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04-07-2022 | Metastasis | Head and Neck

The expression and significance of vascular endothelial growth factor A in adenoid cystic carcinoma of palatal salivary gland

Authors: Haitao Liu, Linlin Chen, Chenliang Wang, Haibo Zhou

Published in: European Archives of Oto-Rhino-Laryngology | Issue 12/2022

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Abstract

Objective

To explore the VEGF-A expression in salivary gland adenoid cystic carcinoma tissues and detect the relationship between the mechanism of occurrence, development and metastasis of jaws with salivary gland adenoid cystic carcinoma and VEGF-A expression.

Methods

Paraffin samples from 58 cases of SACC of the palate and ten cases of normal salivary gland tissues were collected. The expression levels of VEGF-A protein were detected using the immunohistochemistry EnVision system.

Results

Among the 58 cases, there were 20 cases of the cribriform type, 17 cases of the tubular type, and 21 cases of the solid type. There were 9 cases with lymph node metastasis and 21 cases without lymph node metastasis. And there were 8 cases of T1, 15 cases of T2, and 7 cases of T3/T4. The positive expression rate of VEGF-A in SACC of the palate was 74.1%, which was higher than that found in normal salivary gland tissues (10%). The VEGF-A was localized in the cytoplasm/cell membrane.

Conclusion

VEGF-A is highly expressed in SACC of the palate. The level of expression is closely related to the pathological grade, lymph node metastasis, and clinical stage of the tumor, and it can thus be used as an important indicator for judging the biological behavior of SACC of the palate.
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Metadata
Title
The expression and significance of vascular endothelial growth factor A in adenoid cystic carcinoma of palatal salivary gland
Authors
Haitao Liu
Linlin Chen
Chenliang Wang
Haibo Zhou
Publication date
04-07-2022
Publisher
Springer Berlin Heidelberg
Keyword
Metastasis
Published in
European Archives of Oto-Rhino-Laryngology / Issue 12/2022
Print ISSN: 0937-4477
Electronic ISSN: 1434-4726
DOI
https://doi.org/10.1007/s00405-022-07502-8