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Open Access 01-02-2025 | Mild Neurocognitive Disorder | Research

Predictive risk model of mild cognitive impairment in patients with malignant haematological diseases after haematopoietic stem cell transplantation

Authors: Si Chen, Ying Zhang, Yuanyuan Feng, Lili Sun, Xiaoqin Qi, Tingting Chen, Yuan Liu, Yu Jian, Xianwen Li

Published in: Supportive Care in Cancer | Issue 2/2025

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Abstract

Objective

This study is to develop and validate a robust risk prediction model for mild cognitive impairment (MCI) in patients with malignant haematological diseases after haematopoietic stem cell transplantation (HSCT).

Methods

In this study, we analysed the clinical data of the included patients. Logistic regression analysis was used to identify independent risk factors for cognitive impairment after HSCT in patients with malignant haematological diseases, and a risk prediction model was constructed. Multiple cohorts of patients with haematological malignancies after HSCT (282 cases) from the Affiliated Hospital of Xuzhou Medical University and the First People’s Hospital of Yancheng City between April 2019 and February 2022, and patients from the Affiliated Huaian No.1 People’s Hospital of Nanjing Medical University between March 2022 and July 2023 were used for external validation. Logistic regression analysis was performed to develop the predictive model. The predictive value and consistency of the model were evaluated using the area under the curve (AUC) and calibration method, respectively. Decision curve analysis (DCA) was performed to access the utility of the model.

Results

Approximately half (52.26%) of the patients in the study developed mild cognitive impairment (MCI). Older age, allogeneic HSCT, anxiety, graft-versus-host disease, and longer hospital stay were associated with a higher risk of developing MCI. ROC curve analysis confirmed the sound performance of the predictive model and external validation, with AUC of 0.897 and 0.789 respectively. The direction of the calibration curves of the training and validation sets is closer to the diagonal (ideal curve), indicating good model consistency; the DCA curves also show that the model has good predictive ability and stability.

Conclusions

We conclude that it is possible to predict mild cognitive impairment with readily available, mostly pretransplant predictors. The accuracy of the risk prediction models can be improved for use in clinical practice, possibly by adding pretransplant patient-reported functioning and comorbidities.
Literature
2.
go back to reference Gratwohl A, Pasquini MC, Aljurf M et al (2015) One million haemopoietic stem-cell transplants: a retrospective observational study. Lancet Haematol 2(3):e91-100PubMedCrossRef Gratwohl A, Pasquini MC, Aljurf M et al (2015) One million haemopoietic stem-cell transplants: a retrospective observational study. Lancet Haematol 2(3):e91-100PubMedCrossRef
3.
go back to reference Yang G, Wang X, Huang S et al (2022) Generalist in allogeneic hematopoietic stem cell transplantation for MDS or AML: epigenetic therapy. Front Immunol 13PubMedPubMedCentralCrossRef Yang G, Wang X, Huang S et al (2022) Generalist in allogeneic hematopoietic stem cell transplantation for MDS or AML: epigenetic therapy. Front Immunol 13PubMedPubMedCentralCrossRef
4.
go back to reference van Lier YF, Vos J, Blom B, Hazenberg MD (2023) Allogeneic hematopoietic cell transplantation, the microbiome, and graft-versus-host disease. Gut Microbes 15(1)PubMedPubMedCentralCrossRef van Lier YF, Vos J, Blom B, Hazenberg MD (2023) Allogeneic hematopoietic cell transplantation, the microbiome, and graft-versus-host disease. Gut Microbes 15(1)PubMedPubMedCentralCrossRef
5.
go back to reference Jerry Teng CL, Wang PN, Chen YC, Ko BS (2021) Cytomegalovirus management after allogeneic hematopoietic stem cell transplantation: a mini-review. J Microbiol Immunol Infect 54(3):341–348PubMedCrossRef Jerry Teng CL, Wang PN, Chen YC, Ko BS (2021) Cytomegalovirus management after allogeneic hematopoietic stem cell transplantation: a mini-review. J Microbiol Immunol Infect 54(3):341–348PubMedCrossRef
6.
go back to reference Sinatora F, Traverso A, Zanato S et al (2017) Quality of life and psychopathology in adults who underwent hematopoietic stem cell transplantation (HSCT) in childhood: a qualitative and quantitative analysis. Front Psychol 8PubMedPubMedCentralCrossRef Sinatora F, Traverso A, Zanato S et al (2017) Quality of life and psychopathology in adults who underwent hematopoietic stem cell transplantation (HSCT) in childhood: a qualitative and quantitative analysis. Front Psychol 8PubMedPubMedCentralCrossRef
7.
go back to reference Wilhelmsson M, Vatanen A, Borgström B et al (2015) Adverse health events and late mortality after pediatric allogeneic hematopoietic SCT-two decades of longitudinal follow-up. Bone Marrow Transplant 50(6):850–857PubMedCrossRef Wilhelmsson M, Vatanen A, Borgström B et al (2015) Adverse health events and late mortality after pediatric allogeneic hematopoietic SCT-two decades of longitudinal follow-up. Bone Marrow Transplant 50(6):850–857PubMedCrossRef
8.
go back to reference Nakamura ZM, Nash RP, Quillen LJ, Richardson DR, McCall RC, Park EM (2019) Psychiatric care in hematopoietic stem cell transplantation. Psychosomatics 60(3):227–237PubMedPubMedCentralCrossRef Nakamura ZM, Nash RP, Quillen LJ, Richardson DR, McCall RC, Park EM (2019) Psychiatric care in hematopoietic stem cell transplantation. Psychosomatics 60(3):227–237PubMedPubMedCentralCrossRef
9.
10.
go back to reference Viggiano D, Wagner CA, Martino G et al (2020) Mechanisms of cognitive dysfunction in CKD. Nat Rev Nephrol 16(8):452–469PubMedCrossRef Viggiano D, Wagner CA, Martino G et al (2020) Mechanisms of cognitive dysfunction in CKD. Nat Rev Nephrol 16(8):452–469PubMedCrossRef
11.
go back to reference Harrison RA, Sharafeldin N, Rexer JL et al (2021) Neurocognitive impairment after hematopoietic stem cell transplant for hematologic malignancies: phenotype and mechanisms. Oncologist 26(11):e2021–e2033PubMedPubMedCentralCrossRef Harrison RA, Sharafeldin N, Rexer JL et al (2021) Neurocognitive impairment after hematopoietic stem cell transplant for hematologic malignancies: phenotype and mechanisms. Oncologist 26(11):e2021–e2033PubMedPubMedCentralCrossRef
12.
go back to reference Buchbinder D, Kelly DL, Duarte RF et al (2018) Neurocognitive dysfunction in hematopoietic cell transplant recipients: expert review from the late effects and Quality of Life Working Committee of the CIBMTR and complications and Quality of Life Working Party of the EBMT. Bone Marrow Transplant 53(5):535–555PubMedPubMedCentralCrossRef Buchbinder D, Kelly DL, Duarte RF et al (2018) Neurocognitive dysfunction in hematopoietic cell transplant recipients: expert review from the late effects and Quality of Life Working Committee of the CIBMTR and complications and Quality of Life Working Party of the EBMT. Bone Marrow Transplant 53(5):535–555PubMedPubMedCentralCrossRef
13.
go back to reference Lacy M, Fong M, Bolton C, Maranzano M, Bishop M, Artz A (2021) Cognitive functioning of older adults prior to hematopoietic stem cell transplantation. Bone Marrow Transplant 56(10):2575–2581PubMedCrossRef Lacy M, Fong M, Bolton C, Maranzano M, Bishop M, Artz A (2021) Cognitive functioning of older adults prior to hematopoietic stem cell transplantation. Bone Marrow Transplant 56(10):2575–2581PubMedCrossRef
14.
go back to reference Jones D, Vichaya EG, Wang XS, Sailors MH, Cleeland CS, Wefel JS (2013) Acute cognitive impairment in patients with multiple myeloma undergoing autologous hematopoietic stem cell transplant. Cancer 119(23):4188–4195PubMedCrossRef Jones D, Vichaya EG, Wang XS, Sailors MH, Cleeland CS, Wefel JS (2013) Acute cognitive impairment in patients with multiple myeloma undergoing autologous hematopoietic stem cell transplant. Cancer 119(23):4188–4195PubMedCrossRef
15.
go back to reference Friedman MA, Fernandez M, Wefel JS, Myszka KA, Champlin RE, Meyers CA (2009) Course of cognitive decline in hematopoietic stem cell transplantation: a within-subjects design. Arch Clin Neuropsychol 24(7):689–698PubMedCrossRef Friedman MA, Fernandez M, Wefel JS, Myszka KA, Champlin RE, Meyers CA (2009) Course of cognitive decline in hematopoietic stem cell transplantation: a within-subjects design. Arch Clin Neuropsychol 24(7):689–698PubMedCrossRef
16.
go back to reference Syrjala KL, Langer SL, Abrams JR et al (2004) Recovery and long-term function after hematopoietic cell transplantation for leukemia or lymphoma. JAMA 291(19):2335–2343PubMedCrossRef Syrjala KL, Langer SL, Abrams JR et al (2004) Recovery and long-term function after hematopoietic cell transplantation for leukemia or lymphoma. JAMA 291(19):2335–2343PubMedCrossRef
17.
go back to reference Booth-Jones M, Jacobsen PB, Ransom S, Soety E (2005) Characteristics and correlates of cognitive functioning following bone marrow transplantation. Bone Marrow Transplant 36(8):695–702PubMedCrossRef Booth-Jones M, Jacobsen PB, Ransom S, Soety E (2005) Characteristics and correlates of cognitive functioning following bone marrow transplantation. Bone Marrow Transplant 36(8):695–702PubMedCrossRef
18.
go back to reference Sharafeldin N, Bosworth A, Patel SK et al (2018) Cognitive functioning after hematopoietic cell transplantation for hematologic malignancy: results from a prospective longitudinal study. J Clin Oncol 36(5):463–475PubMedCrossRef Sharafeldin N, Bosworth A, Patel SK et al (2018) Cognitive functioning after hematopoietic cell transplantation for hematologic malignancy: results from a prospective longitudinal study. J Clin Oncol 36(5):463–475PubMedCrossRef
19.
go back to reference Smith PJ, Lew M, Lowder Y et al (2022) Cognitive impairment in candidates for allogeneic hematopoietic stem cell transplantation. Bone Marrow Transplant 57(1):89–94PubMedCrossRef Smith PJ, Lew M, Lowder Y et al (2022) Cognitive impairment in candidates for allogeneic hematopoietic stem cell transplantation. Bone Marrow Transplant 57(1):89–94PubMedCrossRef
20.
go back to reference Mayo SJ, Wozniczka I, Brennenstuhl S et al (2021) Late cognitive outcomes among allogeneic stem cell transplant survivors: follow-up data from a 6-year longitudinal study. Support Care Cancer 29(5):2621–2630PubMedCrossRef Mayo SJ, Wozniczka I, Brennenstuhl S et al (2021) Late cognitive outcomes among allogeneic stem cell transplant survivors: follow-up data from a 6-year longitudinal study. Support Care Cancer 29(5):2621–2630PubMedCrossRef
21.
go back to reference Guo L, Zhang M, Namassevayam G et al (2023) Effectiveness of health management among individuals at high risk of stroke: an intervention study based on the health ecology model and self-determination theory (HEM-SDT). Heliyon 9(11)PubMedPubMedCentralCrossRef Guo L, Zhang M, Namassevayam G et al (2023) Effectiveness of health management among individuals at high risk of stroke: an intervention study based on the health ecology model and self-determination theory (HEM-SDT). Heliyon 9(11)PubMedPubMedCentralCrossRef
22.
go back to reference Correa DD, Wang Y, West JD et al (2016) Prospective assessment of white matter integrity in adult stem cell transplant recipients. Brain Imaging Behav 10(2):486–496PubMedPubMedCentralCrossRef Correa DD, Wang Y, West JD et al (2016) Prospective assessment of white matter integrity in adult stem cell transplant recipients. Brain Imaging Behav 10(2):486–496PubMedPubMedCentralCrossRef
23.
go back to reference Kelly DL, Buchbinder D, Duarte RF et al (2018) Neurocognitive dysfunction in hematopoietic cell transplant recipients: expert review from the late effects and quality of life working committee of the center for international blood and marrow transplant research and complications and quality of life working party of the European Society for Blood and Marrow Transplantation. Biol Blood Marrow Transplant 24(2):228–241PubMedCrossRef Kelly DL, Buchbinder D, Duarte RF et al (2018) Neurocognitive dysfunction in hematopoietic cell transplant recipients: expert review from the late effects and quality of life working committee of the center for international blood and marrow transplant research and complications and quality of life working party of the European Society for Blood and Marrow Transplantation. Biol Blood Marrow Transplant 24(2):228–241PubMedCrossRef
24.
go back to reference Jim HS, Small B, Hartman S et al (2012) Clinical predictors of cognitive function in adults treated with hematopoietic cell transplantation. Cancer 118(13):3407–3416PubMedCrossRef Jim HS, Small B, Hartman S et al (2012) Clinical predictors of cognitive function in adults treated with hematopoietic cell transplantation. Cancer 118(13):3407–3416PubMedCrossRef
25.
go back to reference Kurosawa S, Oshima K, Yamaguchi T et al (2017) Quality of life after allogeneic hematopoietic cell transplantation according to affected organ and severity of chronic graft-versus-host disease. Biol Blood Marrow Transplant 23(10):1749–1758PubMedCrossRef Kurosawa S, Oshima K, Yamaguchi T et al (2017) Quality of life after allogeneic hematopoietic cell transplantation according to affected organ and severity of chronic graft-versus-host disease. Biol Blood Marrow Transplant 23(10):1749–1758PubMedCrossRef
26.
go back to reference Kim HJ, Barsevick AM, Fang CY, Miaskowski C (2012) Common biological pathways underlying the psychoneurological symptom cluster in cancer patients. Cancer Nurs 35(6):E1–E20PubMedCrossRef Kim HJ, Barsevick AM, Fang CY, Miaskowski C (2012) Common biological pathways underlying the psychoneurological symptom cluster in cancer patients. Cancer Nurs 35(6):E1–E20PubMedCrossRef
27.
go back to reference Tometich DB, Small BJ, Carroll JE et al (2019) Pretreatment psychoneurological symptoms and their association with longitudinal cognitive function and quality of life in older breast cancer survivors. J Pain Symptom Manage 57(3):596–606PubMedCrossRef Tometich DB, Small BJ, Carroll JE et al (2019) Pretreatment psychoneurological symptoms and their association with longitudinal cognitive function and quality of life in older breast cancer survivors. J Pain Symptom Manage 57(3):596–606PubMedCrossRef
28.
go back to reference Mandelblatt JS, Zhai W, Ahn J et al (2020) Symptom burden among older breast cancer survivors: The Thinking and Living With Cancer (TLC) study. Cancer 126(6):1183–1192PubMedCrossRef Mandelblatt JS, Zhai W, Ahn J et al (2020) Symptom burden among older breast cancer survivors: The Thinking and Living With Cancer (TLC) study. Cancer 126(6):1183–1192PubMedCrossRef
29.
go back to reference Kim HJ, McGuire DB, Tulman L, Barsevick AM (2005) Symptom clusters: concept analysis and clinical implications for cancer nursing. Cancer Nurs 28(4):270–282 (quiz 283–4)PubMedCrossRef Kim HJ, McGuire DB, Tulman L, Barsevick AM (2005) Symptom clusters: concept analysis and clinical implications for cancer nursing. Cancer Nurs 28(4):270–282 (quiz 283–4)PubMedCrossRef
30.
go back to reference Dodd MJ, Miaskowski C, Paul SM (2001) Symptom clusters and their effect on the functional status of patients with cancer. Oncol Nurs Forum 28(3):465–470PubMed Dodd MJ, Miaskowski C, Paul SM (2001) Symptom clusters and their effect on the functional status of patients with cancer. Oncol Nurs Forum 28(3):465–470PubMed
31.
go back to reference Starkweather AR, Lyon DE, Elswick RK Jr, Montpetit AJ, Conley Y, McCain NL (2013) A Conceptual model of psychoneurological symptom cluster variation in women with breast cancer: bringing nursing research to personalized medicine. Curr Pharmacogenomics Person Med 11(3):224–230PubMedPubMedCentralCrossRef Starkweather AR, Lyon DE, Elswick RK Jr, Montpetit AJ, Conley Y, McCain NL (2013) A Conceptual model of psychoneurological symptom cluster variation in women with breast cancer: bringing nursing research to personalized medicine. Curr Pharmacogenomics Person Med 11(3):224–230PubMedPubMedCentralCrossRef
32.
go back to reference Dodd MJ, Cho MH, Cooper BA, Miaskowski C (2010) The effect of symptom clusters on functional status and quality of life in women with breast cancer. Eur J Oncol Nurs 14(2):101–110PubMedCrossRef Dodd MJ, Cho MH, Cooper BA, Miaskowski C (2010) The effect of symptom clusters on functional status and quality of life in women with breast cancer. Eur J Oncol Nurs 14(2):101–110PubMedCrossRef
33.
go back to reference Cleeland CS, Mayer M, Dreyer NA et al (2014) Impact of symptom burden on work-related abilities in patients with locally recurrent or metastatic breast cancer: Results from a substudy of the VIRGO observational cohort study. Breast 23(6):763–769PubMedCrossRef Cleeland CS, Mayer M, Dreyer NA et al (2014) Impact of symptom burden on work-related abilities in patients with locally recurrent or metastatic breast cancer: Results from a substudy of the VIRGO observational cohort study. Breast 23(6):763–769PubMedCrossRef
34.
go back to reference Kim HJ, Barsevick AM, Beck SL, Dudley W (2012) Clinical subgroups of a psychoneurologic symptom cluster in women receiving treatment for breast cancer: a secondary analysis. Oncol Nurs Forum 39(1):E20-30PubMedCrossRef Kim HJ, Barsevick AM, Beck SL, Dudley W (2012) Clinical subgroups of a psychoneurologic symptom cluster in women receiving treatment for breast cancer: a secondary analysis. Oncol Nurs Forum 39(1):E20-30PubMedCrossRef
35.
go back to reference Jiménez A, Madero R, Alonso A et al (2011) Symptom clusters in advanced cancer. J Pain Symptom Manage 42(1):24–31PubMedCrossRef Jiménez A, Madero R, Alonso A et al (2011) Symptom clusters in advanced cancer. J Pain Symptom Manage 42(1):24–31PubMedCrossRef
36.
go back to reference Aktas A, Walsh D, Rybicki L (2012) Symptom clusters and prognosis in advanced cancer. Support Care Cancer 20(11):2837–2843PubMedCrossRef Aktas A, Walsh D, Rybicki L (2012) Symptom clusters and prognosis in advanced cancer. Support Care Cancer 20(11):2837–2843PubMedCrossRef
37.
go back to reference Peduzzi P, Concato J, Feinstein AR, Holford TR (1995) Importance of events per independent variable in proportional hazards regression analysis. II. Accuracy and precision of regression estimates. J Clin Epidemiol. 48(12):1503–1510PubMedCrossRef Peduzzi P, Concato J, Feinstein AR, Holford TR (1995) Importance of events per independent variable in proportional hazards regression analysis. II. Accuracy and precision of regression estimates. J Clin Epidemiol. 48(12):1503–1510PubMedCrossRef
38.
go back to reference Costa D, Loh V, Birney DP et al (2018) The structure of the FACT-Cog v3 in cancer patients, students, and older adults. J Pain Symptom Manage 55(4):1173–1178PubMedCrossRef Costa D, Loh V, Birney DP et al (2018) The structure of the FACT-Cog v3 in cancer patients, students, and older adults. J Pain Symptom Manage 55(4):1173–1178PubMedCrossRef
39.
go back to reference Byrd-Bredbenner C, Eck K, Quick V (2021) GAD-7, GAD-2, and GAD-mini: psychometric properties and norms of university students in the United States. Gen Hosp Psychiatry 69:61–66PubMedCrossRef Byrd-Bredbenner C, Eck K, Quick V (2021) GAD-7, GAD-2, and GAD-mini: psychometric properties and norms of university students in the United States. Gen Hosp Psychiatry 69:61–66PubMedCrossRef
40.
go back to reference Levis B, Benedetti A, Thombs BD (2019) Accuracy of Patient Health Questionnaire-9 (PHQ-9) for screening to detect major depression: individual participant data meta-analysis. BMJ 365PubMedPubMedCentralCrossRef Levis B, Benedetti A, Thombs BD (2019) Accuracy of Patient Health Questionnaire-9 (PHQ-9) for screening to detect major depression: individual participant data meta-analysis. BMJ 365PubMedPubMedCentralCrossRef
41.
go back to reference Costantini L, Pasquarella C, Odone A et al (2021) Screening for depression in primary care with Patient Health Questionnaire-9 (PHQ-9): A systematic review. J Affect Disord 279:473–483PubMedCrossRef Costantini L, Pasquarella C, Odone A et al (2021) Screening for depression in primary care with Patient Health Questionnaire-9 (PHQ-9): A systematic review. J Affect Disord 279:473–483PubMedCrossRef
42.
go back to reference Hartung TJ, Friedrich M, Johansen C et al (2017) The Hospital Anxiety and Depression Scale (HADS) and the 9-item Patient Health Questionnaire (PHQ-9) as screening instruments for depression in patients with cancer. Cancer 123(21):4236–4243PubMedCrossRef Hartung TJ, Friedrich M, Johansen C et al (2017) The Hospital Anxiety and Depression Scale (HADS) and the 9-item Patient Health Questionnaire (PHQ-9) as screening instruments for depression in patients with cancer. Cancer 123(21):4236–4243PubMedCrossRef
43.
go back to reference Pilz LK, Keller LK, Lenssen D, Roenneberg T (2018) Time to rethink sleep quality: PSQI scores reflect sleep quality on workdays. Sleep 41(5):zsy029 Pilz LK, Keller LK, Lenssen D, Roenneberg T (2018) Time to rethink sleep quality: PSQI scores reflect sleep quality on workdays. Sleep 41(5):zsy029
44.
go back to reference Sancho-Domingo C, Carballo JL, Coloma-Carmona A, Buysse DJ (2021) Brief version of the Pittsburgh Sleep Quality Index (B-PSQI) and measurement invariance across gender and age in a population-based sample. Psychol Assess 33(2):111–121PubMedCrossRef Sancho-Domingo C, Carballo JL, Coloma-Carmona A, Buysse DJ (2021) Brief version of the Pittsburgh Sleep Quality Index (B-PSQI) and measurement invariance across gender and age in a population-based sample. Psychol Assess 33(2):111–121PubMedCrossRef
45.
go back to reference Manzar MD, BaHammam AS, Hameed UA et al (2018) Dimensionality of the Pittsburgh Sleep Quality Index: a systematic review. Health Qual Life Outcomes 16(1):89PubMedPubMedCentralCrossRef Manzar MD, BaHammam AS, Hameed UA et al (2018) Dimensionality of the Pittsburgh Sleep Quality Index: a systematic review. Health Qual Life Outcomes 16(1):89PubMedPubMedCentralCrossRef
46.
go back to reference Ahles TA, Saykin A (2001) Cognitive effects of standard-dose chemotherapy in patients with cancer. Cancer Invest 19(8):812–820PubMedCrossRef Ahles TA, Saykin A (2001) Cognitive effects of standard-dose chemotherapy in patients with cancer. Cancer Invest 19(8):812–820PubMedCrossRef
47.
go back to reference Ahles TA, Saykin AJ, Noll WW et al (2003) The relationship of APOE genotype to neuropsychological performance in long-term cancer survivors treated with standard dose chemotherapy. Psychooncology 12(6):612–619PubMedCrossRef Ahles TA, Saykin AJ, Noll WW et al (2003) The relationship of APOE genotype to neuropsychological performance in long-term cancer survivors treated with standard dose chemotherapy. Psychooncology 12(6):612–619PubMedCrossRef
48.
go back to reference Fliessbach K, Urbach H, Helmstaedter C et al (2003) Cognitive performance and magnetic resonance imaging findings after high-dose systemic and intraventricular chemotherapy for primary central nervous system lymphoma. Arch Neurol 60(4):563–568PubMedCrossRef Fliessbach K, Urbach H, Helmstaedter C et al (2003) Cognitive performance and magnetic resonance imaging findings after high-dose systemic and intraventricular chemotherapy for primary central nervous system lymphoma. Arch Neurol 60(4):563–568PubMedCrossRef
49.
go back to reference Fleischman DA, Leurgans S, Arfanakis K et al (2014) Gray-matter macrostructure in cognitively healthy older persons: associations with age and cognition. Brain Struct Funct 219(6):2029–2049PubMedCrossRef Fleischman DA, Leurgans S, Arfanakis K et al (2014) Gray-matter macrostructure in cognitively healthy older persons: associations with age and cognition. Brain Struct Funct 219(6):2029–2049PubMedCrossRef
50.
go back to reference Monk JP, Phillips G, Waite R et al (2006) Assessment of tumor necrosis factor alpha blockade as an intervention to improve tolerability of dose-intensive chemotherapy in cancer patients. J Clin Oncol 24(12):1852–1859PubMedCrossRef Monk JP, Phillips G, Waite R et al (2006) Assessment of tumor necrosis factor alpha blockade as an intervention to improve tolerability of dose-intensive chemotherapy in cancer patients. J Clin Oncol 24(12):1852–1859PubMedCrossRef
51.
go back to reference Braamse AM, Yi JC, Visser OJ et al (2016) Developing a risk prediction model for long-term physical and psychological functioning after hematopoietic cell transplantation. Biol Blood Marrow Transplant 22(3):549–556PubMedCrossRef Braamse AM, Yi JC, Visser OJ et al (2016) Developing a risk prediction model for long-term physical and psychological functioning after hematopoietic cell transplantation. Biol Blood Marrow Transplant 22(3):549–556PubMedCrossRef
52.
go back to reference Rizzo JD, Wingard JR, Tichelli A et al (2006) Recommended screening and preventive practices for long-term survivors after hematopoietic cell transplantation: joint recommendations of the European Group for Blood and Marrow Transplantation, the Center for International Blood and Marrow Transplant Research, and the American Society of Blood and Marrow Transplantation. Biol Blood Marrow Transplant 12(2):138–151PubMedCrossRef Rizzo JD, Wingard JR, Tichelli A et al (2006) Recommended screening and preventive practices for long-term survivors after hematopoietic cell transplantation: joint recommendations of the European Group for Blood and Marrow Transplantation, the Center for International Blood and Marrow Transplant Research, and the American Society of Blood and Marrow Transplantation. Biol Blood Marrow Transplant 12(2):138–151PubMedCrossRef
53.
go back to reference Guo M, Hu KX, Yu CL et al (2011) Infusion of HLA-mismatched peripheral blood stem cells improves the outcome of chemotherapy for acute myeloid leukemia in elderly patients. Blood 117(3):936–941PubMedCrossRef Guo M, Hu KX, Yu CL et al (2011) Infusion of HLA-mismatched peripheral blood stem cells improves the outcome of chemotherapy for acute myeloid leukemia in elderly patients. Blood 117(3):936–941PubMedCrossRef
54.
go back to reference (2012) HLA-mismatched stem-cell microtransplantation as postremission therapy for acute myeloid leukemia: long-term follow-up. J Clin Oncol Off J Am Soc Clin Oncol 30(33): 4084–90 (2012) HLA-mismatched stem-cell microtransplantation as postremission therapy for acute myeloid leukemia: long-term follow-up. J Clin Oncol Off J Am Soc Clin Oncol 30(33): 4084–90
55.
go back to reference Guo M, Chao NJ, Li JY et al (2018) HLA-mismatched microtransplant in older patients newly diagnosed with acute myeloid leukemia: results from the microtransplantation interest group. JAMA Oncol 4(1):54PubMedCrossRef Guo M, Chao NJ, Li JY et al (2018) HLA-mismatched microtransplant in older patients newly diagnosed with acute myeloid leukemia: results from the microtransplantation interest group. JAMA Oncol 4(1):54PubMedCrossRef
56.
go back to reference Lindbergh CA, Dishman RK, Miller LS (2016) Functional disability in mild cognitive impairment: a systematic review and meta-analysis. Neuropsychol Rev 26(2):129–159PubMedCrossRef Lindbergh CA, Dishman RK, Miller LS (2016) Functional disability in mild cognitive impairment: a systematic review and meta-analysis. Neuropsychol Rev 26(2):129–159PubMedCrossRef
57.
go back to reference Hu KX, Du X, Guo M et al (2020) Comparative study of micro-transplantation from HLA fully mismatched unrelated and partly matched related donors in acute myeloid leukemia. Am J Hematol 95(6):630–636PubMedCrossRef Hu KX, Du X, Guo M et al (2020) Comparative study of micro-transplantation from HLA fully mismatched unrelated and partly matched related donors in acute myeloid leukemia. Am J Hematol 95(6):630–636PubMedCrossRef
58.
go back to reference Cai B, Sun Q, Qiao J et al (2020) Comparison of microtransplantation, chemotherapy and allogeneic transplantation in post-remission therapy for Philadelphia chromosome-positive acute lymphoblastic leukemia. Am J Cancer Res 10(11):3852–3866PubMedPubMedCentral Cai B, Sun Q, Qiao J et al (2020) Comparison of microtransplantation, chemotherapy and allogeneic transplantation in post-remission therapy for Philadelphia chromosome-positive acute lymphoblastic leukemia. Am J Cancer Res 10(11):3852–3866PubMedPubMedCentral
59.
go back to reference Pan B, Lazarus HM, Gale RP (2020) Microtransplantation for acute myeloid leukemia: a systematic review. JAMA Oncol 6(10):1614–1620PubMedCrossRef Pan B, Lazarus HM, Gale RP (2020) Microtransplantation for acute myeloid leukemia: a systematic review. JAMA Oncol 6(10):1614–1620PubMedCrossRef
60.
go back to reference Yang Y, Hendrix CC (2018) Cancer-related cognitive impairment in breast cancer patients: influences of psychological variables. Asia Pac J Oncol Nurs 5(3):296–306PubMedPubMedCentralCrossRef Yang Y, Hendrix CC (2018) Cancer-related cognitive impairment in breast cancer patients: influences of psychological variables. Asia Pac J Oncol Nurs 5(3):296–306PubMedPubMedCentralCrossRef
61.
go back to reference Bedillion MF, Ansell EB, Thomas GA (2019) Cancer treatment effects on cognition and depression: the moderating role of physical activity. Breast 44:73–80PubMedCrossRef Bedillion MF, Ansell EB, Thomas GA (2019) Cancer treatment effects on cognition and depression: the moderating role of physical activity. Breast 44:73–80PubMedCrossRef
62.
go back to reference Henneghan AM, Carter P, Stuifbergan A, Parmelee B, Kesler S (2018) Relationships between self-reported sleep quality components and cognitive functioning in breast cancer survivors up to 10 years following chemotherapy. Psychooncology 27(8):1937–1943PubMedCrossRef Henneghan AM, Carter P, Stuifbergan A, Parmelee B, Kesler S (2018) Relationships between self-reported sleep quality components and cognitive functioning in breast cancer survivors up to 10 years following chemotherapy. Psychooncology 27(8):1937–1943PubMedCrossRef
63.
go back to reference Henneghan A, Stuifbergen A, Becker H, Kesler S, King E (2018) Modifiable correlates of perceived cognitive function in breast cancer survivors up to 10 years after chemotherapy completion. J Cancer Surviv 12(2):224–233PubMedCrossRef Henneghan A, Stuifbergen A, Becker H, Kesler S, King E (2018) Modifiable correlates of perceived cognitive function in breast cancer survivors up to 10 years after chemotherapy completion. J Cancer Surviv 12(2):224–233PubMedCrossRef
64.
go back to reference Tager FA, McKinley PS, Schnabel FR et al (2010) The cognitive effects of chemotherapy in post-menopausal breast cancer patients: a controlled longitudinal study. Breast Cancer Res Treat 123(1):25–34PubMedCrossRef Tager FA, McKinley PS, Schnabel FR et al (2010) The cognitive effects of chemotherapy in post-menopausal breast cancer patients: a controlled longitudinal study. Breast Cancer Res Treat 123(1):25–34PubMedCrossRef
65.
go back to reference Caudle DD, Senior AC, Wetherell JL et al (2007) Cognitive errors, symptom severity, and response to cognitive behavior therapy in older adults with generalized anxiety disorder. Am J Geriatr Psychiatry 15(8):680–689PubMedCrossRef Caudle DD, Senior AC, Wetherell JL et al (2007) Cognitive errors, symptom severity, and response to cognitive behavior therapy in older adults with generalized anxiety disorder. Am J Geriatr Psychiatry 15(8):680–689PubMedCrossRef
66.
go back to reference Thompson DG, Kesler SR, Sudheimer K et al (2015) FMRI activation during executive function predicts response to cognitive behavioral therapy in older, depressed adults. Am J Geriatr Psychiatry 23(1):13–22PubMedCrossRef Thompson DG, Kesler SR, Sudheimer K et al (2015) FMRI activation during executive function predicts response to cognitive behavioral therapy in older, depressed adults. Am J Geriatr Psychiatry 23(1):13–22PubMedCrossRef
67.
go back to reference Vinkers DJ, Gussekloo J, Stek ML, Westendorp RG, van der Mast RC (2004) Temporal relation between depression and cognitive impairment in old age: prospective population based study. BMJ 329(7471):881PubMedPubMedCentralCrossRef Vinkers DJ, Gussekloo J, Stek ML, Westendorp RG, van der Mast RC (2004) Temporal relation between depression and cognitive impairment in old age: prospective population based study. BMJ 329(7471):881PubMedPubMedCentralCrossRef
Metadata
Title
Predictive risk model of mild cognitive impairment in patients with malignant haematological diseases after haematopoietic stem cell transplantation
Authors
Si Chen
Ying Zhang
Yuanyuan Feng
Lili Sun
Xiaoqin Qi
Tingting Chen
Yuan Liu
Yu Jian
Xianwen Li
Publication date
01-02-2025
Publisher
Springer Berlin Heidelberg
Published in
Supportive Care in Cancer / Issue 2/2025
Print ISSN: 0941-4355
Electronic ISSN: 1433-7339
DOI
https://doi.org/10.1007/s00520-025-09159-5

ASH 2024 Annual Meeting Coverage

inMIND supports tafasitamab addition in follicular lymphoma

Combining tafasitamab with lenalidomide and rituximab significantly improves progression-free survival for patients with relapsed or refractory follicular lymphoma.

Featuring the official presentation video

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SPONSORED

Recent advances in the use of CAR T-cell therapies in relapsed/refractory diffuse large B-cell lymphoma and follicular lymphoma

In this webinar, Professor Martin Dreyling and an esteemed international panel of CAR T-cell therapy experts discuss the latest data on the safety, efficacy, and clinical impact of CAR T-cell therapies in the treatment of r/r DLBCL and r/r FL.

Please note, this webinar is not intended for healthcare professionals based in the US and UK.

Sponsored by:
  • Novartis Pharma AG
Chaired by: Prof. Martin Dreyling
Developed by: Springer Healthcare
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