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Drugs

Elinzanetant: First Approval

  • Open Access
  • 12-11-2025
  • Menopause
  • AdisInsight Report
Published in:
Author
Arnold Lee
Published in
Drugs | Issue 1/2026

Abstract

Elinzanetant (Lynkuet™) is a non-hormonal, small-molecule neurokinin 1 (NK1) and 3 (NK3) antagonist being developed by Bayer for the treatment of vasomotor symptoms (VMS), which received its first approval in the UK in July 2025. As a neurokinin-targeted therapy, elinzanetant modulates the activity of hyperactive kisspeptin/neurokinin B/dynorphin neurones to reduce the frequency and severity of VMS, which was demonstrated during the OASIS clinical trials. This article summarizes the milestones in the development of elinzanetant leading to this first approval for the treatment of moderate to severe VMS associated with menopause.
Title
Elinzanetant: First Approval
Author
Arnold Lee
Publication date
12-11-2025
Publisher
Springer International Publishing
Published in
Drugs / Issue 1/2026
Print ISSN: 0012-6667
Electronic ISSN: 1179-1950
DOI
https://doi.org/10.1007/s40265-025-02244-3
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