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Published in: Journal of Cancer Research and Clinical Oncology 1/2024

Open Access 01-01-2025 | Metastasis | Research

The poor prognosis of lacrimal gland adenocarcinoma: a clinical study and literature review

Authors: Rui Liu, Tingting Ren, Jing Li, Nan Wang, Liangyuan Xu, Qihan Guo, Hong Zhang, Jianmin Ma

Published in: Journal of Cancer Research and Clinical Oncology | Issue 1/2024

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Abstract

Purpose

The incidence of lacrimal gland adenocarcinoma is low. This study was designed to analyze the clinical and prognostic characteristics of lacrimal gland adenocarcinoma.

Methods

This was a clinical study and literature review; 25 patients diagnosed with lacrimal gland adenocarcinoma by histopathology were enrolled and their medical history data were collected.

Results

The incidence of bone destruction and surrounding tissue invasion was 52% and 44%, respectively. The incidence of distant metastasis of lacrimal gland adenocarcinoma was about 50%. The 5-year overall survival rate of death or metastasis was 33.5%. Age, sex, laterality, tumor size, pathology type, bone destruction, nerve or perineural invasion, invasion of peripheral tissue, T stage, AR, Her-2 and treatment had no significant correlation with lacrimal adenocarcinoma’s prognosis (P > 0.05), while the higher expression of Ki-67 may have higher risk of death or metastasis (P = 0.020).

Conclusion

The incidence of bone destruction and distant metastasis of lacrimal adenocarcinoma is high and the imaging examination is necessary to assess the risk of distant metastasis. The 5-year survival rate of death or metastasis is 33.5% and the high expression of Ki-67 predicts poor prognosis of lacrimal adenocarcinoma.
Appendix
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Literature
go back to reference Alkatan H, Roberts F, White VA (2018) Adenocarcinoma of the lacrimal gland. In: Grossniklaus HE, Eberhart CG, Kivelä TT (eds) WHO classification of tumours of the eye. WHO Press, Geneva Alkatan H, Roberts F, White VA (2018) Adenocarcinoma of the lacrimal gland. In: Grossniklaus HE, Eberhart CG, Kivelä TT (eds) WHO classification of tumours of the eye. WHO Press, Geneva
go back to reference Luna-Ortiz K, Dominguez-Malagon H, Corredor-Alonso GE, Reynoso-Noveron N, Herrera-Ponzanelli C, Luna-Peteuil Z, Zacarias-Ramon LC (2022) Clinicopathological and immunohistochemical behavior of ductal carcinoma of the salivary and lacrimal gland in a Mexican Mestizo population. Eur Arch Otorhinolaryngol 279(1):327–333. https://doi.org/10.1007/s00405-021-06757-xCrossRefPubMed Luna-Ortiz K, Dominguez-Malagon H, Corredor-Alonso GE, Reynoso-Noveron N, Herrera-Ponzanelli C, Luna-Peteuil Z, Zacarias-Ramon LC (2022) Clinicopathological and immunohistochemical behavior of ductal carcinoma of the salivary and lacrimal gland in a Mexican Mestizo population. Eur Arch Otorhinolaryngol 279(1):327–333. https://​doi.​org/​10.​1007/​s00405-021-06757-xCrossRefPubMed
Metadata
Title
The poor prognosis of lacrimal gland adenocarcinoma: a clinical study and literature review
Authors
Rui Liu
Tingting Ren
Jing Li
Nan Wang
Liangyuan Xu
Qihan Guo
Hong Zhang
Jianmin Ma
Publication date
01-01-2025
Publisher
Springer Berlin Heidelberg
Published in
Journal of Cancer Research and Clinical Oncology / Issue 1/2024
Print ISSN: 0171-5216
Electronic ISSN: 1432-1335
DOI
https://doi.org/10.1007/s00432-023-05510-7

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