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14-07-2024 | Metformin | Research

Effects of exercise mimetics as putative therapeutics on brain health, aging, and neurodegenerative diseases

Author: Reza Sabzevari Rad

Abstract

There is growing evidence that an active lifestyle can benefit brain health, delay the onset of neurodegenerative diseases and aging, and improve mood and cognitive function. Results seem to show that exercise-inspired or exercise-like drugs such as AICAR, metformin, GW501516, resveratrol, epicatechin, transfer plasma, platelet factor 4 and selenium effectively reduce excitotoxicity and mitochondrial dysfunction and improve neurodegenerative disease, angiogenesis and neurogenesis. The beneficial effects of exercise on the brain probably cannot be replaced by a single pill. Despite new discoveries, it is unlikely that a single molecule will ever be able to replicate all the benefits of exercise. Scientists developing drugs that mimic the effects of exercise do not aim to replace regular exercise throughout a person's life, but rather to use it in specific circumstances. However, not everyone is able to play sports due to age-related illnesses, injuries or frailty. The long-term goal is to understand how exercise increases neurogenesis and to try to develop new ways to mimic exercise-induced neurogenesis in people who cannot exercise. Identification of cellular targets activated by exercise could lead to the development of new compounds that can, to some extent, mimic the systemic and central effects of exercise. This review focuses on putative exercise mimetics such as AICAR, resveratrol, metformin, epicatechin, GW501516, transfer plasma, platelet factor 4 and selenium on brain health, neurodegenerative diseases and aging.

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Title: Effects of exercise mimetics as putative therapeutics on brain health, aging, and neurodegenerative diseases
Author: Reza Sabzevari Rad
Publication date: 14-07-2024
Publisher: Springer Milan
Keyword: Metformin
Published in: Sport Sciences for Health
Print ISSN: 1824-7490
Electronic ISSN: 1825-1234
DOI: https://doi.org/10.1007/s11332-024-01187-8

Keynote webinar | Spotlight on modern management of frailty

Springer Medicine

Effects of exercise mimetics as putative therapeutics on brain health, aging, and neurodegenerative diseases

Abstract

Keynote webinar | Spotlight on modern management of frailty

Springer Medicine

Abstract

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