Huang, Peng Luo, Quan Cheng

Biomolecular phase separation in tumorigenesis: from aberrant condensates to therapeutic vulnerabilities

  • Open Access
  • Review

Lan Hu, Zikun Huang, Zhaoyong Liu, Ying Zhang

Single-cell multi-omics in cancer immunotherapy: from tumor heterogeneity to personalized precision treatment

Jiayuan Le, Yating Dian, Deze Zhao, Ziyu Guo, Zehao Luo, Xiang Chen, Furong Zeng, Guangtong Deng

The application of organoids in treatment decision-making for digestive system cancers: progress and challenges

Yufei Wang, Limin Zhang, Louis Zizhao Wang, Yang Cao, Lulu Huang, Gautam Sethi, Xiaoguang Chen, Lingzhi Wang, Boon-Cher Goh

Retraction Note: m6A demethylase ALKBH5 inhibits pancreatic cancer tumorigenesis by decreasing WIF-1 RNA methylation and mediating Wnt signaling

Bo Tang, Yihua Yang, Min Kang, Yunshan Wang, Yan Wang, Yin Bi, Songqing He, Fumio Shimamoto

Advances in novel cell death mechanisms in breast cancer: intersecting perspectives on ferroptosis, cuproptosis, disulfidptosis, and pyroptosis

Zhengjun Jing, Wenqin Huang, Jun Mei, Sudhanshu Bhushan, Xinhong Wu, Chengbiao Yan, Hongmei Zheng, Yalong Yang

Engineered iron oxide nanoplatforms: reprogramming immunosuppressive niches for precision cancer theranostics

Chao Yang, Shenglong Li, Liming Wang

Correction: Bridging the tumor microenvironment: the pivotal role of cancer-associated fibroblasts in tumor cachexia development

Guoming Chen, Bonan Chen, Yilin Wu, Hao Nie, Zilan Zhong, Shuyang Yang, Rui Qin, Wei Kang, Cheng Zhang, Ning Wang, Yibin Feng

Retraction Note: Long non-coding RNA PVT1 promotes tumor progression by regulating the miR-143/HK2 axis in gallbladder cancer

Jianan Chen, Yan Yu, Hua Li, Qiuyue Hu, Xiaolong Chen, Yuting He, Chen Xue, Fang Ren, Zhigang Ren, Juan Li, Liwen Liu, Zhenfeng Duan, Guangying Cui, Ranran Sun

Evolution of direct RAS inhibitors: from undruggable target to clinical breakthroughs

  • Open Access
  • NSCLC
  • Review

Xia Wang, Jing Wu, Aotian Xiao, Jie Wang, Jun Tian

Multifunctional gold nanoparticles: bridging detection, diagnosis, and targeted therapy in cancer

Lianting Zhuang, Yi Lian, Tiantong Zhu

Epigenetic modification of cuproptosis by non-coding RNAs in cancer drug resistance

Fei Du, Lu Tang, Fang Wang, Xian Jiang, Junxin Li, Guojun Wang, Zhuo Zhang

The role of acetylcholine and its receptors in tumor immune regulation: mechanisms and potential therapeutic targets

  • Open Access
  • Review

Chunyu Zhang, Xiangdong Guo, Yanan Wang, Shuo Zhang, Zhihua Wang

​​The immune microenvironment of pathogen-associated cancers and current clinical therapeutics

Xiao-Yu Wei, Hui-Jing Feng, Ying-Yin Zhu, Shi-Jing Guo, Hong Wang, Ming Li, Qi Mei

Efficacy and safety of TAS-102 plus Surufatinib in third and later line metastatic pancreatic cancer: a prospective, single center and biomarker exploratory, phase II study

Yunxin Lu, Qingguang Lin, Yongxin Mo, Furong Liu, Mengwei Zhang, Runjie Huang, Yun Wang, Yinnan Wang, Zhiqiang Wang, Huiyan Luo, Guifang Guo, Jianwen Chen, Yu Liu, Mingming He, Fenghua Wang, Feng Wang, Dongsheng Zhang

Decoding the ubiquitin network: molecular mechanisms and therapeutic vulnerabilities for precision radio-sensitization in cancer

Fu-Ying Zhao, Li-Ye Shi, Lu-Jiao Yu, Si-Qi Wang, Chu-Yao Sun, Na Zhang, Hua-Qin Wang

P23 acts as a negative regulator of ferroptosis in NSCLC by blocking GPX4 degradation via chaperone-mediated autophagy

  • Open Access
  • NSCLC
  • Research

Junlin Chen, Yulin Peng, Meirong Zhou, Yilin Che, Shilei Zhao, Chengjian He, Wen Zhang, Xiangge Tian, Wenhao Zhang, Zhe Liu, Minghao Zhou, Guobiao Liang, Xiaokui Huo, Yan Wang, Zhenlong Yu, Xiaochi Ma

Lipid reprogramming and ferroptosis crosstalk in clear cell renal cell carcinoma: metabolic vulnerabilities and therapeutic targeting

Qing Deng, Yu Ji, Jian Liu, Tao Wen

Reprogramming cellular senescence and aging clocks for advanced cancer immunotherapy

Huiting Yang, Dong Liu, Liewang Qiu, Rui Wang, Chuchu Zhang, Danqing Yu, Qingping Zhong, Nitta Yuki, Zhentao Song, Taotao Zhu, Haixing Ju, Weifeng Hong, Ji Zhu

Hsa_circ_0038737 promotes PARPi resistance in castration-resistant prostate cancer via IGF2BP3-mediated DNPH1 mRNA stabilization

Zhongyuan Wang, Qintao Ge, Aihetaimujiang Anwaier, Shiwei Liu, Xi Tian, Zihao Zhang, Tao Feng, Zhe Hong, Dingwei Ye, Wenhao Xu, Xiaojian Qin

BRD9-p53-E2F1 circuit orchestrates cell growth and DNA damage repair in gastric cancer

Qingqing Zhou, Qi Wang, Yantao Duan, Chi Zhang, Tengfei Liu, Hengrui Liu, Mindi Zhao, Zhihuang Hu

Microbiome-metabolome interplay in pancreatic cancer progression: insights from multi-omics analysis

Dong Luo, Qizhen Chen, Yixiong Li, Jianbo Yang, Yongguang Tao, Liandong Ji, Xuejun Gong

HPGD induces ferroptosis and autophagy to suppress esophageal squamous cell carcinoma through the LXA4–ERK1/2–U2AF2–TFRC axis

  • Open Access
  • Research

Tianyun Ma, Xiamei Guo, Jueying Zhao, Chenlong Wang, Xiaojuan Yu, Rongliang Mo, Zhuoying Han, Lulu Feng, Longfei Liu, Weiyong Yu, Fangyi Xu, Li Zhang, Qilong Wang, Chao Luo

Circulating tumor cells: mechanisms and clinical significance in colorectal cancer metastasis

Xuanyu Ren, Mei Song, Xianzhi Liu, Weiling He

A circRNA promotes esophageal squamous cell carcinoma progression by inhibiting TRIM25-mediated degradation of IGF2BP family members

  • Open Access
  • Research

Shuangyan Tan, Yue Ming, Jiawei Guo, Wenrong Liu, Hulin Ma, Yu Liu, Zhijie Xu, A-Lai Gu-Ha, Lunzhi Dai, Yi-Dan Lin, Yong Peng

Non-coding RNAs in gastric cancer: mechanisms and therapeutic prospects

Zhifei Han, Wenjuan Liu, Yigao Zhu, Yinggang Sun, Dong Sun, Ruyue Jia, Yanting Yang, Houbao Qi, Long Zhang, Yanfei Huo, Nasha Zhang, Jie Chai, Ming Yang

MALAT1 as a molecular driver of tumor progression, immune evasion, and resistance to therapy

Amirreza Bitaraf, Alireza Zafarani, Pardis Jahandideh, Benyamin Hakak-Zargar, Atousa Haghi, Golareh Asgaritarghi, Sadegh Babashah

Overcoming resistance to anti-PD-L1 immunotherapy: mechanisms, combination strategies, and future directions

Kartik Mandal, Ganesh Kumar Barik, Manas Kumar Santra

Exosome-mediated metabolic reprogramming: effects on thyroid cancer progression and tumor microenvironment remodeling

Shouhua Li, Hengtong Han, Kaili Yang, Xiaoxiao Li, Libin Ma, Ze Yang, Yong-xun Zhao

Microplastics as emerging carcinogens: from environmental pollutants to oncogenic drivers

  • Open Access
  • Review

Sarvesh Kumar Mishra, Tapojyoti Sanyal, Pritha Kundu, Rupesh Kumar, Dipanjan Ghosh, Gopal Chakrabarti, Nilabja Sikdar, Sayan Bhattacharya, Santanu Paul, Amlan Das

Immunometabolism: crosstalk with tumor metabolism and implications for cancer immunotherapy

Huiru Zhang, Jialiang Fan, Deyang Kong, Yu Sun, Qi Zhang, Renshen Xiang, Shuaibing Lu, Wenjing Yang, Lin Feng, Haizeng Zhang

Emerging role of cancer-associated fibroblasts in the premetastatic niche

Shuaixi Yang, Ying Guo, Jiachi Jia, Wenming Cui, Xinhao Zhang, Yuhang Wang, Zhiyuan Xie, Yingshuai Fang, Xianfei Ding, Lei Chang, Ying Liu

Advances in RNA-based cancer therapeutics: pre-clinical and clinical implications

Yubo Yan, Shuang Liu, Jie Wen, Yunlong He, Chenyang Duan, Noushin Nabavi, Milad Ashrafizadeh, Gautam Sethi, Lubin Liu, Rong Ma

Medical importance and pharmacokinetics of gold nanoparticles in the human body

Priyanka Singh, Abhayraj S. Joshi, Hina Singh, Ivan Mijakovic

Harnessing exDNA for precision exatecan delivery in cancer: a novel antibody-drug conjugate approach

Zaira Ianniello, Huimei Lu, Elias Quijano, Daniel A. Colón-Ríos, Madison Rackear, Venu Bommireddy, Dale L. Ludwig, Zhiyuan Shen, Peter M. Glazer

Turning cold tumors into hot tumors to ignite immunotherapy

  • Open Access
  • Review

Yuan-Tong Liu, Yun-Long Wang, Shuo Wang, Jia-Jun Li, Wei He, Xin-Juan Fan, Xiang-Bo Wan

Purine metabolism: a pan-cancer metabolic dysregulation across circulation and tissues

  • Open Access
  • Research

Mengjie Yu, Cheng Liu, Minmin Cao, Dou Yang, Tongshan Wang, Jing Xu, Danxia Zhu, Guangji Wang, Jiye Aa, Wei Zhu

Thyroid hormone receptor beta signaling is a targetable driver of prostate cancer growth

Aleksandra Fesiuk, Daniel Pölöske, Elvin D. de Araujo, Geordon A. Frere, Timothy B. Wright, Gary Tin, Yasir S. Raouf, Olasunkanmi O. Olaoye, Ji Sung Park, Nicolas Blavet, Boris Tichý, Michaela Schlederer, Sandra Högler, Michael Wolf, Cécile Philippe, Osman Aksoy, Adam Varady, Alejandro Medaglia Mata, Maxim Varenicja, Boglárka Szabó, Theresa Weiss, Gabriel Wasinger, Torben Redmer, Heidi A. Neubauer, Martin Susani, Clemens P. Spielvogel, Jing Ning, Maik Dahlhoff, Martin Schepelmann, Richard Kennedy, Richard Moriggl, Geoffrey Brown, Jenny Persson, Christopher Gerner, Vojtech Bystry, Oldamur Hollóczki, David M. Heery, Patrick T. Gunning, Olaf Merkel, Brigitte Hantusch#, Lukas Kenner

Harnessing ovarian cancer ascites for translational science: models, biomarkers, and therapeutics

Samrita Dogra, Laura Adhikari, Doris M. Benbrook, Jacqueline A. Bohn, Anthony Burgett, Vishal Chandra, Lauren Dockery, Amit Singh, Lacey McNally, Rajani Rai, Zitha Redempta Isingizwe, Debra L. Richardson, Zhibo Yang, Bethany N. Hannafon

Reversal of tumour immune evasion via enhanced MHC-Class-I antigen presentation by a dual-functional RNA regulated system

Chaoyang Meng, Huipeng Zhang, Xuewen Yi, Gangcheng Kong, Xiaoge Zhang, Bei Wang, Yan Xu, Haoxiang Qi, Qing Wu, Ke Zhang, Jiaying Cao, Xiaohan Lin, Huiheng Feng, Jianxiang Chen, Shusen Zheng, Zhen Gu, Hongjun Li, Qi Ling

Exploring personalized prediction of clinical chemotherapy efficacy and revealing tumor heterogeneity using patient-derived 3D bioprinting gastric cancer models

Liwei Du, Zicheng Zheng, Kai Zhang, Hang Sun, Yuce Lu, Minghao Sun, Mingchang Pang, Shangze Jiang, Yixuan He, Shunda Du, Haitao Zhao, Yilei Mao, Weiming Kang, Penglei Ge, Huayu Yang

Targeting metalloptosis in tumor therapy: from molecular mechanisms to application of metal nanoparticles

Jinxiang Wang, Qin Tian, Yuchen Liu, Chao-Yun Cai, Shuying Fu, Jia Li, Yupeng Guan, Xuankai Liao, Danting Su, Tuanwei Sun, Yong Zhang, Rubing Lin, Yuzhi Xu, Jun Pang, Leli Zeng, Yihang Pan

Tumor-associated macrophages: untapped molecular targets to improve T cell-based immunotherapy

  • Open Access
  • Review

Rui M. L. Coelho, Reno Debets, Dora Hammerl

Integrated multi-omics identifies a CD54+ iCAF-ITGAL+ macrophage niche driving immunosuppression via CXCL8-PDL1 axis in cervical cancer

Fanghua Chen, Gaigai Bai, Qinqin Liu, Guangping He, Ziyang Ding, Jiali Liang, Nan Wang, Junjun Qiu, Keqin Hua

ACOX2 destabilizes the MRE11-RAD50-NBS1 complex and boosts anticancer immunity via the cGAS-STING pathway in clear cell renal cell carcinoma

Shiqi Ye, Wenhao Xu, Zheqi Chen, Chuanying Zhu, Qintao Ge, Jiahe Lu, Kun Chang, Xi Tian, Aihetaimujiang Anwaier, Shuxuan Zhu, Siqi Zhou, Wei Zhang, Yue Wang, Jianyuan Zhao, Lingling Li, Yan Shi, Tingting Cai, Danfeng Xu, Xiangyu Zhou, Dingwei Ye, Hailiang Zhang

Ex vivo modelling of human colorectal cancer liver metastasis by normothermic machine perfusion

Manuel Trebo, Thomas Maurer, Felix J. Krendl, Stefan Salcher, Agnieszka Martowicz, Theresa Hautz, Sieghart Sopper, Arno Amann, Benno Cardini, Lukas H. Poelsler, Anna Mair, Julia Hofmann, Andras T. Meszaros, Martin Hermann, Michael Günther, Steffen Ormanns, Zlatko Trajanoski, Stefan Schneeberger, Dominik Wolf, Rupert Oberhuber, Andreas Pircher

Targeting proteostasis for cancer therapy: current advances, challenges, and future perspectives

Chenliang Zhang, Jielang Li, Qiulin Tang, Liping Li, Dan Cao

Novel molecular mechanisms of FLT3 deregulation: from the acute myeloid leukemia experience to therapeutic insights in acute lymphoblastic leukemia

F. Lo Schiavo, C. Salvesi, M. Jandoubi, F. Pirini, J. Garbetta, G. Martinelli, G. Simonetti, A. Ferrari

Orchestrating movement: the role of Caveolin-1 in migration and metastasis

Jiri Navratil, Martina Raudenska, Monika Kratochvilova, Jan Balvan, Yoav David Shaul, Michal Masarik

Efferocytosis: the art of cellular clearance and novel perspectives in disease therapy

  • Open Access
  • Review

Gege Li, Jiashuai Xu, Xiaohan Tian, Jingyi Xiao, Junqi Long, Yining Chen, Wenzhi Shen, Shuangtao Zhao

Safe delivery of a highly toxic anthracycline derivative through liposomal nanoformulation achieves complete cancer regression

András Füredi, Szilárd Tóth, Kristóf Hegedüs, Pál T. Szabó, Anikó Gaál, Gergő Barta, Lívia N. Naszályi, Krisztina Kiss, Kata Bölcskei, Zoltán Szeltner, Eszter Bajtai, Balázs Gombos, Dániel Kiss, Mihály T. Cserepes, Attila Kiss, Peter Pokreisz, Lukas Kenner, Sandra Högler, Csaba Magyar, Jamie D. Cowles, Agnes Csiszar, József Tóvári, Dávid Szüts, Zsuzsanna Helyes, Zoltán Varga, Gábor Mező, Gergely Szakács

Correction: ZEB1 transcriptionally regulated carbonic anhydrase 9 mediates the chemoresistance of tongue cancer via maintaining intracellular pH

  • Open Access
  • Correction

Guopei Zheng, Cong Peng, Xiaoting Jia, Yixue Gu, Zhijie Zhang, Yingen Deng, Chengkun Wang, Nan Li, Jiang Yin, Xiaorong Liu, Minying Lu, Hailin Tang, Zhimin He

Advances in engineering immune–tumor microenvironments on-a-chip: integrative microfluidic platforms for immunotherapy and drug discovery

  • Open Access
  • Review

Farnaz Dabbagh Moghaddam, Ali Anvar, Ehsan Ilkhani, Delara Dadgar, Maedeh Rafiee, Najmeh Ranjbaran, Pejman Mortazavi, Seyed Majid Ghoreishian, Yun Suk Huh, Pooyan Makvandi

IFITM3-MET interaction drives osimertinib resistance through AKT pathway activation in EGFR-mutant non–small cell lung cancer

  • Open Access
  • Research

Ritsu Ibusuki, Eiji Iwama, Atsushi Shimauchi, Hiromu Kawano, Shun Mizusaki, Satoshi Nakamura, Yui Miyazaki, Yu Inutsuka, Mikiko Hashisako, Taishi Harada, Yuko Tsuchiya-Kawano, Hirono Tsutsumi, Takayuki Nakanishi, Noriaki Nakagaki, Yuichiro Koga, Shinichi Kimura, Shun Mashimoto, Daisuke Shibahara, Kohei Otsubo, Yasuto Yoneshima, Kentaro Tanaka, Yoshinao Oda, Isamu Okamoto

Targeting CXCR2 in prostate cancer cells can block CD47-SIRPα interaction and reverse M2 macrophage polarization in the TME

Yi Sun, Shangqing Ren, Wei Wen, Jun Jing, Xu Luo, Shuai Shao, Ruiqi Duan, Guohua Zeng, Ju Guo

Artificial intelligence in cancer: applications, challenges, and future perspectives

Cillian H. Cheng, Su-sheng Shi

Context-dependent impact of type I interferon signaling in cancer

Ainhoa Ruiz-Iglesias, Emma Guilbaud, Lorenzo Galluzzi, Santos Mañes

Microbiome-targeted nanoplatforms and engineering approaches in breast cancer therapy

Zufa Sabeel, Zhao Yang

Therapeutic targeting of cell death-immune crosstalk in cancer to rewire the tumor immune microenvironment

  • Open Access
  • Review

Haixia Zhang, Shizhen Li, Siyang Liu, Yaqi Liao, Huiqin Liu, Minghua Yang, Pan Chen

Lung endothelial PEAR1 induces tumor cell dormancy

Kenneth Anthony Roquid, Adriana Vucetic, Elena Dyukova, Mika J. Hanssen, Haaglim Cho, Rémy Bonnavion, Kenny Mattonet, Mario Looso, Miloslav Sanda, Boris Strilic, Stefan Offermanns

Antibody–drug conjugates in cancer therapy: current landscape, challenges, and future directions

Bonan Chen, Xiaohong Zheng, Jialin Wu, Guoming Chen, Jun Yu, Yi Xu, William K. K. Wu, Gary M. K. Tse, Ka Fai To, Wei Kang

SHIP2–PLK1 crosstalk promotes sensitivity to dual inhibition in esophageal squamous cell carcinoma

Ana Raquel Ramos, Giacomo Bregni, Nadia Gillet, Kunie Ando, Cyril Bodart, Alizée Vercauteren Drubbel, Louison Descampe, Fabiana Moresi, Xavier Bisteau, Quentin Verheye, Sheleya Pirard, Christophe Erneux, Benjamin Beck

Nanoparticle-based strategy in CAR-T cell immunotherapy: challenges, implications, and perspectives

  • Open Access
  • Review

Dong Shang, Zhaokai Zhou, Run Shi, Zhan Wang, Pengpeng Zhang, Fu Peng, Huabing Li, Guangyang Cheng, Hongzhuo Qin, Ziyu Xie, Yudi Xu, Xing Zhou, Wenjie Chen, Yajun Chen, Shuai Yang, Lina Chen, Qiong Lu, Ran Xu

Spatial and functional dissection of cancer-associated fibroblasts-mediated immune modulation in H. pylori-associated gastric cancer

Bonan Chen, Hongzhen Tang, Xiaohong Zheng, Fuda Xie, Peiyao Yu, Yang Lyu, Tiejun Feng, Jialin Wu, Jingya Liu, Yi Xu, Alvin H. K. Cheung, Canbin Fang, Zhangding Wang, Shouyu Wang, Justin Chak Ting Cheung, Yujuan Dong, Ruoxi Tian, Yigan Zhang, Cheng Lu, Chi Chun Wong, Jun Yu, William K. K. Wu, Elke Burgermeister, Man Tong, Fengbin Zhang, Wei Kang, Kam Tong Leung, Ka Fai To

The controversial role of senescence-associated secretory phenotype (SASP) in cancer therapy

Luhong Cao, Kaixiu Li, Qiang Li, Qiang Tong, Yi Wang, Linxue Huang

Neoadjuvant immunotherapy in squamous cell carcinoma of the head and neck: current evidence and future perspectives

Bocheng Zhang, Haolei Tan, Jingyu Kuang, Bo Zhou, Shixuan Liang, Xiao Pang, Yu Ouyang, Zhang Zhang, Ying Long, Hailin Zhang

A novel protein cPFKFB4 encoded by hsa_circ_0065394 strengthens PKM2-mediated glucose metabolic reprogramming to facilitate pancreatic cancer progression under hypoxia

Hang Chen, Molin Li, Fuming Xie, Shan Liu, Aining Yang, Jingyang Yin, Xianxing Wang, Yuxi Long, Shitao Wu, Lei Cai, Junxia Chen, Huaizhi Wang

Decoding cancer dormancy: integrative genomic, phenotypic and live-cell imaging analysis to reveal the hidden cancer cell reservoir

Gaetana Porcelli, Caterina D’Accardo, Francesca Angeloro, Martina Cucchiara, Paola Bianca, Vincenzo Davide Pantina, Narges Roozafzay, Chiara Modica, Miriam Gaggianesi, Sebastiano Di Bella, Giorgio Stassi, Alice Turdo, Matilde Todaro

The landscape of dynamic tumor immunophenotyping on neoadjuvant chemotherapy combined with trastuzumab for the treatment of HER2-positive breast cancer

Hongtao Jin, Yaru Yang, Changjian Yan, Mei Liu, Xue He, Dan Yuan, Wei Zhang, Yunqing Mu, Chaoling Wu, Xiaoni Liu, Jinyuan Xiao, Qizhao Long, Min Li, Xiaoyu Hao, Yuqi Zhang, Wenxin Qi, Yan Liu, Zining Yu, Dan Guo, Zijian Zhao, Yanzhao Li, Weilong Zhang, Xiuru Zhang

Advances in PLGA-based polymeric nanocarriers for colorectal cancer therapy: overcoming chemoresistance through controlled delivery strategies

Mohammad Sakib Khan, Urushi Rehman, Taha Alqahtani, Humood Al Shmrany, Garima Gupta, Khang Wen Goh, Amirhossein Sahebkar, Prashant Kesharwani

Enhancement of CAR-T cell efficacy and persistence via CD30 costimulation and NF-κB signaling

  • Open Access
  • Research

Yang Su, Guang Yang, Bi Chen, Yiguan Qian, Wenjie Ma, Xiaotian Jiang, Qing Yu, Yang Li, Luwei Xu

The enhanced cancer nanovaccine by bidirectionally blocking CXCL12/CXCR4 axis to inhibit the recurrence and metastasis of triple-negative breast cancer

Miao Liu, Weiliang Ye, Qifeng Ji, Bangle Zhang, Zhifu Yang, Daozhou Liu, Siyuan Zhou

Correction: Circular RNA hsa_circ_0008305 (circPTK2) inhibits TGF-induced epithelialmesenchymal transition and metastasis by controlling TIF1 in non-small cell lung cancer

  • Open Access
  • NSCLC
  • Correction

Longqiang Wang, Xin Tong, Zhengyu Zhou, Shengjie Wang, Zhe Lei, Tianze Zhang, Zeyi Liu, Yuanyuan Zeng, Chang Li, Jun Zhao, Zhiyue Su, Cuijuan Zhang, Xia Liu, Guangquan Xu, Hong-Tao Zhang

Bispecific antibodies and nanotechnology: a strategic alliance in cancer immunotherapy

  • Open Access
  • Review

Elisa Battistini, Philipp Lapuhs, Alberto Jiménez, Sergio Garrido-Areal, Lucía Rivas-Gómez, Ivana Zagorac, Luis Álvarez-Vallina, María José Alonso, Lucía Sanjurjo

GRPR-induced FAM135A expression promote perineural invasion in prostate cancer

Ning Zhang, Xiaohao Ruan, Siteng Chen, Ruofan Shi, Xiaoqun Yang, Yongle Zhan, Stacia Chun, Chi Yao, Salida Ali, Brian Sze-Ho Ho, Ada Tsui-Lin Ng, Richard KY Lo, Rong Na

Long non-coding RNA AFAP1-AS1 promotes alternative splicing of AXIN2 by facilitating SRSFs phase separation to induce drug resistance in lung adenocarcinoma

Jiawei Ouyang, Yijie Zhang, Xiangchan Hou, Fang Xiong, Lei Shi, Yu Zhong, Liting Yang, Can Guo, Zhaoyang Zeng, Qijia Yan, Pan Chen, Wei Xiong

ZNF526 drives tumor growth by enhancing SHMT1-dependent serine metabolism and antioxidant capability in TNBC

  • Open Access
  • Research

Wenxing Qin, Lujing Shao, Qi Li, Dan Zhang, Xinyan Jia, Chunyan Dong

Increased plasma concentrations of acyl-coenzyme A binding protein (ACBP) predict future lung cancer development in smokers at risk of cardiovascular disease

Marine Fidelle, Hui Chen, Léa Montégut, David Boulate, Pamela Abdayem, Magalie Martineau, Tatiana Kuznetsova, Carlijn M. van der Aalst, Harry J. de Koning, Laurence Zitvogel, Guido Kroemer

Pyroptosis in cancer therapy: a double-edged sword for immune activation and tumor progression

Ali Alishvandi, Cena Aram, Farzaneh Faraji Shahrivar, Prashant Kesharwani, Amirhossein Sahebkar

Senescent SPP1+ macrophages remodel the tumor microenvironment and promote the progression of early-stage lung adenocarcinoma featured with mixed ground glass nodule

  • Open Access
  • Research

Hong Zheng, Yan-qi Li, Xiao Lu, Jiao Zhang, Sha-sha Yu, Xu-feng Deng, Xiao-bing Liu, Man-yuan Li, Yi Cao, Qian Chen, Yuan Qiu, Quan-xing Liu, Dong Zhou, Ji-gang Dai

Modeling CIC::DUX4 sarcoma reveals oncogene-mediated MHCI-dependent immune evasion

  • Open Access
  • Research

Ajay Ram Vachanaram, Erdong Wei, Ana Mitanoska, William Bassett, Michael Kyba, Darko Bosnakovski

Downregulation of Sod2 increases atypical flat lesions and dysplasia to advance pancreatic ductal adenocarcinoma

Alicia K. Fleming Martinez, Heike R. Döppler, Ryan Argo, Ligia I. Bastea, Brandy H. Edenfield, Irene Espositio, Peter Storz

Correction: Proteogenomic characterization of molecular and cellular targets for treatment‑resistant subtypes in locally advanced cervical cancers

Do Young Hyeon, Dowoon Nam, Hye‑Jin Shin, Juhee Jeong, Eunsoo Jung, Soo Young Cho, Dong Hoon Shin, Ja‑Lok Ku, Hye Jung Baek, Chong Woo Yoo, Eun‑Kyung Hong, Myong Cheol Lim, Sang‑Jin Lee, Young‑Ki Bae, Jong Kwang Kim, Jingi Bae, Wonyoung Choi, Su‑Jin Kim, Seunghoon Back, Chaewon Kang, Inamul Hasan Madar, Hokeun Kim, Suhwan Kim, Duk Ki Kim, Jihyung Kang, Geon Woo Park, Ki Seok Park, Yourae Shin, Sang Soo Kim, Keehoon Jung, Daehee Hwang, Sang‑Won Lee, Joo‑Young Kim

Retraction Note: Preclinical analysis of the anti-tumor and anti-metastatic effects of Raf265 on colon cancer cells and CD26+ cancer stem cells in colorectal carcinoma

Ariel KM Chow, Nathan SM Cheng, Colin SC Lam, Lui Ng, Sunny KM Wong, Timothy MH Wan, Johnny HW Man, Alvin HK Cheung, Thomas CC Yau, Jensen TC Poon, Wai-Lun Law, Roberta WC Pang

Ferroptosis in cancer: metabolism, mechanisms and therapeutic prospects

  • Open Access
  • Review

Yansheng Wu, Hao Li, Kai Yue, Chao Jing, Yuansheng Duan

Correction: Harnessing ExDNA for precision Exatecan delivery in cancer: a novel antibody-drug conjugate approach

Zaira Ianniello, Huimei Lu, Elias Quijano, Daniel A. Colón-Ríos, Madison Rackear, Venu Bommireddy, Dale L. Ludwig, Zhiyuan Shen, Peter M. Glazer

CircZFAND6 suppresses gastric cancer metastasis and reduces resistance to TKI therapy

Zi-Jian Deng, Li-Ying OuYang, Jian-Ping Guo, Huan-Ting Yao, Jun-Jie Liu, Shu-Li Ma, Dong-Wen Chen, Xian-Zhe Li, Lei Lian, Jun-Sheng Peng, Shi Chen

Transcriptional dynamics of CD8+ T-cell exhaustion in immune checkpoint inhibitor resistance at single-cell resolution

Tzu-Yang Tseng, Ching-Hung Hsieh, Hsuan-Cheng Huang, Yu-Ching Wu, Chiun Hsu, Chia-Lang Hsu, Da-Liang Ou, Hsueh-Fen Juan

Amino acids metabolism: a potential target for cancer treatment

  • Open Access
  • Review

Shiqi Ren, Xinyi Zhou, Zhen Wang, Kefei Yuan

Immune cell senescence drives responsiveness to immunotherapy in melanoma

  • Open Access
  • Research

Pavlos Pantelis, Dimitrios Christos Tremoulis, Konstantinos Evangelou, Panagiotis Bakouros, Sophia Magkouta, Orestis A. Ntintas, Dimitris Veroutis, Giorgos Theocharous, Ioannis V. Kostopoulos, Dimitris-Foivos Thanos, Eftychia Chatziioannou, Ioanna A. Anastasiou, Nefeli Lagopati, Dimitrios Valakos, Dimitrios Skaltsas, Oltin Tiberiu Pop, Marie Therese Abdou, Sarantis Gagos, Dimitris Kletsas, Dimitris Thanos, Alexandros J. Stratigos, Martin Röcken, Lukas Flatz, George P. Chrousos, Dimitrios Vlachakis, Ourania E. Tsitsilonis, Russell Petty, Timokratis Karamitros, Vassilis G. Gorgoulis

Correction: Circular RNA ACVR2A suppresses bladder cancer cells proliferation and metastasis through miR-626/EYA4 axis

Wei Dong, Junming Bi, Hongwei Liu, Dong Yan, Qingqing He, Qianghua Zhou, Qiong Wang, Ruihui Xie, Yinjie Su, Meihua Yang, Tianxin Lin, Jian Huang

Targeting the tumor cell-intrinsic ITGB2 axis inhibits melanoma progression

  • Open Access
  • Research

Erik Rasbach, Laure Migayron, Anne Brandenburg, Praveen Singh, Christina Martins, Ali Kassem, Anastasia I. Karkempetzaki, Nadine Suessner, Zsofi Kulcsar, Jessica Riopedre, Mariana Silva, Ethan Zhen, Shuyun Xu, Kyla Mucciarone, Julia Holzgruber, Jason B. Williams, Emrullah Birgin, Mitchell P. Levesque, Julia M. Martínez-Gómez, Reinhard Dummer, Jennifer Landsberg, Christine G. Lian, George F. Murphy, Emma L. Berdan, Shannan Ho Sui, Thomas S. Kupper, Nuh N. Rahbari, Nayoung Lee, Steven R. Barthel, Tobias Schatton

RHOA lactylation at oncogenic hotspots promotes oncogenic activity and protein stabilization

  • Open Access
  • Research

Chenglong Ma, Ruocen Liao, Xingyu Chen, Qianhua Cao, Xinyue Deng, Zhijun Dai, Chenfang Dong

Correction: Overcoming acquired resistance to cetuximab by dual targeting HER family receptors with antibody-based therapy

Mari Iida, Toni M. Brand, Megan M. Starr, Evan J. Huppert, Neha Luthar, Harsh Bahrar, John P. Coan, Hannah E. Pearson, Ravi Salgia, Deric L. Wheeler

Gut microbiota reshaping the pancreatic cancer immune microenvironment: new avenues for immunotherapy

Shi-Hang Zheng, Ke-Zhu Li, Ge Feng, Yu-Tong Wang, Jia-Ning Wang, Shu-Qiang Li, Ying-Dong Sun

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Keynote webinar | Spotlight on progress in colorectal cancer

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CRC remains a major global health burden, but advances in screening, treatment, and lifestyle-based prevention continue to reshape clinical practice. Gain insights into how the latest research can be leveraged to optimize patient care across the CRC continuum.

Prof. Antoni Castells
Prof. Harpreet Wasan
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